Full Text Journal Articles by
Author Sang Yoon Park

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A single-arm phase II study of olaparib maintenance with pembrolizumab and bevacizumab in BRCA non-mutated patients with platinum-sensitive recurrent ovarian cancer (OPEB-01).

Yong Jae Lee, Myong Cheol Lim, Byoung Gie Kim, Natalie Yl Ngoi, Chel Hun Choi, Sang Yoon Park, David Sp Tan, Yunjung Go, Jung Yun Lee,

<h4>Background</h4>The optimal treatment of <i>BRCA</i> wild-type patients with platinum-sensitive recurrent ovarian cancer remains unknown. Recently, there is an increase in the evidence to support the role of the combination of a poly(adenosine diphosphate-ribose) polymerase inhibitor, anti-angiogenic agents, and immunotherapy as maintenance therapy in <i>BRCA</i> wild-type patients with platinum-sensitive recurrence. We ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e31]

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Survival Effects of Cytoreductive Surgery for Refractory Patients after Neoadjuvant Chemotherapy in Advanced Epithelial Ovarian Cancer.

Wonkyo Shin, Joseph J Noh, Sang Soo Seo, Sokbom Kang, Chel Hun Choi, Sang Yoon Park, Byoung Gie Kim, Myong Cheol Lim,

<h4>Purpose</h4>Salvage second-line chemotherapy is usually recommended for patients with advanced epithelial ovarian cancer (AEOC) who develop progressive disease (PD) after neoadjuvant chemotherapy (NAC). Herein, we investigated the role of cytoreductive surgery (CRS) for such patients.<h4>Materials and methods</h4>We retrospectively reviewed the medical records of 36 patients with AEOC who developed PD ... Read more >>

Yonsei Med J (Yonsei medical journal)
[2020, 61(11):935-941]

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Narrative review of liver mobilization, diaphragm peritonectomy, full-thickness diaphragm resection, and reconstruction.

Wonkyo Shin, Jaehee Mun, Sang-Yoon Park, Myong Cheol Lim,

Epithelial ovarian cancer is the most lethal among gynecologic cancers. Despite advances in research efforts to cure this disease, the recurrence and survival rates have not significantly improved. Primary cytoreductive surgery and adjuvant chemotherapy are the standard treatment options for patients with epithelial ovarian cancer. Two randomized trials recently introduced ... Read more >>

Gland Surg (Gland surgery)
[2021, 10(3):1212-1217]

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Ultra-radical surgery in ovarian cancer.

Sang-Yoon Park, Jae-Weon Kim,

Gland Surg (Gland surgery)
[2021, 10(3):1171-1172]

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The Knowledge and Attitude of Patients Diagnosed with Epithelial Ovarian Cancer towards Genetic Testing.

Wonkyo Shin, Gowoon Jeong, Yedong Son, Sang-Soo Seo, Sokbom Kang, Sang-Yoon Park, Myong Cheol Lim,

This study assessed the knowledge and attitude of patients with ovarian cancer (OC) toward OC and next generation sequencing (NGS). The data, including characteristics of patients, their knowledge about OC and their knowledge and attitude of NGS, were collected from June to October 2018. Of the 103 participants, 70.9% (<i>n</i> ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(5):]

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How to Manage Synchronous Endometrial and Ovarian Cancer Patients?

Wonkyo Shin, Sang-yoon Park, Sokbom Kang, Myongcheol Lim, Sang-Soo Seo,

Purpose : We aimed to evaluate the prognosis in patients with synchronous endometrial and ovarian cancer (SEOC) by comparing the differences between double primary cancer (DPC) and metastatic cancer (MC). <h4>Methods: </h4> The medical records of 47 patients diagnosed synchronously with endometrial and ovarian cancer between January 2006 and December ... Read more >>

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Pembrolizumab plus GX-188E therapeutic DNA vaccine in patients with HPV-16-positive or HPV-18-positive advanced cervical cancer: interim results of a single-arm, phase 2 trial.

Jin Won Youn, Soo-Young Hur, Jung Won Woo, Yong-Man Kim, Myong Cheol Lim, Sang Yoon Park, Sang Soo Seo, Jae Hong No, Byoung-Gie Kim, Jae-Kwan Lee, So Jin Shin, Kyungun Kim, Marya F Chaney, Yoon-Jeong Choi, You Suk Suh, Jong Sup Park, Young Chul Sung,

<h4>Background</h4>Survival outcomes for patients with recurrent or advanced cervical cancer are poor. Pembrolizumab has been approved for the treatment of recurrent or metastatic cervical cancer, with an overall response rate of 14·3%. GX-188E vaccination has been shown to induce human papillomavirus (HPV) E6-specific and E7-specific T-cell responses and cervical lesion ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2020, 21(12):1653-1660]

Cited: 3 times

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Relationship Between Retinal Capillary Nonperfusion Area and Renal Function in Patients With Type 2 Diabetes.

