Full Text Journal Articles by
Author Sarah J Stock

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FIGO good practice recommendations on the use of prenatal corticosteroids to improve outcomes and minimize harm in babies born preterm.

Jane Norman, Andrew Shennan, Bo Jacobsson, Sarah J Stock, ,

For women with a singleton or a multiple pregnancy in situations where active neonatal care is appropriate, and for whom preterm birth is anticipated between 24 and 34 weeks of gestation, one course of prenatal corticosteroids should ideally be offered 18 to 72 h before preterm birth is expected to improve outcomes ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):26-30]

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A prognostic model, including quantitative fetal fibronectin, to predict preterm labour: the QUIDS meta-analysis and prospective cohort study.

Sarah J Stock, Margaret Horne, Merel Bruijn, Helen White, Robert Heggie, Lisa Wotherspoon, Kathleen Boyd, Lorna Aucott, Rachel K Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna David, Asma Khalil, Andrew Shennan, Gert-Jan van Baaren, Victoria Hodgetts-Morton, Tina Lavender, Ewoud Schuit, Susan Harper-Clarke, Ben Mol, Richard D Riley, Jane Norman, John Norrie,

<h4>Background</h4>The diagnosis of preterm labour is challenging. False-positive diagnoses are common and result in unnecessary, potentially harmful treatments (e.g. tocolytics, antenatal corticosteroids and magnesium sulphate) and costly hospital admissions. Measurement of fetal fibronectin in vaginal fluid is a biochemical test that can indicate impending preterm birth.<h4>Objectives</h4>To develop an externally validated ... Read more >>

Health Technol Assess (Health technology assessment (Winchester, England))
[2021, 25(52):1-168]

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Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes.

Jessica R Ivy, Roderic N Carter, Jin-Feng Zhao, Charlotte Buckley, Helena Urquijo, Eva A Rog-Zielinska, Emma Panting, Lenka Hrabalkova, Cara Nicholson, Emma J Agnew, Matthew W Kemp, Nicholson N Morton, Sarah J Stock, Caitlin Wyrwoll, Ian G Ganley, Karen E Chapman,

<h4>Key points</h4>Glucocorticoids are steroid hormones that play a vital role in late pregnancy in maturing fetal organs, including the heart. In fetal cardiomyocytes in culture, glucocorticoids promote mitochondrial fatty acids oxidation, suggesting they facilitate the perinatal switch from carbohydrates to fatty acids as the predominant energy substrate. Administration of a ... Read more >>

J Physiol (The Journal of physiology)
[2021, :]

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Cohort Profile: Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II) Database.

Rachel H Mulholland, Eleftheria Vasileiou, Colin R Simpson, Chris Robertson, Lewis D Ritchie, Utkarsh Agrawal, Mark Woolhouse, Josephine Lk Murray, Helen R Stagg, Annemarie B Docherty, Colin McCowan, Rachael Wood, Sarah J Stock, Aziz Sheikh,

Int J Epidemiol (International journal of epidemiology)
[2021, 50(4):1064-1074]

Cited: 1 time

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COVID-19 and maternal and perinatal outcomes.

Lizbeth Burgos Ochoa, Meredith Brockway, Sarah J Stock, Jasper V Been,

Lancet Glob Health (The Lancet. Global health)
[2021, 9(8):e1063-e1064]

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The Arabin pessary to prevent preterm birth in women with a twin pregnancy and a short cervix: the STOPPIT 2 RCT.

Jane E Norman, John Norrie, Graeme MacLennan, David Cooper, Sonia Whyte, Sushila Chowdhry, Sarah Cunningham-Burley, Aileen R Neilson, Xue W Mei, Joel Be Smith, Andrew Shennan, Stephen C Robson, Steven Thornton, Mark D Kilby, Neil Marlow, Sarah J Stock, Philip R Bennett, Jane Denton,

<h4>Background</h4>Preterm birth is common in twins and accounts for significant mortality and morbidity. There are no effective preventative treatments. Some studies have suggested that, in twin pregnancy complicated by a short cervix, the Arabin pessary, which fits around the cervix and can be inserted as an outpatient procedure, reduces preterm ... Read more >>

Health Technol Assess (Health technology assessment (Winchester, England))
[2021, 25(44):1-66]

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Antenatal Exposure to UV-B Radiation and Preeclampsia: A Retrospective Cohort Study.

