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Author Sara Mertz

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Age-dependent Interactions Among Clinical Characteristics, Viral Loads and Disease Severity in Young Children With Respiratory Syncytial Virus Infection.

Helena Brenes-Chacon, Cristina Garcia-Mauriño, Melissa Moore-Clingenpeel, Sara Mertz, Fang Ye, Daniel M Cohen, Octavio Ramilo, Asuncion Mejias,

<h4>Background</h4>Age-dependent differences in clinical presentation and viral loads in infants and young children with respiratory syncytial virus (RSV) infection, and their correlation with disease severity are poorly defined.<h4>Methods</h4>Previously healthy children <2 years old with mild (outpatients) and severe (inpatients) RSV infection were enrolled and viral loads measured by polymerase chain ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(2):116-122]

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1465. Age-Dependent Interactions Among Clinical Characteristics, Viral Loads and Disease Severity in Young Children with Respiratory Syncytial Virus Infection (RSV) Infection

Helena Brenes-Chacon, Cristina Garcia-Maurino, Melissa Moore-Clingenpeel, Sara Mertz, Fang Ye, Daniel M Cohen, Octavio Ramilo, Asuncion Mejias,

Abstract <h4>Background</h4> Differences in clinical presentation and viral loads according to age in young children with RSV, and their correlation with disease severity are poorly defined. The aim of this study was to define age-dependent the differences in demographic, clinical factors and viral loads between children < 2 years of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S734-S735]

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131. The Protective Role of Mucosal Interferons in Infants with Respiratory Syncytial Virus (RSV) Infection

Jeanette Taveras, Cristina Garcia-Maurino, Melissa Moore-Clingenpeel, Sara Mertz, Mark E Peeples, Octavio Ramilo, Asuncion Mejias,

Abstract <h4>Background</h4> Despite the high burden associated with RSV infection in young children the factors that determine disease severity are not well understood. The objective of this study was to assess the association of mucosal cytokine profiles, RSV loads (VL) and RSV disease severity. <h4>Methods</h4> Single-center, prospective study in previously ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S195-S196]

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Immune profiles provide insights into respiratory syncytial virus disease severity in young children.

Santtu Heinonen, Victoria M Velazquez, Fang Ye, Sara Mertz, Santiago Acero-Bedoya, Bennett Smith, Eleonora Bunsow, Cristina Garcia-Mauriño, Silvia Oliva, Daniel M Cohen, Melissa Moore-Clingenpeel, Mark E Peeples, Octavio Ramilo, Asuncion Mejias,

Respiratory syncytial virus (RSV) is associated with major morbidity in infants, although most cases result in mild disease. The pathogenesis of the disease is incompletely understood, especially the determining factors of disease severity. A better characterization of these factors may help with development of RSV vaccines and antivirals. Hence, identification ... Read more >>

Sci Transl Med (Science translational medicine)
[2020, 12(540):]

Cited: 5 times

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79. Mucosal Interferon (IFN) Responses in Infants with Respiratory Syncytial Virus (RSV) Infection to Inform Live Attenuated Vaccine (LAV) Development.

Jeanette Taveras, Cristina Garcia-Maurino, Sara Mertz, Mark E Peeples, Octavio Ramilo, Octavio Ramilo, Asuncion Mejias,

AbstractBackgroundRespiratory syncytial virus (RSV) is a leading cause of hospitalization for infants. Several vaccine strategies for RSV are being developed. Among those, live attenuated vaccine (LAV) represent an attractive alternative for young children as they mimic natural infection and induce protective immunity without causing enhanced disease. However, markers of reactogenicity ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S2-S3]

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Viral Load Dynamics and Clinical Disease Severity in Infants With Respiratory Syncytial Virus Infection.

