Full Text Journal Articles by
Author Sandra Althouse

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Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer.

Diane M Demas, Susan Demo, Yassi Fallah, Robert Clarke, Kenneth P Nephew, Sandra Althouse, George Sandusky, Wei He, Ayesha N Shajahan-Haq,

Dependence on the glutamine pathway is increased in advanced breast cancer cell models and tumors regardless of hormone receptor status or function. While 70% of breast cancers are estrogen receptor positive (ER+) and depend on estrogen signaling for growth, advanced ER+ breast cancers grow independent of estrogen. Cellular changes in ... Read more >>

Front Oncol (Frontiers in oncology)
[2019, 9:686]

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Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer.

Diane M. Demas, Susan Demo, Yassi Fallah, Robert Clarke, Kenneth P. Nephew, Sandra Althouse, George Sandusky, Wei He, Ayesha N. Shajahan-Haq,

Dependence on the glutamine pathway is increased in advanced breast cancer cell models and tumors regardless of hormone receptor status or function. While 70% of breast cancers are estrogen receptor positive (ER+) and depend on estrogen signaling for growth, advanced ER+ breast cancers grow independent of estrogen. Cellular changes in ... Read more >>

Front Oncol (Frontiers in Oncology)
[2019, 9:]

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Adverse Health Outcomes in Relationship to Hypogonadism After Chemotherapy: A Multicenter Study of Testicular Cancer Survivors.

Mohammad Abu Zaid, Paul C Dinh, Patrick O Monahan, Chunkit Fung, Omar El-Charif, Darren R Feldman, Robert J Hamilton, David J Vaughn, Clair J Beard, Ryan Cook, Sandra Althouse, Shirin Ardeshir-Rouhani-Fard, Howard D Sesso, Robert Huddart, Taisei Mushiroda, Michiaki Kubo, M Eileen Dolan, Lawrence H Einhorn, Sophie D Fossa, Lois B Travis, ,

BACKGROUND:This study examined the prevalence of hypogonadism, its clinical and genetic risk factors, and its relationship to adverse health outcomes (AHOs) in North American testicular cancer survivors (TCS) after modern platinum-based chemotherapy. PATIENTS AND METHODS:Eligible TCS were <55 years of age at diagnosis and treated with first-line platinum-based chemotherapy. Participants ... Read more >>

J Natl Compr Canc Netw (Journal of the National Comprehensive Cancer Network : JNCCN)
[2019, 17(5):459-468]

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Impact of including quantitative information in a decision aid for colorectal cancer screening: A randomized controlled trial.

Peter H Schwartz, Thomas F Imperiale, Susan M Perkins, Karen K Schmidt, Sandra Althouse, Susan M Rawl,

OBJECTIVE:Guidelines recommend that decision aids provide quantitative information about risks and benefits of available options. Impact of providing this information is unknown. METHODS:Randomized trial comparing two decision aids about colorectal cancer (CRC) screening with colonoscopy or fecal immunochemical test (FIT). 688 primary care patients due for CRC screening viewed a ... Read more >>

Patient Educ Couns (Patient education and counseling)
[2019, 102(4):726-734]

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Factors associated with a prolonged hospital stay during induction chemotherapy in newly diagnosed high risk pediatric acute lymphoblastic leukemia.

Kasper Warrick, Sandra K Althouse, April Rahrig, Joy Rupenthal, Sandeep Batra,

BACKGROUND:High Risk (HR) or Very High Risk (VHR) acute lymphoblastic leukemia (ALL) treated with 4 drug induction chemotherapy is often associated with adverse events. The aim of this study was to identify risk factors associated with a prolonged inpatient length of stay LOS during induction chemotherapy. PROCEDURE:Data from patients (N = 73) ... Read more >>

Leuk. Res. (Leukemia research)
[2018, 71:36-42]

Cited: 0 times

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Impact of primary breast cancer therapy on energetic capacity and body composition.

Tarah J Ballinger, Anurag Reddy, Sandra K Althouse, Emily M Nelson, Kathy D Miller, Jeffrey S Sledge,

PURPOSE:This observational study was designed to measure baseline energy parameters and body composition in early-stage breast cancer patients, and to follow changes during and after various modalities of treatment. This will provide information to aid in the development of individualized physical activity intervention strategies. METHODS:Patients with newly diagnosed stage 0-III ... Read more >>

Breast Cancer Res. Treat. (Breast cancer research and treatment)
[2018, 172(2):445-452]

Cited: 1 time

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Histology, Tumor Volume, and Radiation Dose Predict Outcomes in NSCLC Patients After Stereotactic Ablative Radiotherapy.

