Full Text Journal Articles by
Author Sanjay K Shukla

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Proteomics, lipidomics, metabolomics and 16S DNA sequencing of dental plaque from patients with diabetes and periodontal disease.

Katherine A Overmyer, Timothy W Rhoads, Anna E Merrill, Zhan Ye, Michael S Westphall, Amit Acharya, Sanjay K Shukla, Joshua J Coon,

Oral microbiome influences human health, specifically pre- and type 2 diabetes (Pre-DM/DM) and periodontal diseases (PD), through complex microbial interactions. To explore these relations, we performed 16S rDNA sequencing, metabolomics, lipidomics, and proteomics analyses on supragingival dental plaque collected from individuals with Pre-DM/DM (n=39), Pre-DM/DM and PD (n=37), PD alone ... Read more >>

Mol Cell Proteomics (Molecular & cellular proteomics : MCP)
[2021, :100126]

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Manure Microbial Communities and Resistance Profiles Reconfigure after Transition to Manure Pits and Differ from Those in Fertilized Field Soil.

Kimberley V Sukhum, Rhiannon C Vargas, Manish Boolchandani, Alaric W D'Souza, Sanket Patel, Akhil Kesaraju, Gretchen Walljasper, Harshad Hegde, Zhan Ye, Robert K Valenzuela, Paul Gunderson, Casper Bendixsen, Gautam Dantas, Sanjay K Shukla,

In agricultural settings, microbes and antimicrobial resistance genes (ARGs) have the potential to be transferred across diverse environments and ecosystems. The consequences of these microbial transfers are unclear and understudied. On dairy farms, the storage of cow manure in manure pits and subsequent application to field soil as a fertilizer ... Read more >>

mBio (mBio)
[2021, 12(3):]

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Omadacycline compared to vancomycin when combined with germinants to disrupt the life cycle of Clostridioides difficile.

Noah Budi, Jared J Godfrey, Nasia Safdar, Sanjay K Shukla, Warren E Rose,

<i>Clostridioides difficile</i> (<i>C. difficile</i>) infections (CDI) are commonly treated with antibiotics that do not impact the dormant spore form of the pathogen. CDI-directed antibiotics, such as vancomycin and metronidazole, can destroy the vegetative form of <i>C. difficile</i> and protective microbiota. After treatment, spores can germinate into vegetative cells causing clinical ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2021, :]

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Prolonged Exposure to β-Lactam Antibiotics Reestablishes Susceptibility of Daptomycin-Nonsusceptible Staphylococcus aureus to Daptomycin.

Rachel E Jenson, Sarah L Baines, Benjamin P Howden, Nagendra N Mishra, Sabrina Farah, Cassandra Lew, Andrew D Berti, Sanjay K Shukla, Arnold S Bayer, Warren E Rose,

Daptomycin-nonsusceptible (DAP-NS) <i>Staphylococcus aureus</i> often exhibits gain-in-function mutations in the <i>mprF</i> gene (involved in positive surface charge maintenance). Standard β-lactams, although relatively inactive against methicillin-resistant <i>S. aureus</i> (MRSA), may prevent the emergence of <i>mprF</i> mutations and DAP-NS. We determined if β-lactams might also impact DAP-NS isolates already possessing an <i>mprF</i> ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2020, 64(9):]

Cited: 1 time

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Association of variants in selected genes mediating host immune response with duration of Staphylococcus aureus bacteremia.

Tonia C Carter, Zhan Ye, Lynn C Ivacic, Noah Budi, Warren E Rose, Sanjay K Shukla,

Host genetic variation may be a contributing factor to variability in Staphylococcus aureus bacteremia duration. We assessed whether 28 single nucleotide polymorphisms (SNPs) in seven genes (TLR2, TLR4, TIRAP, IRAK4, TRAF6, NOD2, and CISH) that mediate host immune response were associated with S. aureus bacteremia duration. Subjects included 158 patients ... Read more >>

Genes Immun (Genes and immunity)
[2020, 21(4):240-248]

Cited: 1 time

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Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms.

