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Cell lineage specification during development of the anterior lateral plate mesoderm and forelimb field

Axel Newton, Sarah Williams, Andrew Major, Craig Smith,

The lateral plate mesoderm (LPM) is a transient embryonic tissue that gives rise to a diverse range of mature cell types, including the cardiovascular system, the urogenital system, endoskeleton of the limbs, and mesenchyme of the gut. While the genetic processes that drive development of these tissues are well defined, ... Read more >>

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Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues.

Sarah E Williams, Maxence Noel, Sylvain Lehoux, Murat Cetinbas, Ramnik J Xavier, Ruslan I Sadreyev, Edward M Scolnick, Jordan W Smoller, Richard D Cummings, Robert G Mealer,

Glycosylation is essential to brain development and function, but prior studies have often been limited to a single analytical technique and excluded region- and sex-specific analyses. Here, using several methodologies, we analyze Asn-linked and Ser/Thr/Tyr-linked protein glycosylation between brain regions and sexes in mice. Brain N-glycans are less complex in ... Read more >>

Nat Commun (Nature communications)
[2022, 13(1):275]

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Real-world Effectiveness of the Pfizer-BioNTech BNT162b2 and Oxford-AstraZeneca ChAdOx1-S Vaccines Against SARS-CoV-2 in Solid Organ and Islet Transplant Recipients.

Chris J Callaghan, Lisa Mumford, Rebecca M K Curtis, Sarah V Williams, Heather Whitaker, Nick Andrews, Jamie Lopez Bernal, Ines Ushiro-Lumb, Gavin J Pettigrew, Douglas Thorburn, John L R Forsythe, Rommel Ravanan, ,

<h4>Background</h4>The clinical effectiveness of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in immunosuppressed solid organ and islet transplant (SOT) recipients is unclear.<h4>Methods</h4>We linked 4 national registries to retrospectively identify laboratory-confirmed SARS-CoV-2 infections and deaths within 28 d in England between September 1, 2020, and August 31, 2021, comparing ... Read more >>

Transplantation (Transplantation)
[2022, :]

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Periodic Breathing in Cardiopulmonary Exercise Testing: Exercise Oscillatory Ventilation in Heart Failure.

Steven J Cassady, Danielle R Glick, Sarah R Williams, Gregory D Lewis,

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2022, 19(1):120-126]

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Assessing the efficacy of coproduction to better understand the barriers to achieving sustainability in NHS chronic kidney services and create alternate pathways.

Leah Mc Laughlin, Gail Williams, Gareth Roberts, David Dallimore, David Fellowes, Joanne Popham, Joanna Charles, James Chess, Sarah Hirst Williams, Jonathan Mathews, Teri Howells, Judith Stone, Linzi Isaac, Jane Noyes,

<h4>Context</h4>Too many people living with chronic kidney disease are opting for and starting on hospital-based dialysis compared to a home-based kidney replacement therapy. Dialysis services are becoming financially unsustainable.<h4>Objective</h4>This study aimed to assess the efficacy of coproductive research in chronic kidney disease service improvement to achieve greater sustainability.<h4>Design</h4>A 2-year coproductive ... Read more >>

Health Expect (Health expectations : an international journal of public participation in health care and health policy)
[2021, :]

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De-novo generation of novel phenotypically active molecules for Chagas disease from biological signatures using AI-driven generative chemistry

Michal Pikusa, Olivier René, Sarah Williams, Yen-Liang Chen, Eric Martin, William Godinez, Srinivasa Rao, Armand Guiguemde, Florian Nigsch,

<h4>Design: </h4> ing novel molecules with targeted biological activities and optimized physicochemical properties is a challenging endeavor in drug discovery. Recent developments in artificial intelligence have enhanced the early steps of de novo drug design and compound optimization. Herein, we present a generative adversarial network trained to design new chemical ... Read more >>

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Bioengineering Strategies to Develop Podocyte Culture Systems.

Sarah Williams, Joseph L Charest, Martin R Pollak, Balajikarthick Subramanian,

Unraveling the complex behavior of healthy and disease podocytes by analyzing the changes in their unique arrangement of foot processes, slit diaphragm, and the three-dimensional (3D) morphology is a long-standing goal in kidney-glomerular research. The complexities surrounding the podocytes' accessibility in animal models and growing evidence of differences between humans ... Read more >>

Tissue Eng Part B Rev (Tissue engineering. Part B, Reviews)
[2021, :]

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Reinfection with new variants of SARS-CoV-2 after natural infection: a prospective observational cohort in 13 care homes in England.

