Full Text Journal Articles by
Author Sandy R Shultz

Advertisement

Find full text journal articles






Diffusion Imaging Reveals Sex Differences in the White Matter Following Sports-Related Concussion.

David K Wright, Georgia F Symons, William T O'Brien, Stuart J McDonald, Akram Zamani, Brendan Major, Zhibin Chen, Daniel Costello, Rhys D Brady, Mujun Sun, Meng Law, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz,

Sports-related concussion (SRC) is a serious health concern. However, the temporal profile of neuropathophysiological changes after SRC and how these relate to biological sex are still poorly understood. This preliminary study investigated whether diffusion-weighted magnetic resonance imaging (dMRI) was sensitive to neuropathophysiological changes following SRC; whether these changes were sex-specific; ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2021, :]

Cited: 0 times

View full text PDF listing >>



Targeting the Cerebrovascular System: Next-Generation Biomarkers and Treatment for Mild Traumatic Brain Injury.

Tamara L Baker, Denes V Agoston, Rhys D Brady, Brendan Major, Stuart J McDonald, Richelle Mychasiuk, David K Wright, Glenn R Yamakawa, Mujun Sun, Sandy R Shultz,

The diagnosis, prognosis, and treatment of mild traumatic brain injuries (mTBIs), such as concussions, are significant unmet medical issues. The kinetic forces that occur in mTBI adversely affect the cerebral vasculature, making cerebrovascular injury (CVI) a pathophysiological hallmark of mTBI. Given the importance of a healthy cerebrovascular system in overall ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211012264]

Cited: 0 times

View full text PDF listing >>



Advertisement

The Known Unknowns: An Overview of the State of Blood-based Protein Biomarkers of Mild Traumatic Brain Injury.

Stuart John McDonald, Sandy R Shultz, Denes V Agoston,

Blood-based protein biomarkers have revolutionized several fields of medicine by enabling molecular level diagnosis, as well as monitoring disease progression and treatment efficacy. Traumatic brain injury (TBI) so far has benefitted only moderately from using protein biomarkers to improve injury outcome. Due to its complexity and dynamic nature, TBI, especially ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Temporal profile and utility of serum neurofilament light in a rat model of mild traumatic brain injury.

William T O'Brien, Louise Pham, Rhys D Brady, Jesse Bain, Glenn R Yamakawa, Mujun Sun, Richelle Mychasiuk, Terence J O'Brien, Mastura Monif, Sandy R Shultz, Stuart J McDonald,

There is a widely recognized need for blood biomarkers to assist clinical decisions surrounding mild traumatic brain injury (mTBI). Serum neurofilament light (NfL), an indicator of neuroaxonal damage, is one such candidate, with early mTBI clinical investigations demonstrating significant promise. To facilitate the translation of pre-clinical mTBI findings, clinically relevant ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 341:113698]

Cited: 0 times

View full text PDF listing >>



A systemic immune challenge to model hospital-acquired infections independently regulates immune responses after pediatric traumatic brain injury.

Rishabh Sharma, Akram Zamani, Larissa K Dill, Mujun Sun, Erskine Chu, Marcus J Robinson, Terence J O'Brien, Sandy R Shultz, Bridgette D Semple,

<h4>Background</h4>Traumatic brain injury (TBI) is a major cause of disability in young children, yet the factors contributing to poor outcomes in this population are not well understood. TBI patients are highly susceptible to nosocomial infections, which are mostly acquired within the first week of hospitalization, and such infections may modify ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2021, 18(1):72]

Cited: 0 times

View full text PDF listing >>



Pain in the Developing Brain: Early Life Factors Alter Nociception and Neurobiological Function in Adolescent Rats.

Sabrina Salberg, Glenn R Yamakawa, Yannick Griep, Jesse Bain, Jaimie K Beveridge, Mujun Sun, Stuart J McDonald, Sandy R Shultz, Rhys D Brady, David K Wright, Melanie Noel, Richelle Mychasiuk,

Although adverse early experiences prime individuals to be at increased risk for chronic pain, little research has examined the trauma-pain relationship in early life or the underlying mechanisms that drive pathology over time. Given that early experiences can potentiate the nociceptive response, this study aimed to examine the effects of ... Read more >>

Cereb Cortex Commun (Cerebral cortex communications)
[2021, 2(2):tgab014]

Cited: 0 times

View full text PDF listing >>



Neurological heterotopic ossification: novel mechanisms, prognostic biomarkers and prophylactic therapies.