Claire E Hastie, Daniel F Mackay, Tom L Clemens, Mark P C Cherrie, Lauren J Megaw, Gordon C S Smith, Sarah J Stock, Chris Dibben, Jill P Pell,

Background Risk of preeclampsia varies by month of delivery. We tested whether this seasonal patterning may be mediated through maternal vitamin D concentration using antenatal exposure to UV-B radiation as an instrumental variable. Methods and Results Scottish maternity records were linked to antenatal UV-B exposure derived from satellites between 2000 ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, 10(13):e020246]

Cited: 1 time

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Development and validation of a risk prediction model of preterm birth for women with preterm labour symptoms (the QUIDS study): A prospective cohort study and individual participant data meta-analysis.

Sarah J Stock, Margaret Horne, Merel Bruijn, Helen White, Kathleen A Boyd, Robert Heggie, Lisa Wotherspoon, Lorna Aucott, Rachel K Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna L David, Asma Khalil, Andrew Shennan, Gert-Jan van Baaren, Victoria Hodgetts-Morton, Tina Lavender, Ewoud Schuit, Susan Harper-Clarke, Ben W Mol, Richard D Riley, Jane E Norman, John Norrie,

<h4>Background</h4>Timely interventions in women presenting with preterm labour can substantially improve health outcomes for preterm babies. However, establishing such a diagnosis is very challenging, as signs and symptoms of preterm labour are common and can be nonspecific. We aimed to develop and externally validate a risk prediction model using concentration ... Read more >>

PLoS Med (PLoS medicine)
[2021, 18(7):e1003686]

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Evaluation of the Arabin cervical pessary for prevention of preterm birth in women with a twin pregnancy and short cervix (STOPPIT-2): An open-label randomised trial and updated meta-analysis.

Jane E Norman, John Norrie, Graeme MacLennan, David Cooper, Sonia Whyte, Sue Chowdhry, Sarah Cunningham-Burley, Xue W Mei, Joel B E Smith, Andrew Shennan, Stephen C Robson, Steven Thornton, Mark D Kilby, Neil Marlow, Sarah J Stock, Phillip R Bennett, Jane Denton, ,

<h4>Background</h4>Preterm-labour-associated preterm birth is a common cause of perinatal mortality and morbidity in twin pregnancy. We aimed to test the hypothesis that the Arabin pessary would reduce preterm-labour-associated preterm birth by 40% or greater in women with a twin pregnancy and a short cervix.<h4>Methods and findings</h4>We conducted an open-label randomised ... Read more >>

PLoS Med (PLoS medicine)
[2021, 18(3):e1003506]

Cited: 1 time

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Enabling a healthy start for vulnerable newborns.

Sarah J Stock, Meredith Brockway, Helga Zoega, Jasper V Been, Aziz Sheikh, Zulfiqar A Bhutta, David P Burgner, Meghan B Azad,

Lancet (Lancet (London, England))
[2020, 396(10261):1490]

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Maternal smoking and preterm birth: An unresolved health challenge.

Sarah J Stock, Linda Bauld,

PLoS Med (PLoS medicine)
[2020, 17(9):e1003386]

Cited: 1 time

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Impact of COVID-19 on accident and emergency attendances and emergency and planned hospital admissions in Scotland: an interrupted time-series analysis.

Rachel H Mulholland, Rachael Wood, Helen R Stagg, Colin Fischbacher, Jaime Villacampa, Colin R Simpson, Eleftheria Vasileiou, Colin McCowan, Sarah J Stock, Annemarie B Docherty, Lewis D Ritchie, Utkarsh Agrawal, Chris Robertson, Josephine Lk Murray, Fiona MacKenzie, Aziz Sheikh,

<h4>Objectives</h4>Following the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and the subsequent global spread of the 2019 novel coronavirus disease (COVID-19), health systems and the populations who use them have faced unprecedented challenges. We aimed to measure the impact of COVID-19 on the uptake of hospital-based ... Read more >>

J R Soc Med (Journal of the Royal Society of Medicine)
[2020, 113(11):444-453]

Cited: 12 times

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Postal recruitment for genetic studies of preterm birth: A feasibility study.

Oonagh E Keag, Lee Murphy, Aoibheann Bradley, Naomi Deakin, Sonia Whyte, Jane E Norman, Sarah J Stock,

<b>Background:</b> Preterm birth (PTB) represents the leading cause of neonatal death. Large-scale genetic studies are necessary to determine genetic influences on PTB risk, but prospective cohort studies are expensive and time-consuming. We investigated the feasibility of retrospective recruitment of post-partum women for efficient collection of genetic samples, with self-collected saliva ... Read more >>

Wellcome Open Res (Wellcome open research)
[2020, 5:26]

Cited: 1 time

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Prophylactic Intra-Uterine β-Cyclodextrin Administration during Intra-Uterine Ureaplasma parvum Infection Partly Prevents Liver Inflammation without Interfering with the Enterohepatic Circulation of the Fetal Sheep.