Anna Jeffery-Smith, Thomas A J Rowland, Monika Patel, Heather Whitaker, Nalini Iyanger, Sarah V Williams, Rebecca Giddings, Leah Thompson, Maria Zavala, Felicity Aiano, Joanna Ellis, Angie Lackenby, Katja Höschler, Kevin Brown, Mary E Ramsay, Robin Gopal, J Yimmy Chow, Shamez N Ladhani, Maria Zambon,

<h4>Background</h4>Understanding the duration of protection and risk of reinfection after natural infection is crucial to planning COVID-19 vaccination for at-risk groups, including care home residents, particularly with the emergence of more transmissible variants. We report on the duration, neutralising activity, and protection against the alpha variant of previous SARS-CoV-2 infection ... Read more >>

Lancet Healthy Longev (The Lancet. Healthy longevity)
[2021, 2(12):e811-e819]

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Author Correction: High-throughput and high-efficiency sample preparation for single-cell proteomics using a nested nanowell chip.

Jongmin Woo, Sarah M Williams, Lye Meng Markillie, Song Feng, Chia-Feng Tsai, Victor Aguilera-Vazquez, Ryan L Sontag, Ronald J Moore, Dehong Hu, Hardeep S Mehta, Joshua Cantlon-Bruce, Tao Liu, Joshua N Adkins, Richard D Smith, Geremy C Clair, Ljiljana Pasa-Tolic, Ying Zhu,

Nat Commun (Nature communications)
[2021, 12(1):7075]

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Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

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<h4>Background</h4>Aspirin has been proposed as a treatment for COVID-19 on the basis of its anti-thrombotic properties. We aimed to evaluate the efficacy and safety of aspirin in patients admitted to hospital with COVID-19.<h4>Methods</h4>In this randomised, controlled, open-label, platform trial, several possible treatments were compared with usual care in patients hospitalised ... Read more >>

Lancet (Lancet (London, England))
[2022, 399(10320):143-151]

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British Gynaecological Cancer Society recommendations for women with gynecological cancer who received non-standard care during the COVID-19 pandemic.

Alexandra Taylor, Sudha S Sundar, Rebecca Bowen, Rick Clayton, Sarah Coleridge, Christina Fotopoulou, Sadaf Ghaem-Maghami, Jonathan Ledermann, Ranjit Manchanda, Hilary Maxwell, Agnieszka Michael, Tracie Miles, Shibani Nicum, Andrew Nordin, Bruce Ramsay, Stuart Rundle, Sarah Williams, Nicholas J Wood, Dennis Yiannakis, Jo Morrison,

During the COVID-19 pandemic, pressures on clinical services required adaptation to how care was prioritised and delivered for women with gynecological cancer. This document discusses potential 'salvage' measures when treatment has deviated from the usual standard of care. The British Gynaecological Cancer Society convened a multidisciplinary working group to develop ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2022, 32(1):9-14]

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Highly-Sensitive Lineage Discrimination of SARS-CoV-2 Variants through Allele-Specific Probe Polymerase Chain Reaction

Jeremy Ratcliff, Farah Al-Beidh, Sagida Bibi, David Bonsall, Sue Ann Costa Clemens, Lise Estcourt, Amy Evans, Matthew Fish, Pedro Folegatti, Anthony Gordon, Cecilia Jay, Aislinn Jennings, Emma Laing, Teresa Lambe, George MacIntyre-Cockett, David Menon, Paul Mouncey, Dung Nguyen, Andrew Pollard, Maheshi Ramasamy, David Roberts, Kathryn Rowan, Jennifer Rynne, Manu Shankar-Hari, Sarah Williams, Heli Harvala, Tanya Golubchik, Peter Simmonds, ,

<h4>Introduction</h4> Tools to detect SARS-Coronavirus-2 variants of concern and track the ongoing evolution of the virus are necessary to support public health efforts and the design and evaluation of novel COVID-19 therapeutics and vaccines. Although next-generation sequencing (NGS) has been adopted as the gold standard method for discriminating SARS-CoV-2 lineages, ... Read more >>

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Solvation dynamics-powered structure and function of multi-molecular cellular systems exemplified by non-equilibrium cereblon-degrader-CK1α ternary complex formation

Hongbin Wan, Vibhas Aravamuthan, Sarah Williams, Charles Wartchow, José Duca, Robert Pearlstein,

Cellular functions are executed via a form of analog computing that is based on the switchable covalent and non-covalent states of multi-molecular fluxes (i.e., time-dependent species/state concentrations) operating in the non-linear dynamics regime. We and others have proposed that the non-covalent states and state transitions of aqueous fluxes are powered ... Read more >>

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Making good care essential: The impact of increased obstetric interventions and decreased services during the COVID-19 pandemic.