Ker Rui Wong, Richelle Mychasiuk, Terence J O'Brien, Sandy R Shultz, Stuart J McDonald, Rhys D Brady,

Neurological heterotopic ossification (NHO) is a debilitating condition where bone forms in soft tissue, such as muscle surrounding the hip and knee, following an injury to the brain or spinal cord. This abnormal formation of bone can result in nerve impingement, pain, contractures and impaired movement. Patients are often diagnosed ... Read more >>

Bone Res (Bone research)
[2020, 8(1):42]

Cited: 1 time

View full text PDF listing >>



Contrast enhanced magnetic resonance imaging highlights neurovasculature changes following experimental traumatic brain injury in the rat.

David K Wright, Jamie N Mayo, Mujun Sun, Terence J O'Brien, Sandy R Shultz,

Neurovascular injury has been proposed as a universal pathological hallmark of traumatic brain injury (TBI) with molecular markers of angiogenesis and endothelial function associated with injury severity and morbidity. Sex differences in the neurovasculature response post-TBI may contribute to the differences seen in how males and females respond to injury. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):21252]

Cited: 0 times

View full text PDF listing >>



Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: Novel insights using a clinically relevant rat model.

Louise Pham, David K Wright, William T O'Brien, Jesse Bain, Cheng Huang, Mujun Sun, Pablo M Casillas-Espinosa, Anup D Shah, Ralf B Schittenhelm, Christopher G Sobey, Rhys D Brady, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz, Stuart J McDonald,

A history of mild traumatic brain injury (mTBI) is linked to a number of chronic neurological conditions, however there is still much unknown about the underlying mechanisms. To provide new insights, this study used a clinically relevant model of repeated mTBI in rats to characterize the acute and chronic neuropathological ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2021, 148:105151]

Cited: 3 times

View full text PDF listing >>



Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties.

Jennaya Christensen, Glenn R Yamakawa, Sandy R Shultz, Richelle Mychasiuk,

Until recently, both the purpose of the biological need for sleep and the mechanism by which the central nervous system eliminated metabolic waste products were unknown. The glymphatic system is the recently discovered macroscopic waste clearance system for the CNS, which predominantly functions during sleep states. Important implications for the ... Read more >>

Prog Neurobiol (Progress in neurobiology)
[2021, 198:101917]

Cited: 2 times

View full text PDF listing >>



Experimental traumatic brain injury does not lead to lung infection.

Mujun Sun, Rhys D Brady, Brooke Wanrooy, Richelle Mychasiuk, Glenn R Yamakawa, Pablo M Casillas-Espinosa, Connie H Y Wong, Sandy R Shultz, Stuart J McDonald,

Traumatic brain injury (TBI) patients often experience post-traumatic infections, especially in the lung. Pulmonary infection is associated with unfavorable outcomes and increased mortality rates in TBI patients; however, our understanding of the underlying mechanisms is poor. Here we used a lateral fluid percussion injury (LFPI) model in rats to investigate ... Read more >>

J Neuroimmunol (Journal of neuroimmunology)
[2020, 343:577239]

Cited: 1 time

View full text PDF listing >>



Repetitive Mild Traumatic Brain Injury Alters Glymphatic Clearance Rates in Limbic Structures of Adolescent Female Rats.

Jennaya Christensen, David K Wright, Glenn R Yamakawa, Sandy R Shultz, Richelle Mychasiuk,

The glymphatic system is the macroscopic waste clearance system for the central nervous system. Glymphatic dysfunction has been linked to several neurological conditions, including traumatic brain injury (TBI). Adolescents are at particularly high risk for experiencing a TBI, particularly mild TBI (mTBI) and repetitive mTBI (RmTBI); however, glymphatic clearance, and ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):6254]

Cited: 1 time

View full text PDF listing >>



Beyond the Brain: Peripheral Interactions after Traumatic Brain Injury.

Stuart J McDonald, Jessica M Sharkey, Mujun Sun, Lola M Kaukas, Sandy R Shultz, Renee J Turner, Anna V Leonard, Rhys D Brady, Frances Corrigan,

Traumatic brain injury (TBI) is a leading cause of death and disability, and there are currently no pharmacological treatments known to improve patient outcomes. Unquestionably, contributing toward a lack of effective treatments is the highly complex and heterogenous nature of TBI. In this review, we highlight the recent surge of ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, 37(5):770-781]

Cited: 15 times

View full text PDF listing >>



A novel rat model of heterotopic ossification after polytrauma with traumatic brain injury.

