Camilla Muccini, Trevor A Crowell, Suteeraporn Pinyakorn, Eugène Kroon, Carlo Sacdalan, Jintanat Ananworanich, Sandhya Vasan, Nittaya Phanuphak, Donn J Colby, ,
<h4>Background</h4>Syphilis has been increasing in the past years, especially among men who have sex with men (MSM). The aim of the study was to assess syphilis prevalence and incidence and changes in CD4 count and viremia in the RV254 cohort of persons living with HIV who initiated antiretroviral therapy during ... Read more >>
J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):219-223]
Cited: 0 times
Ryan Handoko, Phillip Chan, Linda Jagodzinski, Suteeraporn Pinyakorn, Sasiwimol Ubolyam, Nittaya Phanuphak, Carlo Sacdalan, Eugene Kroon, Netsiri Dumrongpisutikul, Robert Paul, Victor Valcour, Jintanat Ananworanich, Sandhya Vasan, Serena Spudich, ,
<h4>Objective</h4>Despite suppression of HIV-1 replication in the periphery by antiretroviral therapy (ART), up to 10% of treated individuals have quantifiable HIV-1 in the CSF, termed CSF escape. CSF escape may be asymptomatic but has also been linked to progressive neurological disease, and may indicate persistence of HIV in the central ... Read more >>
AIDS (AIDS (London, England))
[2020, :]
Cited: 0 times
Kerri G Lal, Yuwadee Phuang-Ngern, Suchada Suhkumvittaya, Edwin Leeansyah, Aljawharah Alrubayyi, Joana Dias, Adam Waickman, Dohoon Kim, Eugène Kroon, Suteeraporn Pinyakorn, Leigh Anne Eller, Milton Maciel, Rungsun Rerknimitr, Nitiya Chomchey, Nittaya Phanuphak, Mark S S de Souza, Sorachai Nitayaphan, Julie A Ake, Sandhya Vasan, Merlin L Robb, Jintanat Ananworanich, Johan K Sandberg, Alexandra Schuetz, Michael A Eller, Dominic Paquin-Proulx,
CD161 expression on CD4<sup>+</sup> T cells is associated with a Th17 functional phenotype, as well as with an innate capacity to respond to interleukin (IL)-12 and IL-18 without T cell receptor (TCR) stimulation. Chronic HIV-1 infection is associated with loss of the CD161<sup>+</sup> CD4 T cell population, and non-human primate ... Read more >>
Viruses (Viruses)
[2020, 12(12):]
Cited: 0 times
Blessing O Kayode, Andrew Mitchell, Nicaise Ndembi, Afoke Kokogho, Habib O Ramadhani, Sylvia Adebajo, Merlin L Robb, Stefan D Baral, Julie A Ake, Manhattan E Charurat, Trevor A Crowell, Rebecca G Nowak, ,
<h4>Introduction</h4>Men who have sex with men (MSM), and transgender women (TGW), face specific obstacles to retention in care, particularly in settings with stigmatization such as sub-Saharan Africa. We evaluated the impacts of HIV status and other factors on loss-to-follow-up (LTFU) and visit adherence among MSM and TGW in Abuja and ... Read more >>
J Int AIDS Soc (Journal of the International AIDS Society)
[2020, 23 Suppl 6:e25592]
Cited: 0 times
Joanna Hellmuth, Camilla Muccini, Donn J Colby, Eugène Kroon, Mark de Souza, Trevor A Crowell, Phillip Chan, Carlo Sacdalan, Jintana Intasan, Khunthalee Benjapornpong, Somporn Tipsuk, Suwanna Puttamaswin, Nitiya Chomchey, Victor Valcour, Michal Sarnecki, Frank Tomaka, Shelly J Krebs, Bonnie M Slike, Linda L Jagodzinski, Netsiri Dumrongpisutikul, Napapon Sailasuta, Vishal Samboju, Nelson L Michael, Merlin L Robb, Sandhya Vasan, Jintanat Ananworanich, Praphan Phanuphak, Nittaya Phanuphak, Robert Paul, Serena Spudich,
<h4>Background</h4>The central nervous system (CNS) is a likely reservoir of HIV, vulnerable to viral rebound, inflammation, and clinical changes upon stopping antiretroviral therapy (ART). It is critical to evaluate the CNS safety of studies using analytic treatment interruption (ATI) to assess HIV remission.<h4>Methods</h4>Thirty participants who started ART during acute HIV ... Read more >>
Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]
Cited: 0 times
Catherine W Cai, Suteeraporn Pinyakorn, Eugène Kroon, Mark de Souza, Donn J Colby, Tippawan Pankam, Supanit Pattanachaiwit, Sasiwimol Ubolyam, Adam Rupert, Perrine Lallemand, Robin Dewar, Helene C Highbarger, Jintanat Ananworanich, Sandhya Vasan, Irini Sereti,
Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and interleukin-6, indicating that seronegativity does not affect chronic ... Read more >>
Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(9):ofaa383]
