Full Text Journal Articles by
Author Savita Kumari

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Acute febrile illness with choreoathetosis: a rare presentation of brucellosis.

Ashok Kumar Pannu, Gauri Jangpangi, Bharath Chhabria, Vikas Suri, Ashish Bhalla, Savita Kumari,

Postgrad Med J (Postgraduate medical journal)
[2021, :]

Cited: 0 times

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Nephroprotective effect of Vanillic acid in STZ-induced diabetic rats.

Savita Kumari, Anjoo Kamboj, Manish Wanjari, Anil Kumar Sharma,

<h4>Purpose</h4>To investigate the protective effect of vanillic acid (VA) in streptozotocin (STZ)-induced diabetic nephropathy (DN) in rats.<h4>Methods</h4>Experimental diabetes mellitus in rats was induced by intraperitoneally administration of single dose of STZ (55 mg/kg). The animals were divided into 5 groups viz., normal control, diabetic control, glimepiride (0.5 mg/kg, orally) and VA treatment ... Read more >>

J Diabetes Metab Disord (Journal of diabetes and metabolic disorders)
[2021, 20(1):571-582]

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Splenic abscess in a tertiary care centre in India: clinical characteristics and prognostic factors.

Anupam K Singh, Saurabh Karmani, Jayanta Samanta, Pankaj Gupta, Vikas Gupta, Thakur D Yadav, Savita Kumari, Usha Dutta, Saroj K Sinha, Rakesh Kochhar,

<h4>Background</h4>Splenic abscess has been an uncommon entity which is now being encountered more frequently due to increased prevalence of immunodeficiency disorders and chronic illnesses. This study was aimed to audit our experience with splenic abscesses at a tertiary care centre in India highlighting usefulness of an algorithmic approach.<h4>Methods</h4>Retrospective analysis of ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2021, 91(9):1819-1825]

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Eosin Y-Catalyzed Synthesis of 3-Aminoimidazo[1,2-a]Pyridines via the HAT Process under Visible Light through Formation of the C-N Bond.

Himanshu Kumar Singh, Arsala Kamal, Savita Kumari, Dhirendra Kumar, Suresh Kumar Maury, Vandana Srivastava, Sundaram Singh,

A comfortable, environment-friendly, and metal-free approach for synthesizing the biologically important moiety aminoimidazopyridine through the multicomponent reaction of benzylamine, 2-aminopyridine, and <i>t</i>-butyl isocyanide under visible light using eosin Y as a photocatalyst has been developed. Inexpensive, nontoxic, the effortless accessibility of starting materials, and nonparticipation of particular glassware and a ... Read more >>

ACS Omega (ACS omega)
[2020, 5(46):29854-29863]

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Cerebrospinal fluid cytology in a young adult with seizures.

Aleena Jain, Parikshaa Gupta, Gaurav Prakash, Savita Kumari, Radhika Srinivasan,

Cytopathology (Cytopathology : official journal of the British Society for Clinical Cytology)
[2021, 32(2):270-273]

Cited: 0 times

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The epidemiology and clinical spectrum of infections of the central nervous system in adults in north India.

Devender Kumar, Ashok Kumar Pannu, Deba Prasad Dhibar, Rajveer Singh, Savita Kumari,

Infections of the central nervous system (CNS) are a leading cause of mortality in low- and middle-income countries. We studied the spectrum, aetiology and outcome of CNS infections in 401 consecutive patients aged ≥12 years admitted at the medical emergency centre of PGIMER, Chandigarh, India. An aetiological diagnosis was made ... Read more >>

Trop Doct (Tropical doctor)
[2021, 51(1):48-57]

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Uric acid as a predictor of endothelial dysfunction in patients with metabolic syndrome.

