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Author Satoru Kyo

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The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.

Hideki Tokunaga, Mikio Mikami, Satoru Nagase, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Toyomi Satoh, Yasuyuki Hirashima, Noriomi Matsumura, Yoshihito Yokoyama, Kei Kawana, Satoru Kyo, Daisuke Aoki, Hidetaka Katabuchi,

The fifth edition of the Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer was published in 2020. The guidelines contain 6 chapters-namely, (1) overview of the guidelines; (2) epithelial ovarian cancer, fallopian tube cancer, and primary peritoneal cancer; (3) ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e49]

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Detection of pure Leydig cell ovarian tumor not visible on imaging by selective venous blood sampling in a woman with secondary amenorrhea and hirsutism: A case report.

Aki Oride, Haruhiko Kanasaki, Hiroe Okada, Satoru Kyo,

A 39-year-old woman (gravida 1, para 1) was referred to a university hospital with a high serum testosterone level and secondary amenorrhea, hirsutism, and weight gain. Her voice was deep, and hirsutism was observed on her chin, arms, and back. She also had clitoromegaly. Her serum testosterone levels were markedly ... Read more >>

Case Rep Womens Health (Case reports in women's health)
[2021, 30:e00298]

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Whole-Exome Sequencing of Rare Site Endometriosis-Associated Cancer.

Sonomi Kurose, Kentaro Nakayama, Sultana Razia, Masako Ishikawa, Tomoka Ishibashi, Hitomi Yamashita, Seiya Sato, Asuka Sakiyama, Shinya Yoshioka, Misa Kobayashi, Satoru Nakayama, Yoshiro Otuski, Noriyoshi Ishikawa, Satoru Kyo,

Malignant transformation of extraovarian endometriosis is rare, with the carcinogenesis mechanism unclear. To clarify the actionable variants of rare-site endometriosis-associated cancer (RSEAC), we performed whole-exome sequencing for the tumor, in two patients. The intestine was affected in both cases, although the histology was that of clear cell carcinoma and undifferentiated ... Read more >>

Diseases (Diseases (Basel, Switzerland))
[2021, 9(1):]

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Pregnancy by Assisted Reproductive Technology Is Associated with Shorter Telomere Length in Neonates.

Toshiko Minamoto, Kentaro Nakayama, Tomoka Ishibashi, Masako Ishikawa, Kohei Nakamura, Hitomi Yamashita, Kamrunnahar Shanta, Hossain Mohammad Mahmud, Sultana Razia, Kouji Iida, Gyosuke Sakashita, Tsukasa Nakamura, Hideyuki Kanda, Satoru Kyo,

Telomere length (TL) influences the development of lifestyle-related diseases, and neonatal TL may influence their prevalence. Various factors have been reported to affect neonatal TL. Although the fetus is exposed to multiple conditions in utero, the main factors affecting the shortening of neonatal TL are still not known. In this ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(24):]

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Nucleus Accumbens-Associated Protein 1 Binds DNA Directly through the BEN Domain in a Sequence-Specific Manner.

Naomi Nakayama, Gyosuke Sakashita, Takashi Nagata, Naohiro Kobayashi, Hisashi Yoshida, Sam-Yong Park, Yuko Nariai, Hiroaki Kato, Eiji Obayashi, Kentaro Nakayama, Satoru Kyo, Takeshi Urano,

Nucleus accumbens-associated protein 1 (NAC1) is a nuclear protein that harbors an amino-terminal BTB domain and a carboxyl-terminal BEN domain. NAC1 appears to play significant and diverse functions in cancer and stem cell biology. Here we demonstrated that the BEN domain of NAC1 is a sequence-specific DNA-binding domain. We selected ... Read more >>

Biomedicines (Biomedicines)
[2020, 8(12):]

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Pathological findings in the endometrium after microwave endometrial ablation.

Kentaro Nakayama, Sultana Razia, Tomoka Ishibashi, Masako Ishikawa, Hitomi Yamashita, Kohei Nakamura, Kiyoka Sawada, Yuki Yoshimura, Nagisa Tatsumi, Sonomi Kurose, Toshiko Minamoto, Kouji Iida, Noriyoshi Ishikawa, Satoru Kyo,

The acceptance of MEA in Japan is well demand due to its outstanding effectiveness and safety. Infrequently, a repeat MEA or hysterectomy is needed for recurrent menorrhagia in case of failure ablation. The reasons of recurrent menorrhagia subsequent MEA treatment are unclear. The objective of current study is to identify ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):20766]

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Endometrial Cancer as a Metabolic Disease with Dysregulated PI3K Signaling: Shedding Light on Novel Therapeutic Strategies.

