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Author Satoru Nagase

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The trend and outcome of postsurgical therapy for high-risk early-stage cervical cancer with lymph node metastasis in Japan: a report from the Japan Society of Gynecologic Oncology (JSGO) guidelines evaluation committee.

Masae Ikeda, Masako Shida, Shogo Shigeta, Satoru Nagase, Fumiaki Takahashi, Wataru Yamagami, Hidetaka Katabuchi, Nobuo Yaegashi, Daisuke Aoki, Mikio Mikami,

<h4>Objective</h4>The Japan Society of Gynecologic Oncology published the first guidelines for the treatment of cervical cancer in 2007. The aim of this research was to evaluate the influence of the introduction of the first guideline on clinical trends and outcomes of patients with early-stage cervical cancer who underwent surgery.<h4>Methods</h4>This analysis ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e44]

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The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.

Hideki Tokunaga, Mikio Mikami, Satoru Nagase, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Toyomi Satoh, Yasuyuki Hirashima, Noriomi Matsumura, Yoshihito Yokoyama, Kei Kawana, Satoru Kyo, Daisuke Aoki, Hidetaka Katabuchi,

The fifth edition of the Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer was published in 2020. The guidelines contain 6 chapters-namely, (1) overview of the guidelines; (2) epithelial ovarian cancer, fallopian tube cancer, and primary peritoneal cancer; (3) ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e49]

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Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual patient report for 2017 and annual treatment report for 2012.

Satoru Nagase, Tsuyoshi Ohta, Fumiaki Takahashi, Nobuo Yaegashi, ,

<h4>Aim</h4>To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2017 and the Annual Treatment Report for 2012, on the outcomes of patients who started treatment in 2012.<h4>Methods</h4>The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2021, :]

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Time for enhancing government-led primary prevention of cervical cancer.

Kyung Jin Min, Dong Hoon Suh, Tsukasa Baba, Xiaojun Chen, Jae Weon Kim, Yusuke Kobayashi, Janice Kwon, Myong Cheol Lim, Jung Yun Lee, Satoru Nagase, Jeong Yeol Park, Siriwan Tangjitgamol, Hidemichi Watari,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(1):e12]

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High Parity Is an Independent Risk Factor for Tooth Loss in Women: A Community-Based Takahata Study in Japan.

Shigeo Ishikawa, Tsuneo Konta, Shinji Susa, Kaoru Edamatsu, Kenichi Ishizawa, Hitoshi Togashi, Satoru Nagase, Yoshiyuki Ueno, Isao Kubota, Hidetoshi Yamashita, Takamasa Kayama, Mitsuyoshi Iino,

Risk factors for tooth loss have been widely examined previously. However, no previous study has comprehensively investigated the risk factors, including lifestyle-related specific factors (parity, oral health habits, and socioeconomic status), for fewer than 20 teeth among women in the general population in Japan. This cross-sectional study explored the association ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2021, 253(1):77-84]

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Impact of lymphadenectomy on the treatment of endometrial cancer using data from the JSOG cancer registry.

Keiko Saotome, Wataru Yamagami, Hiroko Machida, Yasuhiko Ebina, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Takayuki Enomoto, Daisuke Aoki, Mikio Mikami,

<h4>Objective</h4>Regional lymph node (LN) dissection is a standard surgical procedure for endometrial cancer, but there is currently no clear consensus on its therapeutic significance. We aimed to determine the impact of regional LN dissection on the outcome of endometrial cancer.<h4>Methods</h4>Study subjects comprised 36,813 patients who were registered in the gynecological ... Read more >>

Obstet Gynecol Sci (Obstetrics & gynecology science)
[2021, 64(1):80-89]

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Analysis of pathological and clinical characteristics of cervical conization according to age group in Japan.

Isao Murakami, Akiko Ohno, Masae Ikeda, Hiroshi Yamashita, Mikio Mikami, Yoichi Kobayashi, Satoru Nagase, Masatoshi Yokoyama, Takayuki Enomoto, Hidetaka Katabuchi,

<h4>Objective</h4>With increased screening, more patients with precancerous or early cervical cancer are now being identified. Age at pregnancy, and thus number of patients requiring fertility preservation, have also increased, resulting in more diagnostic and therapeutic cervical conization (conization) procedures. We here investigated the pathological and clinical characteristics of patients undergoing ... Read more >>

Heliyon (Heliyon)
[2020, 6(10):e05193]

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Impact of endoplasmic reticulum stress on oocyte aging mechanisms.

