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Using methylome data to inform exposome-health association studies: An application to the identification of environmental drivers of child body mass index.

Solène Cadiou, Mariona Bustamante, Lydiane Agier, Sandra Andrusaityte, Xavier Basagaña, Angel Carracedo, Leda Chatzi, Regina Grazuleviciene, Juan R Gonzalez, Kristine B Gutzkow, Léa Maitre, Dan Mason, Frédéric Millot, Mark Nieuwenhuijsen, Eleni Papadopoulou, Gillian Santorelli, Pierre-Jean Saulnier, Marta Vives, John Wright, Martine Vrijheid, Rémy Slama,

BACKGROUND:The exposome is defined as encompassing all environmental exposures one undergoes from conception onwards. Challenges of the application of this concept to environmental-health association studies include a possibly high false-positive rate. OBJECTIVES:We aimed to reduce the dimension of the exposome using information from DNA methylation as a way to more ... Read more >>

Environ Int (Environment international)
[2020, 138:105622]

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Perceived Stress among Different Occupational Groups and the Interaction with Sedentary Behaviour.

Audrius Dėdelė, Auksė Miškinytė, Sandra Andrušaitytė, Žydrūnė Bartkutė,

Sedentary lifestyle and low physical activity are associated with health issues, including both physical and mental health, non-communicable diseases, overweight, obesity and reduced quality of life. This study investigated differences in physical activity and other individual factors among different occupational groups, highlighting the impact of sedentary behaviour on perceived stress ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(23):]

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Diet as a Source of Exposure to Environmental Contaminants for Pregnant Women and Children from Six European Countries.

Eleni Papadopoulou, Line Småstuen Haug, Amrit Kaur Sakhi, Sandra Andrusaityte, Xavier Basagaña, Anne Lise Brantsaeter, Maribel Casas, Sílvia Fernández-Barrés, Regina Grazuleviciene, Helle Katrine Knutsen, Lea Maitre, Helle Margrete Meltzer, Rosemary R C McEachan, Theano Roumeliotaki, Remy Slama, Marina Vafeiadi, John Wright, Martine Vrijheid, Cathrine Thomsen, Leda Chatzi,

BACKGROUND:Pregnant women and children are especially vulnerable to exposures to food contaminants, and a balanced diet during these periods is critical for optimal nutritional status. OBJECTIVES:Our objective was to study the association between diet and measured blood and urinary levels of environmental contaminants in mother-child pairs from six European birth ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2019, 127(10):107005]

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The effect of residential greenness and city park visiting habits on preschool Children's mental and general health in Lithuania: A cross-sectional study.

Sandra Andrusaityte, Regina Grazuleviciene, Audrius Dedele, Birute Balseviciene,

AIM:The aim of this study was to determine the association between levels of residential surrounding greenness, preschool children's park use, sedentary behaviour, and mental and general health. METHODS:This cross-sectional study included 1489 4-6-year-old children - residents of Kaunas city, Lithuania. Responses to the questionnaires completed by parents were used to ... Read more >>

Int J Hyg Environ Health (International journal of hygiene and environmental health)
[2020, 223(1):142-150]

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Early-Life Environmental Exposures and Blood Pressure in Children.

Charline Warembourg, Léa Maitre, Ibon Tamayo-Uria, Serena Fossati, Theano Roumeliotaki, Gunn Marit Aasvang, Sandra Andrusaityte, Maribel Casas, Enrique Cequier, Lida Chatzi, Audrius Dedele, Juan-Ramon Gonzalez, Regina Gražulevičienė, Line Smastuen Haug, Carles Hernandez-Ferrer, Barbara Heude, Marianna Karachaliou, Norun Hjertager Krog, Rosemary McEachan, Mark Nieuwenhuijsen, Inga Petraviciene, Joane Quentin, Oliver Robinson, Amrit Kaur Sakhi, Rémy Slama, Cathrine Thomsen, Jose Urquiza, Marina Vafeiadi, Jane West, John Wright, Martine Vrijheid, Xavier Basagaña,

BACKGROUND:Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously. OBJECTIVES:This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2019, 74(10):1317-1328]

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Seasonality of physical activity and its association with socioeconomic and health factors among urban-dwelling adults of Kaunas, Lithuania.