Satoru Kyo, Kentaro Nakayama,

Endometrial cancer (EC) is one of the most common malignancies of the female reproductive organs. The most characteristic feature of EC is the frequent association with metabolic disorders. However, the components of these disorders that are involved in carcinogenesis remain unclear. Accumulating epidemiological studies have clearly revealed that hyperinsulinemia, which ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(17):]

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Comparison between bidirectional Stratafix® barbed suture and conventional suture in laparoscopic myomectomy: a retrospective study.

Kentaro Nakayama, Sultana Razia, Masako Ishikawa, Hitomi Yamashita, Tomoka Ishibashi, Hiroki Sasamori, Kiyoka Sawada, Sonomi Kurose, Seiya Sato, Satoru Kyo,

<h4>Background</h4>Laparoscopic myomectomy (LM) is one of the techniques feasible for the treatment of intramural myoma. This technique is reported to be difficult when large fibroids are involved because of excessive blood loss during surgery. Skillful and fast suturing appears to be associated with reduced blood loss during LM. In this ... Read more >>

BMC Womens Health (BMC women's health)
[2020, 20(1):164]

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Cancer-associated mutations in normal human endometrium: Surprise or expected?

Satoru Kyo, Seiya Sato, Kentaro Nakayama,

The human endometrium is an essential component in human reproduction that has the unique characteristic of undergoing cyclic regeneration during each menstrual cycle. Vigorous regeneration after shedding may be sustained by stem/progenitor cells, for which molecular markers have not been fully identified. Although clonality analysis using X chromosome inactivation patterns ... Read more >>

Cancer Sci (Cancer science)
[2020, 111(10):3458-3467]

Cited: 2 times

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Roles of intracerebral activin, inhibin, and follistatin in the regulation of Kiss-1 gene expression: Studies using primary cultures of fetal rat neuronal cells.

Zolzaya Tumurgan, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Aki Oride, Hiroe Okada, Satoru Kyo,

Hypothalamic kisspeptin, encoded by the Kiss-1 gene, governs the hypothalamic-pituitary-gonadal axis by directly regulating the release of gonadotropin-releasing hormone. In this study, we examined the roles of activin, inhibin, and follistatin in the regulation of Kiss-1 gene expression using primary cultures of fetal rat neuronal cells, which express the Kiss-1 ... Read more >>

Biochem Biophys Rep (Biochemistry and biophysics reports)
[2020, 23:100785]

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Mucinous borderline ovarian tumors with BRAFV600E mutation may have low risk for progression to invasive carcinomas.

Kaori Ohnishi, Kentaro Nakayama, Masako Ishikawa, Tomoka Ishibashi, Hitomi Yamashita, Kohei Nakamura, Toshiko Minamoto, Kouji Iida, Sultana Razia, Noriyoshi Ishikawa, Satoru Kyo,

<h4>Purpose</h4>Mucinous ovarian carcinomas (MOCs) are relatively rare. It has been proposed that a subset of mucinous cystadenomas (MCAs) may progress to mucinous borderline tumors (MBTs), and then to MOCs. KRAS is the predominantly mutated gene in MOC; however, other associated mutations and the mechanism underlying carcinogenesis in MOC remain unclear. ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2020, 302(2):487-495]

Cited: 1 time

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High PD-1 expression level is associated with an unfavorable prognosis in patients with cervical adenocarcinoma.

Masako Ishikawa, Kentaro Nakayama, Kohei Nakamura, Hitomi Yamashita, Tomoka Ishibashi, Toshiko Minamoto, Kouji Iida, Sultana Razia, Noriyoshi Ishikawa, Satoru Nakayama, Yoshiro Otsuki, Satoru Kyo,

PURPOSE:The effectiveness of immunotherapy for cervical adenocarcinoma (CA) has not been demonstrated yet. Programmed cell death 1 (PD-1), programmed cell death-ligand 1 (PD-L1), and CD8 may be used as biomarkers of response to immune therapy in CA patients. In the present study, we aimed to investigate whether the expression levels ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2020, 302(1):209-218]

Cited: 3 times

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Prognostic Value of Peripheral Blood Lymphocyte Telomere Length in Gynecologic Malignant Tumors.