Ji Won Min, Hyung Duk Kim, Sang Yoon Park, Jun Hyuk Lee, Jae Hyun Park, Anna Lee, Ho Ra, Jiwon Baek,

<h4>Purpose</h4>We sought to assess the relationship between retinal nonperfusion area (NPA) on ultra-widefield fluorescein angiography (UWFA) and renal function in type 2 diabetes mellitus (DM) patients with diabetic retinopathy (DR) and nephropathy.<h4>Methods</h4>UWFA was performed in 248 eyes (124 patients) with DR, comprising 94 eyes from patients with chronic kidney disease ... Read more >>

Invest Ophthalmol Vis Sci (Investigative ophthalmology & visual science)
[2020, 61(14):14]

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Multifunctional reduced graphene oxide-CVD graphene core-shell fibers.

Yong Seok Choi, Chang-Su Yeo, Sang Jin Kim, Jin-Young Lee, Youngsoo Kim, Kang Rae Cho, Sanghyun Ju, Byung Hee Hong, Sang Yoon Park,

The insufficient electrical conductivity and mechanical stretchability of conventional graphene fibers based on reduced graphene oxide liquid crystals (rGO-LCs) has limited their applications to numerous textile devices. Here, we report a simple method to fabricate multifunctional fibers with mechanically strong rGO cores and highly conductive CVD graphene shells ([email protected] fibers), ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(26):12637-12642]

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Glycolytic phenotypes in an evaluation of ovarian carcinoma based on carcinogenesis and BRCA mutation.

Sohyun Park, Tae-Sung Kim, Myong Cheol Lim, Sang-Soo Seo, Sokbom Kang, Seok-Ki Kim, Chong Woo Yoo, Sang-Yoon Park,

<h4>Backgrounds</h4>Recently, a dualistic carcinogenesis model of ovarian cancer has emerged. We aimed to investigate differences in the glycolytic phenotypes of type I and type II ovarian carcinoma on the basis of FDG uptake and in the pathological features according to tumour grade and histology.<h4>Materials and methods</h4>In total, 386 epithelial ovarian ... Read more >>

Eur J Radiol (European journal of radiology)
[2020, 133:109391]

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A phase II study of neoadjuvant chemotherapy plus durvalumab and tremelimumab in advanced-stage ovarian cancer: a Korean Gynecologic Oncology Group Study (KGOG 3046), TRU-D.

Jung Yun Lee, Jae Weon Kim, Myong Cheol Lim, Sunghoon Kim, Hee Seung Kim, Chel Hun Choi, Ju Yeon Yi, Sang Yoon Park, Byoung Gie Kim, ,

<h4>Background</h4>A single-arm phase II study of neoadjuvant chemotherapy plus durvalumab and tremelimumab in the treatment of advanced-stage ovarian cancer has begun in Korea. We hypothesized that adding durvalumab (anti-programmed death-ligand 1 antibody) and tremelimumab (anti-cytotoxic T-lymphocyte-associated protein 4 antibody) to chemotherapy in treating this cancer can increase progression-free survival (PFS) ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2019, 30(6):e112]

Cited: 2 times

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A multicentre, randomised, open-label, parallel-group Phase 2b study of belotecan versus topotecan for recurrent ovarian cancer.

Hee Seung Kim, Sang-Yoon Park, Chan-Yong Park, Young Tae Kim, Beob-Jong Kim, Yong Jung Song, Byoung-Gie Kim, Yong Beom Kim, Chi-Heum Cho, Jong-Hyeok Kim, Yong Sang Song,

<h4>Background</h4>This Phase 2b study compared the efficacy and toxicity of belotecan and topotecan in recurrent ovarian cancer.<h4>Methods</h4>Patients with platinum-sensitive recurrent or platinum-resistant recurrent ovarian cancer (PRROC) were randomised 1:1 to receive belotecan 0.5 mg/m<sup>2</sup> or topotecan 1.5 mg/m<sup>2</sup> for five consecutive days every 3 weeks. The primary endpoint was overall response rate ... Read more >>

Br J Cancer (British journal of cancer)
[2021, 124(2):375-382]

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Real world effectiveness and safety of pegylated liposomal doxorubicin in platinum-sensitive recurrent ovarian, fallopian, or primary peritoneal cancer: a Korean multicenter retrospective cohort study.