Kevin Shiue, Alberto Cerra-Franco, Ronald Shapiro, Neil Estabrook, Edward M Mannina, Christopher R Deig, Sandra Althouse, Sheng Liu, Jun Wan, Yong Zang, Namita Agrawal, Pericles Ioannides, Yongmei Liu, Chen Zhang, Colleen DesRosiers, Greg Bartlett, Marvene Ewing, Mark P Langer, Gordon Watson, Richard Zellars, Feng-Ming Kong, Tim Lautenschlaeger,

INTRODUCTION:It remains unclear if histology should be independently considered when choosing stereotactic ablative body radiotherapy dose prescriptions for NSCLC. METHODS:The study population included 508 patients with 561 lesions between 2000 and 2016, of which 442 patients with 482 lesions had complete dosimetric information. Eligible patients had histologically or clinically diagnosed ... Read more >>

J Thorac Oncol (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer)
[2018, 13(10):1549-1559]

Cited: 1 time

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Differences between Supportive Music and Imagery and Music Listening during Outpatient Chemotherapy and Potential Moderators of Treatment Effects.

Debra S Burns, Anthony N Meadows, Sandra Althouse, Susan M Perkins, Larry D Cripe,

Background:Supportive music and imagery and music listening interventions have been effective in decreasing distress and improving mood in cancer patients receiving chemotherapy, but it is unclear whether the two interventions differ in their treatment benefits. Furthermore, previous studies have not examined moderators to determine which subgroup(s) of patients may benefit ... Read more >>

J Music Ther (Journal of music therapy)
[2018, 55(1):83-108]

Cited: 0 times

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Clinical and Genetic Risk Factors for Adverse Metabolic Outcomes in North American Testicular Cancer Survivors.

Mohammad Abu Zaid, Wambui G Gathirua-Mwangi, Chunkit Fung, Patrick O Monahan, Omar El-Charif, Annalynn M Williams, Darren R Feldman, Robert J Hamilton, David J Vaughn, Clair J Beard, Ryan Cook, Sandra K Althouse, Shirin Ardeshir-Rouhani-Fard, Paul C Dinh, Howard D Sesso, Lawrence H Einhorn, Sophie D Fossa, Lois B Travis, ,

Background: Testicular cancer survivors (TCS) are at significantly increased risk for cardiovascular disease (CVD), with metabolic syndrome (MetS) an established risk factor. No study has addressed clinical and genetic MetS risk factors in North American TCS. Patients and Methods: TCS were aged <55 years at diagnosis and received first-line chemotherapy. ... Read more >>

J Natl Compr Canc Netw (Journal of the National Comprehensive Cancer Network : JNCCN)
[2018, 16(3):257-265]

Cited: 1 time

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Providing Quantitative Information and a Nudge to Undergo Stool Testing in a Colorectal Cancer Screening Decision Aid: A Randomized Clinical Trial.

Peter H Schwartz, Susan M Perkins, Karen K Schmidt, Paul F Muriello, Sandra Althouse, Susan M Rawl,

Guidelines recommend that patient decision aids should provide quantitative information about probabilities of potential outcomes, but the impact of this information is unknown. Behavioral economics suggests that patients confused by quantitative information could benefit from a "nudge" towards one option. We conducted a pilot randomized trial to estimate the effect ... Read more >>

Med Decis Making (Medical decision making : an international journal of the Society for Medical Decision Making)
[2017, 37(6):688-702]

Cited: 2 times

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Role of Stereotactic Body Radiation Therapy Before Orthotopic Liver Transplantation: Retrospective Evaluation of Pathologic Response and Outcomes.

Edward Michael Mannina, Higinia Rosa Cardenes, Foster D Lasley, Benjamin Goodman, Jennifer Zook, Sandra Althouse, John Alvin Cox, Romil Saxena, Joseph Tector, Mary Maluccio,

To analyze the results of stereotactic body radiation therapy (SBRT) in patients with early-stage, localized hepatocellular carcinoma who underwent definitive orthotopic liver transplantation (OLT).The subjects of this retrospective report are 38 patients diagnosed with hepatocellular carcinoma who underwent SBRT per institutional phase 1 to 2 eligibility criteria, before definitive OLT. Pre-OLT ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2017, 97(5):931-938]

Cited: 6 times

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Multi-Institutional Assessment of Adverse Health Outcomes Among North American Testicular Cancer Survivors After Modern Cisplatin-Based Chemotherapy.