Lloyd S Miller, Vance G Fowler, Sanjay K Shukla, Warren E Rose, Richard A Proctor,

Invasive Staphylococcus aureus infections are a leading cause of morbidity and mortality in both hospital and community settings, especially with the widespread emergence of virulent and multi-drug resistant methicillin-resistant S. aureus strains. There is an urgent and unmet clinical need for non-antibiotic immune-based approaches to treat these infections as the ... Read more >>

FEMS Microbiol Rev (FEMS microbiology reviews)
[2020, 44(1):123-153]

Cited: 29 times

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Modeling of Effective Antimicrobials to Reduce Staphylococcus aureus Virulence Gene Expression Using a Two-Compartment Hollow Fiber Infection Model.

Sanjay K Shukla, Tonia C Carter, Zhan Ye, Madhulatha Pantrangi, Warren E Rose,

Toxins produced by community-associated methicillin-resistant <i>Staphylococcus aureus</i> (CA-MRSA) contribute to virulence. We developed a statistical approach to determine an optimum sequence of antimicrobials to treat CA-MRSA infections based on an antimicrobial's ability to reduce virulence. In an in vitro pharmacodynamic hollow fiber model, expression of six virulence genes (<i>lukSF</i><i>-PV</i>, <i>sek</i>, ... Read more >>

Toxins (Basel) (Toxins)
[2020, 12(2):]

Cited: 1 time

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Virulence factor landscape of a Staphylococcus aureus sequence type 45 strain, MCRF184.

Vijay Aswani, Fares Najar, Madhulatha Pantrangi, Bob Mau, William R Schwan, Sanjay K Shukla,

<h4>Background</h4>We describe the virulence factors of a methicillin-sensitive Staphylococcus aureus sequence type (ST) 45 strain, MCRF184, (spa type t917), that caused severe necrotizing fasciitis in a 72-year-old diabetic male. The genome of MCRF184 possesses three genomic islands: a relatively large type III νSaα with 42 open reading frames (ORFs) that ... Read more >>

BMC Genomics (BMC genomics)
[2019, 20(1):123]

Cited: 0 times

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Wisconsin microbiome study, a cross-sectional investigation of dietary fibre, microbiome composition and antibiotic-resistant organisms: rationale and methods.

Shoshannah Eggers, Kristen Mc Malecki, Paul Peppard, Julie Mares, Daniel Shirley, Sanjay K Shukla, Keith Poulsen, Ronald Gangnon, Megan Duster, Ashley Kates, Garret Suen, Ajay K Sethi, Nasia Safdar,

<h4>Introduction</h4>Prevention of multidrug-resistant organism (MDRO) infections, such as those caused by methicillin-resistant <i>Staphylococcus aureus</i>, vancomycin-resistant enterococci, fluoroquinolone-resistant Gram-negative bacteria and <i>Clostridium difficile</i> is crucial. Evidence suggests that dietary fibre increases gut microbial diversity, which may help prevent colonisation and subsequent infection by MDROs. The aim of the Winning the War ... Read more >>

BMJ Open (BMJ open)
[2018, 8(3):e019450]

Cited: 10 times

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Phylogenetic distribution and expression of a penicillin-binding protein homologue, Ear and its significance in virulence of Staphylococcus aureus.

Vineet K Singh, Robert P Ring, Vijay Aswani, Mary E Stemper, Jennifer Kislow, Zhan Ye, Sanjay K Shukla,

<h4>Purpose</h4>Staphylococcus aureus is an opportunistic human pathogen that can cause serious infections in humans. A plethora of known and putative virulence factors are produced by staphylococci that collectively orchestrate pathogenesis. Ear protein (Escherichia coli ampicillin resistance) in S. aureus is an exoprotein in COL strain, predicted to be a superantigen, ... Read more >>

J Med Microbiol (Journal of medical microbiology)
[2017, 66(12):1811-1821]

Cited: 2 times

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Pro-inflammatory immune responses are associated with clinical signs and symptoms of human anaplasmosis.

Anna M Schotthoefer, Steven J Schrodi, Jennifer K Meece, Thomas R Fritsche, Sanjay K Shukla,

Human anaplasmosis (HA) is an emerging tick-borne disease that may present as a mild flu-like illness or a life threatening, sepsis-like condition. Although disease severity is hypothesized to relate to immunopathology and immune dysfunction in humans, studies to directly measure immune responses in infected humans have been very limited. We ... Read more >>

PLoS One (PloS one)
[2017, 12(6):e0179655]

Cited: 3 times

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The lysine deacetylase Sirtuin 1 modulates the localization and function of the Notch1 receptor in regulatory T cells.

