Full Text Journal Articles by
Author Saniya Rattan

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Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.

Emmi Rotgers, Barbara Nicol, Karina Rodriguez, Saniya Rattan, Jodi A Flaws, Humphrey Hung-Chang Yao,

Steroid hormones regulate various aspects of physiology, from reproductive functions to metabolic homeostasis. Steroidogenic factor-1 (NR5A1) plays a central role in the development of steroidogenic tissues and their ability to produce steroid hormones. Inactivation of Nr5a1 in the mouse results in a complete gonadal and adrenal agenesis, absence of gonadotropes ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(8):e21770]

Cited: 0 times

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Multi and transgenerational epigenetic effects of di-(2-ethylhexyl) phthalate (DEHP) in liver.

Yi Wen, Saniya Rattan, Jodi A Flaws, Joseph Irudayaraj,

Di-(2-ethylhexyl) phthalate (DEHP), a ubiquitous industrial pollutant, is a known endocrine disrupter implicated in metabolic diseases. Prenatal DEHP exposure promotes epigenetic multi- and transgenerational inheritance of adult onset disease in subsequent generations (F1-F3). However, the epigenetic toxicity is less understood in the liver. In this study, CD-1 mice were prenatally ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2020, 402:115123]

Cited: 0 times

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Germline-dependent transmission of male reproductive traits induced by an endocrine disruptor, di-2-ethylhexyl phthalate, in future generations.

Radwa Barakat, Po-Ching Lin, Chan Jin Park, Mohamed Zeineldin, Sherry Zhou, Saniya Rattan, Emily Brehm, Jodi A Flaws, CheMyong J Ko,

In males, defective reproductive traits induced by an exposure to an endocrine disruptor are transmitted to future generations via epigenetic modification of the germ cells. Interestingly, the impacted future generations display a wide range of heterogeneity in their reproductive traits. In this study, the role that the Y chromosome plays ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5705]

Cited: 2 times

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The effects of a phthalate metabolite mixture on antral follicle growth and sex steroid synthesis in mice.

Daryl D Meling, Genoa R Warner, Jason R Szumski, Liying Gao, Andressa V Gonsioroski, Saniya Rattan, Jodi A Flaws,

Phthalates are used as solvents and plasticizers in a wide variety of consumer products. Most people are exposed to phthalates as parent compounds through ingestion, inhalation, and dermal contact. However, these parent compounds are quickly metabolized to more active compounds in several tissues. Although studies indicate that phthalate metabolites reach ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2020, 388:114875]

Cited: 6 times

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The epigenetic impacts of endocrine disruptors on female reproduction across generations†.

Saniya Rattan, Jodi A Flaws,

Humans and animals are repeatedly exposed to endocrine disruptors, many of which are ubiquitous in the environment. Endocrine disruptors interfere with hormone action; thus, causing non-monotonic dose responses that are atypical of standard toxicant exposures. The female reproductive system is particularly susceptible to the effects of endocrine disruptors. Likewise, exposures ... Read more >>

Biol Reprod (Biology of reproduction)
[2019, 101(3):635-644]

Cited: 12 times

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Prenatal exposure to di-(2-ethylhexyl) phthalate and high-fat diet synergistically disrupts mouse fetal oogenesis and affects folliculogenesis†.

Supipi Mirihagalle, Tianming You, Lois Suh, Chintan Patel, Liying Gao, Saniya Rattan, Huanyu Qiao,

Di-(2-ethylhexyl) phthalate (DEHP) is a chemical that is widely used as a plasticizer. Exposure to DEHP has been shown to alter ovarian function in humans. Additionally, foods high in fat content, regularly found in the western diet, have been shown to be another potential disruptor of fetal ovarian function. Due ... Read more >>

Biol Reprod (Biology of reproduction)
[2019, 100(6):1561-1570]

Cited: 1 time

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Exposure to di-(2-ethylhexyl) phthalate transgenerationally alters anxiety-like behavior and amygdala gene expression in adult male and female mice.

Katherine M Hatcher, Jari Willing, Catheryne Chiang, Saniya Rattan, Jodi A Flaws, Megan M Mahoney,

Phthalates are industrial plasticizers and stabilizers commonly found in polyvinyl chloride plastic and consumer products, including food packaging, cosmetics, medical devices, and children's toys. Di-(2-ethylhexyl) phthalate (DEHP), one of the most commonly used phthalates, exhibits endocrine-disrupting characteristics and direct exposure leads to reproductive deficits and abnormalities in anxiety-related behaviors. Importantly, ... Read more >>

Physiol Behav (Physiology & behavior)
[2019, 207:7-14]

Cited: 3 times

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Prenatal and ancestral exposure to di(2-ethylhexyl) phthalate alters gene expression and DNA methylation in mouse ovaries.

