Full Text Journal Articles by
Author Santosh K Padala

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Pacing of Specialized Conduction System.

Santosh K Padala, Kenneth A Ellenbogen,

Right ventricular pacing for bradycardia remains the mainstay of pacing therapy. Chronic right ventricular pacing may lead to pacing-induced cardiomyopathy. We focus on the anatomy of the conduction system and the clinical feasibility of pacing the His bundle and/or left bundle conduction system. We review the hemodynamics of conduction system ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):755-784]

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Electrocardiographic characteristics and ablation of ventricular arrhythmias originating from the basal inferoseptal area.

Timothy R Larsen, Richard K Shepard, Jayanthi N Koneru, José-Angel Cabrera, Kenneth A Ellenbogen, Santosh K Padala,

<h4>Aims </h4>Ventricular arrhythmias (VAs) from the basal inferoseptal (BIS) area are rare and can pose unique challenges during catheter ablation (CA) due to the anatomic complexity. The study sought to describe the electrocardiographic and clinical characteristics of VAs originating from the BIS area.<h4>Methods and results </h4>Patients with VAs and successful ablation at ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, :]

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Autonomic Modulation for Treatment of Repolarization Alternans and Refractory Ventricular Electrical Storm.

Ajay Pillai, Jayanthi N Koneru, Kenneth A Ellenbogen, Santosh K Padala,

Macroscopic T-wave alternans (TWA) is a rare finding on surface electrocardiogram and has been associated with an increased risk of impending sudden cardiac death. We highlight a case of macroscopic TWA in a patient with markedly prolonged QTc interval preceding ventricular electrical storm, which was refractory to medical management. Autonomic ... Read more >>

JACC Case Rep (JACC. Case reports)
[2021, 3(12):1438-1443]

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Safety and feasibility of left bundle branch area pacing following valvular interventions: Multicenter study.

Enes Elvin Gul, Rajiv A Kabadi, Santosh K Padala, Paula Sanchez Somonte, Jordana Kron, Richard K Shepard, Jayanthi N Koneru, Gautham Kalahasty, Maria Terricabras, Bernice Tsang, Yaariv Khaykin, Zaev Wulffhart, Alfredo Pantano, Kenneth A Ellenbogen, Atul Verma,

<h4>Objectives</h4>To evaluate the safety and feasibility of left bundle branch area pacing (LBBAP) in patients with valvular interventions.<h4>Methods</h4>Eighty-four patients were included in this study. All patients underwent recent surgical or percutaneous valvular interventions. LBBAP was attempted in all patients. Implant success rates, peri- and postprocedure electrocardiogram, pacing parameters, and complications ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(9):2515-2521]

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Taking the Heat Out of Cardiac Resynchronization Therapy and Conduction System Pacing: Whither Simple CRT?

Kenneth A Ellenbogen, Santosh K Padala,

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, 7(7):893-895]

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Impact of His bundle pacing on right ventricular performance in patients undergoing permanent pacemaker implantation.

Domenico Grieco, Edoardo Bressi, Karol Curila, Santosh K Padala, Kamil Sedlacek, Jordana Kron, Elisa Fedele, Oana Ionita, Sara Giannuzzi, Alessandro Fagagnini, Germana Panattoni, Ermenegildo De Ruvo, Kenneth A Ellenbogen, Leonardo Calò,

<h4>Background</h4>His-Bundle pacing (HBP) is an emerging technique for physiological pacing. However, its effects on right ventricle (RV) performance are still unknown.<h4>Methods</h4>We enrolled consecutive patients with an indication for pacemaker (PM) implantation to compare HBP versus RV pacing (RVP) effects on RV performance. Patients were evaluated before implantation and after 6 ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(6):986-994]

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Spectrum of arrhythmogenic substrate post minimally invasive maze surgery in patients with recurrent.

Timothy R Larsen, Jayanthi N Koneru, Santosh K Padala, Vigneshwar Kasirajan, Kenneth A Ellenbogen,

<h4>Background</h4>Advancements in minimally invasive surgical ablation (MISA) have focused on improving pulmonary vein isolation. Additional ablation targets have been developed (such as posterior wall isolation). The mid- and long-term effects of current techniques (including electrophysiologic findings and recurrent arrhythmia mechanisms) have not previously been reported.<h4>Methods</h4>Twenty eight patients with recurrent atrial ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(6):1054-1061]

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A Tale of 2 Blocks.

Ajay Pillai, Kenneth A Ellenbogen, Santosh K Padala,

Circulation (Circulation)
[2021, 143(10):1062-1065]

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An Unusual Complication of Transseptal Puncture.

