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Author Sangeeta Mehta

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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Impact of Gender on Clinical Evaluation of Trainees in the Intensive Care Unit

Jenna Spring, Caroline Abrahams, Shiphra Ginsburg, Dominique Piquette, Fernando Martinez Guasch, Alex Kiss, Sangeeta Mehta,

Background: Gender disparities in medical education are increasingly demonstrated, including in trainee assessment. Objective: This study aimed to evaluate whether gender differences exist in trainees’ evaluation during intensive care unit (ICU) rotations, which has not been previously studied. Methods: We reviewed the in-training evaluation reports (ITERs) for trainees rotating through ... Read more >>

ATS Sch (ATS scholar)
[2021, 2(3):442-451]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Utilization and effect of neuromuscular blockade in a randomized trial of high-frequency oscillation.

Sangeeta Mehta, Qi Zhou, Ruxandra Pinto, Jan O Friedrich, François Lamontagne, Niall D Ferguson, Maureen O Meade, Neill K J Adhikari, ,

<h4>Purpose</h4>We evaluated characteristics associated with neuromuscular blockade (NMB) use, center-level variation, and whether NMB mediated excess mortality among patients assigned to high-frequency oscillatory ventilation (HFOV) in the OSCILLATE trial.<h4>Materials and methods</h4>NMB exposure was defined as receipt after randomization; the primary outcome was hospital mortality. Descriptive analyses compared NMB-exposed vs unexposed ... Read more >>

J Crit Care (Journal of critical care)
[2021, 66:86-92]

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Perspectives on Advance Care Planning for Patients with Hematologic Malignancy: An International Clinician Questionnaire.

Jenna Spring, Jerrad McKinlay, Kathryn Puxty, Victoria Metaxa, Michael Detsky, Sangeeta Mehta, Santhosh Thyagu, Kelly McGuigan, Laveena Munshi,

<b>Rationale:</b> Critical illness is common in patients with hematologic malignancy (HM). Advance care planning (ACP) can allow these patients to express their care preferences before life-threatening illnesses. <b>Objectives:</b> To evaluate physicians' perspectives surrounding ACP in patients with HM. <b>Methods:</b> We administered a survey to intensivists and hematologic oncologists who care ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(9):1533-1539]

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Venous Thromboembolism Prophylaxis in Critically Ill Adults: A Systematic Review and Network Meta-analysis.

Shannon M Fernando, Alexandre Tran, Wei Cheng, Behnam Sadeghirad, Yaseen M Arabi, Deborah J Cook, Morten Hylander Møller, Sangeeta Mehta, Robert A Fowler, Karen E A Burns, Philip S Wells, Marc Carrier, Mark A Crowther, Damon C Scales, Shane W English, Kwadwo Kyeremanteng, Salmaan Kanji, Michelle E Kho, Bram Rochwerg,

<h4>Background</h4>Critically ill adults are at increased risk of VTE, including DVT, and pulmonary embolism. Various agents exist for venous thromboprophylaxis in this population.<h4>Research question</h4>What is the comparative efficacy and safety of prophylaxis agents for prevention of VTE in critically ill adults?<h4>Study design and methods</h4>Systematic review and network meta-analysis of randomized ... Read more >>

Chest (Chest)
[2021, :]

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Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial.