Audrius Dėdelė, Auksė Miškinytė, Sandra Andrušaitytė, Jolanta Nemaniūtė-Gužienė,

BACKGROUND:Physical activity (PA) has been declining dramatically over time in many countries worldwide. The decrease of PA levels affects a person's health and quality of life as it is a significant risk factor for many noncommunicable diseases. Understanding the factors that determine PA is particularly important in promoting greater PA ... Read more >>

BMC Public Health (BMC public health)
[2019, 19(1):1067]

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Association between the living environment and the risk of arterial hypertension and other components of metabolic syndrome.

Agne Braziene, Abdonas Tamsiunas, Dalia Luksiene, Ricardas Radisauskas, Sandra Andrusaityte, Audrius Dedele, Jone Vencloviene,

BACKGROUND:Metabolic syndrome (MS) is characterized by numerous metabolic risk factors. We investigated the associations between a long-term exposure to ambient air pollution and the residential distance to green spaces (GS) and major roads with the development of arterial hypertension (AH) and some components of MS. These associations were assessed among ... Read more >>

J Public Health (Oxf) (Journal of public health (Oxford, England))
[2019, :]

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Dog ownership, the natural outdoor environment and health: a cross-sectional study.

Wilma L Zijlema, Hayley Christian, Margarita Triguero-Mas, Marta Cirach, Magdalena van den Berg, Jolanda Maas, Christopher J Gidlow, Hanneke Kruize, Wanda Wendel-Vos, Sandra Andrušaitytė, Regina Grazuleviciene, Jill Litt, Mark J Nieuwenhuijsen,

OBJECTIVES:Dog owners walking their dog in natural outdoor environments (NOE) may benefit from the physical activity facilitated by dog walking and from time spent in nature. However, it is unclear whether dog owners receive additional health benefits associated with having access to NOE above the physical activity benefit of walking ... Read more >>

BMJ Open (BMJ open)
[2019, 9(5):e023000]

Cited: 1 time

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Socioeconomic position and exposure to multiple environmental chemical contaminants in six European mother-child cohorts.

Parisa Montazeri, Cathrine Thomsen, Maribel Casas, Jeroen de Bont, Line S Haug, Léa Maitre, Eleni Papadopoulou, Amrit K Sakhi, Rémy Slama, Pierre Jean Saulnier, Jose Urquiza, Regina Grazuleviciene, Sandra Andrusaityte, Rosie McEachan, John Wright, Leda Chatzi, Xavier Basagaña, Martine Vrijheid,

BACKGROUND:Human exposure to environmental chemical contaminants at critical periods of development can lead to lifelong health consequences. Traditionally, socioeconomically disadvantaged groups are thought to experience higher contaminant exposures; however, this relationship may not hold for all contaminants. METHODS:Using data from six European birth cohorts (1301 mother-child pairs), we determined biomarkers ... Read more >>

Int J Hyg Environ Health (International journal of hygiene and environmental health)
[2019, 222(5):864-872]

Cited: 1 time

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Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort.

Lydiane Agier, Xavier Basagaña, Lea Maitre, Berit Granum, Philippa K Bird, Maribel Casas, Bente Oftedal, John Wright, Sandra Andrusaityte, Montserrat de Castro, Enrique Cequier, Leda Chatzi, David Donaire-Gonzalez, Regina Grazuleviciene, Line S Haug, Amrit K Sakhi, Vasiliki Leventakou, Rosemary McEachan, Mark Nieuwenhuijsen, Inga Petraviciene, Oliver Robinson, Theano Roumeliotaki, Jordi Sunyer, Ibon Tamayo-Uria, Cathrine Thomsen, Jose Urquiza, Antonia Valentin, Rémy Slama, Martine Vrijheid, Valérie Siroux,

BACKGROUND:Several single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range of prenatal and postnatal lifestyle and environmental exposures and lung function in children. METHODS:In this analysis, we used data ... Read more >>

Lancet Planet Health (The Lancet. Planetary health)
[2019, 3(2):e81-e92]

Cited: 1 time

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The early-life exposome: Description and patterns in six European countries.

