Full Text Journal Articles by
Author Sarah M Cohen

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Transcriptional Response to a Dauer-Inducing Ascaroside Cocktail in Late L1 in C. elegans.

Sarah M Cohen, Jessica J Sun, Frank C Schroeder, Paul W Sternberg,

The dauer diapause stage in <i>C. elegans</i> is a non-feeding alternative to the L3 larval stage that is highly resistant to harsh environmental conditions. The decision to enter dauer is a two-step process. First, L1 larvae encounter adverse conditions such as lack of food or overcrowding and decide to enter ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 2 times

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Genome editing of Caenorhabditis briggsae using CRISPR/Cas9 co-conversion marker dpy-10.

Sarah Cohen, Paul Sternberg,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 1 time

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Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival.

Chester J J Wrobel, Jingfang Yu, Pedro R Rodrigues, Andreas H Ludewig, Brian J Curtis, Sarah M Cohen, Bennett W Fox, Michael P O'Donnell, Paul W Sternberg, Frank C Schroeder,

The recently discovered <i>mo</i>dular <i>gl</i>ucosides (MOGLs) form a large metabolite library derived from combinatorial assembly of moieties from amino acid, neurotransmitter, and lipid metabolism in the model organism <i>C. elegans</i>. Combining CRISPR-Cas9 genome editing, comparative metabolomics, and synthesis, we show that the carboxylesterase homologue Cel-CEST-1.2 is responsible for specific 2-<i>O</i>-acylation ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2021, 143(36):14676-14683]

Cited: 0 times

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Normal labor curve in twin gestation.

Hila Hochler, Joshua Guedalia, Michal Lipschuetz, Asnat Walfisch, Simcha Yagel, Efrat Guedalia Friedman, Ron Unger, Ruslan Sergienko, Israel Yoles, Doron Kabiri, Sarah M Cohen, Eyal Sheiner,

<h4>Background</h4>Failure to progress is one of the leading indications for cesarean delivery in trials of labor in twin gestations. However, assessment of labor progression in twin labors is managed according to singleton labor curves.<h4>Objective</h4>This study aimed to establish a partogram for twin deliveries that reflects normal and abnormal labor progression ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, :]

Cited: 1 time

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The impact of peak and duration of maternal intrapartum fever on perinatal outcomes.

Hila Hochler, Michal Lipschuetz, Joshua Guedalia, Gilad Karavani, Sarah M Cohen, Simcha Yagel, Doron Kabiri, Asnat Walfisch,

<h4>Background</h4>Intrapartum fever is a common perinatal complication, associated with short- and long-term adverse outcomes. Limited data exist regarding the association between the peak and duration of maternal fever and the extent and severity of maternal and neonatal complications.<h4>Objective</h4>This study aimed to examine the association between maternal intrapartum fever peak and ... Read more >>

Am J Obstet Gynecol MFM (American journal of obstetrics & gynecology MFM)
[2021, 3(4):100390]

Cited: 0 times

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An integrated model of preeclampsia: a multifaceted syndrome of the maternal cardiovascular-placental-fetal array.

Simcha Yagel, Sarah M Cohen, Debra Goldman-Wohl,

Maternal tolerance of the semiallogenic fetus necessitates conciliation of competing interests. Viviparity evolved with a placenta to mediate the needs of the fetus and maternal adaptation to the demands of pregnancy and to ensure optimal survival for both entities. The maternal-fetal interface is imagined as a 2-dimensional porous barrier between ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, :]

Cited: 1 time

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Successful vaginal birth after cesarean in the second delivery is not associated with the stage of labor of the primary unplanned cesarean delivery.

Aya A Lewkowicz, Michal Lipschuetz, Sarah M Cohen, Joshua Guedalia, Tomer Shwartz, Gabriel Levin, Amihai Rottenstreich, Simcha Yagel,

<h4>Background</h4>Candidates for trial of labor after cesarean must be carefully screened to maximize success and minimize morbidity. Demographic and obstetric characteristics affecting success rates must be delineated.<h4>Objective</h4>We examined whether the labor stage of the primary delivery in which a woman underwent an unplanned cesarean delivery would affect the likelihood that ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2021, 256:109-113]

Cited: 0 times

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Real-time data analysis using a machine learning model significantly improves prediction of successful vaginal deliveries.

