Full Text Journal Articles by
Author Sayako Katada

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Neural stem/precursor cells dynamically change their epigenetic landscape to differentially respond to BMP signaling for fate switching during brain development.

Sayako Katada, Jun Takouda, Takumi Nakagawa, Mizuki Honda, Katsuhide Igarashi, Takuya Imamura, Yasuyuki Ohkawa, Shoko Sato, Hitoshi Kurumizaka, Kinichi Nakashima,

During neocortical development, tight regulation of neurogenesis-to-astrogenesis switching of neural precursor cells (NPCs) is critical to generate a balanced number of each neural cell type for proper brain functions. Accumulating evidence indicates that a complex array of epigenetic modifications and the availability of extracellular factors control the timing of neuronal ... Read more >>

Genes Dev (Genes & development)
[2021, 35(21-22):1431-1444]

Cited: 0 times

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SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia.

Jun Takouda, Sayako Katada, Takuya Imamura, Tsukasa Sanosaka, Kinichi Nakashima,

The brain consists of three major cell types: neurons and two glial cell types (astrocytes and oligodendrocytes). Although they are generated from common multipotent neural stem/precursor cells (NS/PCs), embryonic NS/PCs cannot generate all of the cell types at the beginning of brain development. NS/PCs first undergo extensive self-renewal to expand ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(6):e00749]

Cited: 1 time

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scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse.

Marie-Theres Wittmann, Sayako Katada, Elisabeth Sock, Philipp Kirchner, Arif B Ekici, Michael Wegner, Kinichi Nakashima, Dieter Chichung Lie, André Reis,

Transcription factor 4 (TCF4) is a crucial regulator of neurodevelopment and has been linked to the pathogenesis of autism, intellectual disability and schizophrenia. As a class I bHLH transcription factor (TF), it is assumed that TCF4 exerts its neurodevelopmental functions through dimerization with proneural class II bHLH TFs. Here, we ... Read more >>

Development (Development (Cambridge, England))
[2021, 148(14):]

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Coadaptation of the chemosensory system with voluntary exercise behavior in mice.

Quynh Anh Thi Nguyen, David Hillis, Sayako Katada, Timothy Harris, Crystal Pontrello, Theodore Garland, Sachiko Haga-Yamanaka,

Ethologically relevant chemical senses and behavioral habits are likely to coadapt in response to selection. As olfaction is involved in intrinsically motivated behaviors in mice, we hypothesized that selective breeding for a voluntary behavior would enable us to identify novel roles of the chemosensory system. Voluntary wheel running (VWR) is ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0241758]

Cited: 0 times

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Coadaptation of the chemosensory system with voluntary exercise behavior in mice

Quynh Anh Thi Nguyen, David Hillis, Sayako Katada, Timothy Harris, Crystal Pontrello, Theodore Garland, Sachiko Haga-Yamanaka,

Ethologically relevant chemical senses and behavioral habits are likely to coadapt in response to selection. As olfaction is involved in intrinsically motivated behaviors in mice, we hypothesized that selective breeding for a voluntary behavior would enable us to identify novel roles of the chemosensory system. Voluntary wheel running (VWR) is ... Read more >>

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Epigenetic regulation for acquiring glial identity by neural stem cells during cortical development.

Takumi Nakagawa, Yoshikuni Wada, Sayako Katada, Yusuke Kishi,

The nervous system consists of several hundred neuronal subtypes and glial cells that show specific gene expression and are generated from common ancestors, neural stem cells (NSCs). As the experimental techniques and molecular tools to analyze epigenetics and chromatin structures are rapidly advancing, the comprehensive events and genome-wide states of ... Read more >>

Glia (Glia)
[2020, 68(8):1554-1567]

Cited: 2 times

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Emerging mechanisms underlying astrogenesis in the developing mammalian brain.

Jun Takouda, Sayako Katada, Kinichi Nakashima,

In the developing brain, the three major cell types, i.e., neurons, astrocytes and oligodendrocytes, are generated from common multipotent neural stem cells (NSCs). In particular, astrocytes eventually occupy a great fraction of the brain and play pivotal roles in the brain development and functions. However, NSCs cannot produce the three ... Read more >>

Proc Jpn Acad Ser B Phys Biol Sci (Proceedings of the Japan Academy. Series B, Physical and biological sciences)
[2017, 93(6):386-398]

Cited: 7 times

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Epigenetic Regulation of Human Neural Stem Cell Differentiation.

