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Author Sarah Shizuko Morimoto

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Targeting Cognitive Control Deficits With Neuroplasticity-Based Computerized Cognitive Remediation in Patients With Geriatric Major Depression: A Randomized, Double-Blind, Controlled Trial.

Sarah Shizuko Morimoto, Roger Alan Altizer, Faith M Gunning, Willie Hu, Jiacheng Liu, Sarah E Cote, Juliana Nitis, George S Alexopoulos,

Late life major depression (LLD) is often accompanied by cognitive deficits. When patients have specific deficits in cognitive control functions (CCD), they are not only distressing and debilitating, they often predict poor clinical outcomes such as reduced response to SSRI/SNRI antidepressants, increased disability, suicide and all-cause mortality. We recently reported ... Read more >>

Am J Geriatr Psychiatry (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry)
[2020, 28(9):971-980]

Cited: 0 times

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A Lifespan Model of Interference Resolution and Inhibitory Control: Risk for Depression and Changes with Illness Progression.

Katie L Bessette, Aimee J Karstens, Natania A Crane, Amy T Peters, Jonathan P Stange, Kathleen H Elverman, Sarah Shizuko Morimoto, Sara L Weisenbach, Scott A Langenecker,

The cognitive processes involved in inhibitory control accuracy (IC) and interference resolution speed (IR) or broadly - inhibition - are discussed in this review, and both are described within the context of a lifespan model of mood disorders. Inhibitory control (IC) is a binary outcome (success or no for response ... Read more >>

Neuropsychol Rev (Neuropsychology review)
[2020, :]

Cited: 2 times

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Cognitive Control Network Homogeneity and Executive Functions in Late-Life Depression.

Matteo Respino, Matthew J Hoptman, Lindsay W Victoria, George S Alexopoulos, Nili Solomonov, Aliza T Stein, Maria Coluccio, Sarah Shizuko Morimoto, Chloe J Blau, Lila Abreu, Katherine E Burdick, Conor Liston, Faith M Gunning,

BACKGROUND:Late-life depression is characterized by network abnormalities, especially within the cognitive control network. We used alternative functional connectivity approaches, regional homogeneity (ReHo) and network homogeneity, to investigate late-life depression functional homogeneity. We examined the association between cognitive control network homogeneity and executive functions. METHODS:Resting-state functional magnetic resonance imaging data were ... Read more >>

Biol Psychiatry Cogn Neurosci Neuroimaging (Biological psychiatry. Cognitive neuroscience and neuroimaging)
[2020, 5(2):213-221]

Cited: 0 times

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White matter abnormalities predict residual negative self-referential thinking following treatment of late-life depression with escitalopram: A preliminary study.

Lindsay W Victoria, George S Alexopoulos, Irena Ilieva, Aliza T Stein, Matthew J Hoptman, Naib Chowdhury, Matteo Respino, Sarah Shizuko Morimoto, Dora Kanellopoulos, Jimmy N Avari, Faith M Gunning,

BACKGROUND:Negative self-referential thinking is a common symptom of depression associated with poor treatment response. In late-life depression, white matter abnormalities may contribute to negative self-referential thoughts following antidepressant treatment. We investigated the association of fractional anisotropy (FA) in select regions of the negative valence system (NVS) with residual negative self-referential ... Read more >>

J Affect Disord (Journal of affective disorders)
[2019, 243:62-69]

Cited: 1 time

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Short-term repeat cognitive testing and its relationship to hippocampal volumes in older adults.

Kevin Duff, Jeffrey S Anderson, Atul K Mallik, Kayla R Suhrie, Taylor J Atkinson, Bonnie C A Dalley, Sarah Shizuko Morimoto, John M Hoffman,

BACKGROUND:Practice effects are improvements in cognitive test scores due to repeated exposure to testing materials. If practice effects provide information about Alzheimer's disease pathology, then they could be useful for clinical trials enrichment. The current study sought to add to the limited literature on short-term practice effects on cognitive tests ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2018, 57:121-125]

Cited: 2 times

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Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression.