Cathelijne Heymans, Lara R Heij, Kaatje Lenaerts, Marcel den Dulk, Mhamed Hadfoune, Chantal van Heugten, Owen B Spiller, Michael L Beeton, Sarah J Stock, Alan H Jobe, Matthew S Payne, Matthew W Kemp, Boris W Kramer, Jogchum Plat, Wim G van Gemert, Tim G A M Wolfs,

Chorioamnionitis can lead to inflammation and injury of the liver and gut, thereby predisposing patients to adverse outcomes such as necrotizing enterocolitis (NEC). In addition, intestinal bile acids (BAs) accumulation is causally linked to NEC development. Plant sterols are a promising intervention to prevent NEC development, considering their anti-inflammatory properties ... Read more >>

Nutrients (Nutrients)
[2020, 12(5):]

Cited: 1 time

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Quantitative fetal fibronectin for prediction of preterm birth in asymptomatic twin pregnancy.

Katy Kuhrt, Natasha Hezelgrave-Elliott, Sarah J Stock, Rachel Tribe, Paul T Seed, Andrew H Shennan,

<b>Introduction: </b>To evaluate cervicovaginal fluid quantitative fetal fibronectin, measured by a bedside analyzer, to predict spontaneous preterm birth in twin pregnancy before 30 weeks of gestation.<br><br><b>Material and methods: </b>In a prospective cohort study, we studied the accuracy of quantitative fetal fibronectin measured between 18 and 27<sup>+6</sup> weeks of gestation in ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2020, 99(9):1191-1197]

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Corrigendum: Chronic Intra-Uterine Ureaplasma parvum Infection Induces Injury of the Enteric Nervous System in Ovine Fetuses.

Cathelijne Heymans, Ilse H de Lange, Matthias C Hütten, Kaatje Lenaerts, Nadine J E de Ruijter, Lilian C G A Kessels, Glenn Rademakers, Veerle Melotte, Werend Boesmans, Masatoshi Saito, Haruo Usuda, Sarah J Stock, Owen B Spiller, Michael L Beeton, Matthew S Payne, Boris W Kramer, John P Newnham, Alan H Jobe, Matthew W Kemp, Wim G van Gemert, Tim G A M Wolfs,

[This corrects the article DOI: 10.3389/fimmu.2020.00189.]. ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:672]

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Chronic Intra-Uterine Ureaplasma parvum Infection Induces Injury of the Enteric Nervous System in Ovine Fetuses.

Cathelijne Heymans, Ilse H de Lange, Matthias C Hütten, Kaatje Lenaerts, Nadine J E de Ruijter, Lilian C G A Kessels, Glenn Rademakers, Veerle Melotte, Werend Boesmans, Masatoshi Saito, Haruo Usuda, Sarah J Stock, Owen B Spiller, Michael L. Beeton, Matthew S Payne, Boris W Kramer, John P Newnham, Alan H Jobe, Matthew W Kemp, Wim G van Gemert, Tim G A M Wolfs,

<b>Background:</b> Chorioamnionitis, inflammation of the fetal membranes during pregnancy, is often caused by intra-amniotic (IA) infection with single or multiple microbes. Chorioamnionitis can be either acute or chronic and is associated with adverse postnatal outcomes of the intestine, including necrotizing enterocolitis (NEC). Neonates with NEC have structural and functional damage ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:189]

Cited: 4 times

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Inflammation-mediated generation and inflammatory potential of human placental cell-free fetal DNA.

Sara R van Boeckel, Heather Macpherson, Jane E Norman, Donald J Davidson, Sarah J Stock,

<h4>Introduction</h4>Circulating DNA can be pro-inflammatory when detected by leukocytes via toll-like receptor 9 (TLR9). Cell-free fetal DNA (cff-DNA) of placental origin, circulates in pregnancy, and increased concentrations are seen in conditions associated with placental and maternal inflammation such as pre-eclampsia. However, whether cff-DNA is directly pro-inflammatory in pregnant women and ... Read more >>

Placenta (Placenta)
[2020, 93:49-55]

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Cervical epithelial damage promotes Ureaplasma parvum ascending infection, intrauterine inflammation and preterm birth induction in mice.