Kathleen F Rice, Sarah A Williams,

<h4>Problem & background</h4>Since the onset of the COVID-19 pandemic in Canada, policies have been implemented to limit interpersonal contact in clinical and community settings. The impacts of pandemic-related policies on experiences of pregnancy and birth are crucial to investigate and learn from.<h4>Aim</h4>To examine the impact of pandemic policy changes on ... Read more >>

Women Birth (Women and birth : journal of the Australian College of Midwives)
[2021, :]

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General structure-free energy relationships of hERG blocker binding under native cellular conditions

Hongbin Wan, Kristina Spiru, Sarah Williams, Robert Pearlstein,

We proposed previously that aqueous non-covalent barriers arise from solute-induced perturbation of the H-bond network of solvating water (“the solvation field”) relative to bulk solvent, where the association barrier equates to enthalpic losses incurred from incomplete replacement of the H- bonds of expelled H-bond enriched solvation by inter-partner H-bonds, and ... Read more >>

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Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.

, Lise J Estcourt, Alexis F Turgeon, Zoe K McQuilten, Bryan J McVerry, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Donald M Arnold, Abigail Beane, Philippe Bégin, Wilma van Bentum-Puijk, Lindsay R Berry, Zahra Bhimani, Janet E Birchall, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Meredith Buxton, Jeannie L Callum, Michaël Chassé, Allen C Cheng, Matthew E Cove, James Daly, Lennie Derde, Michelle A Detry, Menno De Jong, Amy Evans, Dean A Fergusson, Matthew Fish, Mark Fitzgerald, Claire Foley, Herman Goossens, Anthony C Gordon, Iain B Gosbell, Cameron Green, Rashan Haniffa, Heli Harvala, Alisa M Higgins, Thomas E Hills, Veronica C Hoad, Christopher Horvat, David T Huang, Cara L Hudson, Nao Ichihara, Emma Laing, Abigail A Lamikanra, François Lamontagne, Patrick R Lawler, Kelsey Linstrum, Edward Litton, Elizabeth Lorenzi, Sheila MacLennan, John Marshall, Daniel F McAuley, John F McDyer, Anna McGlothlin, Shay McGuinness, Gail Miflin, Stephanie Montgomery, Paul R Mouncey, Srinivas Murthy, Alistair Nichol, Rachael Parke, Jane C Parker, Nicole Priddee, Damian F J Purcell, Luis F Reyes, Peter Richardson, Nancy Robitaille, Kathryn M Rowan, Jennifer Rynne, Hiroki Saito, Marlene Santos, Christina T Saunders, Ary Serpa Neto, Christopher W Seymour, Jon A Silversides, Alan A Tinmouth, Darrell J Triulzi, Anne M Turner, Frank van de Veerdonk, Timothy S Walsh, Erica M Wood, Scott Berry, Roger J Lewis, David K Menon, Colin McArthur, Ryan Zarychanski, Derek C Angus, Steve A Webb, David J Roberts, Manu Shankar-Hari,

<h4>Importance</h4>The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive.<h4>Objective</h4>To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19.<h4>Design, setting, and participants</h4>The ongoing Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) enrolled and randomized 4763 adults with suspected or ... Read more >>

JAMA (JAMA)
[2021, :]

Cited: 2 times

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Low Risk of Coronavirus Disease 2019 (COVID-19) Among Patients Exposed to Infected Healthcare Workers.

Meghan A Baker, Karen Fiumara, Chanu Rhee, Sarah A Williams, Robert Tucker, Paige Wickner, Andrew Resnick, Michael Klompas,

Many patients are fearful of acquiring coronavirus disease 2019 (COVID-19) in hospitals and clinics. We characterized the risk of COVID-19 among 226 patients exposed to healthcare workers with confirmed COVID-19. One patient may have been infected, suggesting that the risk of COVID-19 transmission from healthcare workers to patients is generally ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 73(7):e1878-e1880]

Cited: 8 times

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Maternal experience of intermittent kangaroo mother care for late preterm infants: a mixed-methods study in four postnatal wards in China.