Charanpreet Singh, Sanjay Jain, Veena Dhawan, Naveen Kalra, Savita Kumari,

<h4>Objective</h4>We conducted a study to examine the association of endothelial dysfunction and oxidative stress with uric acid levels in patients of metabolic syndrome.<h4>Methods</h4>One hundred and two patients of Metabolic Syndrome (International Diabetes Federation definition) were included in the study. Anthropometric measurements, serum uric acid levels, fasting blood sugar levels and ... Read more >>

Arch Endocrinol Metab (Archives of endocrinology and metabolism)
[2021, 64(6):810-815]

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Development and validation of chemical kindling in adult zebrafish: A simple and improved chronic model for screening of antiepileptic agents.

Savita Kumari, Pallavi Sharma, Arindam Ghosh Mazumder, Anil Kumar Rana, Supriya Sharma, Damanpreet Singh,

<h4>Background</h4>Zebrafish has emerged as a potential animal model of acute convulsion for early screening of antiepileptic agents. There is a need for alternative chronic zebrafish models of epilepsy with more correlation to the clinical condition.<h4>New method</h4>Adult zebrafish were repeatedly exposed to subeffective concentrations of pentylenetetrazole (PTZ), until appearance to tonic-clonic ... Read more >>

J Neurosci Methods (Journal of neuroscience methods)
[2020, 346:108916]

Cited: 1 time

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Aetiology of pyrexia of unknown origin in north India.

Ashok Kumar Pannu, Rithvik Golla, Savita Kumari, Vikas Suri, Pankaj Gupta, Rajender Kumar,

The aetiology of pyrexia of unknown origin (PUO) varies dramatically according to epidemiology. We studied the cause and spectrum of PUO in Indian adults. A total of 152 patients (112 prospectively and 40 retrospectively) met Petersdorf and Beeson's criteria. The diagnostic evaluation was guided by potentially diagnostic clues, based on ... Read more >>

Trop Doct (Tropical doctor)
[2021, 51(1):34-40]

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Xpert MTB/RIF for diagnosis of tubercular liver abscess. A case series.

Roshan Agarwala, Sahajal Dhooria, Niranjan S Khaire, Shubhra Mishra, Samman Verma, Jimil Shah, Harshal S Mandavdhare, Savita Kumari, Usha Dutta, Vishal Sharma,

Hepatic involvement is an infrequent manifestation of abdominal tuberculosis and could occur in form of granulomatous hepatitis, nodular involvement or abscess formation. Tubercular liver abscess (TLA) is uncommon, and diagnosing this entity is a challenge. Xpert MTB/RIF (Cepheid, Sunnyvale, CA, USA) assay has been widely used for diagnosing pulmonary tuberculosis ... Read more >>

Infez Med (Le infezioni in medicina)
[2020, 28(3):420-424]

Cited: 1 time

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How to Use a Prioritised Approach for Treating Hematological Disorders During the COVID-19 Pandemic in India?

Arihant Jain, Charanpreet Singh, Rishi Dhawan, Nishant Jindal, Ritin Mohindra, Deepesh Lad, Gaurav Prakash, Alka Khadwal, Vikas Suri, Ashish Bhalla, Savita Kumari, Neelam Varma, M Joseph John, Manoranjan Mahapatra, Pankaj Malhotra,

The current pandemic coronavirus, SARS-CoV-2, is known to cause severe infection (COVID-19) in patients with comorbidities, particularly cancer or an immunosuppressed state. Most healthcare systems in the country are likely to be overwhelmed soon if the pandemic moves to a stage of community transmission. Currently, limited evidence is available for ... Read more >>

Indian J Hematol Blood Transfus (Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion)
[2020, :1-11]

Cited: 4 times

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Association of mild cognitive impairment and metabolic syndrome in patients with hypertension.

Aseem Mehra, Vikas Suri, Savita Kumari, Ajit Avasthi, Sandeep Grover,

<h4>Aim</h4>The aim of this study was to evaluate the prevalence of mild cognitive impairment (MCI) in patients with hypertension and to evaluate the association of MCI with metabolic syndrome (MetS).<h4>Methodology</h4>186 subjects with hypertension were evaluated on Montreal Cognitive Assessment (MoCA) and Patient Health Questionnaire (PHQ-9) for cognitive decline and depression, ... Read more >>

Asian J Psychiatr (Asian journal of psychiatry)
[2020, 53:102185]

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Hesperidin Interacts With CREB-BDNF Signaling Pathway to Suppress Pentylenetetrazole-Induced Convulsions in Zebrafish.