Jennie Johnstone, Maureen Meade, François Lauzier, John Marshall, Erick Duan, Joanna Dionne, Yaseen M Arabi, Diane Heels-Ansdell, Lehana Thabane, Daphnee Lamarche, Michael Surette, Nicole Zytaruk, Sangeeta Mehta, Peter Dodek, Lauralyn McIntyre, Shane English, Bram Rochwerg, Tim Karachi, William Henderson, Gordon Wood, Daniel Ovakim, Margaret Herridge, John Granton, M Elizabeth Wilcox, Alberto Goffi, Henry T Stelfox, Daniel Niven, John Muscedere, François Lamontagne, Frédérick D'Aragon, Charles St-Arnaud, Ian Ball, Dave Nagpal, Martin Girard, Pierre Aslanian, Emmanuel Charbonney, David Williamson, Wendy Sligl, Jan Friedrich, Neill K Adhikari, François Marquis, Patrick Archambault, Kosar Khwaja, Arnold Kristof, James Kutsogiannis, Ryan Zarychanski, Bojan Paunovic, Brenda Reeve, François Lellouche, Paul Hosek, Jennifer Tsang, Alexandra Binnie, Sébastien Trop, Osama Loubani, Richard Hall, Robert Cirone, Steve Reynolds, Paul Lysecki, Eyal Golan, Rodrigo Cartin-Ceba, Robert Taylor, Deborah Cook, ,

<h4>Importance</h4>Growing interest in microbial dysbiosis during critical illness has raised questions about the therapeutic potential of microbiome modification with probiotics. Prior randomized trials in this population suggest that probiotics reduce infection, particularly ventilator-associated pneumonia (VAP), although probiotic-associated infections have also been reported.<h4>Objective</h4>To evaluate the effect of Lactobacillus rhamnosus GG on ... Read more >>

JAMA (JAMA)
[2021, 326(11):1024-1033]

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Moral Distress and Other Wellness Measures in Canadian Critical Care Physicians.

Peter M Dodek, Elaine O Cheung, Karen E A Burns, Claudio M Martin, Patrick M Archambault, Francois Lauzier, Aimee J Sarti, Sangeeta Mehta, Alison E Fox-Robichaud, Andrew J E Seely, Christopher Parshuram, Daniel Garros, Davinia E Withington, Deborah J Cook, Dominique Piquette, Franco A Carnevale, J Gordon Boyd, James Downar, D James Kutsogiannis, Michael Chassé, Patricia Fontela, Robert A Fowler, Sean Bagshaw, Sonny Dhanani, Srinivas Murthy, Paige Gehrke, Tomoko Fujii,

<b>Rationale:</b> Understanding the magnitude of moral distress and its associations may point to solutions. <b>Objectives:</b> To understand the magnitude of moral distress and other measures of wellness in Canadian critical care physicians, to determine any associations among these measures, and to identify potentially modifiable factors. <b>Methods:</b> This was an online ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(8):1343-1351]

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Diversity of Authors of Publications From the Canadian Critical Care Trials Group.

Sangeeta Mehta, Nanki Ahluwalia, Kiyan Heybati, Karen E A Burns, Sawayra Owais, Deborah J Cook, ,

<h4>Objectives</h4>Diverse perspectives improve the quality of scholarly initiatives. The demographic and professional diversity of scientists who contribute to critical care research and publications has not been described for the Canadian Critical Care Trials Group. Our objective was to describe the diversity of authors of publications from the Canadian Critical Care ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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Consequences of visitor restriction policies in the intensive care unit during the COVID-19 pandemic.

Kimia Honarmand, Sangeeta Mehta,

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2021, 68(10):1465-1470]

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Survival in Immunocompromised Patients Ultimately Requiring Invasive Mechanical Ventilation: A Pooled Individual Patient Data Analysis.

Guillaume Dumas, Virginie Lemiale, Nisha Rathi, Andrea Cortegiani, Frédéric Pène, Vincent Bonny, Jorge Salluh, Guillermo M Albaiceta, Marcio Soares, Ayman O Soubani, Emmanuel Canet, Tarik Hanane, Achille Kouatchet, Djamel Mokart, Pia Lebiedz, Melda Türkoğlu, Rémi Coudroy, Kyeongman Jeon, Alexandre Demoule, Sangeeta Mehta, Pedro Caruso, Jean-Pierre Frat, Kuang-Yao Yang, Oriol Roca, John Laffey, Jean-François Timsit, Elie Azoulay, Michael Darmon,

<b>Rationale:</b> Acute respiratory failure (ARF) is associated with high mortality in immunocompromised patients, particularly when invasive mechanical ventilation is needed. Therefore, noninvasive oxygenation/ventilation strategies have been developed to avoid intubation, with uncertain impact on mortality, especially when intubation is delayed. <b>Objectives:</b> We sought to report trends of survival over time ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(2):187-196]

Cited: 1 time

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Association of Thoracic Computed Tomographic Measurements and Outcomes in Patients with Hematologic Malignancies Requiring Mechanical Ventilation.