Ibon Tamayo-Uria, Léa Maitre, Cathrine Thomsen, Mark J Nieuwenhuijsen, Leda Chatzi, Valérie Siroux, Gunn Marit Aasvang, Lydiane Agier, Sandra Andrusaityte, Maribel Casas, Montserrat de Castro, Audrius Dedele, Line S Haug, Barbara Heude, Regina Grazuleviciene, Kristine B Gutzkow, Norun H Krog, Dan Mason, Rosemary R C McEachan, Helle M Meltzer, Inga Petraviciene, Oliver Robinson, Theano Roumeliotaki, Amrit K Sakhi, Jose Urquiza, Marina Vafeiadi, Dagmar Waiblinger, Charline Warembourg, John Wright, Rémy Slama, Martine Vrijheid, Xavier Basagaña,

Characterization of the "exposome", the set of all environmental factors that one is exposed to from conception onwards, has been advocated to better understand the role of environmental factors on chronic diseases. Here, we aimed to describe the early-life exposome. Specifically, we focused on the correlations between multiple environmental exposures, ... Read more >>

Environ Int (Environment international)
[2019, 123:189-200]

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Determinants of the urinary and serum metabolome in children from six European populations.

Chung-Ho E Lau, Alexandros P Siskos, Léa Maitre, Oliver Robinson, Toby J Athersuch, Elizabeth J Want, Jose Urquiza, Maribel Casas, Marina Vafeiadi, Theano Roumeliotaki, Rosemary R C McEachan, Rafaq Azad, Line S Haug, Helle M Meltzer, Sandra Andrusaityte, Inga Petraviciene, Regina Grazuleviciene, Cathrine Thomsen, John Wright, Remy Slama, Leda Chatzi, Martine Vrijheid, Hector C Keun, Muireann Coen,

BACKGROUND:Environment and diet in early life can affect development and health throughout the life course. Metabolic phenotyping of urine and serum represents a complementary systems-wide approach to elucidate environment-health interactions. However, large-scale metabolome studies in children combining analyses of these biological fluids are lacking. Here, we sought to characterise the ... Read more >>

BMC Med (BMC medicine)
[2018, 16(1):202]

Cited: 6 times

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In-utero and childhood chemical exposome in six European mother-child cohorts.

Line Småstuen Haug, Amrit Kaur Sakhi, Enrique Cequier, Maribel Casas, Léa Maitre, Xavier Basagana, Sandra Andrusaityte, Georgia Chalkiadaki, Leda Chatzi, Muireann Coen, Jeroen de Bont, Audrius Dedele, Joane Ferrand, Regina Grazuleviciene, Juan Ramon Gonzalez, Kristine Bjerve Gutzkow, Hector Keun, Rosie McEachan, Helle Margrete Meltzer, Inga Petraviciene, Oliver Robinson, Pierre-Jean Saulnier, Rémy Slama, Jordi Sunyer, José Urquiza, Marina Vafeiadi, John Wright, Martine Vrijheid, Cathrine Thomsen,

BACKGROUND:Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited. OBJECTIVES:To characterize concentrations of a large number of environmental contaminants in pregnant women from Europe and their children, based on chemical analysis of biological samples from mother-child pairs. METHODS:We relied ... Read more >>

Environ Int (Environment international)
[2018, 121(Pt 1):751-763]

Cited: 2 times

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Active commuting through natural environments is associated with better mental health: Results from the PHENOTYPE project.

Wilma L Zijlema, Ione Avila-Palencia, Margarita Triguero-Mas, Christopher Gidlow, Jolanda Maas, Hanneke Kruize, Sandra Andrusaityte, Regina Grazuleviciene, Mark J Nieuwenhuijsen,

BACKGROUND:Commuting routes with natural features could promote walking or cycling for commuting. Commuting through natural environments (NE) could have mental health benefits as exposure to NE can reduce stress and improve mental health, but there is little evidence. This study evaluates the association between NE and commuting, whether active or ... Read more >>

Environ Int (Environment international)
[2018, 121(Pt 1):721-727]

Cited: 0 times

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Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children.