Ioannis Pavlidis, Owen B Spiller, Gabriella Sammut Demarco, Heather MacPherson, Sarah E M Howie, Jane E Norman, Sarah J Stock,

Around 40% of preterm births are attributed to ascending intrauterine infection, and Ureaplasma parvum (UP) is commonly isolated in these cases. Here we present a mouse model of ascending UP infection that resembles human disease, using vaginal inoculation combined with mild cervical injury induced by a common spermicide (Nonoxynol-9, as ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):199]

Cited: 9 times

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Gestational age at delivery of twins and perinatal outcomes: a cohort study in Aberdeen, Scotland.

Sarah R Murray, Sohinee Bhattacharya, Sarah J Stock, Jill P Pell, Jane E Norman,

<b>Background:</b> Twin pregnancy is associated with a threefold increase in perinatal death compared to singletons.  The objective of this study was to determine the risk of perinatal death in twins by week of gestation and to quantify the effect of known risk factors. <b>Methods:</b> A cohort analysis was performed using ... Read more >>

Wellcome Open Res (Wellcome open research)
[2019, 4:65]

Cited: 0 times

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Preterm labour decision-making and experiences of care for women and clinicians (QUIDS Qualitative): A qualitative exploration.

Helen White, Victoria Hodgetts Morton, Sarah J Stock, Tina Lavender,

<h4>Background</h4>Minimising the risks of mortality, morbidities, and the costs associated with preterm birth is reliant on accurate prediction, appropriate decision-making and timely intervention. This study aimed to determine for the first time the decisional and informational requirements of women and clinicians during preterm labour diagnosis and intervention. A secondary objective ... Read more >>

Sex Reprod Healthc (Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives)
[2019, 21:95-101]

Cited: 2 times

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Cathelicidins and the Onset of Labour.

Sara R van Boeckel, Lenka Hrabalkova, Tina L Baker, Heather MacPherson, Lorraine Frew, Ashley K Boyle, Brian J McHugh, Kirsten Wilson, Jane E Norman, Julia R Dorin, Donald J Davidson, Sarah J Stock,

Preterm birth, defined as delivery before 37 weeks of gestation, is the leading cause of neonatal mortality and morbidity. Infection and inflammation are frequent antecedents of spontaneous preterm birth. Cathelicidin, an antimicrobial host defence peptide, is induced by infection and inflammation and although expressed in the reproductive tract and fetal ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):7356]

Cited: 1 time

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Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols.

Charlotte van Gorp, Ilse H de Lange, Owen B Spiller, Frédéric Dewez, Berta Cillero Pastor, Ron M A Heeren, Lilian Kessels, Nico Kloosterboer, Wim G van Gemert, Michael L Beeton, Sarah J Stock, Alan H Jobe, Matthew S Payne, Matthew W Kemp, Luc J Zimmermann, Boris W Kramer, Jogchum Plat, Tim G A M Wolfs,

Chorioamnionitis, clinically most frequently associated with <i>Ureaplasma</i>, is linked to intestinal inflammation and subsequent gut injury. No treatment is available to prevent chorioamnionitis-driven adverse intestinal outcomes. Evidence is increasing that plant sterols possess immune-modulatory properties. Therefore, we investigated the potential therapeutic effects of plant sterols in lambs intra-amniotically (IA) exposed ... Read more >>

Nutrients (Nutrients)
[2019, 11(5):]

Cited: 3 times

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HPV infection and pre-term birth: a data-linkage study using Scottish Health Data.

Marian C Aldhous, Ramya Bhatia, Roz Pollock, Dionysis Vragkos, Kate Cuschieri, Heather A Cubie, Jane E Norman, Sarah J Stock,

<b>Background:</b> We aimed to investigate whether infection with high-risk (HR) types of human papilloma virus (HPV) or HPV-associated cervical disease were associated with preterm birth (<37 weeks gestation). In a sub-group of younger women who were eligible for the HPV vaccine, we aimed to determine whether prior vaccination against the ... Read more >>

Wellcome Open Res (Wellcome open research)
[2019, 4:48]

Cited: 3 times

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Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection.

Holger W Unger, Annjaleen P Hansa, Christelle Buffet, Wina Hasang, Andrew Teo, Louise Randall, Maria Ome-Kaius, Stephan Karl, Ayen A Anuan, James G Beeson, Ivo Mueller, Sarah J Stock, Stephen J Rogerson,

Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP) and SP plus azithromycin (SPAZ) reduces low birthweight (<2,500 g) in women without malarial and reproductive tract infections. This study investigates the impact of SPAZ on associations between plasma biomarkers of inflammation and angiogenesis and adverse pregnancy outcomes in 2,012 Papua New Guinean women. Concentrations ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):2260]

Cited: 6 times

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