Soo Jin Park, Jihye Kim, Hee Seung Kim, Jeong Won Lee, Ha Kyun Chang, Keun Ho Lee, Dae Yeon Kim, Sunghoon Kim, Suk Joon Chang, Seung Su Han, Sang Yoon Park, Seung Hyuk Shim,

OBJECTIVE:To evaluate the effectiveness and safety of the combination of pegylated liposomal doxorubicin with carboplatin (CD) compared with those of carboplatin and paclitaxel (CP) for platinum-sensitive recurrent ovarian, fallopian, or primary peritoneal cancer in a real-world setting in Korea. METHODS:We enrolled relevant patients from 9 institutions. All patients received CD ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2020, 31(2):e15]

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Collapsin response mediator protein 4 enhances radio-sensitivity through calcium-mediated cell signaling

Sang Yoon Park, Jong-Tae Kim, Eun Sun Park, Yo Sep Hwang, Hyang Ran Yoon, Kyoung Eun Baek, Haiyoung Jung, Suk Ran Yoon, Bo Yeon Kim, Hee Jun Cho, Hee Gu Lee,

<h4>Background: </h4> Radiation therapy, an effective treatment modality against various types of cancer including colorectal cancer, reduces local recurrence rate despite damaging both normal and cancer cells. However, the presence of cancer cells resistant to radiation therapy remains a major therapeutic obstacle; thus, understanding the mechanisms underlying radiation resistance is ... Read more >>

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The survival effect of ovary preservation in early stage endometrial cancer: a single institution retrospective analysis.

Wonkyo Shin, Sang-Yoon Park, Sokbom Kang, Myong Cheol Lim, Sang-Soo Seo,

<h4>Purpose</h4>We investigated the effect of ovary preserving surgery in early International Federation of Obstetrics and Gynecology (FIGO) stage endometrial cancer patients.<h4>Methods</h4>Medical records were retrospectively reviewed for 539 patients who were diagnosed with early stage endometrial cancer between Jan 2006 and Dec 2017. Patients were categorized into ovary preservation and ovary ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):97]

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Uptake of Family-Specific Mutation Genetic Testing Among Relatives of Patients with Ovarian Cancer with BRCA1 or BRCA2 Mutation.

Go Woon Jeong, Wonkyo Shin, Dong Ock Lee, Sang-Soo Seo, Sokbom Kang, Sang-Yoon Park, Myong Cheol Lim,

<h4>Purpose</h4>The BRCA1 or BRCA2 gene is transmitted in an autosomal dominant fashion, and genetic testing of first-degree relatives of patients with family-specific mutation (FSM) is recommended. This study examined factors affecting the uptake of FSM testing among relatives of patients with peritoneal, ovarian, or fallopian tube (POFT) cancer with confirmed ... Read more >>

Cancer Res Treat (Cancer research and treatment)
[2021, 53(1):207-211]

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Trebananib or placebo plus carboplatin and paclitaxel as first-line treatment for advanced ovarian cancer (TRINOVA-3/ENGOT-ov2/GOG-3001): a randomised, double-blind, phase 3 trial.

Ignace Vergote, Giovanni Scambia, David M O'Malley, Ben Van Calster, Sang-Yoon Park, Josep M Del Campo, Werner Meier, Aristotelis Bamias, Nicoletta Colombo, Robert M Wenham, Al Covens, Christian Marth, Mansoor Raza Mirza, Judith R Kroep, Haijun Ma, Cheryl A Pickett, Bradley J Monk, ,

<h4>Background</h4>Angiopoietin 1 and 2 regulate angiogenesis and vascular remodelling by interacting with the tyrosine kinase receptor Tie2, and inhibition of angiogenesis has shown promise in the treatment of ovarian cancer. We aimed to assess whether trebananib, a peptibody that inhibits binding of angiopoietin 1 and 2 to Tie2, improved progression-free ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2019, 20(6):862-876]

Cited: 9 times

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Salvage surgery with second free flap reconstruction for recurrent oral squamous cell carcinoma.