Saniya Rattan, Hannah K Beers, Athilakshmi Kannan, Anujaianthi Ramakrishnan, Emily Brehm, Indrani Bagchi, Joseph M K Irudayaraj, Jodi A Flaws,

Di(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer and known endocrine disrupting chemical, which causes transgenerational reproductive toxicity in female rodents. However, the mechanisms of action underlying the transgenerational toxicity of DEHP are not understood. Therefore, this study determined the effects of prenatal and ancestral DEHP exposure on various ovarian ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2019, 379:114629]

Cited: 7 times

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Di(2-Ethylhexyl) Phthalate Exposure During Prenatal Development Causes Adverse Transgenerational Effects on Female Fertility in Mice.

Saniya Rattan, Emily Brehm, Liying Gao, Jodi A Flaws,

Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental toxicant and endocrine disrupting chemical, but little is known about its effects on female reproduction. Thus, we tested the hypothesis that prenatal exposure to DEHP accelerates the onset of puberty, disrupts estrous cyclicity, disrupts birth outcomes, and reduces fertility in the F1, F2, ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2018, 163(2):420-429]

Cited: 14 times

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Prenatal exposure to di(2-ethylhexyl) phthalate disrupts ovarian function in a transgenerational manner in female mice.

Saniya Rattan, Emily Brehm, Liying Gao, Sarah Niermann, Jodi A Flaws,

Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer found in polyvinyl chloride products such as vinyl flooring, plastic food containers, medical devices, and children's toys. DEHP is a ubiquitous environmental contaminant and is a known endocrine disrupting chemical. Little is known about the effects of prenatal DEHP exposure on the ovary and ... Read more >>

Biol Reprod (Biology of reproduction)
[2018, 98(1):130-145]

Cited: 21 times

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Prenatal Exposure to Di(2-Ethylhexyl) Phthalate Causes Long-Term Transgenerational Effects on Female Reproduction in Mice.

Emily Brehm, Saniya Rattan, Liying Gao, Jodi A Flaws,

Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer in many consumer products. Although DEHP is a known endocrine disruptor, little is known about the effects of DEHP exposure on female reproduction. Thus, this study tested the hypothesis that prenatal DEHP exposure affects follicle numbers, estrous cyclicity, and hormone levels in multiple generations ... Read more >>

Endocrinology (Endocrinology)
[2018, 159(2):795-809]

Cited: 29 times

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Exposure to endocrine disruptors during adulthood: consequences for female fertility.

Saniya Rattan, Changqing Zhou, Catheryne Chiang, Sharada Mahalingam, Emily Brehm, Jodi A Flaws,

Endocrine disrupting chemicals are ubiquitous chemicals that exhibit endocrine disrupting properties in both humans and animals. Female reproduction is an important process, which is regulated by hormones and is susceptible to the effects of exposure to endocrine disrupting chemicals. Disruptions in female reproductive functions by endocrine disrupting chemicals may result ... Read more >>

J Endocrinol (The Journal of endocrinology)
[2017, 233(3):R109-R129]

Cited: 42 times

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Prenatal Exposure to DEHP Induces Premature Reproductive Senescence in Male Mice.

Radwa Barakat, Po-Ching Patrick Lin, Saniya Rattan, Emily Brehm, Igor F Canisso, Mohamed E Abosalum, Jodi A Flaws, Rex Hess, CheMyong Ko,

Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used phthalate, and it is an endocrine-disrupting chemical. This study tested a hypothesis that prenatal exposure to DEHP lays the foundation for premature gonadal dysfunction and subsequent reproductive senescence in male mice. Pregnant female CD-1 mice were orally dosed with vehicle control (tocopherol-stripped ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2017, 156(1):96-108]

Cited: 23 times

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Effects of Endocrine-Disrupting Chemicals on the Ovary.

Shreya Patel, Changqing Zhou, Saniya Rattan, Jodi A Flaws,

Endocrine-disrupting chemicals (EDCs) are found abundantly in the environment, resulting in daily human exposure. This is of concern because many EDCs are known to target the female reproductive system and, more specifically, the ovary. In the female, the ovary is the key organ responsible for reproductive and endocrine functions. Exposure ... Read more >>

Biol Reprod (Biology of reproduction)
[2015, 93(1):20]

Cited: 38 times

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Prenatal exposure to di-(2-ethylhexyl) phthalate (DEHP) affects reproductive outcomes in female mice.

Sarah Niermann, Saniya Rattan, Emily Brehm, Jodi A Flaws,

This study tested the hypothesis that prenatal DEHP exposure affects female reproduction. To test this hypothesis, pregnant female CD-1 mice were orally dosed daily with tocopherol-stripped corn oil (vehicle control) or DEHP (20 μg/kg/day-750 mg/kg/day) from gestation day 11-birth. Pups were counted, weighed, and sexed at birth, ovaries were subjected ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2015, 53:23-32]

Cited: 36 times

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