Sarah Shizuko Morimoto, Faith M Gunning, Bruce E Wexler, Willie Hu, Irena Ilieva, Jiacheng Liu, Juliana Nitis, George S Alexopoulos,

OBJECTIVES:Executive dysfunction (ED) is a predictor of poor treatment response of late-life depression to pharmacotherapy. In response to the consistency of these findings, we designed neuroplasticity-based computerized cognitive remediation (nCCR-GD) intervention to target and improve ED in patients who failed to remit with antidepressant treatment. This study tests the hypothesis ... Read more >>

Am J Geriatr Psychiatry (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry)
[2016, 24(10):816-820]

Cited: 8 times

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Diagnosis and treatment of depression and cognitive impairment in late life.

Sarah Shizuko Morimoto, Dora Kanellopoulos, Kevin J Manning, George S Alexopoulos,

Cognitive impairment in late-life depression is prevalent, disabling, and heterogeneous. Although mild cognitive impairment in depression does not usually progress to dementia, accurate assessment of cognition is vital to prognosis and treatment planning. For example, executive dysfunction often accompanies late-life depression, influences performance across cognitive domains, and is associated with ... Read more >>

Ann N Y Acad Sci (Annals of the New York Academy of Sciences)
[2015, 1345:36-46]

Cited: 16 times

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Reward-related decision making in older adults: relationship to clinical presentation of depression.

Amanda R McGovern, George S Alexopoulos, Genevieve S Yuen, Sarah Shizuko Morimoto, Faith M Gunning-Dixon,

Impairment in reward processes has been found in individuals with depression and in the aging population. The purpose of this study was twofold: (1) to use an affective neuroscience probe to identify abnormalities in reward-related decision making in late-life depression; and (2) to examine the relationship of reward-related decision making ... Read more >>

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[2014, 29(11):1125-1131]

Cited: 3 times

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Cognitive Impairment in Depressed Older Adults: Implications for Prognosis and Treatment.

Sarah Shizuko Morimoto, Dora Kanellopoulos, George S Alexopoulos,

Psychiatr Ann (Psychiatric annals)
[2014, 44(3):138-142]

Cited: 7 times

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Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression.

Sarah Shizuko Morimoto, Bruce E Wexler, Jiacheng Liu, Willie Hu, Joanna Seirup, George S Alexopoulos,

Executive dysfunction (ED) in geriatric depression (GD) is common, predicts poor clinical outcomes and often persists despite remission of symptoms. Here we develop a neuroplasticity-based computerized cognitive remediation-geriatric depression treatment (nCCR-GD) to target ED in GD. Our assumption is that remediation of these deficits may modulate the underlying brain network ... Read more >>

Nat Commun (Nature communications)
[2014, 5:4579]

Cited: 22 times

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Cognitive deficits in geriatric depression: clinical correlates and implications for current and future treatment.

Sarah Shizuko Morimoto, George S Alexopoulos,

The purpose of this article is to identify the cognitive deficits commonly associated with geriatric depression and describe their clinical significance. The complex relationship between geriatric depression and dementia is summarized and possible shared mechanisms discussed. Evidence regarding whether the cognitive deficits in depression may be mitigated with medication or ... Read more >>

Psychiatr. Clin. North Am. (The Psychiatric clinics of North America)
[2013, 36(4):517-531]

Cited: 21 times

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Executive functioning complaints and escitalopram treatment response in late-life depression.

Kevin J Manning, George S Alexopoulos, Samprit Banerjee, Sarah Shizuko Morimoto, Joanna K Seirup, Sibel A Klimstra, Genevieve Yuen, Theodora Kanellopoulos, Faith Gunning-Dixon,

Executive dysfunction may play a key role in the pathophysiology of late-life depression. Executive dysfunction can be assessed with cognitive tests and subjective report of difficulties with executive skills. The present study investigated the association between subjective report of executive functioning complaints and time to escitalopram treatment response in older ... Read more >>

Am J Geriatr Psychiatry (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry)
[2015, 23(5):440-445]

Cited: 12 times

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Neuroplasticity-based computerized cognitive remediation for geriatric depression.