Kamrunnahar Shanta, Kentaro Nakayama, Masako Ishikawa, Tomoka Ishibashi, Hitomi Yamashita, Seiya Sato, Hiroki Sasamori, Kiyoka Sawada, Sonomi Kurose, Hossain Mohammad Mahmud, Sultana Razia, Kouji Iida, Noriyoshi Ishikawa, Satoru Kyo,

<i>Background:</i> Lymphocyte telomere length is strongly correlated with patient prognosis in several malignant tumor types and is thought to be related to tumor immunity. However, this correlation has not been studied in gynecological cancers. We determined the prognostic significance of peripheral blood lymphocyte telomere length in gynecologic cancers. <i>Methods:</i> Telomere ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(6):]

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SUN-244 Role of Activin, Follistatin, and Inhibin in the Regulation of KISS-1 Gene Expression in Hypothalamic Cell Models

Aki Oride, Haruhiko Kanasaki, Zolzaya Tumurgan, Tuvshintugs Tumurbaatar, Satoru Kyo,

Abstract Kisspeptin (encoded by the Kiss-1 gene) in the arcuate nucleus (ARC) of the hypothalamus governs the hypothalamic-pituitary-gonadal (HPG) axis by regulating pulsatile release of gonadotropin-releasing hormone (GnRH). Meanwhile, kisspeptin in the anteroventral periventricular nucleus (AVPV) region has been implicated in estradiol (E2)-induced GnRH surges. Kiss-1-expressing cell model mHypoA-55 exhibits ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(Suppl 1):]

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SUN-250 Effects of Anti-Mullerian Hormone on the Expression of Gonadotropin Subunits in Pituitary Gonadotroph Cell Models

Haruhiko Kanasaki, Aki Oride, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Satoru Kyo,

Abstract Aim: We examined the effect of anti-Müllerian hormone (AMH) on the expression of gonadotropin subunits in pituitary gonadotrophs.Methods: The mouse pituitary gonadotroph cell line LβT2 was stimulated with AMH and the expression levels of gonadotropin subunits were determined by real-time PCR. We also examined the involvement of the Kiss-1 ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(Suppl 1):]

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Diagnosis of a small Leydig cell tumor by dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging.

Kazuya Okamura, Takeshi Yoshizako, Rika Yoshida, Asuka Araki, Satoru Kyo, Hajime Kitagaki,

Leydig cell tumors are usually small and resemble normal ovarian stroma, so they are often difficult to localize. Here, we present a rare case in 39-year-old woman which dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging findings showed some differences between a Leydig cell tumor and normal ovarian stroma. Combining these ... Read more >>

Radiol Case Rep (Radiology case reports)
[2020, 15(7):875-878]

Cited: 1 time

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Olaparib Monotherapy for BRIP1-Mutated High-Grade Serous Endometrial Cancer.

Kohei Nakamura, Eriko Aimono, Shigeki Tanishima, Mitsuho Imai, Akiko Kawano Nagatsuma, Hideyuki Hayashi, Yuki Yoshimura, Kentaro Nakayama, Satoru Kyo, Hiroshi Nishihara,

JCO Precis Oncol (JCO precision oncology)
[2020, 4:]

Cited: 3 times

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Comparative Retrospective Study of Tension-Free Vaginal Mesh Surgery, Native Tissue Repair, and Laparoscopic Sacrocolpopexy for Pelvic Organ Prolapse Repair.

Haruhiko Kanasaki, Aki Oride, Tomomi Hara, Satoru Kyo,

<h4>Methods</h4>We identified that 308 women who had undergone surgical repair of POP were followed up for at least 6 months. Recurrence rates of POP after tension-free vaginal mesh (TVM) surgery (<i>n</i> = 243), native tissue repair (NTR) (vaginal hysterectomy with colpopexy, anterior and posterior colpoplasty, or circumferential suturing of the levator ani ... Read more >>

Obstet Gynecol Int (Obstetrics and gynecology international)
[2020, 2020:7367403]

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Intratumoral Genomic Heterogeneity May Hinder Precision Medicine Strategies in Patients with Serous Ovarian Carcinoma.

Kohei Nakamura, Eriko Aimono, Shigeki Tanishima, Mitsuho Imai, Akiko Kawano Nagatsuma, Hideyuki Hayashi, Yuki Yoshimura, Kentaro Nakayama, Satoru Kyo, Hiroshi Nishihara,

Precision medicine, which includes comprehensive genome sequencing, is a potential therapeutic option for treating high-grade serous carcinoma (HGSC). However, HGSC is a heterogeneous tumor at the architectural, cellular, and molecular levels. Intratumoral molecular heterogeneity currently limits the precision of medical strategies based on the gene mutation status. This study was ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 10(4):]

Cited: 3 times

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Effects of the Fertility Drugs Clomiphene Citrate and Letrozole on Kiss-1 Expression in Hypothalamic Kiss-1-Expressing Cell Models.