Isao Takehara, Hideki Igarashi, Jun Kawagoe, Koki Matsuo, Kyoko Takahashi, Michi Nishi, Satoru Nagase,

Endoplasmic reticulum (ER) stress is associated with several aging-related diseases; however, the mechanism underlying age-related deterioration of oocyte quality is unclear. Here, we used post-ovulatory, in vivo aged mouse oocytes as a model. Super-ovulated oocytes harvested from the oviduct at 14 h and 20 h post-hCG injection were designated as ... Read more >>

Mol Hum Reprod (Molecular human reproduction)
[2020, 26(8):567-575]

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Lymphadenectomy for primary ovarian cancer: a systematic review and meta-analysis.

Tatsuyuki Chiyoda, Manabu Sakurai, Toyomi Satoh, Satoru Nagase, Mikio Mikami, Hidetaka Katabuchi, Daisuke Aoki,

<h4>Objective</h4>To assess the effectiveness of lymphadenectomy at primary debulking surgery (PDS) on the survival of patients with epithelial ovarian cancer (EOC).<h4>Methods</h4>We searched PubMed, Ichushi, and the Cochrane Library. Randomized controlled trials (RCTs) and retrospective cohort studies comparing survival of women with EOC undergoing lymphadenectomy at PDS with that of women ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2020, 31(5):e67]

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Squamous cell carcinoma arising from a mature cystic teratoma of the ovary: Successful treatment with carboplatin, paclitaxel, and bevacizumab.

Mika Fukase, Tsuyoshi Ohta, Norikazu Watanabe, Yuriko Suzuki, Manabu Seino, Takeshi Sudo, Satoru Nagase,

Ovarian mature cystic teratomas (MCT) are usually benign. However, squamous cell carcinoma (SCC) develops in 0.17-2% of MCT. Because of its low frequency, the optimal treatment for this disease is unclear. We present a case of SCC arising from MCT. Our patient was a 30-year-old nulliparous woman complaining of right ... Read more >>

Gynecol Oncol Rep (Gynecologic oncology reports)
[2020, 34:100632]

Cited: 1 time

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Epidemiological guideline influence on the therapeutic trend and patient outcome of uterine cervical cancer in Japan: Japan society of gynecologic oncology guideline evaluation committee project.

Shogo Shigeta, Masako Shida, Satoru Nagase, Masae Ikeda, Fumiaki Takahashi, Takeo Shibata, Wataru Yamagami, Hidetaka Katabuchi, Nobuo Yaegashi, Daisuke Aoki, Mikio Mikami,

<h4>Objective</h4>The Japan Society of Gynecologic Oncology published its first clinical guidelines for uterine cervical cancer in 2007 which has been revised twice in 2011 and 2017. The aim of this study was to investigate the influence of the first guideline publication on the therapeutic trend and patient outcome by analyzing ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 159(1):248-255]

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MicroRNA Let-7c Contributes to Paclitaxel Resistance via Aurora-B in Endometrial Serous Carcinoma.

Izumi Sato, Masumi Ishibashi, Hideki Tokunaga, Shogo Shigeta, Shoko Sakurada, Muneaki Shimada, Satoru Nagase, Yoh Watanabe, Nobuo Yaegashi,

The incidence of endometrial cancer has rapidly risen over recent years. Paclitaxel, a key drug for endometrial cancer treatment, inhibits microtubule depolymerization and induces apoptosis in cancer cells. Endometrial serous carcinoma (ESC) accounts for < 10% of all endometrial carcinomas, but its aggressive nature makes it responsible for close to ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2020, 251(4):263-272]

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xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma.

Akiko Sugiyama, Tsuyoshi Ohta, Miyuki Obata, Kanako Takahashi, Manabu Seino, Satoru Nagase,

Glutathione (GSH) is a primary antioxidant that protects cells against reactive oxygen species (ROS), and high levels of GSH promote cancer cell survival and resistance to chemotherapy. The glutamine transporter xCT is essential for the intracellular synthesis of GSH, whereby xCT determines the intracellular redox balance. However, whether xCT inhibition ... Read more >>

Oncol Lett (Oncology letters)
[2020, 20(3):2689-2700]

Cited: 2 times

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Clinical and image features: large-vessel vasculitis after granulocyte colony stimulating factor administration.

Yasuhiro Sugai, Yuuki Toyoguchi, Masafumi Kanoto, Kazukuni Kirii, Toshitada Hiraka, Yoshihiro Konno, Fumika Watarai, Yukinori Kamio, Manabu Seino, Tsuyoshi Ohta, Satoru Nagase,

<h4>Background</h4>Granulocyte colony stimulating factor (G-CSF) is known to cause vasculitis, mainly in the small vessels. Several cases of large-vessel vasculitis (LVV) caused by G-CSF have recently been reported in the literature; we retrospectively suspect that some cases of LVV in our institution were associated with administration of G-CSF.<h4>Purpose</h4>To evaluate the ... Read more >>

Acta Radiol (Acta radiologica (Stockholm, Sweden : 1987))
[2020, :284185120931685]

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Proposal of a Two-Tier System in Grouping Adenocarcinoma of the Uterine Cervix.