Nimi Marcel, Lakshmi R Perumalsamy, Sanjay K Shukla, Apurva Sarin,

The ability to tune cellular functions in response to nutrient availability has important consequences for immune homeostasis. The activity of the receptor Notch in regulatory T (T<sub>reg</sub>) cells, which suppress the functions of effector T cells, is indispensable for T<sub>reg</sub> cell survival under conditions of diminished nutrient supply. Anti-apoptotic signaling ... Read more >>

Sci Signal (Science signaling)
[2017, 10(473):]

Cited: 9 times

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Performance of an electronic health record-based phenotype algorithm to identify community associated methicillin-resistant Staphylococcus aureus cases and controls for genetic association studies.

Kathryn L Jackson, Michael Mbagwu, Jennifer A Pacheco, Abigail S Baldridge, Daniel J Viox, James G Linneman, Sanjay K Shukla, Peggy L Peissig, Kenneth M Borthwick, David A Carrell, Suzette J Bielinski, Jacqueline C Kirby, Joshua C Denny, Frank D Mentch, Lyam M Vazquez, Laura J Rasmussen-Torvik, Abel N Kho,

<h4>Background</h4>Community associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is one of the most common causes of skin and soft tissue infections in the United States, and a variety of genetic host factors are suspected to be risk factors for recurrent infection. Based on the CDC definition, we have developed and validated an ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2016, 16(1):684]

Cited: 3 times

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Developing Research Priorities for Prediction and Prevention of Preterm Birth.

William A Agger, Charles W Schauberger, James K Burmester, Sanjay K Shukla,

Clin Med Res (Clinical medicine & research)
[2016, 14(3-4):123-125]

Cited: 1 time

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Complete Genome Sequence of Staphylococcus aureus MCRF184, a Necrotizing Fasciitis-Causing Methicillin-Sensitive Sequence Type 45 Staphylococcus Strain.

Vijay Aswani, Bob Mau, Sanjay K Shukla,

We report here the complete genome sequence of a highly virulent methicillin-sensitive Staphylococcus aureus strain, MCRF184, belonging to sequence type 45. This staphylococcal strain was isolated from a surgical biopsy specimen from a patient with necrotizing fasciitis. ... Read more >>

Genome Announc (Genome announcements)
[2016, 4(3):]

Cited: 3 times

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Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Sanjay K Shukla, Dane Cook, Jacob Meyer, Suzanne D Vernon, Thao Le, Derek Clevidence, Charles E Robertson, Steven J Schrodi, Steven Yale, Daniel N Frank,

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease characterized by intense and debilitating fatigue not due to physical activity that has persisted for at least 6 months, post-exertional malaise, unrefreshing sleep, and accompanied by a number of secondary symptoms, including sore throat, memory and concentration impairment, headache, and muscle/joint pain. ... Read more >>

PLoS One (PloS one)
[2015, 10(12):e0145453]

Cited: 38 times

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Personalized medicine going precise: from genomics to microbiomics.

Sanjay K Shukla, Narayana S Murali, Murray H Brilliant,

Trends Mol Med (Trends in molecular medicine)
[2015, 21(8):461-462]

Cited: 17 times

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Progress in oral personalized medicine: contribution of 'omics'.

Ingrid Glurich, Amit Acharya, Murray H Brilliant, Sanjay K Shukla,

BACKGROUND:Precision medicine (PM), representing clinically applicable personalized medicine, proactively integrates and interprets multidimensional personal health data, including clinical, 'omics', and environmental profiles, into clinical practice. Realization of PM remains in progress. OBJECTIVE:The focus of this review is to provide a descriptive narrative overview of: 1) the current status of oral ... Read more >>

J Oral Microbiol (Journal of oral microbiology)
[2015, 7:28223]

Cited: 1 time

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Complex host genetic susceptibility to Staphylococcus aureus infections.

Sanjay K Shukla, Warren Rose, Steven J Schrodi,

Understanding of the host genetic susceptibility to carriage of, and infections, due to Staphylococcus aureus, a nosocomial pathogen, is still in its nascent stages. Mouse models show variable susceptibility to S. aureus infections across mouse strains and disease models with roles for signaling pathways involving Toll-like receptors (TLR-1, TLR-2, and ... Read more >>

Trends Microbiol (Trends in microbiology)
[2015, 23(9):529-536]

Cited: 15 times

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Significance of four methionine sulfoxide reductases in Staphylococcus aureus.