Mizuki Honda, Kinichi Nakashima, Sayako Katada,

Emerging evidence has demonstrated that epigenetic programs influence many aspects of neural stem cell (NSC) behavior, including proliferation and differentiation. It is becoming apparent that epigenetic mechanisms, such as DNA methylation, histone modifications, and noncoding RNA expression, are spatiotemporally regulated and that these intracellular programs, in concert with extracellular signals, ... Read more >>

Results Probl Cell Differ (Results and problems in cell differentiation)
[2018, 66:125-136]

Cited: 2 times

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Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain.

Yoichiro Kawamura, Sayako Katada, Hirofumi Noguchi, Hiroyuki Yamamoto, Tsukasa Sanosaka, Koji Iihara, Kinichi Nakashima,

Astrocytes, which support diverse neuronal functions, are generated from multipotent neural stem/precursor cells (NS/PCs) during brain development. Although many astrocyte-inducing factors have been identified and studied in vitro, the regions and/or cells that produce these factors in the developing brain remain elusive. Here, we show that meninges-produced factors induce astrocytic differentiation ... Read more >>

FEBS Lett (FEBS letters)
[2017, 591(22):3709-3720]

Cited: 4 times

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PRMT1 regulates astrocytic differentiation of embryonic neural stem/precursor cells.

Mizuki Honda, Kinichi Nakashima, Sayako Katada,

Arginine methylation is a post-translational modification which is catalyzed by protein arginine methyltransferases (PRMTs). Here, we report that PRMT1 is highly expressed in neural stem/precursor cells (NS/PCs) of mouse embryos, and knockdown of PRMT1 in NS/PCs suppresses the generation of astrocytes. The luciferase assay demonstrated that knockdown of PRMT1 inhibits ... Read more >>

J Neurochem (Journal of neurochemistry)
[2017, 142(6):901-907]

Cited: 9 times

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NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1.

Lorena Aguilar-Arnal, Sayako Katada, Ricardo Orozco-Solis, Paolo Sassone-Corsi,

The circadian clock controls the transcription of hundreds of genes through specific chromatin-remodeling events. The histone methyltransferase mixed-lineage leukemia 1 (MLL1) coordinates recruitment of CLOCK-BMAL1 activator complexes to chromatin, an event associated with cyclic trimethylation of histone H3 Lys4 (H3K4) at circadian promoters. Remarkably, in mouse liver circadian H3K4 trimethylation ... Read more >>

Nat Struct Mol Biol (Nature structural & molecular biology)
[2015, 22(4):312-318]

Cited: 46 times

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Goofy coordinates the acuity of olfactory signaling.

Tomomi Kaneko-Goto, Yuki Sato, Sayako Katada, Emi Kinameri, Sei-ichi Yoshihara, Atsushi Nishiyori, Mitsuhiro Kimura, Hiroko Fujita, Kazushige Touhara, Randall R Reed, Yoshihiro Yoshihara,

The basic scheme of odor perception and signaling from olfactory cilia to the brain is well understood. However, factors that affect olfactory acuity of an animal, the threshold sensitivity to odorants, are less well studied. Using signal sequence trap screening of a mouse olfactory epithelium cDNA library, we identified a ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2013, 33(32):12987-96, 12996a]

Cited: 20 times

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Connecting threads: epigenetics and metabolism.

Sayako Katada, Axel Imhof, Paolo Sassone-Corsi,

Chromatin-modifying enzymes have long been proposed to be the authors of an epigenetic language, but the origin and meaning of the messages they write in chromatin are still mysterious. Recent studies suggesting that the effects of diet can be passed on epigenetically to offspring add weight to the idea that ... Read more >>

Cell (Cell)
[2012, 148(1-2):24-28]

Cited: 162 times

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The circadian clock transcriptional complex: metabolic feedback intersects with epigenetic control.

Selma Masri, Loredana Zocchi, Sayako Katada, Eugenio Mora, Paolo Sassone-Corsi,

Chromatin remodeling is a prerequisite for most nuclear functions, including transcription, silencing, and DNA replication. Accumulating evidence shows that many physiological processes require highly sophisticated events of chromatin remodeling. Recent findings have linked cellular metabolism, epigenetic state, and the circadian clock. The control of a large variety of neuronal, behavioral, ... Read more >>

Ann N Y Acad Sci (Annals of the New York Academy of Sciences)
[2012, 1264:103-109]

Cited: 27 times

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The histone methyltransferase MLL1 permits the oscillation of circadian gene expression.

Sayako Katada, Paolo Sassone-Corsi,

The classical view of the molecular clock is based on interlocked transcriptional-translational feedback loops. Because a substantial fraction of the mammalian genome is expressed in a circadian manner, chromatin remodeling has been proposed to be crucial in clock function. Here we show that Lys4 (K4) trimethylation of histone H3 is ... Read more >>

Nat Struct Mol Biol (Nature structural & molecular biology)
[2010, 17(12):1414-1421]

Cited: 139 times

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PER2 controls lipid metabolism by direct regulation of PPARγ.