Cristina Garcia-Mauriño, Melissa Moore-Clingenpeel, Jessica Thomas, Sara Mertz, Daniel M Cohen, Octavio Ramilo, Asuncion Mejias,

<h4>Background</h4>The association between respiratory syncytial virus (RSV) loads and clinical outcomes in children remains to be defined. In most studies, viral loads (VL) were evaluated in hospitalized children and at a single time-point. We investigated the relationship between VLs and disease severity in both outpatients and inpatients with RSV infection.<h4>Methods</h4>We ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2019, 219(8):1207-1215]

Cited: 8 times

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118. Nasopharyngeal (NP) Bacterial Detection in Infants With Respiratory Syncytial Virus (RSV) Infection: Impact on Clinical Outcomes

Alejandro Diaz, Eleonora Bunsow, Cristina Garcia-Maurino, Jeffrey Naples, Alexis Juergensen, Sara Mertz, Huanyu Wang, Douglas Salamon, Amy Leber, Octavio Ramilo, Asuncion Mejias,

Abstract Background Previous studies suggest that RSV increases NP bacterial colonization and may facilitate infection. However, the role of NP colonization with potentially pathogenic bacteria (PPB) in the pathogenesis of RSV bronchiolitis is not well understood. We sought to determine the frequency, type, and density of NP PPB detection in ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S4-S5]

Cited: 0 times

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The psychoactive substance of cannabis Δ9-tetrahydrocannabinol (THC) negatively regulates CFTR in airway cells.

Sheng-Wei Chang, Jack Wellmerling, Xiaoli Zhang, Rachael E Rayner, Wissam Osman, Sara Mertz, Amal O Amer, Mark E Peeples, Prosper N Boyaka, Estelle Cormet-Boyaka,

<h4>Background</h4>Marijuana consumption is on the rise in the US but the health benefits of cannabis smoking are controversial and the impact of cannabis components on lung homeostasis is not well-understood. Lung function requires a fine regulation of the ion channel CFTR, which is responsible for fluid homeostasis and mucocilliary clearance. ... Read more >>

Biochim Biophys Acta Gen Subj (Biochimica et biophysica acta. General subjects)
[2018, 1862(9):1988-1994]

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A Systems Analysis Approach to Define the Protective Host Immune Responses of Children with Mild Respiratory Syncytial Virus Infection.

Santtu Heinonen, Victoria M Velazquez, Fang Ye, Daniel M Cohen, Sara Mertz, Bennett Smith, Cristina Garcia-Maurino, Octavio Ramilo, Asuncion Mejias,

AbstractBackgroundAlmost all children are infected with RSV by 2 yrs of age, yet <3% are hospitalized. The immune response of children with mild RSV infection who do not develop severe disease is not fully understood. Characterization of such response may have implications for vaccine development. We sought to define the ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S694-S695]

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Differences in antibody responses between trivalent inactivated influenza vaccine and live attenuated influenza vaccine correlate with the kinetics and magnitude of interferon signaling in children.

Raquel G Cao, Nicolas M Suarez, Gerlinde Obermoser, Santiago M C Lopez, Emilio Flano, Sara E Mertz, Randy A Albrecht, Adolfo García-Sastre, Asuncion Mejias, Hui Xu, Huanying Qin, Derek Blankenship, Karolina Palucka, Virginia Pascual, Octavio Ramilo,

<h4>Background</h4>Live attenuated influenza vaccine (LAIV) and trivalent inactivated influenza vaccine (TIV) are effective for prevention of influenza virus infection in children, but the mechanisms associated with protection are not well defined.<h4>Methods</h4>We analyzed the differences in B-cell responses and transcriptional profiles in children aged 6 months to 14 years immunized with ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2014, 210(2):224-233]

Cited: 26 times

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Lack of effect of bovine lactoferrin in respiratory syncytial virus replication and clinical disease severity in the mouse model.

Lucien Gualdi, Sara Mertz, Ana M Gomez, Octavio Ramilo, Anja Wittke, Asuncion Mejias,

<h4>Background</h4>Lactoferrin (LF) is a glycoprotein present in human milk with known antimicrobial effects. In vitro, LF has demonstrated antiviral activity against respiratory syncytial virus (RSV). We sought to assess the effect of bovine (b)LF in RSV replication, lung inflammation and function, cytokine profiles and clinical disease in an in vivo ... Read more >>

Antiviral Res (Antiviral research)
[2013, 99(2):188-195]

Cited: 4 times

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Behavior change following implementation of home-based life-saving skills in Liberia, West Africa.