Bo Zhang, Jieya Yue, Zhiying Duan, Yingxi Zhao, Sarah Williams, Limin Huang, Xiaoqin Zhang, Wenli Wu, Lin Zhang, Jun Liu, Gengli Zhao,

<h4>Objective</h4>To describe how mothers of late preterm infants experienced the provision of intermittent kangaroo mother care (KMC) in four postnatal wards in different hospitals in China, under a pilot KMC project.<h4>Design</h4>A concurrent mixed-methods approach incorporating quantitative maternal questionnaires and qualitative semistructured interviews.<h4>Setting</h4>Four postnatal wards in level-III hospitals based in different ... Read more >>

BMJ Open (BMJ open)
[2021, 11(9):e050221]

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Protocol for a scoping review of neonatal emollient therapy and massage practices throughout sub-Saharan Africa

Keona J.H. Blanks, Milton Musaba, Lily Ren, Kathy Burgoine, David Mukunya, Andrew Clarke, Sarah Williams, Tewodros Gebremichael, Peter Waiswa, Gary Darmstadt,

Background: Serious infections and other complications from very low birth weight and prematurity are the leading causes of death for neonates worldwide. Infections partly result from the compromised skin barrier function in preterm neonates. Optimal skin care practices for neonates, especially in settings with limited access to adequate hygienic conditions, ... Read more >>

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Effects of arousal reappraisal on the anxiety responses to stress: Breaking the cycle of negative arousal intensity and arousal interpretation.

Annie T Ginty, Benjamin J Oosterhoff, Danielle A Young, Sarah E Williams,

Arousal reappraisal has been shown to be an effective strategy during stress to improve anxiety. However, the exact psychological mechanism through which arousal reappraisal improves anxiety is unknown. In a large, cross-sectional study (Study 1, N = 455) participants engaged in an acute psychological stress task and rated their levels of physiological ... Read more >>

Br J Psychol (British journal of psychology (London, England : 1953))
[2022, 113(1):131-152]

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Comparability of six different immunoassays measuring SARS-CoV-2 antibodies with neutralizing antibody levels in convalescent plasma: From utility to prediction.

Abigail Lamikanra, Dung Nguyen, Peter Simmonds, Sarah Williams, Emma M Bentley, Cathy Rowe, Ashley David Otter, Tim Brooks, Kimberly Gilmour, Annabelle Mai, Jusvinder Dadhra, Mabel Csatari, Sheba Ziyenge, Marta Oliveira, Rutger Ploeg, Pat Tsang, Maria Zambon, Robin Gopal, Julie Huiyuan Xiao, Alain Townsend, David Roberts, Heli Harvala,

<h4>Background</h4>Convalescent plasma (CP) therapy for coronavirus disease (COVID-19) provides virus-neutralizing antibodies that may ameliorate the outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. The effectiveness of CP likely depends on its antiviral neutralizing potency and is determined using in vitro neutralizing antibody assays.<h4>Study design and methods</h4>We evaluated abilities ... Read more >>

Transfusion (Transfusion)
[2021, 61(10):2837-2843]

Cited: 4 times

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Seven-month kinetics of SARS-CoV-2 antibodies and role of pre-existing antibodies to human coronaviruses.

Natalia Ortega, Marta Ribes, Marta Vidal, Rocío Rubio, Ruth Aguilar, Sarah Williams, Diana Barrios, Selena Alonso, Pablo Hernández-Luis, Robert A Mitchell, Chenjerai Jairoce, Angeline Cruz, Alfons Jimenez, Rebeca Santano, Susana Méndez, Montserrat Lamoglia, Neus Rosell, Anna Llupià, Laura Puyol, Jordi Chi, Natalia Rodrigo Melero, Daniel Parras, Pau Serra, Edwards Pradenas, Benjamin Trinité, Julià Blanco, Alfredo Mayor, Sonia Barroso, Pilar Varela, Anna Vilella, Antoni Trilla, Pere Santamaria, Carlo Carolis, Marta Tortajada, Luis Izquierdo, Ana Angulo, Pablo Engel, Alberto L García-Basteiro, Gemma Moncunill, Carlota Dobaño,

Unraveling the long-term kinetics of antibodies to SARS-CoV-2 and the individual characteristics influencing it, including the impact of pre-existing antibodies to human coronaviruses causing common cold (HCoVs), is essential to understand protective immunity to COVID-19 and devise effective surveillance strategies. IgM, IgA and IgG levels against six SARS-CoV-2 antigens and ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4740]

Cited: 7 times

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Mastery learning improves simulated central venous catheter insertion by emergency medicine teaching faculty.