Maribel Casas, Xavier Basagaña, Amrit K Sakhi, Line S Haug, Claire Philippat, Berit Granum, Cyntia B Manzano-Salgado, Céline Brochot, Florence Zeman, Jeroen de Bont, Sandra Andrusaityte, Leda Chatzi, David Donaire-Gonzalez, Lise Giorgis-Allemand, Juan R Gonzalez, Esther Gracia-Lavedan, Regina Grazuleviciene, Mariza Kampouri, Sarah Lyon-Caen, Pau Pañella, Inga Petraviciene, Oliver Robinson, Jose Urquiza, Marina Vafeiadi, Céline Vernet, Dagmar Waiblinger, John Wright, Cathrine Thomsen, Rémy Slama, Martine Vrijheid,

BACKGROUND:Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions. OBJECTIVES:We evaluated the variability of urinary concentrations of 24 non-persistent chemicals: 10 phthalate metabolites, 7 phenols, 6 organophosphate (OP) pesticide metabolites, and cotinine, between weeks from different pregnancy trimesters in pregnant ... Read more >>

Environ Int (Environment international)
[2018, 121(Pt 1):561-573]

Cited: 5 times

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Impact of the Social and Natural Environment on Preschool-Age Children Weight.

Inga Petraviciene, Regina Grazuleviciene, Sandra Andrusaityte, Audrius Dedele, Mark J Nieuwenhuijsen,

Background: The complex impact of environmental and social factors on preschool children being overweight/obese is unclear. We examined the associations between the levels of green space exposure and the risk of being overweight/obese for 4-6 year-old children and assessed the impact of maternal education on these associations. Methods: This cross-sectional ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2018, 15(3):]

Cited: 1 time

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Impact of Psychosocial Environment on Young Children's Emotional and Behavioral Difficulties.

Regina Grazuleviciene, Sandra Andrusaityte, Inga Petraviciene, Birute Balseviciene,

Objective: The impact of maternal psychosocial stress on young children's mental difficulties is unclear. This study investigated the joint effects of the socioeconomic status and parent-child relationships on emotional and behavioral difficulties in preschool children. Methods: The case-control study included 1416 mothers and their 4-6 year-old children pairs, living in ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2017, 14(10):]

Cited: 2 times

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Effect of diet and maternal education on allergies among preschool children: A case-control study.

Sandra Andrusaityte, Regina Grazuleviciene, Inga Petraviciene,

The prevalence of asthma and allergy has increased among children. This increase in prevalence might be related to dietary patterns.The present epidemiological study investigated the relationship between the consumption of fruit, vegetables, nuts, meat and fish, and the prevalence of wheeze, asthma, and eczema among preschool children.This nested case-control study ... Read more >>

Environ. Res. (Environmental research)
[2017, 159:374-380]

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Does the Health Impact of Exposure to Neighbourhood Green Space Differ between Population Groups? An Explorative Study in Four European Cities.

Annemarie Ruijsbroek, Mariël Droomers, Hanneke Kruize, Elise van Kempen, Christopher J Gidlow, Gemma Hurst, Sandra Andrusaityte, Mark J Nieuwenhuijsen, Jolanda Maas, Wim Hardyns, Karien Stronks, Peter P Groenewegen,

It has been suggested that certain residents, such as those with a low socioeconomic status, the elderly, and women, may benefit more from the presence of neighbourhood green space than others. We tested this hypothesis for age, gender, educational level, and employment status in four European cities. Data were collected ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2017, 14(6):]

Cited: 6 times

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Psychosocial stress and obesity among children residing in Kaunas City.

Regina Grazuleviciene, Inga Petraviciene, Sandra Andrusaityte, Birute Balseviciene,

An unfavorable psychosocial environment has been associated with an increased prevalence of obesity among children. However, the available evidence on the association of low socioeconomic status and parent-child relationships with childhood obesity is scarce. The aim of our study was to conduct a simultaneous evaluation of the risks associated with ... Read more >>

Environ. Res. (Environmental research)
[2017, 157:37-43]

Cited: 3 times

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Neighbourhood green space, social environment and mental health: an examination in four European cities.