Michael D Elfassy, Bruno L Ferreyro, Dmitry Rozenberg, Michael C Sklar, Sunita Mathur, Michael E Detsky, Ewan C Goligher, Sangeeta Mehta, Anca Prica, Santhosh Thyagu, Sophia Kerzner, Kate Hanneman, Laveena Munshi,

<b>Rationale:</b> Patients with hematologic malignancies requiring mechanical ventilation have historically experienced poor outcomes.<b>Objectives:</b> We aimed to determine whether body composition characteristics derived from thoracic computed tomographic (CT) imaging were associated with time to liberation from mechanical ventilation.<b>Methods:</b> We evaluated mechanically ventilated patients with hematological malignancies admitted between 2014 and 2018. ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(7):1219-1226]

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Evolution Over Time of Ventilatory Management and Outcome of Patients With Neurologic Disease.

Eva E Tejerina, Paolo Pelosi, Chiara Robba, Oscar Peñuelas, Alfonso Muriel, Deisy Barrios, Fernando Frutos-Vivar, Konstantinos Raymondos, Bin Du, Arnaud W Thille, Fernando Ríos, Marco González, Lorenzo Del-Sorbo, Maria Del Carmen Marín, Bruno Valle Pinheiro, Marco Antonio Soares, Nicolas Nin, Salvatore M Maggiore, Andrew Bersten, Pravin Amin, Nahit Cakar, Gee Young Suh, Fekri Abroug, Manuel Jibaja, Dimitros Matamis, Amine Ali Zeggwagh, Yuda Sutherasan, Antonio Anzueto, Andrés Esteban, ,

<h4>Objectives</h4>To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality.<h4>Design</h4>Secondary analysis of three prospective, observational, multicenter studies.<h4>Setting</h4>Cohort studies conducted in 2004, 2010, and 2016.<h4>Patients</h4>Adult patients who received mechanical ventilation for more than 12 hours.<h4>Interventions</h4>None.<h4>Measurements ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(7):1095-1106]

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Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study.

Tài Pham, Antonio Pesenti, Giacomo Bellani, Gordon Rubenfeld, Eddy Fan, Guillermo Bugedo, José Angel Lorente, Antero do Vale Fernandes, Frank Van Haren, Alejandro Bruhn, Fernando Rios, Andres Esteban, Luciano Gattinoni, Anders Larsson, Daniel F McAuley, Marco Ranieri, B Taylor Thompson, Hermann Wrigge, Laurent J Brochard, John G Laffey, ,

<h4>Background</h4>Current incidence and outcome of patients with acute hypoxaemic respiratory failure requiring mechanical ventilation in the intensive care unit (ICU) are unknown, especially for patients not meeting criteria for acute respiratory distress syndrome (ARDS).<h4>Methods</h4>An international, multicentre, prospective cohort study of patients presenting with hypoxaemia early in the course of mechanical ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 57(6):]

Cited: 6 times

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Gender disparity in critical care publications: a novel Female First Author Index.

Sowmya Chary, Karin Amrein, Djøra I Soeteman, Sangeeta Mehta, Kenneth B Christopher,

<h4>Background</h4>Bibliometric analyses show gender bias against women in scientific publications and citations. We hypothesized that a metric of an individual senior author's inclusivity of women as first authors in critical care publications would predict gender inequality.<h4>Methods</h4>Using PubMed and Web of Science, we conducted a bibliometric analysis of original research publications ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):103]

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Bacteremia in critically ill immunocompromised patients with acute hypoxic respiratory failure: A post-hoc analysis of a prospective multicenter multinational cohort.

