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Author Sanna Kettunen

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RNA interference-based therapies for the control of atherosclerosis risk factors.

Sanna Kettunen, Anna-Kaisa Ruotsalainen, Seppo Ylä-Herttuala,

<h4>Purpose of review</h4>Atherosclerosis, characterized by lipid accumulation and chronic inflammation in the arterial wall, is the leading causes of death worldwide. The purpose of this article is to review the status of RNA interference (RNAi) based therapies in clinical trials for the treatment and prevention of atherosclerosis risk factors.<h4>Recent findings</h4>There ... Read more >>

Curr Opin Cardiol (Current opinion in cardiology)
[2022, 37(4):364-371]

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SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice.

Erika Gurzeler, Anna-Kaisa Ruotsalainen, Anssi Laine, Teemu Valkama, Sanna Kettunen, Markku Laakso, Seppo Ylä-Herttuala,

<h4>Background and aims</h4>Diabetes is a major risk factor of atherosclerosis and its complications. The loss-of-function mutation E1506K in the sulfonylurea receptor 1 (SUR1-E1506K) induces hyperinsulinemia in infancy, leading to impaired glucose tolerance and increased risk of type 2 diabetes. In this study, we investigate the effect of SUR1-E1506K mutation on ... Read more >>

PLoS One (PloS one)
[2021, 16(11):e0258408]

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