Hiroko Machida, Koji Matsuo, Shinya Matsuzaki, Wataru Yamagami, Yasuhiko Ebina, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Takayuki Enomoto, Mikio Mikami,

(1) Background: This study examined the use of a two-tier system in grouping cervical adenocarcinoma for survival discrimination. (2) Methods: A nationwide retrospective observational cohort study was conducted using the Japan Society of Gynecologic Oncology tumor registry database from 2001 to 2015 (n = 86,754). Adenocarcinoma subtypes were grouped as ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(5):]

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Successful laparoscopic resection of virilizing ovarian steroid cell tumor, not otherwise specified, in a 22-year-old woman: a case report and evaluation of the steroidogenic pathway.

Jun Matsukawa, Toshifumi Takahashi, Yurika Hada, Wataru Kameda, Kuniaki Ota, Mika Fukase, Kyoko Takahashi, Koki Matsuo, Hideki Mizunuma, Satoru Nagase,

OBJECTIVE:Ovarian steroid cell tumor (SCT) is a rare tumor with steroid-producing ability. We report a 22-year-old woman with secondary amenorrhea and hirsutism caused by an ovarian SCT-not otherwise specified (NOS), who underwent successfully laparoscopic resection of the tumor. CASE REPORT:A 22-year-old null gravida woman presented to a hospital, having amenorrhea ... Read more >>

Fukushima J Med Sci (Fukushima journal of medical science)
[2020, 65(3):133-139]

Cited: 1 time

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A retrospective study for investigating the relationship between old and new staging systems with prognosis in ovarian cancer using gynecologic cancer registry of Japan Society of Obstetrics and Gynecology (JSOG): disparity between serous carcinoma and clear cell carcinoma.

Wataru Yamagami, Satoru Nagase, Fumiaki Takahashi, Kazuhiko Ino, Toru Hachisuga, Mikio Mikami, Takayuki Enomoto, Hidetaka Katabuchi, Daisuke Aoki,

OBJECTIVE:International Federation of Gynecology and Obstetrics (FIGO) staging for ovarian, fallopian tube, and peritoneal cancers was revised in 2014. The aim of this study is to clarify whether the revised FIGO2014 staging reflects the prognosis of patients with ovarian cancer by histological type in Japan. METHODS:We extracted 9,747 patients who ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2020, 31(4):e45]

Cited: 2 times

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Clinical and reproductive outcomes of fertility-sparing surgery in stage I epithelial ovarian cancer.

Takafumi Watanabe, Shu Soeda, Hiroshi Nishiyama, Yuichiroh Kiko, Hideki Tokunaga, Shogo Shigeta, Nobuo Yaegashi, Hidekazu Yamada, Tsuyoshi Ohta, Satoru Nagase, Tadahiro Shoji, Masahiro Kagabu, Tsukasa Baba, Dai Shimizu, Naoki Sato, Yukihiro Terada, Masayuki Futagami, Yoshihito Yokoyama, Keiya Fujimori,

The aim of the present study was to evaluate the oncologic safety and reproductive outcome in patients with stage I epithelial ovarian cancer (EOC) treated with fertility-sparing surgery (FSS). Women aged ≤40 years with stage I EOC who had undergone FSS between 2000 and 2010 were retrospectively reviewed. Survival was ... Read more >>

Mol Clin Oncol (Molecular and clinical oncology)
[2020, 12(1):44-50]

Cited: 2 times

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Survival outcome and perioperative complication related to neoadjuvant chemotherapy with carboplatin and paclitaxel for advanced ovarian cancer: A systematic review and meta-analysis.

Hiroko Machida, Hideki Tokunaga, Koji Matsuo, Noriomi Matsumura, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Mikio Mikami,

<h4>Objective</h4>To compare the effectiveness and safety of neoadjuvant chemotherapy with carboplatin/paclitaxel followed by interval debulking surgery (NACT-IDS) to primary debulking surgery plus postoperative chemotherapy (PDS) for advanced ovarian cancer.<h4>Methods</h4>A comprehensive systematic review and meta-analysis were conducted by an Expert Panel of the Japan Society of Gynecologic Oncology Ovarian Cancer Committee. ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2020, 46(5):868-875]

Cited: 2 times

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Japan Society of Gynecologic Oncology 2018 guidelines for treatment of uterine body neoplasms.