Andry Van de Louw, Jordi Rello, Ignacio Martin-Loeches, Djamel Mokart, Victoria Metaxa, Dominique Benoit, Andreas Barratt-Due, Marcio Soares, Peter Pickkers, Massimo Antonelli, Alexandre Demoule, Peter Schellongowski, Achille Kouatchet, Sangeeta Mehta, Martin Balik, Philippe R Bauer, Virginie Lemiale, Vonn Walter, Elie Azoulay, ,

<h4>Purpose</h4>The characteristics and impact of bacteremia have not been widely investigated in immunocompromised patients with acute respiratory failure (ARF).<h4>Methods</h4>We performed a secondary analysis of a prospective cohort of immunocompromised patients with ARF (EFRAIM study). After exclusion of blood cultures positive for coagulase negative Staphylococci, we compared patients with (n = ... Read more >>

J Crit Care (Journal of critical care)
[2021, 64:114-119]

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Improving Diversity in Activities of Critical Care Societies: Missed Opportunities Due to Missing Data.

Jenny E Han, Karen E A Burns, Peter M Dodek, Sangeeta Mehta,

Chest (Chest)
[2021, 159(4):1334-1337]

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Death in hospital following ICU discharge: insights from the LUNG SAFE study.

Fabiana Madotto, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, John G Laffey, Giacomo Bellani, , ,

<h4>Background</h4>To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward.<h4>Methods</h4>The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):144]

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Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method.

Prashant Nasa, Elie Azoulay, Ashish K Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M Arabi, Jan Bakker, Laurent J Brochard, Adam M Deane, Bin Du, Sharon Einav, Andrés Esteban, Ognjen Gajic, Samuel M Galvagno, Claude Guérin, Samir Jaber, Gopi C Khilnani, Younsuck Koh, Jean-Baptiste Lascarrou, Flavia R Machado, Manu L N G Malbrain, Jordi Mancebo, Michael T McCurdy, Brendan A McGrath, Sangeeta Mehta, Armand Mekontso-Dessap, Mervyn Mer, Michael Nurok, Pauline K Park, Paolo Pelosi, John V Peter, Jason Phua, David V Pilcher, Lise Piquilloud, Peter Schellongowski, Marcus J Schultz, Manu Shankar-Hari, Suveer Singh, Massimiliano Sorbello, Ravindranath Tiruvoipati, Andrew A Udy, Tobias Welte, Sheila N Myatra,

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory failure (C-ARF) has resulted in wide variation in clinical practice.<h4>Methods</h4>Using a Delphi process, an international panel of 39 experts developed clinical practice statements on the ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):106]

Cited: 6 times

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COVID-19: a heavy toll on health-care workers.

Sangeeta Mehta, Flavia Machado, Arthur Kwizera, Laurent Papazian, Marc Moss, Élie Azoulay, Margaret Herridge,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(3):226-228]

Cited: 34 times

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Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery.

Allison Tong, Amanda Baumgart, Nicole Evangelidis, Andrea K Viecelli, Simon A Carter, Luciano Cesar Azevedo, Tess Cooper, Andrew Bersten, Lilia Cervantes, Derek P Chew, Sally Crowe, Ivor S Douglas, Ella Flemyng, Julian H Elliott, Elyssa Hannan, Peter Horby, Martin Howell, Angela Ju, Jaehee Lee, Eduardo Lorca, Deena Lynch, Karine E Manera, John C Marshall, Andrea Matus Gonzalez, Anne McKenzie, Sangeeta Mehta, Mervyn Mer, Andrew Conway Morris, Dale M Needham, Saad Nseir, Pedro Povoa, Mark Reid, Yasser Sakr, Ning Shen, Alan R Smyth, A John Simpson, Tom Snelling, Giovanni F M Strippoli, Armando Teixeira-Pinto, Antoni Torres, Tari Turner, Steve Webb, Paula R Williamson, Laila Woc-Colburn, Junhua Zhang, Jonathan C Craig, ,

<h4>Objectives</h4>Respiratory failure, multiple organ failure, shortness of breath, recovery, and mortality have been identified as critically important core outcomes by more than 9300 patients, health professionals, and the public from 111 countries in the global coronavirus disease 2019 core outcome set initiative. The aim of this project was to establish ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):503-516]

Cited: 5 times

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Resumption of Cardiac Activity after Withdrawal of Life-Sustaining Measures.