Cited: 1 time
Abdulwasiu B Tiamiyu, John Lawlor, Fengming Hu, Afoke Kokogho, Manhattan E Charurat, Charles Ekeh, Merlin L Robb, Sylvia Adebajo, George Eluwa, Julie A Ake, Stefan D Baral, Rebecca G Nowak, Trevor A Crowell, ,
<h4>Background</h4>Men who have sex with men (MSM) and transgender women (TGW) are disproportionately impacted by HIV and may face barriers to HIV status disclosure with negative ramifications for HIV prevention and care. We evaluated HIV status disclosure to sexual partners, HIV treatment outcomes, and stigma patterns of MSM and TGW ... Read more >>
BMC Public Health (BMC public health)
[2020, 20(1):1282]
Cited: 0 times
Bethany Dearlove, Eric Lewitus, Hongjun Bai, Yifan Li, Daniel B Reeves, M Gordon Joyce, Paul T Scott, Mihret F Amare, Sandhya Vasan, Nelson L Michael, Kayvon Modjarrad, Morgane Rolland,
The magnitude of the COVID-19 pandemic underscores the urgency for a safe and effective vaccine. Many vaccine candidates focus on the Spike protein, as it is targeted by neutralizing antibodies and plays a key role in viral entry. Here we investigate the diversity seen in severe acute respiratory syndrome coronavirus ... Read more >>
Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(38):23652-23662]
Cited: 10 times
Catherine W Cai, Suteeraporn Pinyakorn, Eugène Kroon, Mark de Souza, Donn J Colby, Tippawan Pankam, Supanit Pattanachaiwit, Sasiwimol Ubolyam, Adam Rupert, Perrine Lallemand, Robin Dewar, Helene C Highbarger, Jintanat Ananworanich, Sandhya Vasan, Irini Sereti,
Abstract Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and interleukin-6, indicating that seronegativity does not affect ... Read more >>
Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(9):]
Cited: 0 times
Tanyaporn Wansom, Suteeraporn Pinyakorn, Christy J Kolsteeg, Eugene Kroon, Carlo P Sacdalan, Nitiya Chomchey, Jintanat Ananworanich, Sandhya Vasan, Nittaya Phanuphak, Donn J Colby,
BACKGROUND:Increased rates of hepatitis C virus (HCV) infection among HIV-infected men who have sex with men (MSM) and who deny injecting drugs have been reported in resource-rich settings. SETTING:We measured HCV prevalence and incidence in a predominantly MSM cohort with acute HIV infection in Bangkok, Thailand. METHODS:In 2009-2018, participants with ... Read more >>
J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, 84(4):331-335]
Cited: 0 times
Win M Han, Donn J Colby, Apichaya Khlaiphuengsin, Tanakorn Apornpong, Stephen J Kerr, Sasiwimol Ubolyam, Eugène Kroon, Nittaya Phanuphak, Sandhya Vasan, Gail V Matthews, Anchalee Avihingsanon, Kiat Ruxrungtham, Praphan Phanuphak, Pisit Tangkijvanich,
A rapidly emerging and highly concentrated hepatitis C virus (HCV) outbreak has recently been observed among both acute and chronic HIV-positive men who have sex with men (MSM) in Bangkok, Thailand. NS5B regions of the HCV genome were amplified using nested PCR and sequenced. Phylogenetic inference was constructed by Maximum ... Read more >>
Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2020, 40(9):2104-2109]
Cited: 0 times
Evan M Cale, Hongjun Bai, Meera Bose, Michael A Messina, Donn J Colby, Eric Sanders-Buell, Bethany Dearlove, Yifan Li, Emily Engeman, Daniel Silas, Anne Marie O'Sullivan, Brendan Mann, Suteeraporn Pinyakorn, Jintana Intasan, Khunthalee Benjapornpong, Carlo Sacdalan, Eugène Kroon, Nittaya Phanuphak, Robert Gramzinski, Sandhya Vasan, Merlin L Robb, Nelson L Michael, Rebecca M Lynch, Robert T Bailer, Amélie Pagliuzza, Nicolas Chomont, Amarendra Pegu, Nicole A Doria-Rose, Lydie Trautmann, Trevor A Crowell, John R Mascola, Jintanat Ananworanich, Sodsai Tovanabutra, Morgane Rolland, ,
Infusion of the broadly neutralizing antibody VRC01 has been evaluated in individuals chronically infected with HIV-1. Here, we studied how VRC01 infusions affected viral rebound after cessation of antiretroviral therapy (ART) in 18 acutely treated and durably suppressed individuals. Viral rebound occurred in all individuals, yet VRC01 infusions modestly delayed ... Read more >>
J Clin Invest (The Journal of clinical investigation)
[2020, 130(6):3299-3304]
Cited: 0 times
