Full Text Journal Articles by
Author Satoru K Nishimoto

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CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model.

Ruisong Ye, Min Pi, John V Cox, Satoru K Nishimoto, L Darryl Quarles,

GPRC6A is implicated in the pathogenesis of prostate cancer, but its role remains uncertain because of a purported tolerant gene variant created by substitution of a K..Y polymorphism in the 3rd intracellular loop (IL) that evolved in the majority of humans and replaces the ancestral RKLP present in 40% of ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2017, 36(1):90]

Cited: 5 times

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Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues.

Min Pi, Karan Kapoor, Yunpeng Wu, Ruisong Ye, Susan E Senogles, Satoru K Nishimoto, Dong-Jin Hwang, Duane D Miller, Ramesh Narayanan, Jeremy C Smith, Jerome Baudry, L Darryl Quarles,

G protein-coupled receptor (GPCR) family C group 6 member A (GPRC6A) is a multiligand GPCR that is activated by cations, L-amino acids, and osteocalcin. GPRC6A plays an important role in the regulation of testosterone (T) production and energy metabolism in mice. T has rapid, transcription-independent (nongenomic) effects that are mediated ... Read more >>

Mol. Endocrinol. (Molecular endocrinology (Baltimore, Md.))
[2015, 29(12):1759-1773]

Cited: 12 times

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Osteocalcin protects against nonalcoholic steatohepatitis in a mouse model of metabolic syndrome.

Anisha A Gupte, Omaima M Sabek, Daniel Fraga, Laurie J Minze, Satoru K Nishimoto, Joey Z Liu, Solmaz Afshar, Lillian Gaber, Christopher J Lyon, A Osama Gaber, Willa A Hsueh,

Nonalcoholic fatty liver disease, particularly its more aggressive form, nonalcoholic steatohepatitis (NASH), is associated with hepatic insulin resistance. Osteocalcin, a protein secreted by osteoblast cells in bone, has recently emerged as an important metabolic regulator with insulin-sensitizing properties. In humans, osteocalcin levels are inversely associated with liver disease. We thus ... Read more >>

Endocrinology (Endocrinology)
[2014, 155(12):4697-4705]

Cited: 14 times

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The Chlamydia trachomatis CT149 protein exhibits esterase activity in vitro and catalyzes cholesteryl ester hydrolysis when expressed in HeLa cells.

Jan Peters, Vijaya Onguri, Satoru K Nishimoto, Tony N Marion, Gerald I Byrne,

Chlamydia, like other intracellular bacteria, are auxotrophic for a variety of essential metabolites and obtain cholesterol and fatty acids from their eukaryotic host cell, however not many Chlamydia-specific enzymes have been identified that are involved in lipid metabolism. In silico analysis of one candidate Chlamydia trachomatis enzyme, annotated as a ... Read more >>

Microbes Infect. (Microbes and infection)
[2012, 14(13):1196-1204]

Cited: 6 times

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Intra-Golgi formation of IgM-glycosaminoglycan complexes promotes Ig deposition.

Salar N Khan, John V Cox, Satoru K Nishimoto, Ching Chen, Marvin J Fritzler, Linda M Hendershot, Martin Weigert, Marko Radic,

Immune complexes arise from interactions between secreted Ab and Ags in the surrounding milieu. However, it is not known whether intracellular Ag-Ab interactions also contribute to the formation of extracellular immune complexes. In this study, we report that certain murine B cell hybridomas accumulate intracellular IgM and release large, spherical ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2011, 187(6):3198-3207]

Cited: 4 times

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Novel template-casting technique for fabricating beta-tricalcium phosphate scaffolds with high interconnectivity and mechanical strength and in vitro cell responses.

Yongxing Liu, Joong-Hyun Kim, Daniel Young, Sungwoo Kim, Satoru K Nishimoto, Yunzhi Yang,

A novel template-casting method was developed to produce completely interconnected, macroporous biodegradable beta-tricalcium phosphate (beta-TCP) scaffolds, whose architecture and chemistry can be fully manipulated by varying the templates and casting materials. The processing route includes preparation of beta-TCP slurry; casting and shaping into preformed templates comprised of paraffin beads; solidifying, ... Read more >>

J Biomed Mater Res A (Journal of biomedical materials research. Part A)
[2010, 92(3):997-1006]

Cited: 15 times

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A chitosan/beta-glycerophosphate thermo-sensitive gel for the delivery of ellagic acid for the treatment of brain cancer.

Sungwoo Kim, Satoru K Nishimoto, Joel D Bumgardner, Warren O Haggard, M Waleed Gaber, Yunzhi Yang,

We report here the development of a chitosan/beta-glycerophosphate(Ch/beta-GP) thermo-sensitive gel to deliver ellagic acid (EA) for cancer treatment. The properties of the Ch/beta-GP gels were characterized regarding chemical structure, surface morphology, and viscoelasticity. In vitro EA release rate from the EA loaded Ch/beta-GP gel and chitosan degradation rate were investigated. ... Read more >>

Biomaterials (Biomaterials)
[2010, 31(14):4157-4166]

Cited: 63 times

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The effect of titanium surface roughening on protein absorption, cell attachment, and cell spreading.

Satoru K Nishimoto, Miyako Nishimoto, Sang-Won Park, Kwang-Min Lee, Hyun-Seung Kim, Jeong-Tae Koh, Joo L Ong, Yongxing Liu, Yunzhi Yang,

PURPOSE: The purpose of this study was to compare properties of roughened and polished titanium with respect to their ability to attach to cells and bind to protein as well as their cell spreading behavior. MATERIALS AND METHODS: Three different titanium surface treatments were compared for their ability to support ... Read more >>

Int J Oral Maxillofac Implants (The International journal of oral & maxillofacial implants)
[2008, 23(4):675-680]

Cited: 29 times

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Matrix Gla protein C-terminal region binds to vitronectin. Co-localization suggests binding occurs during tissue development.

Satoru K Nishimoto, Miyako Nishimoto,

Matrix Gla protein (MGP) regulates calcification in cartilage and arteries. MGP synthesis during embryonic development and its binding and regulation of growth factors and morphogens of the TGF-beta/BMP superfamily suggests that it has additional functions. Assay by far-western gel overlays and gel filtration shift shows MGP binds vitronectin. Binding is ... Read more >>

Matrix Biol. (Matrix biology : journal of the International Society for Matrix Biology)
[2005, 24(5):353-361]

Cited: 18 times

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Structure, activity, and distribution of fish osteocalcin.

Satoru K Nishimoto, J Herbert Waite, Miyako Nishimoto, Richard W Kriwacki,

Osteocalcin (bone Gla protein) is an extracellular matrix protein synthesized by osteoblasts that is a marker of bone. Osteocalcin probably originated in the ancestors of Teleostei or bony fish and of the Tetrapoda or amphibians, reptiles, birds, and mammals. We have characterized the Cyprinus carpio (carp) osteocalcin for mineral binding ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2003, 278(14):11843-11848]

Cited: 18 times

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