Benedetto Grimaldi, Marina Maria Bellet, Sayako Katada, Giuseppe Astarita, Jun Hirayama, Rajesh H Amin, James G Granneman, Daniele Piomelli, Todd Leff, Paolo Sassone-Corsi,

Accumulating evidence highlights intriguing interplays between circadian and metabolic pathways. We show that PER2 directly and specifically represses PPARγ, a nuclear receptor critical in adipogenesis, insulin sensitivity, and inflammatory response. PER2-deficient mice display altered lipid metabolism with drastic reduction of total triacylglycerol and nonesterified fatty acids. PER2 exerts its inhibitory ... Read more >>

Cell Metab (Cell metabolism)
[2010, 12(5):509-520]

Cited: 211 times

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Amino acids involved in conformational dynamics and G protein coupling of an odorant receptor: targeting gain-of-function mutation.

Aya Kato, Sayako Katada, Kazushige Touhara,

Thousands of different odorants are recognized and discriminated by odorant receptors (ORs) in the guanine nucleotide-binding protein (G protein)-coupled seven-transmembrane receptor family. Odorant-bound ORs stimulate Gs-type G proteins, Galphaolf, which in turn activates cAMP-mediated signaling pathway in olfactory sensory neurons. To better understand the molecular basis for OR activation and ... Read more >>

J Neurochem (Journal of neurochemistry)
[2008, 107(5):1261-1270]

Cited: 24 times

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Odorant receptor map in the mouse olfactory bulb: in vivo sensitivity and specificity of receptor-defined glomeruli.

Yuki Oka, Yuki Oka, Sayako Katada, Masayo Omura, Makiko Suwa, Yoshihiro Yoshihara, Kazushige Touhara,

Odorant identity is represented in the olfactory bulb (OB) by the glomerular activity pattern, which reflects a combination of activated odorant receptors (ORs) in the olfactory epithelium. To elucidate this neuronal circuit at the molecular level, we established a functional OR identification strategy based on glomerular activity by combining in ... Read more >>

Neuron (Neuron)
[2006, 52(5):857-869]

Cited: 108 times

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Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site.

Sayako Katada, Takatsugu Hirokawa, Yuki Oka, Makiko Suwa, Kazushige Touhara,

The olfactory receptor (OR) superfamily provides a basis for the remarkable ability to recognize and discriminate a large number of odorants. In mice, the superfamily includes approximately 1000 members, and they recognize overlapping sets of odorants with distinct affinities and specificities. To address the molecular basis of odor discrimination by ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2005, 25(7):1806-1815]

Cited: 156 times

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Structural determinants for membrane trafficking and G protein selectivity of a mouse olfactory receptor.

Sayako Katada, Motonari Tanaka, Kazushige Touhara,

The G protein-coupled olfactory receptor (OR) superfamily plays a critical role in recognizing a broad range of odorants. Each OR appears to recognize odorants based on similarities in molecular structures such that mOR-EG, a mouse OR, binds eugenol, vanillin, and some other structurally related odorants. Only a few ORs, however, ... Read more >>

J Neurochem (Journal of neurochemistry)
[2004, 90(6):1453-1463]

Cited: 48 times

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[A molecular basis for odorant recognition: olfactory receptor pharmacology].

Sayako Katada, Kazushige Touhara,

Olfactory receptors (ORs) comprise the largest super-family of rhodopsin-like G-protein coupled receptors (GPCR) that involve the recognition and discrimination of thousands of odorants. We recently succeeded in functional reconstitution of mouse ORs in mammalian cell lines and provided molecular evidence that structurally-related ORs recognized overlapping sets of odorants with distinct ... Read more >>

Nihon Yakurigaku Zasshi (Nihon yakurigaku zasshi. Folia pharmacologica Japonica)
[2004, 124(4):201-209]

Cited: 2 times

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Odorant response assays for a heterologously expressed olfactory receptor.

Sayako Katada, Takao Nakagawa, Hiroshi Kataoka, Kazushige Touhara,

Odorant responsiveness of a mouse olfactory receptor, mOR-EG, was investigated in various heterologous cells using a variety of detection methods. Odorant-induced Ca(2+) response was observed in HEK293 cells that coexpressed mOR-EG and the promiscuous G protein, G alpha 15. Without G alpha 15, a robust increase in cAMP level was ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2003, 305(4):964-969]

Cited: 75 times

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