Joshua Guedalia, Michal Lipschuetz, Michal Novoselsky-Persky, Sarah M Cohen, Amihai Rottenstreich, Gabriel Levin, Simcha Yagel, Ron Unger, Yishai Sompolinsky,

BACKGROUND:The process of childbirth is one of the most crucial events in the future health and development of the offspring. The vulnerability of parturients and fetuses during the delivery process led to the development of intrapartum monitoring methods and to the emergence of alternative methods of delivery. However, current monitoring ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2020, 223(3):437.e1-437.e15]

Cited: 0 times

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Cervical dilation at the time of epidural catheter insertion is not associated with the degree of prolongation of the first or second stages of labor, or the rate of instrumental vaginal delivery.

Michal Lipschuetz, Eshel A Nir, Sarah M Cohen, Joshua Guedalia, Hila Hochler, Hagai Amsalem, Gilad Karavani, Drorith Hochner-Celnikier, Ron Unger, Simcha Yagel,

INTRODUCTION:Epidural analgesia (EA) is an established option for efficient intrapartum analgesia. Meta-analyses have shown that EA differentially affects the first stage of labor but prolongs the second. The question of EA timing remains open. We aimed to investigate whether EA prolongs delivery in total and whether the EA administration timing ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2020, 99(8):1039-1049]

Cited: 0 times

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Prediction of vaginal birth after cesarean deliveries using machine learning.

Michal Lipschuetz, Joshua Guedalia, Amihai Rottenstreich, Michal Novoselsky Persky, Sarah M Cohen, Doron Kabiri, Gabriel Levin, Simcha Yagel, Ron Unger, Yishai Sompolinsky,

BACKGROUND:Efforts to reduce cesarean delivery rates to 12-15% have been undertaken worldwide. Special focus has been directed towards parturients who undergo a trial of labor after cesarean delivery to reduce the burden of repeated cesarean deliveries. Complication rates are lowest when a vaginal birth is achieved and highest when an ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2020, 222(6):613.e1-613.e12]

Cited: 7 times

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Unplanned Cesarean Delivery in the Second Stage of Labor Holds Higher Odds of Complications than in the First Stage, while Similar in Primiparas and Multiparas.

Michal Lipschuetz, Joshua Guedalia, Sarah M Cohen, Aya A Lewkowicz, Hagai Amsalem, Gilad Karavani, Simcha Yagel, Ron Unger,

<h4>Background</h4>While endeavors to reduce cesarean delivery (CD) rates are given priority worldwide, it is important to evaluate if these efforts place parturients and neonates at risk. CD performed in the second stage of labor carries higher risks of maternal and fetal complications and is a more challenging surgical procedure than ... Read more >>

Fetal Diagn Ther (Fetal diagnosis and therapy)
[2020, 47(7):565-571]

Cited: 0 times

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[PROLONGED SECOND STAGE OF LABOR: CAUSES AND OUTCOMES].

Michal Lipschuetz, Sarah M Cohen, Aya A Lewkowicz, Hagai Amsalem, Rani Haj Yahya, Lorinne Levitt, Simcha Yagel,

<h4>Introduction</h4>Professional bodies have published guidelines defining the length of the second stage of labor and when it is "prolonged", according to parity and epidural anesthesia administration. Recently these guidelines have been extended, aiming to reduce rates of unplanned cesarean deliveries.<h4>Aims</h4>To examine the risk factors and outcomes of a prolonged second ... Read more >>

Harefuah (Harefuah)
[2018, 157(11):685-690]

Cited: 0 times

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Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.