Pallavi Sharma, Savita Kumari, Jatin Sharma, Rituraj Purohit, Damanpreet Singh,

Hesperidin (3,5,7-trihydroxyflavanone 7-rhamnoglucoside) is a β-7-rutinoside of hesperetin (4'-methoxy-3',5,7-trihydroxyflavanone), abundantly found in citrus fruits and known to interact with various cellular pathways to show a variety of pharmacological effects. The present study was envisaged to understand the anticonvulsant effect of hesperidin in a zebrafish model of pentylenetetrazole (PTZ)-induced convulsions, with ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:607797]

Cited: 2 times

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A facile and efficient multicomponent ultrasound-assisted "on water" synthesis of benzodiazepine ring.

Suresh Kumar Maury, Dhirendra Kumar, Arsala Kamal, Himanshu Kumar Singh, Savita Kumari, Sundaram Singh,

A facile and efficient multicomponent synthesis of benzodiazepine ring in water under ultrasound irradiation is reported first time. The current procedure escapes traditional chromatography and purification process and provided the product in excellent yields of 95% as compared to conventional methods. The approach was also validated on gram-scale synthesis. ... Read more >>

Mol Divers (Molecular diversity)
[2021, 25(1):131-142]

Cited: 0 times

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1684. Clinical Profile and Outcome of Scrub Typhus-Related Acute Respiratory Distress Syndrome in Adults Presenting to a Tertiary Care Hospital in North India

Savita Kumari, Vikas Suri, H R Rao, Ashish Bhalla, Inderpaul Singh, Mini P Singh, Manisha Biswal, Kapil Goyal, K Zaman, R K Ratho,

Abstract <h4>Background</h4> To study the clinical profile and outcome of adult patients presenting with Scrub typhus ARDS in emergency at our institute. <h4>Methods</h4> Prospective observational study which included 126 adult patients presenting to emergency department at, PGIMER Chandigarh, a tertiary care referral institute in northwestern India with acute febrile illness ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S616-S617]

Cited: 0 times

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A rare case of malignant metastatic tumor diagnosed on fine-needle aspiration of cervical lymph node.

Arvind Ahuja, Savita Kumari,

Cytojournal (CytoJournal)
[2019, 16:15]

Cited: 0 times

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Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish.

Arindam Ghosh Mazumder, Savita Kumari, Damanpreet Singh,

The role of PI3K/AKT/mTOR signalling pathway has been widely deciphered in pathogenesis of epilepsy. LY294002 is a selective inhibitor of phosphatidylinositol-3-kinase (PI3K). The present study was designed to explore the anticonvulsant potential of LY294002 in a zebrafish model of pentylenetetrazole (PTZ)-mediated convulsions. Zebrafish larvae at 7dpf (days post fertilization) were ... Read more >>

Epilepsy Res (Epilepsy research)
[2019, 157:106207]

Cited: 2 times

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Lemon juice catalyzed C-C bond formation via C-H activation of methylarene: a sustainable synthesis of chromenopyrimidines.

Savita Kumari, Sundaram Singh, Vandana Srivastava,

An economical and proficient approach has been developed for the synthesis of chromenopyrimidines via three-component reaction of thiobarbituric acid/barbituric acid, methylarenes and dimedone/1,3-cyclohexanedione by using lemon juice as a natural, biodegradable catalyst and TBHP as an oxidant. This transformation involves metal-free C-C bond formation via C-H activation of methylarenes under ... Read more >>

Mol Divers (Molecular diversity)
[2020, 24(3):717-725]

Cited: 1 time

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An Unusual Case of Fungating Chest Wall Mass.