Sonny Dhanani, Laura Hornby, Amanda van Beinum, Nathan B Scales, Melanie Hogue, Andrew Baker, Stephen Beed, J Gordon Boyd, Jennifer A Chandler, Michaël Chassé, Frederick D'Aragon, Cameron Dezfulian, Christopher J Doig, Frantisek Duska, Jan O Friedrich, Dale Gardiner, Teneille Gofton, Dan Harvey, Christophe Herry, George Isac, Andreas H Kramer, Demetrios J Kutsogiannis, David M Maslove, Maureen Meade, Sangeeta Mehta, Laveena Munshi, Loretta Norton, Giuseppe Pagliarello, Tim Ramsay, Katerina Rusinova, Damon Scales, Matous Schmidt, Andrew Seely, Jason Shahin, Marat Slessarev, Derek So, Heather Talbot, Walther N K A van Mook, Petr Waldauf, Matthew Weiss, Jentina T Wind, Sam D Shemie, , ,

<h4>Background</h4>The minimum duration of pulselessness required before organ donation after circulatory determination of death has not been well studied.<h4>Methods</h4>We conducted a prospective observational study of the incidence and timing of resumption of cardiac electrical and pulsatile activity in adults who died after planned withdrawal of life-sustaining measures in 20 intensive ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(4):345-352]

Cited: 2 times

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Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65): protocol and statistical analysis plan for a randomised clinical trial.

Marie-Hélène Masse, Marie-Claude Battista, Mary Elizabeth Wilcox, Ruxandra Pinto, Nicole Marinoff, Frédérick D'Aragon, Charles St-Arnaud, Michael Mayette, Marc-André Leclair, Hector Quiroz Martinez, Brian Grondin-Beaudoin, Yannick Poulin, Élaine Carbonneau, Andrew J E Seely, Irene Watpool, Rebecca Porteous, Michaël Chassé, Martine Lebrasseur, François Lauzier, Alexis F Turgeon, David Bellemare, Sangeeta Mehta, Emmanuel Charbonney, Émilie Belley-Côté, Édouard Botton, Dian Cohen, François Lamontagne, Neill K J Adhikari, , ,

<h4>Introduction</h4>Vasodilatory hypotension is common among intensive care unit (ICU) patients; vasopressors are considered standard of care. However, optimal mean arterial pressure (MAP) targets for vasopressor titration are unknown. The objective of the Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65) trial is to ascertain the effect of permissive ... Read more >>

BMJ Open (BMJ open)
[2020, 10(11):e037947]

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Analgesia and sedation in patients with ARDS.

Gerald Chanques, Jean-Michel Constantin, John W Devlin, E Wesley Ely, Gilles L Fraser, Céline Gélinas, Timothy D Girard, Claude Guérin, Matthieu Jabaudon, Samir Jaber, Sangeeta Mehta, Thomas Langer, Michael J Murray, Pratik Pandharipande, Bhakti Patel, Jean-François Payen, Kathleen Puntillo, Bram Rochwerg, Yahya Shehabi, Thomas Strøm, Hanne Tanghus Olsen, John P Kress,

Acute Respiratory Distress Syndrome (ARDS) is one of the most demanding conditions in an Intensive Care Unit (ICU). Management of analgesia and sedation in ARDS is particularly challenging. An expert panel was convened to produce a "state-of-the-art" article to support clinicians in the optimal management of analgesia/sedation in mechanically ventilated ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(12):2342-2356]

Cited: 9 times

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