Hiroyuki Hosokawa, Jonas Ungerbäck, Xun Wang, Masaki Matsumoto, Keiichi I Nakayama, Sarah M Cohen, Tomoaki Tanaka, Ellen V Rothenberg,

Immunity (Immunity)
[2018, 49(4):782]

Cited: 4 times

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Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.

Hiroyuki Hosokawa, Jonas Ungerbäck, Xun Wang, Masaki Matsumoto, Keiichi I Nakayama, Sarah M Cohen, Tomoaki Tanaka, Ellen V Rothenberg,

Transcription factors normally regulate gene expression through their action at sites where they bind to DNA. However, the balance of activating and repressive functions that a transcription factor can mediate is not completely understood. Here, we showed that the transcription factor PU.1 regulated gene expression in early T cell development both ... Read more >>

Immunity (Immunity)
[2018, 48(6):1119-1134.e7]

Cited: 35 times

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Vacuum extraction failure is associated with a large head circumference.

Doron Kabiri, Michal Lipschuetz, Sarah M Cohen, Oren Yagel, Lorinne Levitt, Shmuel Herzberg, Yossef Ezra, Simcha Yagel, Hagai Amsalem,

<b>Objective:</b> To determine whether large head circumference increases the risk of vacuum extraction failure. <b>Study design:</b> This EMR-based study included all attempted vacuum extractions performed in a tertiary center between January 2010 and June 2015. All term singleton live births were eligible. Cases were divided into four groups: head circumference ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, 32(20):3325-3330]

Cited: 3 times

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Sonographic large fetal head circumference and risk of cesarean delivery.

Michal Lipschuetz, Sarah M Cohen, Ariel Israel, Joel Baron, Shay Porat, Dan V Valsky, Oren Yagel, Hagai Amsalem, Doron Kabiri, Yinon Gilboa, Eyal Sivan, Ron Unger, Eyal Schiff, Reli Hershkovitz, Simcha Yagel,

<h4>Background</h4>Persistently high rates of cesarean deliveries are cause for concern for physicians, patients, and health systems. Prelabor assessment might be refined by identifying factors that help predict an individual patient's risk of cesarean delivery. Such factors may contribute to patient safety and satisfaction as well as health system planning and ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2018, 218(3):339.e1-339.e7]

Cited: 5 times

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Higher Rates of Operative Delivery and Maternal and Neonatal Complications in Persistent Occiput Posterior Position with a Large Head Circumference: A Retrospective Cohort Study.

Oren Yagel, Sarah M Cohen, Michal Lipschuetz, Tali Bdolah-Abram, Hagai Amsalem, Doron Kabiri, Simcha Yagel,

<h4>Introduction</h4>We investigated whether large head circumference (HC) combined with persistent occiput posterior (OP) position is associated with higher rates of operative delivery and obstetric and neonatal complications than OP deliveries without large HC or in occiput anterior (OA) position.<h4>Materials and methods</h4>Term singleton deliveries in our centers from January 2010 to ... Read more >>

Fetal Diagn Ther (Fetal diagnosis and therapy)
[2018, 44(1):51-58]

Cited: 2 times

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Pelvic floor trauma and maternal age.

Simcha Yagel, Michal Lipschuetz, Sarah M Cohen,

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2017, 217(3):384-385]

Cited: 0 times

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Biosynthesis of Modular Ascarosides in C. elegans.

Oishika Panda, Allison E Akagi, Alexander B Artyukhin, Joshua C Judkins, Henry H Le, Parag Mahanti, Sarah M Cohen, Paul W Sternberg, Frank C Schroeder,

The nematode Caenorhabditis elegans uses simple building blocks from primary metabolism and a strategy of modular assembly to build a great diversity of signaling molecules, the ascarosides, which function as a chemical language in this model organism. In the ascarosides, the dideoxysugar ascarylose serves as a scaffold to which diverse ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2017, 56(17):4729-4733]

Cited: 20 times

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Third- or Fourth-Degree Intrapartum Anal Sphincter Tears Are Associated With Levator Ani Avulsion in Primiparas.