Chunkit Fung, Howard D Sesso, Annalynn M Williams, Sarah L Kerns, Patrick Monahan, Mohammad Abu Zaid, Darren R Feldman, Robert J Hamilton, David J Vaughn, Clair J Beard, Christian K Kollmannsberger, Ryan Cook, Sandra Althouse, Shirin Ardeshir-Rouhani-Fard, Steve E Lipshultz, Lawrence H Einhorn, Sophie D Fossa, Lois B Travis, ,

Purpose To provide new information on adverse health outcomes (AHOs) in testicular cancer survivors (TCSs) after four cycles of etoposide and cisplatin (EPX4) or three or four cycles of bleomycin, etoposide, cisplatin (BEPX3/BEPX4). Methods Nine hundred fifty-two TCSs > 1 year postchemotherapy underwent physical examination and completed a questionnaire. Multinomial ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2017, 35(11):1211-1222]

Cited: 15 times

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High-Dose Chemotherapy and Autologous Peripheral-Blood Stem-Cell Transplantation for Relapsed Metastatic Germ Cell Tumors: The Indiana University Experience.

Nabil Adra, Rafat Abonour, Sandra K Althouse, Costantine Albany, Nasser H Hanna, Lawrence H Einhorn,

Purpose Patients with relapsed metastatic germ cell tumor (GCT) can be cured with second-line and even third-line regimens. We report survival outcomes of patients treated with high-dose chemotherapy (HDCT) and peripheral-blood stem-cell transplantation (PBSCT) at Indiana University between 2004 and 2014. Patients and Methods We conducted a retrospective analysis of ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2017, 35(10):1096-1102]

Cited: 21 times

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Phase I Study of Lenalidomide and Sorafenib in Patients With Advanced Hepatocellular Carcinoma.

Safi Shahda, Patrick J Loehrer, Romnee S Clark, A John Spittler, Sandra K Althouse, E Gabriella Chiorean,

LESSONS LEARNED:Combination therapies in patients with hepatocellular carcinoma can be associated with overlapping toxicity and are therefore poorly tolerated.Using sorafenib at the maximum tolerated dose can lead to a higher incidence of toxicities. Consequently, combination studies might evaluate sorafenib at alternative schedules or doses to improve tolerance, recognizing this could ... Read more >>

Oncologist (The oncologist)
[2016, 21(6):664-665]

Cited: 2 times

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Long-term safety and efficacy of stereotactic body radiation therapy for hepatic oligometastases.

Benjamin D Goodman, Edward M Mannina, Sandra K Althouse, Mary A Maluccio, Higinia R Cárdenes,

To evaluate long-term outcome and toxicity of stereotactic body radiation therapy (SBRT) for hepatic oligometastases from solid tumors.Eligible patients had 1 to 3 liver metastases, maximum sum diameter 6 cm, without extrahepatic progression. We treated 106 lesions in 81 patients; 67% with colorectal primaries. Median dose was 5400 cGy in ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2016, 6(2):86-95]

Cited: 12 times

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TFAP2C expression in breast cancer: correlation with overall survival beyond 10 years of initial diagnosis.

Susan M Perkins, Casey Bales, Tudor Vladislav, Sandra Althouse, Kathy D Miller, George Sandusky, Sunil Badve, Harikrishna Nakshatri,

Recurrence and death in a significant number of patients with ERα-positive breast cancer occurs 10-20 years after diagnosis. Prognostic markers for late events have been more elusive. TFAP2C (AP2γ) regulates the expression of ERα, the ERα pioneer factors FOXA1 and GATA3, and controls ERα-dependent transcription. The purpose of this investigation ... Read more >>

Breast Cancer Res. Treat. (Breast cancer research and treatment)
[2015, 152(3):519-531]

Cited: 9 times

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Treatment variables related to liver toxicity in patients with hepatocellular carcinoma, Child-Pugh class A and B enrolled in a phase 1-2 trial of stereotactic body radiation therapy.

Foster D Lasley, Edward M Mannina, Cynthia S Johnson, Susan M Perkins, Sandra Althouse, Mary Maluccio, Paul Kwo, Higinia Cárdenes,

An analysis was performed on patients enrolled in a phase 1-2 trial using stereotactic body radiation therapy for hepatocellular carcinoma evaluating variables influencing liver toxicity.Thirty-eight Child-Pugh class A (CPC-A) (39 lesions) and 21 CPC-B patients (26 lesions) were followed for ≥6 months. Six months local control using modified Response Evaluation ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2015, 5(5):e443-e449]

Cited: 31 times

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Piloting an abbreviated dignity therapy intervention using a legacy-building web portal for adults with terminal cancer: a feasibility and acceptability study.