Annemarie Ruijsbroek, Sigrid M Mohnen, Mariël Droomers, Hanneke Kruize, Christopher Gidlow, Regina Gražulevičiene, Sandra Andrusaityte, Jolanda Maas, Mark J Nieuwenhuijsen, Margarita Triguero-Mas, Daniel Masterson, Naomi Ellis, Elise van Kempen, Wim Hardyns, Karien Stronks, Peter P Groenewegen,

OBJECTIVES:This study examines the relationship between neighbourhood green space, the neighbourhood social environment (social cohesion, neighbourhood attachment, social contacts), and mental health in four European cities. METHODS:The PHENOTYPE study was carried out in 2013 in Barcelona (Spain), Stoke-on-Trent (United Kingdom), Doetinchem (The Netherlands), and Kaunas (Lithuania). 3771 adults living in ... Read more >>

Int J Public Health (International journal of public health)
[2017, 62(6):657-667]

Cited: 7 times

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Visiting green space is associated with mental health and vitality: A cross-sectional study in four european cities.

Magdalena van den Berg, Mireille van Poppel, Irene van Kamp, Sandra Andrusaityte, Birute Balseviciene, Marta Cirach, Asta Danileviciute, Naomi Ellis, Gemma Hurst, Daniel Masterson, Graham Smith, Margarita Triguero-Mas, Inga Uzdanaviciute, Puck de Wit, Willem van Mechelen, Christopher Gidlow, Regina Grazuleviciene, Mark J Nieuwenhuijsen, Hanneke Kruize, Jolanda Maas,

Many epidemiological studies have found that people living in environments with more green space report better physical and mental health than those with less green space. However, the association between visits to green space and mental health has seldom been studied. The current study explored the associations between time spent ... Read more >>

Health Place (Health & place)
[2016, 38:8-15]

Cited: 27 times

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Surrounding greenness, proximity to city parks and pregnancy outcomes in Kaunas cohort study.

Regina Grazuleviciene, Asta Danileviciute, Audrius Dedele, Jone Vencloviene, Sandra Andrusaityte, Inga Uždanaviciute, Mark J Nieuwenhuijsen,

There is increasing evidence that green space can improve the health and well-being of urban residents. However, there has been no consistent evidence of the effect of city parks on reproductive health. We investigated whether surrounding greenness levels and/or distance to city parks affect birth outcomes. This study was based ... Read more >>

Int J Hyg Environ Health (International journal of hygiene and environmental health)
[2015, 218(3):358-365]

Cited: 22 times

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Impact of residential greenness on preschool children's emotional and behavioral problems.

Birute Balseviciene, Liuda Sinkariova, Regina Grazuleviciene, Sandra Andrusaityte, Inga Uzdanaviciute, Audrius Dedele, Mark J Nieuwenhuijsen,

This study investigated the effects of the proximity to city parks and the influence of residential greenness on children's emotional and behavioral problems. This cross-sectional study included 1,468 mothers of children (ages 4 to 6) who were residents of the city of Kaunas, Lithuania. The mothers and their children were ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2014, 11(7):6757-6770]

Cited: 25 times

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The impact of tobacco smoke exposure on wheezing and overweight in 4-6-year-old children.

Regina Grazuleviciene, Sandra Andrusaityte, Inga Uzdanaviciute, Jolanta Kudzyte, Rimantas Kevalas, Mark J Nieuwenhuijsen,

AIM: To investigate the association between maternal smoking during pregnancy, second-hand tobacco smoke (STS) exposure, education level, and preschool children's wheezing and overweight. METHODS: This cohort study used data of the KANC cohort--1,489 4-6-year-old children from Kaunas city, Lithuania. Multivariate logistic regression was employed to study the influence of prenatal ... Read more >>

Biomed Res Int (BioMed research international)
[2014, 2014:240757]

Cited: 4 times

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