Dan V Valsky, Sarah M Cohen, Michal Lipschuetz, Drorith Hochner-Celnikier, Hagit Daum, Itai Yagel, Simcha Yagel,

<h4>Objectives</h4>We evaluated primiparous women with clinically diagnosed third- and fourth-degree and anal sphincter tears, to evaluate the rate of levator ani muscle injury compared to primiparous women without sphincter tears.<h4>Methods</h4>Primiparous women delivering in our maternity ward with intrapartum diagnoses of third- or fourth-degree anal sphincter tears, repaired by the overlapping ... Read more >>

J Ultrasound Med (Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine)
[2016, 35(4):709-715]

Cited: 4 times

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Third- or Fourth-Degree Intrapartum Anal Sphincter Tears Are Associated With Levator Ani Avulsion in Primiparas.

Dan V Valsky, Sarah M Cohen, Michal Lipschuetz, Drorith Hochner-Celnikier, Hagit Daum, Itai Yagel, Simcha Yagel,

<h4>Objectives</h4>We evaluated primiparous women with clinically diagnosed third- and fourth-degree and anal sphincter tears, to evaluate the rate of levator ani muscle injury compared to primiparous women without sphincter tears.<h4>Methods</h4>Primiparous women delivering in our maternity ward with intrapartum diagnoses of third- or fourth-degree anal sphincter tears, repaired by the overlapping ... Read more >>

J Ultrasound Med (Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine)
[2016, 35(4):709-715]

Cited: 2 times

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A large head circumference is more strongly associated with unplanned cesarean or instrumental delivery and neonatal complications than high birthweight.

Michal Lipschuetz, Sarah M Cohen, Eliana Ein-Mor, Hanna Sapir, Drorith Hochner-Celnikier, Shay Porat, Hagai Amsalem, Dan V Valsky, Yossef Ezra, Matan Elami-Suzin, Ora Paltiel, Simcha Yagel,

<h4>Objective</h4>Fetal size impacts on perinatal outcomes. We queried whether the fetal head, as the fetal part interfacing with the birth canal, might impact on obstetric outcomes more than birthweight (BW). We examined associations between neonatal head circumference (HC) and delivery mode and risk of perinatal complications as compared to high ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2015, 213(6):833.e1-833.e12]

Cited: 9 times

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Degree of bother from pelvic floor dysfunction in women one year after first delivery.

Michal Lipschuetz, Sarah M Cohen, Michal Liebergall-Wischnitzer, Kifah Zbedat, Drorith Hochner-Celnikier, Yuval Lavy, Simcha Yagel,

<h4>Objective</h4>To investigate rates and range of pelvic floor dysfunction complaints, including anterior and posterior compartments and sexual function, in an unselected population of primiparous women one year from delivery, and examine the degree of bother they cause.<h4>Study design</h4>Cross sectional study. Primiparous women who delivered their first child in our delivery ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2015, 191:90-94]

Cited: 11 times

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Noninvasive prenatal testing and fetal sonographic screening: roundtable discussion.

Simcha Yagel, Sarah M Cohen, Beryl R Benacerraf, Howard Cuckle, Karl O Kagan, Ignatia Van den Veyver, Ron Wapner, Wesley Lee,

J Ultrasound Med (Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine)
[2015, 34(3):363-369]

Cited: 2 times

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Detailed transabdominal fetal anatomic scanning in the late first trimester versus the early second trimester of pregnancy.

Simcha Yagel, Sarah M Cohen, Shay Porat, Hagit Daum, Michal Lipschuetz, Hagai Amsalem, Baruch Messing, Dan V Valsky,

<h4>Objectives</h4>To compare visualization rates for early targeted organ scanning at gestational ages ranging from 11 weeks 3 days to 13 weeks 2 days versus 14 weeks 3 days to 16 weeks 2 days.<h4>Methods</h4>We conducted a prospective longitudinal study of patients who presented for nuchal translucency (NT) screening and targeted organ ... Read more >>

J Ultrasound Med (Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine)
[2015, 34(1):143-149]

Cited: 7 times

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