Ajay Pillai, Santosh K Padala, Kenneth A Ellenbogen, Jayanthi N Koneru,

The interatrial septum is a structure with complex embryological development. The true atrial septum is a circumscribed structure, and transgression outside of this area during transseptal puncture may result in entry into the extracardiac space or aorta that may result in a pericardial effusion or cardiac tamponade. (<b>Level of Difficulty: Intermediate.</b>). ... Read more >>

JACC Case Rep (JACC. Case reports)
[2021, 3(1):41-46]

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A deeper look into conduction system pacing: From the bench to the bedside.

Kenneth A Ellenbogen, Santosh K Padala,

Heart Rhythm (Heart rhythm)
[2021, 18(5):822-823]

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Coronary Artery Laceration During Epicardial Ablation.

Santosh K Padala, Jayanthi N Koneru, Zachary M Gertz, Kenneth A Ellenbogen,

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, 7(2):273-274]

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Outcomes of Premature Ventricular Contraction-Cardiomyopathy in the Veteran Population: A Secondary Analysis of the CHF-STAT Study.

Jose F Huizar, Susan G Fisher, Frederick V Ramsey, Karoly Kaszala, Alex Y Tan, Hans Moore, Jayanthi N Koneru, Jordana Kron, Santosh K Padala, Kenneth A Ellenbogen, Steven N Singh,

<h4>Objectives</h4>This study sought to assess the rate and outcomes of premature ventricular contractions (PVC)-cardiomyopathy from the CHF-STAT (Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure) trial, a population with cardiomyopathy (left ventricular [LV] ejection fraction of <40%) and frequent PVCs (>10 PVCs per hour).<h4>Background</h4>PVCs are associated with heart failure and ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, 7(3):380-390]

Cited: 2 times

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Intermediate-term performance and safety of His-bundle pacing leads: A single-center experience.

Todd Teigeler, Jeffrey Kolominsky, Chau Vo, Richard K Shepard, Gautham Kalahasty, Jordana Kron, Jose F Huizar, Karoly Kaszala, Alex Y Tan, Jayanthi N Koneru, Kenneth A Ellenbogen, Santosh K Padala,

<h4>Background</h4>The short-term safety, feasibility, and performance of His-bundle pacing (HBP) leads have been reported; however, their longer-term performance beyond 1 year remains unclear.<h4>Objective</h4>The purpose of this study was to examine the intermediate-term performance and safety of HBP.<h4>Methods</h4>All HBP lead implants at Virginia Commonwealth University between January 2014 and January 2019 ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, 18(5):743-749]

Cited: 5 times

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Anatomy of the cardiac conduction system.

Santosh K Padala, José-Angel Cabrera, Kenneth A Ellenbogen,

The specialized cardiomyocytes that constitute the conduction system in the human heart, initiate the electric impulse and result in rhythmic and synchronized contraction of the atria and ventricles. Although the atrioventricular (AV) conduction axis was described more than a century ago by Sunao Tawara, the anatomic pathway for propagation of ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(1):15-25]

Cited: 8 times

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Show Me the P Wave: An Old Tool to Discern Atrioventricular Relationships.

Ravi Choxi, Kenneth A Ellenbogen, Santosh K Padala,

Circulation (Circulation)
[2020, 142(16):1596-1598]

Cited: 0 times

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Initial Experience, Safety, and Feasibility of Left Bundle Branch Area Pacing: A Multicenter Prospective Study.

Santosh K Padala, Vivak M Master, Maria Terricabras, Andrea Chiocchini, Aatish Garg, Jordana Kron, Richard Shepard, Gautham Kalahasty, Zahara Azizi, Bernice Tsang, Yaariv Khaykin, Alfredo Pantano, Jayanthi N Koneru, Kenneth A Ellenbogen, Atul Verma,

<h4>Objectives</h4>This study sought to evaluate the safety and feasibility of conduction system pacing by performing left bundle branch area pacing (LBBAP).<h4>Background</h4>There are limited data from single centers showing that LBBAP may circumvent the technical and electrophysiological challenges encountered with His bundle pacing.<h4>Methods</h4>Patients referred for pacemaker implantation at 2 centers between ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2020, 6(14):1773-1782]

Cited: 3 times

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Comparison of Frequency of Atrial Fibrillation in Blacks Versus Whites and the Utilization of Race in a Novel Risk Score.