Rhys D Brady, Michael Z Zhao, Ker R Wong, Pablo M Casilla-Espinosa, Glenn R Yamakawa, Ryan C Wortman, Mujun Sun, Brian L Grills, Richelle Mychasiuk, Terence J O'Brien, Denes V Agoston, Peter V S Lee, Stuart J McDonald, Dale L Robinson, Sandy R Shultz,

Neurological heterotopic ossification (NHO) is characterized by abnormal bone growth in soft tissue and joints in response to injury to the central nervous system. The ectopic bone frequently causes pain, restricts mobility, and decreases the quality of life for those affected. NHO commonly develops in severe traumatic brain injury (TBI) ... Read more >>

Bone (Bone)
[2020, 133:115263]

Cited: 2 times

View full text PDF listing >>



The need to incorporate aged animals into the preclinical modeling of neurological conditions.

Mujun Sun, Stuart J McDonald, Rhys D Brady, Lyndsey Collins-Praino, Glenn R Yamakawa, Mastura Monif, Terence J O'Brien, Geoffrey C Cloud, Christopher G Sobey, Richelle Mychasiuk, David J Loane, Sandy R Shultz,

Neurological conditions such as traumatic brain injury, stroke, Parkinson's disease, epilepsy, multiple sclerosis, and Alzheimer's disease are serious clinical problems that affect millions of people worldwide. The majority of clinical trials for these common conditions have failed, and there is a critical need to understand why treatments in preclinical animal ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2020, 109:114-128]

Cited: 5 times

View full text PDF listing >>



Bone Health in Rats With Temporal Lobe Epilepsy in the Absence of Anti-Epileptic Drugs.

Rhys D Brady, Ker Rui Wong, Dale L Robinson, Richelle Mychasiuk, Stuart J McDonald, Ryan A D'Cunha, Glenn R Yamakawa, Mujun Sun, John D Wark, Peter Vee Sin Lee, Terence J O'Brien, Pablo M Casillas-Espinosa, Sandy R Shultz,

<b>Rationale:</b> Epilepsy patients often exhibit reduced bone mineral density and are at an increased risk of bone fracture. Whether these bone abnormalities are due to the use of anti-epileptic drugs (AED's) or the disease itself is unknown. For example, although decreased bone health in epilepsy patients is generally attributed to ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:1278]

Cited: 0 times

View full text PDF listing >>



Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy.

Pablo M Casillas-Espinosa, Sandy R Shultz, Emma L Braine, Nigel C Jones, Terrance P Snutch, Kim L Powell, Terence J O'Brien,

We evaluated whether pharmacologically targeting T-type Ca<sup>2+</sup> channels with Z944, a potent and selective antagonist, has disease-modifying effects in a model of temporal lobe epilepsy (TLE) that exhibits spontaneous recurrent seizures, and manifests behavioral and cognitive comorbidities commonly experienced by patients with this condition. Wistar rats underwent implantation of EEG ... Read more >>

Prog Neurobiol (Progress in neurobiology)
[2019, 182:101677]

Cited: 0 times

View full text PDF listing >>



Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat.

David K Wright, Rhys D Brady, Alaa Kamnaksh, Jack Trezise, Mujun Sun, Stuart J McDonald, Richelle Mychasiuk, Scott C Kolbe, Meng Law, Leigh A Johnston, Terence J O'Brien, Denes V Agoston, Sandy R Shultz,

A single mild traumatic brain injury (mTBI) typically causes only transient symptoms, but repeated mTBI (RmTBI) is associated with cumulative and chronic neurological abnormalities. Clinical management of mTBI is challenging due to the heterogeneous, subjective and transient nature of symptoms, and thus would be aided by objective biomarkers. Promising biomarkers ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):14626]

Cited: 4 times

View full text PDF listing >>



The genetic ablation of tau improves long-term, but not short-term, functional outcomes after experimental traumatic brain injury in mice.

Xin Lin Tan, Ping Zheng, David K Wright, Mujun Sun, Rhys D Brady, Shijie Liu, Stuart J McDonald, Richelle Mychasiuk, Sitare Cenap, Nigel C Jones, Terence J O'Brien, Sandy R Shultz,

<h4>Primary objective</h4>This study characterized the acute and chronic effects of tau reduction in traumatic brain injury (TBI).<h4>Research design</h4>A fluid percussion injury (FPI) or a sham-injury was administered to wild type (WT) or tau knockout (Tau-/-) mice. Mice were assigned to a one-week or twelve-week recovery period before behavioral testing and ... Read more >>

Brain Inj (Brain injury)
[2020, 34(1):131-139]

Cited: 2 times

View full text PDF listing >>



Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences.