Sarah Shizuko Morimoto, Bruce E Wexler, George S Alexopoulos,

This article describes a novel treatment model designed to target specific neurocognitive deficits in geriatric depression with neuroplasticity-based computerized cognitive remediation (NBCCR).The recent National Institute of Mental Health (NIMH) report "From Discovery to Cure" calls for studies focusing on mechanisms of treatment response with the goal of arriving at new ... Read more >>

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[2012, 27(12):1239-1247]

Cited: 14 times

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Immunity, aging, and geriatric depression.

Sarah Shizuko Morimoto, George S Alexopoulos,

Inflammatory processes are likely to play a causal role in geriatric depression. Geriatric depression occurs in the context of illnesses in which inflammatory processes are part of the pathogenesis. Both aging and depression are associated with immune responses, and the connectivity among mood-regulating structures may be modulated by inflammatory responses. ... Read more >>

Psychiatr Clin North Am (The Psychiatric clinics of North America)
[2011, 34(2):437-49, ix]

Cited: 7 times

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Executive function and short-term remission of geriatric depression: the role of semantic strategy.

Sarah Shizuko Morimoto, Faith M Gunning, Christopher F Murphy, Dora Kanellopoulos, Robert E Kelly, George S Alexopoulos,

This study tested the hypothesis that use of semantic organizational strategy in approaching the Mattis Dementia Rating Scale (MDRS) complex verbal initiation/perseveration (CV I/P) task, a test of semantic fluency, is the function specifically associated with remission of late-life depression.Seventy elders with major depression participated in a 12-week escitalopram treatment ... Read more >>

Am J Geriatr Psychiatry (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry)
[2011, 19(2):115-122]

Cited: 21 times

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Semantic organizational strategy predicts verbal memory and remission rate of geriatric depression.

Sarah Shizuko Morimoto, Faith M Gunning, Dora Kanellopoulos, Christopher F Murphy, Sibel A Klimstra, Robert E Kelly, George S Alexopoulos,

This study tests the hypothesis that the use of semantic organizational strategy during the free-recall phase of a verbal memory task predicts remission of geriatric depression.Sixty-five older patients with major depression participated in a 12-week escitalopram treatment trial. Neuropsychological performance was assessed at baseline after a 2-week drug washout period. ... Read more >>

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[2012, 27(5):506-512]

Cited: 22 times

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The inflammation hypothesis in geriatric depression.

George S Alexopoulos, Sarah Shizuko Morimoto,

A large body of research has focused on "mediating mechanisms" and predisposing brain abnormalities to geriatric depression, but little is known about its etiology. This paper examines whether age-related and comorbid disease-related immune deregulation is an etiologic contributor to geriatric depression.This article reviews findings on neuroinflammation during the aging process ... Read more >>

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[2011, 26(11):1109-1118]

Cited: 58 times

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Hybrid ICA-Seed-Based Methods for fMRI Functional Connectivity Assessment: A Feasibility Study.

Robert E Kelly, Zhishun Wang, George S Alexopoulos, Faith M Gunning, Christopher F Murphy, Sarah Shizuko Morimoto, Dora Kanellopoulos, Zhiru Jia, Kelvin O Lim, Matthew J Hoptman,

Brain functional connectivity (FC) is often assessed from fMRI data using seed-based methods, such as those of detecting temporal correlation between a predefined region (seed) and all other regions in the brain; or using multivariate methods, such as independent component analysis (ICA). ICA is a useful data-driven tool, but reproducibility ... Read more >>

Int J Biomed Imaging (International journal of biomedical imaging)
[2010, 2010:]

Cited: 6 times

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Visual inspection of independent components: defining a procedure for artifact removal from fMRI data.

Robert E Kelly, George S Alexopoulos, Zhishun Wang, Faith M Gunning, Christopher F Murphy, Sarah Shizuko Morimoto, Dora Kanellopoulos, Zhiru Jia, Kelvin O Lim, Matthew J Hoptman,

Artifacts in functional magnetic resonance imaging (fMRI) data, primarily those related to motion and physiological sources, negatively impact the functional signal-to-noise ratio in fMRI studies, even after conventional fMRI preprocessing. Independent component analysis' demonstrated capacity to separate sources of neural signal, structured noise, and random noise into separate components might ... Read more >>

J Neurosci Methods (Journal of neuroscience methods)
[2010, 189(2):233-245]

Cited: 193 times

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