Vineet K Singh, Manisha Vaish, Trintje R Johansson, Kyle R Baum, Robert P Ring, Saumya Singh, Sanjay K Shukla, Jackob Moskovitz,

Staphylococcus aureus is a major human pathogen and emergence of antibiotic resistance in clinical staphylococcal isolates raises concerns about our ability to control these infections. Cell wall-active antibiotics cause elevated synthesis of methionine sulfoxide reductases (Msrs: MsrA1 and MsrB) in S. aureus. MsrA and MsrB enzymes reduce S-epimers and R-epimers ... Read more >>

PLoS One (PloS one)
[2015, 10(2):e0117594]

Cited: 20 times

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Complete Genome Sequence of a Staphylococcus epidermidis Bacteriophage Isolated from the Anterior Nares of Humans.

Vijay H Aswani, Denise M Tremblay, Sylvain Moineau, Sanjay K Shukla,

We report here the complete genome sequence of a virulent Staphylococcus epidermidis siphophage, phage 6ec, isolated from the anterior nares of a human. This viral genome is 93,794 bp in length, with a 3' overhang cos site of 10 nucleotides, and it codes for 142 putative open reading frames. ... Read more >>

Genome Announc (Genome announcements)
[2014, 2(4):]

Cited: 4 times

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Epidemiologic factors and urogenital infections associated with preterm birth in a midwestern U.S. population.

William A Agger, Danish Siddiqui, Steven D Lovrich, Steven M Callister, Andrew J Borgert, Kenneth W Merkitch, Tina C Mason, Dennis J Baumgardner, James K Burmester, Sanjay K Shukla, Joseph D Welter, Katharina S Stewart, M J Washburn, Howard H Bailey,

<h4>Objective</h4>To correlate epidemiologic factors with urogenital infections associated with preterm birth.<h4>Methods</h4>Pregnant women were sequentially included from four Wisconsin cohorts: large urban, midsize urban, small city, and rural city. Demographic, clinical, and current pregnancy data were collected. Cervical and urine specimens were analyzed by microscopy, culture, and polymerase chain reaction for ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2014, 124(5):969-977]

Cited: 15 times

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Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections.

Zhan Ye, Daniel A Vasco, Tonia C Carter, Murray H Brilliant, Steven J Schrodi, Sanjay K Shukla,

<h4>Background</h4>We conducted a genome-wide association study (GWAS) to identify specific genetic variants that underlie susceptibility to diseases caused by Staphylococcus aureus in humans.<h4>Methods</h4>Cases (n = 309) and controls (n = 2925) were genotyped at 508,921 single nucleotide polymorphisms (SNPs). Cases had at least one laboratory and clinician confirmed disease caused ... Read more >>

Front Genet (Frontiers in genetics)
[2014, 5:125]

Cited: 20 times

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Regulation of Staphylococcal Superantigen-Like Gene, ssl8, Expression in Staphylococcus aureus strain, RN6390.

Madhulatha Pantrangi, Vineet K Singh, Sanjay K Shukla,

Staphylococcal superantigen-like (SSL) proteins, which are encoded by a cluster of eleven ssl genes, contribute to the Staphylococcus aureus virulence. Recently we reported ssl8 expression profiles in seven clinically important strains-MW2, USA300FPR3757, MSSA476, Newman, RN6390, Mu50, and N315-and showed the differential expression of ssl8 in Newman, RN6390, and USA300FPR3757 strains, ... Read more >>

Clin Med Res (Clinical medicine & research)
[2015, 13(1):7-11]

Cited: 4 times

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Comparative whole-genome mapping to determine Staphylococcus aureus genome size, virulence motifs, and clonality.

Sanjay K Shukla, Madhulatha Pantrangi, Buffy Stahl, Adam M Briska, Mary E Stemper, Trevor K Wagner, Emily B Zentz, Steven M Callister, Steven D Lovrich, John K Henkhaus, Colin W Dykes,

Despite being a clonal pathogen, Staphylococcus aureus continues to acquire virulence and antibiotic-resistant genes located on mobile genetic elements such as genomic islands, prophages, pathogenicity islands, and the staphylococcal chromosomal cassette mec (SCCmec) by horizontal gene transfer from other staphylococci. The potential virulence of a S. aureus strain is often ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2012, 50(11):3526-3533]

Cited: 15 times

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