Nicholas Pokrajac, Kimberly Schertzer, Kelly N Roszczynialski, Ashley Rider, Sarah R Williams, Cori M Poffenberger, Michael A Gisondi,

<h4>Objectives</h4>Routine competency assessments of procedure skills, such as central venous catheter (CVC) insertion, do not occur beyond residency training. Evidence suggests variable, suboptimal attending physician procedure skills. Our study aimed to assess CVC insertion skill by academic emergency physicians, determine whether a simulation-based mastery learning (SBML) intervention improves performance and ... Read more >>

AEM Educ Train (AEM education and training)
[2021, 5(4):e10703]

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Virological Characterization of Critically Ill Patients With COVID-19 in the United Kingdom: Interactions of Viral Load, Antibody Status, and B.1.1.7 Infection.

Jeremy Ratcliff, Dung Nguyen, Matthew Fish, Jennifer Rynne, Aislinn Jennings, Sarah Williams, Farah Al-Beidh, David Bonsall, Amy Evans, Tanya Golubchik, Anthony C Gordon, Abigail Lamikanra, Pat Tsang, Nick A Ciccone, Ullrich Leuscher, Wendy Slack, Emma Laing, Paul R Mouncey, Sheba Ziyenge, Marta Oliveira, Rutger Ploeg, Kathryn M Rowan, Manu Shankar-Hari, David J Roberts, David K Menon, Lise Estcourt, Peter Simmonds, Heli Harvala, ,

<h4>Background</h4>Convalescent plasma containing neutralizing antibody to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is under investigation for coronavirus disease 2019 (COVID-19) treatment. We report diverse virological characteristics of UK intensive care patients enrolled in the Immunoglobulin Domain of the REMAP-CAP randomized controlled trial that potentially influence treatment outcomes.<h4>Methods</h4>SARS-CoV-2 RNA in ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2021, 224(4):595-605]

Cited: 9 times

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Functional connectomics spanning multiple areas of mouse visual cortex

, Alexander Bae, Mahaly Baptiste, Agnes Bodor, Derrick Brittain, JoAnn Buchanan, Daniel Bumbarger, Manuel Castro, Brendan Celii, Eric Cobos, Forrest Collman, Nuno Macarico da Costa, Sven Dorkenwald, Leila Elabbady, Paul Fahey, Tim Fliss, Emmanouil Froudarakis, Jay Gager, Clare Gamlin, Akhilesh Halageri, James Hebditch, Zhen Jia, Chris Jordan, Dan Kapner, Nico Kemnitz, Sam Kinn, Selden Koolman, Kai Kuehner, Kisuk Lee, Kai Li, Ran Lu, Thomas Macrina, Gayathri Mahalingam, Sarah McReynolds, Elanine Miranda, Eric Mitchell, Shanka Subhra Mondal, Merlin Moore, Shang Mu, Taliah Muhammad, Barak Nehoran, Oluwaseun Ogedengbe, Christos Papadopoulos, Stelios Papadopoulos, Saumil Patel, Xaq Pitkow, Sergiy Popovych, Anthony Ramos, Clay Reid, Jacob Reimer, Casey Schneider-Mizell, Sebastian Seung, Ben Silverman, William Silversmith, Amy Sterling, Fabian Sinz, Cameron Smith, Shelby Suckow, Marc Takeno, Zheng Tan, Andreas Tolias, Russel Torres, Nicholas Turner, Edgar Walker, Tianyu Wang, Grace Williams, Sarah Williams, Kyle Willie, Ryan Willie, William Wong, Jingpeng Wu, Chris Xu, Runzhe Yang, Dimitri Yatsenko, Fei Ye, Wenjing Yin, Szi-chieh Yu,

The value of an integrated approach for understanding the neocortex by combining functional characterization of single neuron activity with the underlying circuit architecture has been understood since the dawn of modern neuroscience. However, in practice, anatomical connectivity and physiology have been studied mostly separately. Following in the footsteps of previous ... Read more >>

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