Wataru Yamagami, Mikio Mikami, Satoru Nagase, Tsutomu Tabata, Yoichi Kobayashi, Masanori Kaneuchi, Hiroaki Kobayashi, Hidekazu Yamada, Kiyoshi Hasegawa, Hiroyuki Fujiwara, Hidetaka Katabuchi, Daisuke Aoki,

The Fourth Edition of the Guidelines for Treatment of Uterine Body Neoplasm was published in 2018. These guidelines include 9 chapters: 1. Overview of the guidelines, 2. Initial treatment for endometrial cancer, 3. Postoperative adjuvant therapy for endometrial cancer, 4. Post-treatment surveillance for endometrial cancer, 5. Treatment for advanced or ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2020, 31(1):e18]

Cited: 4 times

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Successful management of cutaneous lymphangitis carcinomatosa arising from cervical cancer with paclitaxel-cisplatin and bevacizumab combination therapy: a case report and review of the literature.

Fumihiro Nakamura, Manabu Seino, Yuriko Suzuki, Hirotsugu Sakaki, Takeshi Sudo, Tsuyoshi Ohta, Seiji Tsutsumi, Satoru Nagase,

BACKGROUND:Globally, cervical cancer is the fourth most common cancer in women. Here, we report a case of cutaneous lymphangitis carcinomatosa arising from cervical cancer, an extremely rare and treatment-resistant condition. CASE PRESENTATION:A 64-year-old Japanese woman presented with genital bleeding. She was diagnosed as having stage IB1 squamous cell cervical cancer ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2019, 13(1):328]

Cited: 1 time

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Intraoperative Capsule Rupture, Postoperative Chemotherapy, and Survival of Women With Stage I Epithelial Ovarian Cancer.

Koji Matsuo, Hiroko Machida, Wataru Yamagami, Yasuhiko Ebina, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Takayuki Enomoto, Mikio Mikami,

<h4>Objective</h4>To examine the incidence and prognostic effects of intraoperative capsule rupture and to assess the effectiveness of postoperative chemotherapy for intraoperative tumor rupture in apparent stage I epithelial ovarian cancer.<h4>Methods</h4>This is a society-based retrospective observational study in Japan that examined 15,163 women with stage IA-IC1 epithelial ovarian cancer who underwent ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2019, 134(5):1017-1026]

Cited: 5 times

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Value and limitation of conization as a diagnostic procedure for cervical neoplasm.

Rumiko Yamamoto, Kentaro Sekiyama, Toshihiro Higuchi, Masae Ikeda, Mikio Mikami, Yoichi Kobayashi, Satoru Nagase, Masatoshi Yokoyama, Takayuki Enomoto, Hidetaka Katabuchi,

<h4>Aim</h4>In the recent years, the number of cervical conization procedures performed for diagnostic or therapeutic purposes is increasing, accompanied by increased cervical neoplasia among young women. This study aimed to analyze the clinical data of patients who underwent conization in Japan.<h4>Methods</h4>Among the 14 832 cases of conization registered in 205 facilities ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2019, 45(12):2419-2424]

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A phase II randomized controlled study of pegylated liposomal doxorubicin and carboplatin vs. gemcitabine and carboplatin for platinum-sensitive recurrent ovarian cancer (GOTIC003/intergroup study).

Hiroyuki Fujiwara, Kimio Ushijima, Shoji Nagao, Yuji Takei, Muneaki Shimada, Masashi Takano, Kiyoshi Yoshino, Yoshiaki Kawano, Yasuyuki Hirashima, Satoru Nagase, Shin Nishio, Tadaaki Nishikawa, Kimihiko Ito, Tadahiro Shoji, Eizo Kimura, Tadao Takano, Toru Sugiyama, Junzo Kigawa, Keiichi Fujiwara, Mitsuaki Suzuki,

<h4>Purpose</h4>To compare the efficacy, safety, and tolerability profiles of pegylated liposomal doxorubicin and carboplatin (PLDC) with those of gemcitabine and carboplatin (GC) for the treatment of patients with platinum-sensitive recurrent ovarian cancer.<h4>Methods</h4>Ovarian cancer patients with recurrence > 6 months after first-line platinum and taxane-based therapies were randomly assigned to PLDC [pegylated liposomal doxorubicin ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2019, 24(10):1284-1291]

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Successful laparoscopic treatment of an abdominal pregnancy implanted in the utero-ovarian ligament: a case report of a rare form of ectopic pregnancy.

Satoko Suzuki, Toshifumi Takahashi, Kuniaki Ota, Kyoko Nishimura, Mika Fukase, Norikazu Watanabe, Jun Matsukawa, Koki Matsuo, Jun Kawagoe, Hideki Mizunuma, Satoru Nagase,

J Obstet Gynaecol (Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology)
[2019, 39(4):579-580]

Cited: 0 times

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