Tae-Young Jung, Ki-Woong Sung, Sang-Yoon Park, Soung-Min Kim, Jong-Ho Lee,

<h4>Purpose</h4>The purpose of this study was to evaluate the results of the reconstruction using the second free flap following resection of recurrent oral squamous cell carcinoma(OSCC).<h4>Patients and methods</h4>A total of 25 patients from 2005 to 2018 who had undergone salvage surgery and reconstruction using the second free flap for recurrent ... Read more >>

Heliyon (Heliyon)
[2020, 6(6):e04014]

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Survival outcomes of adjuvant radiotherapy and chemotherapy in women with stage I serous papillary and clear cell carcinoma of the endometrium: a Korean multicenter study.

Miseon Kim, Byung Su Kwon, Ha Kyun Chang, Seungmee Lee, Suk Joon Chang, Jin Young Choi, Sang Yoon Park, Maria Lee, Hee Sug Ryu, Yong Beom Kim,

OBJECTIVE:To compare the survival outcomes of adjuvant radiotherapy and chemotherapy in women with uterine-confined endometrial cancer with uterine papillary serous carcinoma (UPSC) or clear cell carcinoma (CCC). METHODS:Medical records of 80 women who underwent surgical staging for endometrial cancer were retrospectively reviewed. Stage I UPSC and CCC were pathologically confirmed ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2019, 30(3):e44]

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The Survival Effect of Ovary Preservation in Early Stage Endometrial Cancer: A Single Institution Retrospective Analysis

Wonkyo Shin, Sang-Yoon Park, Sokbom Kang, Myong Cheol Lim, Sang-Soo Seo,

Purpose: We investigated the effect of ovary preserving surgery in early International Federation of Obstetrics and Gynecology (FIGO) stage endometrial cancer patients. <h4>Methods: </h4> Medical records were retrospectively reviewed for 539 patients who were diagnosed with early stage endometrial cancer between Jan 2006 and Dec 2017. Patients were categorized into ... Read more >>

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Effect of addition of bevacizumab to chemoradiotherapy in newly diagnosed stage IVB cervical cancer: a single institution experience in Korea.

Sang Hee Youn, Yeon-Joo Kim, Sang-Soo Seo, Sokbom Kang, Myong Cheol Lim, Ha Kyun Chang, Sang-Yoon Park, Joo-Young Kim,

OBJECTIVE:The aim of this study was to compare the clinical outcomes of chemoradiotherapy with or without bevacizumab in patients with newly diagnosed International Federation of Gynecology and Obstetrics (FIGO) stage IVB cervical cancer. METHODS:41 patients with stage IVB cervical cancer who underwent chemoradiotherapy between August 2015 and December 2017 were ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(6):764-771]

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Definitive chemoradiotherapy versus radical hysterectomy followed by tailored adjuvant therapy in women with early-stage cervical cancer presenting with pelvic lymph node metastasis on pretreatment evaluation: A propensity score matching analysis

Jongmoo Park, Yeon-Joo Kim, Mi Kyung Song, Joo-Hyun Nam, Sang-Yoon Park, Young Seok Kim, Joo-Young Kim,

<h4>Objective: </h4> To compare the oncologic outcomes between chemoradiotherapy and radical hysterectomy followed by tailored adjuvant therapy in patients with early cervical cancer presenting with pelvic lymph node metastasis. Methods We retrospectively analyzed the medical records of women with early cervical cancer presenting with positive pelvic nodes identified on pretreatment ... Read more >>

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Comprehensive geriatric assessment is correlated to overall survival among gynaecologic oncology patients.

Nadav Michaan, Sang Yoon Park, Myong Cheol Lim,

OBJECTIVE:To investigate the correlation of comprehensive geriatric assessment to overall survival among older gynaecologic oncology patients. METHODS:Between 2011 and 2017, patients >70 years had geriatric assessment before treatment. Geriatric assessment included the following tests: Old American resource and services, instrumental activities of daily living, modified Barthels index, mini-mental state examination, geriatric ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2020, 50(3):276-281]

Cited: 1 time

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Peritoneal cancer index in ovarian cancer.

Wonkyo Shin, Sang Yoon Park, Myong Cheol Lim,

J Gynecol Oncol (Journal of gynecologic oncology)
[2019, 30(1):e14]

Cited: 1 time

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Human sweat monitoring using polymer-based fiber.

Taekyung Lim, Youngseok Kim, Sang-Mi Jeong, Chi-Hyeong Kim, Seong-Min Kim, Sang Yoon Park, Myung-Han Yoon, Sanghyun Ju,

Lightweight nano/microscale wearable devices that are directly attached to or worn on the human body require enhanced flexibility so that they can facilitate body movement and overall improved wearability. In the present study, a flexible poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) fiber-based sensor is proposed, which can accurately measure the amount of salt (i.e., ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):17294]

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