Gurukripa N Kowlgi, Sampath Gunda, Santosh K Padala, Jayanthi N Koneru, Abhishek J Deshmukh, Kenneth A Ellenbogen,

Blacks have a lower prevalence of atrial fibrillation (AF) compared with Whites. We sought to confirm previously reported ethnic trends in AF in Blacks and Whites in a large database, and develop a prediction score for AF. Over 330 million hospital discharges between the years 2003 to 2013 from the ... Read more >>

Am J Cardiol (The American journal of cardiology)
[2020, 135:68-76]

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Imaging-Based Localization of His Bundle Pacing Electrodes: Results From the Prospective IMAGE-HBP Study.

Pugazhendhi Vijayaraman, Gopi Dandamudi, Faiz A Subzposh, Richard K Shepard, Gautham Kalahasty, Santosh K Padala, John S Strobel, Terry D Bauch, Kenneth A Ellenbogen, Tracy Bergemann, Lisa Hughes, Megan L Harris, Dedra H Fagan, Zhongping Yang, Jayanthi N Koneru, ,

<h4>Objectives</h4>This study sought to evaluate the correlation between His bundle (HB) pacing (HBP) implantation characteristics, lead-tip location, and association of intraprocedural His recordings with approximated HB anatomic landmarks using computed tomography (CT) imaging.<h4>Background</h4>HBP continues to grow in clinical practice due to offering true physiological pacing. However, a clear understanding of ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, 7(1):73-84]

Cited: 1 time

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Morbidity and mortality in patients precluded for transvenous pacemaker implantation: Experience with a leadless pacemaker.

Aatish Garg, Jayanthi N Koneru, Dedra H Fagan, Kurt Stromberg, Santosh K Padala, Mikhael F El-Chami, Paul R Roberts, Jonathan P Piccini, Alan Cheng, Kenneth A Ellenbogen,

<h4>Background</h4>The Micra transcatheter pacemaker is a safe and effective alternative to transvenous permanent pacemakers (TV-PPMs). However, the safety profile and mortality outcomes of Micra implantation in patients deemed poor candidates for TV-PPM are incompletely understood.<h4>Objective</h4>The purpose of this study was to evaluate safety and all-cause mortality in patients undergoing Micra ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(12):2056-2063]

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AV Block Post-TAVR: When AV Block Is High, We Go Low (in the Conduction System).

Jordana Kron, Santosh K Padala,

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2020, 6(6):658-660]

Cited: 0 times

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Left bundle branch pacing is the best approach to physiological pacing.

Santosh K Padala, Kenneth A Ellenbogen,

Heart Rhythm O2 (Heart rhythm O2)
[2020, 1(1):59-67]

Cited: 1 time

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Painful Left Bundle Branch Block Syndrome Successfully Treated With Left Bundle Branch Area Pacing.

Aatish Garg, Vivak Master, Kenneth A Ellenbogen, Santosh K Padala,

Chest pain may be rarely associated with left bundle branch block (LBBB)-mediated ventricular dys-synchrony has been reported. This article reports 2 such cases, where left bundle branch area pacing resulted in resolution of the LBBB and associated symptoms. By adjusting the atrioventricular delays, the QRS duration was narrowed further by ... Read more >>

JACC Case Rep (JACC. Case reports)
[2020, 2(4):568-571]

Cited: 0 times

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Multicenter Experience of Subcutaneous Implantable Cardioverter-Defibrillator Therapy in Patients With Dextrocardia.

Jakob Lüker, Santosh K Padala, Óscar Cano, Thomas Beiert, Brigitte Osswald, Jayanthi N Koneru, Jan W Schrickel, Jordana Kron, Hilton Franqui-Rivera, Ariel Gonzalez-Cordero, Bandar S Al-Ghamdi, Paul R Roberts, Scott R Ceresnak, Johannes von Alvensleben, Arian Sultan, Daniel Steven,

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2019, 5(10):1226-1228]

Cited: 1 time

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Electrocardiographic changes in loperamide toxicity: Case report and review of literature.

Todd Teigeler, Heather Stahura, Rizwan Alimohammad, Gautham Kalahasty, Jayanthi N Koneru, Michael Ellenbogen, Kenneth A Ellenbogen, Santosh K Padala,

<h4>Introduction</h4>Loperamide, an antidiarrheal agent, is a µ-opioid receptor agonist increasingly abused to prevent opioid withdrawal or to produce euphoric effects. At supra-therapeutic doses, loperamide can cause cardiac toxicity due to blockade of Na and I<sub>Kr</sub> channels, resulting in wide QRS rhythms, severe bradycardia, prolonged QTc, polymorphic ventricular tachycardia, cardiac arrest, ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2019, 30(11):2618-2626]

Cited: 2 times

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Selective Versus Nonselective His Bundle Pacing: Does it Matter?

Santosh K Padala, Kenneth A Ellenbogen,

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2019, 5(7):775-777]

Cited: 1 time

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