Kyria M Webster, Sandy R Shultz, Ezgi Ozturk, Larissa K Dill, Mujun Sun, Pablo Casillas-Espinosa, Nigel C Jones, Peter J Crack, Terence J O'Brien, Bridgette D Semple,

High mobility group box protein-1 (HMGB1) has been implicated as a key mediator of neuroinflammation and neurodegeneration in a range of neurological conditions including traumatic brain injury (TBI) and epilepsy. To date, however, most studies have examined only acute outcomes, and the adult brain. We have recently demonstrated HMGB1 release ... Read more >>

Exp Neurol (Experimental neurology)
[2019, 320:112979]

Cited: 13 times

View full text PDF listing >>



Clinical Relevance of Behavior Testing in Animal Models of Traumatic Brain Injury.

Sandy R Shultz, Stuart J McDonald, Frances Corrigan, Bridgette D Semple, Sabrina Salberg, Akram Zamani, Nigel C Jones, Richelle Mychasiuk,

Traumatic brain injury (TBI) is a leading cause of morbidity worldwide, with patients often suffering from consequences such as cognitive deficits, social abnormalities, anxiety, depression, pain, and motor dysfunction. Given that these impairments often have a significant impact on the patient's quality of life, a key aim of therapeutic intervention ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, 37(22):2381-2400]

Cited: 0 times

View full text PDF listing >>



Inhibitory neuronal changes following a mixed diffuse-focal model of traumatic brain injury.

Simone F Carron, Mujun Sun, Sandy R Shultz, Ramesh Rajan,

Traumatic brain injury (TBI) can result in excitation: inhibition imbalance, as well as a range of chronic neurological deficits. However, how TBI affects different interneurons, and how this relates to behavioral abnormalities, remains poorly understood. This study examined the effects of a mixed diffuse-focal model of TBI, the lateral fluid ... Read more >>

J Comp Neurol (The Journal of comparative neurology)
[2020, 528(2):175-198]

Cited: 2 times

View full text PDF listing >>



Neuroendocrine Whiplash: Slamming the Breaks on Anabolic-Androgenic Steroids Following Repetitive Mild Traumatic Brain Injury in Rats May Worsen Outcomes.

Jason Tabor, Reid Collins, Chantel T Debert, Sandy R Shultz, Richelle Mychasiuk,

Sport-related concussion is an increasingly common injury among adolescents, with repetitive mild traumatic brain injuries (RmTBI) being a significant risk factor for long-term neurobiological and psychological consequences. It is not uncommon for younger professional athletes to consume anabolic-androgenic steroids (AAS) in an attempt to enhance their performance, subjecting their hormonally ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:481]

Cited: 1 time

View full text PDF listing >>



Aged rats have an altered immune response and worse outcomes after traumatic brain injury.

Mujun Sun, Rhys D Brady, Pablo M Casillas-Espinosa, David K Wright, Bridgette D Semple, Hyun Ah Kim, Richelle Mychasiuk, Christopher G Sobey, Terence J O'Brien, Antony Vinh, Stuart J McDonald, Sandy R Shultz,

Initial studies suggest that increased age is associated with worse outcomes after traumatic brain injury (TBI), though the pathophysiological mechanisms responsible for this remain unclear. Immunosenescence (i.e., dysregulation of the immune system due to aging) may play a significant role in influencing TBI outcomes. This study therefore examined neurological outcomes ... Read more >>

Brain Behav Immun (Brain, behavior, and immunity)
[2019, 80:536-550]

Cited: 3 times

View full text PDF listing >>



Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis.

Pablo M Casillas-Espinosa, Pedro Andrade, Cesar Santana-Gomez, Tomi Paananen, Gregory Smith, Idrish Ali, Robert Ciszek, Xavier Ekolle Ndode-Ekane, Rhys D Brady, Jussi Tohka, Matthew R Hudson, Piero Perucca, Emma L Braine, Riikka Immonen, Noora Puhakka, Sandy R Shultz, Nigel C Jones, Richard J Staba, Asla Pitkänen, Terence J O'Brien,

<h4>Rationale</h4>The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Centre without walls is an NIH funded multicenter consortium. One of EpiBioS4Rx projects is a preclinical post-traumatic epileptogenesis biomarker study that involves three study sites: The University of Eastern Finland, Monash University (Melbourne) and the University of California Los Angeles. Our objective ... Read more >>

Epilepsy Res (Epilepsy research)
[2019, 156:106131]

Cited: 4 times

View full text PDF listing >>



Advertisement

Disclaimer
1.2672 s