Divya Ragate, Charanpreet Singh, Navneet Arora, Arihant Jain, Deepesh Lad, Alka Khadwal, Gaurav Prakash, Savita Kumari, Pankaj Malhotra,

Indian J Hematol Blood Transfus (Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion)
[2020, 36(1):211-212]

Cited: 0 times

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Dengue: Uncommon Neurological Presentations of a Common Tropical Illness.

Harpreet Singh, Ashok Kumar Pannu, Ashish Bhalla, Vikas Suri, Savita Kumari,

Dengue is a common arthropod-borne flavivirus and commonly manifests as fever, bleeding diathesis, and capillary leak syndrome. Neurological manifestations are uncommon except for encephalopathy. We have recently had the opportunity of observing two patients with rare neurological complications of dengue, transverse myelitis, and Guillain-Barré syndrome. Both the cases had good ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2019, 23(6):274-275]

Cited: 0 times

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Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures.

Garima Tanwar, Arindam Ghosh Mazumder, Vijay Bhardwaj, Savita Kumari, Richa Bharti, Yamini, Damanpreet Singh, Pralay Das, Rituraj Purohit,

Pyrrolone-fused benzosuberene (PBS) compounds were semi-synthesized from α,β,γ-Himachalenes extracted from the essential oil of Cedrus deodara following amino-vinyl-bromide substituted benzosuberenes as intermediates. These PBSs compounds classified as an attractive source of therapeutics. The α-isoform of PI3K which is a pivotal modulator of PI3K/AKT/mTOR signaling pathway, responsible for neurological disorders like epilepsy, found as ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):7904]

Cited: 7 times

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A review on biochar modulated soil condition improvements and nutrient dynamics concerning crop yields: Pathways to climate change mitigation and global food security.

T J Purakayastha, T Bera, Debarati Bhaduri, Binoy Sarkar, Sanchita Mandal, Peter Wade, Savita Kumari, Sunanda Biswas, Manoj Menon, H Pathak, Daniel C W Tsang,

The beneficial role of biochar on improvement of soil quality, C sequestration, and enhancing crop yield is widely reported. As such there is not much consolidated information available linking biochar modulated soil condition improvement and soil nutrient availability on crop yields. The present review paper addresses the above issues by ... Read more >>

Chemosphere (Chemosphere)
[2019, 227:345-365]

Cited: 1 time

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Assessment of functional status and daily life problems faced by elderly in a North Indian city.

Sukhpal Kaur, Ashish Bhalla, Savita Kumari, Amarjeet Singh,

BACKGROUND:The increase in proportion of elderly implies that their problems demand more attention of the administrators. The current study was carried out to assess the functional status of the elderly and to explore the extent and pattern of routine daily life problems faced by them. METHODS:An integrated qualitative and quantitative ... Read more >>

Psychogeriatrics (Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society)
[2019, 19(5):419-425]

Cited: 1 time

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Patterns of geriatric anemia: A hospital-based observational study in North India.

Dheeraj Sharma, Vikas Suri, Ashok K Pannu, Savita V Attri, Neelam Varma, Rakesh Kochhar, Subhash Varma, Savita Kumari,

<h4>Background</h4>Geriatric anemia is a global health problem because of its high prevalence and associated significant morbidity and mortality.<h4>Aim</h4>The objectives of this study were to estimate the pattern of anemia in the elderly patients and the underlying etiology of anemia.<h4>Research design and methods</h4>This was a hospital-based prospective observational study, conducted in ... Read more >>

J Family Med Prim Care (Journal of family medicine and primary care)
[2019, 8(3):976-980]

Cited: 1 time

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Early α-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva.

Savita Kumari, Arindam Ghosh Mazumder, Avantika Bhardwaj, Damanpreet Singh,

Over the past few years, there has been a tremendous increase in interest of general population toward food-based therapies for management of chronic clinical conditions due to their lesser adverse effects with prolonged use over pharmacotherapies. Foods enriched with omega-3 fatty acids have shown some promising results in case of ... Read more >>

Prostaglandins Leukot Essent Fatty Acids (Prostaglandins, leukotrienes, and essential fatty acids)
[2019, 143:15-20]

Cited: 3 times

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