Jody R Lori, Elikem E Amable, Sara G Mertz, Kathleen Moriarty,

<h4>Introduction</h4>Home-Based Life-Saving Skills (HBLSS) has been fully integrated into Liberia's long-term plan to decrease maternal and newborn mortality and morbidity, coordinated through the Ministry of Health and Social Welfare. The objective of this article is to disseminate evaluation data from project monitoring and documentation on translation of knowledge and skills ... Read more >>

J Midwifery Womens Health (Journal of midwifery & women's health)
[2012, 57(5):495-501]

Cited: 4 times

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Lambda interferon is the predominant interferon induced by influenza A virus infection in vivo.

Nancy A Jewell, Troy Cline, Sara E Mertz, Sergey V Smirnov, Emilio Flaño, Christian Schindler, Jessica L Grieves, Russell K Durbin, Sergei V Kotenko, Joan E Durbin,

The type I alpha/beta interferons (IFN-α/β) are known to play an important role in host defense against influenza A virus infection, but we have now discovered that the recently identified type III IFNs (IFN-λ) constitute the major response to intranasal infection with this virus. Type III IFNs were present at ... Read more >>

J Virol (Journal of virology)
[2010, 84(21):11515-11522]

Cited: 138 times

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Lambda Interferon Is the Predominant Interferon Induced by Influenza A Virus Infection In Vivo

Nancy A. Jewell, Troy Cline, Sara E. Mertz, Sergey V. Smirnov, Emilio Flaño, Christian Schindler, Jessica L. Grieves, Russell K. Durbin, Sergei V. Kotenko, Joan E. Durbin,

J Virol (Journal of virology)
[2011, 85(1):650-650]

Cited: 0 times

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Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo.

Nancy A Jewell, Negin Vaghefi, Sara E Mertz, Parvis Akter, R Stokes Peebles, Lauren O Bakaletz, Russell K Durbin, Emilio Flaño, Joan E Durbin,

Type I interferon (IFN) induction is an immediate response to virus infection, and very high levels of these cytokines are produced when the Toll-like receptors (TLRs) expressed at high levels by plasmacytoid dendritic cells (pDCs) are triggered by viral nucleic acids. Unlike many RNA viruses, respiratory syncytial virus (RSV) does ... Read more >>

J Virol (Journal of virology)
[2007, 81(18):9790-9800]

Cited: 101 times

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Role for innate IFNs in determining respiratory syncytial virus immunopathology.

Teresa R Johnson, Sara E Mertz, Negin Gitiban, Sue Hammond, Robin Legallo, Russell K Durbin, Joan E Durbin,

Respiratory syncytial virus (RSV) is the major cause of severe lower airway disease in infants and young children, but no safe and effective RSV vaccine is yet available. The difficulties involved in RSV vaccine development were recognized in an early vaccine trial, when children immunized with a formalin-inactivated virus preparation ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2005, 174(11):7234-7241]

Cited: 46 times

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Chinchilla and murine models of upper respiratory tract infections with respiratory syncytial virus.

Negin Gitiban, Joseph A Jurcisek, Randall H Harris, Sara E Mertz, Russell K Durbin, Lauren O Bakaletz, Joan E Durbin,

Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in infants and the elderly. While the primary infection is the most serious, reinfection of the upper airway throughout life is the rule. Although relatively little is known about either RSV infection of the upper respiratory tract ... Read more >>

J Virol (Journal of virology)
[2005, 79(10):6035-6042]

Cited: 30 times

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The role of IFN in respiratory syncytial virus pathogenesis.

Joan E Durbin, Teresa R Johnson, Russell K Durbin, Sara E Mertz, Rafaella A Morotti, R Stokes Peebles, Barney S Graham,

Formalin-inactivated respiratory syncytial virus (RSV) vaccine preparations have been shown to cause enhanced disease in naive hosts following natural infection. In this study we demonstrate a similar pattern of enhanced disease severity following primary RSV infection of IFN-nonresponsive STAT1(-/-) mice. STAT1(-/-) mice showed markedly increased illness compared with wild-type BALB/c ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2002, 168(6):2944-2952]

Cited: 120 times

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