Jennifer Kim Bernat, Paul R Helft, Laura R Wilhelm, Nancy E Hook, Linda F Brown, Sandra K Althouse, Shelley A Johns,

Psychooncology (Psycho-oncology)
[2015, 24(12):1823-1825]

Cited: 1 time

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A phase II study of medroxyprogesterone acetate in patients with hormone receptor negative metastatic breast cancer: translational breast cancer research consortium trial 007.

Kathy D Miller, Sandra K Althouse, Lisle Nabell, Hope Rugo, Lisa Carey, Gretchen Kimmick, David R Jones, Maria J Merino, Patricia S Steeg,

Preclinical data suggest that medroxyprogesterone acetate (MPA) has both anti-metastatic and anti-angiogenic activity in the absence of hormone receptors (HR). This phase II trial assessed the activity of MPA alone or in combination with low-dose chemotherapy in patients with metastatic HR-negative breast cancer. Postmenopausal women with HR-negative disease were eligible ... Read more >>

Breast Cancer Res. Treat. (Breast cancer research and treatment)
[2014, 148(1):99-106]

Cited: 5 times

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Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor.

Ravi P Sahu, Jesus A Ocana, Kathleen A Harrison, Matheus Ferracini, Christopher E Touloukian, Mohammed Al-Hassani, Louis Sun, Mathew Loesch, Robert C Murphy, Sandra K Althouse, Susan M Perkins, Paul J Speicher, Douglas S Tyler, Raymond L Konger, Jeffrey B Travers,

Oxidative stress suppresses host immunity by generating oxidized lipid agonists of the platelet-activating factor receptor (PAF-R). Because many classical chemotherapeutic drugs induce reactive oxygen species (ROS), we investigated whether these drugs might subvert host immunity by activating PAF-R. Here, we show that PAF-R agonists are produced in melanoma cells by ... Read more >>

Cancer Res. (Cancer research)
[2014, 74(23):7069-7078]

Cited: 18 times

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Efficacy of postoperative seizure prophylaxis in intra-axial brain tumor resections.

Shaheryar F Ansari, Bradley N Bohnstedt, Susan M Perkins, Sandra K Althouse, James C Miller,

The effectiveness of seizure prophylaxis in controlling postoperative seizures following craniotomy for tumor resection is unclear. Most patients are seizure-free before surgery. To prevent seizures, it is common to treat tumor craniotomy patients postoperatively with an antiepileptic drug (AED). The authors retrospectively analyzed seizure occurrence with and without postoperative prophylactic ... Read more >>

J. Neurooncol. (Journal of neuro-oncology)
[2014, 118(1):117-122]

Cited: 9 times

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Initiation of prandial insulin therapy with AIR inhaled insulin or insulin lispro in patients with type 2 diabetes: A randomized noninferiority trial.

Jorge L Gross, Masako Nakano, Gildred Colon-Vega, Ramon Ortiz-Carasquillo, Jeffrey A Ferguson, Sandra Althouse, Janet A Tobian, Pierre-Yves Berclaz, Zvonko Milicevic,

BACKGROUND: Insulin initiation in patients with type 2 diabetes is often delayed because of concerns about injections. Our objective was to compare the effects of AIR inhaled insulin (Eli Lilly and Co., Indianapolis, IN) (AIR is a registered trademark of Alkermes, Inc., Cambridge, MA) with those of injectable insulin on ... Read more >>

Diabetes Technol. Ther. (Diabetes technology & therapeutics)
[2009, 11 Suppl 2:S27-34]

Cited: 12 times

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A single-center, randomized, double-blind, three-way crossover study examining postchallenge glucose responses to human insulin 70/30 and insulin lispro fixed mixtures 75/25 and 50/50 in patients with type 2 diabetes mellitus.

Sherwyn Schwartz, Anthony J Zagar, Sandra K Althouse, Jane A Pinaire, John H Holcombe,

OBJECTIVE: The aim of this study was to test the ability of human insulin 70/30, insulin lispro mixture 75/25 (75% neutral protamine lispro [NPL], 25% insulin lispro), and insulin lispro mixture 50/50 (50% NPL, 50% insulin lispro) to control postprandial glucose (PPG) concentrations in patients with type 2 diabetes mellitus ... Read more >>

Clin Ther (Clinical therapeutics)
[2006, 28(10):1649-1657]

Cited: 15 times

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