Aki Oride, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Tumurgan Zolzaya, Hiroe Okada, Tomomi Hara, Satoru Kyo,

Clomiphene citrate (CC) and letrozole stimulate the hypothalamic-pituitary-ovarian axis and are used widely as oral fertility drugs to induce folliculogenesis. We examined whether these drugs increase Kiss-1 expression in hypothalamic cell models. We utilized two hypothalamic cell models, mHypoA-50 and mHypoA-55, which originated from Kiss-1 neurons in the anteroventral periventricular ... Read more >>

Reprod Sci (Reproductive sciences (Thousand Oaks, Calif.))
[2020, 27(3):806-814]

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High PD-1 Expression Level is Associated with an Unfavorable Prognosis in Patients with Cervical Adenocarcinoma

Masako Ishikawa, Kentaro Nakayama, Kohei Nakamura, Hitomi Yamashita, Tomoka Ishibashi, Toshiko Minamoto, Kouji Iida, Sultana Razia, Noriyoshi Ishikawa, Satoru Nakayama, Yoshiro Otsuki, Satoru Kyo,

The effectiveness of immunotherapy for cervical adenocarcinoma (CA) has not been demonstrated yet. It may be possible for us to use programmed cell death 1 (PD-1), programmed cell death-ligand 1 (PD-L1), and CD8 as biomarkers of response to immune therapy in CA patients. In the present study, we aimed to ... Read more >>

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Postoperative Outcomes Following Tension-Free Vaginal Mesh Surgery for Pelvic Organ Prolapse: A Retrospective Study.

Aki Oride, Haruhiko Kanasaki, Tomomi Hara, Satoru Kyo,

PURPOSE:We retrospectively reviewed the postoperative outcomes of patients who underwent tension-free vaginal mesh (TVM) surgery in our institution. METHODS:In total, 195 TVM surgeries were performed at the Shimane University School of Medicine from January 2010 to May 2016 in patients with Pelvic Organ Prolapse-Quantification (POP-Q) stage II or higher. Perioperative ... Read more >>

Urol J (Urology journal)
[2019, 16(6):581-585]

Cited: 1 time

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Prolactin Enhances the Proliferation of Proliferative Endometrial Glandular Cells and Endometrial Cancer Cells.

Munekage Yamaguchi, Chimeddulam Erdenebaatar, Fumitaka Saito, Ritsuo Honda, Takashi Ohba, Satoru Kyo, Hironori Tashiro, Hidetaka Katabuchi,

To elucidate the mechanism of endometrial cancer (EC) development in young hyperprolactinemic women, this study assessed the hormonal receptor expression, proliferation, and signaling induced by prolactin in endometrial glands (EG) and EC. Prolactin receptor (PRLR) and estrogen receptor alpha (ER-α) in EG were evaluated during the menstrual cycle by immunohistochemistry. ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(2):bvz029]

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High Frequency of PIK3CA Mutations in Low-Grade Serous Ovarian Carcinomas of Japanese Patients.

Tomoka Ishibashi, Kentaro Nakayama, Sultana Razia, Masako Ishikawa, Kohei Nakamura, Hitomi Yamashita, Puja Dey, Koji Iida, Hiroko Kurioka, Satoru Nakayama, Yoshiro Otsuki, Noriyoshi Ishikawa, Satoru Kyo,

The frequency of KRAS/BRAF mutations associated with low-grade serous ovarian carcinoma (LGSC)/serous borderline tumors (SBTs) in Japan is unknown. We aimed to identify genetic variations in KRAS, BRAF, PIK3CA, and ERBB2 in LGSC/SBT/serous cystadenomas (SCAs) in a Japanese population. We performed a mutation analysis (by Sanger sequencing) of 33 cases ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2019, 10(1):]

Cited: 1 time

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Sarcopenic Factors May Have No Impact on Outcomes in Ovarian Cancer Patients.

Naomi Nakayama, Kentaro Nakayama, Kohei Nakamura, Sultana Razia, Satoru Kyo,

Although the prognostic value of sarcopenic factors, such as loss of muscle mass and quality, have been widely reported in patients with cancer during the last decade, the value in those with ovarian cancer remains unclear. Therefore, this study evaluated the prognostic impact of sarcopenic factors in patients with ovarian ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2019, 9(4):]

Cited: 2 times

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