Bethany Dearlove, Eric Lewitus, Hongjun Bai, Yifan Li, Daniel Reeves, Gordon Joyce, Paul Scott, Mihret Amare, Sandhya Vasan, Nelson Michael, Kayvon Modjarrad, Morgane Rolland,
The magnitude of the COVID-19 pandemic underscores the urgency for a safe and effective vaccine. Here we analyzed SARS-CoV-2 sequence diversity across 5,700 sequences sampled since December 2019. The Spike protein, which is the target immunogen of most vaccine candidates, showed 93 sites with shared polymorphisms; only one of these ... Read more >>
Cited: 0 times
David Easterhoff, Justin Pollara, Kan Luo, William D Tolbert, Brianna Young, Dieter Mielke, Shalini Jha, Robert J O'Connell, Sandhya Vasan, Jerome Kim, Nelson L Michael, Jean-Louis Excler, Merlin L Robb, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Sorachai Nitayaphan, Faruk Sinangil, James Tartaglia, Sanjay Phogat, Thomas B Kepler, S Munir Alam, Kevin Wiehe, Kevin O Saunders, David C Montefiori, Georgia D Tomaras, M Anthony Moody, Marzena Pazgier, Barton F Haynes, Guido Ferrari,
Induction of protective antibodies is a critical goal of HIV-1 vaccine development. One strategy is to induce nonneutralizing antibodies (NNAbs) that kill virus-infected cells, as these antibody specificities have been implicated in slowing HIV-1 disease progression and in protection. HIV-1 Env constant region 1 and 2 (C1C2) monoclonal antibodies (MAbs) ... Read more >>
J Virol (Journal of virology)
[2020, 94(4):]
Cited: 4 times
Punnee Pitisuttithum, Sorachai Nitayaphan, Suwat Chariyalertsak, Jaranit Kaewkungwal, Peter Dawson, Jittima Dhitavat, Benjaluck Phonrat, Siriwat Akapirat, Nicos Karasavvas, Lindsay Wieczorek, Victoria Polonis, Michael A Eller, Poonam Pegu, Dohoon Kim, Alexandra Schuetz, Surat Jongrakthaitae, Yingjun Zhou, Faruk Sinangil, Sanjay Phogat, Carlos A Diazgranados, James Tartaglia, Elizabeth Heger, Kirsten Smith, Nelson L Michael, Jean-Louis Excler, Merlin L Robb, Jerome H Kim, Robert J O'Connell, Sandhya Vasan, ,
BACKGROUND:The RV144 phase 3 vaccine trial in Thailand demonstrated that ALVAC-HIV (vCP1521) and AIDSVAX B/E administration over 6 months resulted in a 31% efficacy in preventing HIV acquisition. In this trial, we assessed the immunological effect of an additional vaccine boost to the RV144 regimen at varying intervals between the ... Read more >>
Lancet HIV (The lancet. HIV)
[2020, 7(4):e238-e248]
Cited: 0 times
Michael J Peluso, Donn J Colby, Suteeraporn Pinyakorn, Sasiwimol Ubolyam, Jintana Intasan, Rapee Trichavaroj, Nitiya Chomchey, Peeriya Prueksakaew, Bonnie M Slike, Shelly J Krebs, Ningbo Jian, Merlin L Robb, Praphan Phanuphak, Nittaya Phanuphak, Serena Spudich, Jintanat Ananworanich, Eugène Kroon, ,
<h4>Introduction</h4>Liver disease is a common cause of non-AIDS morbidity and mortality in people living with HIV (PLHIV), but the prevalence and significance of liver function test (LFT) abnormalities in early HIV infection is unknown. This study aimed to characterize LFTs in a large cohort of participants with acute HIV infection ... Read more >>
J Int AIDS Soc (Journal of the International AIDS Society)
[2020, 23(1):e25444]
Cited: 1 time
Denise C Hsu, Decha Silsorn, Dutsadee Inthawong, Yanin Kuncharin, Jumpol Sopanaporn, Rawiwan Im-Erbsin, Kesara Chumpolkulwong, Robert J O'connell, Nelson L Michael, Christine A Ege, Sandhya Vasan,
<h4>Objective(s)</h4>Analytical treatment interruption (ATI) studies are often used to evaluate potential HIV cure strategies. This study was conducted to determine the impact of ATI on simian-HIV (SHIV) infection in the central nervous system.<h4>Design</h4>Animal study.<h4>Methods</h4>Nine rhesus macaques were inoculated with SHIV-1157ipd3N4. Antiretroviral therapy (ART) was administered from week 2 to 18. ... Read more >>
AIDS (AIDS (London, England))
[2019, 33 Suppl 2:S189-S196]
Cited: 0 times
Ornella Sortino, Nittaya Phanuphak, Alexandra Schuetz, Alexandra M Ortiz, Nitiya Chomchey, Yasmine Belkaid, Jacquice Davis, Harry A Mystakelis, Mariam Quiñones, Claire Deleage, Brian Ingram, Rungsun Rerknimitr, Suteeraporn Pinyakorn, Adam Rupert, Merlin L Robb, Jintanat Ananworanich, Jason Brenchley, Irini Sereti, ,
<h4>Background</h4>Intestinal microbial dysbiosis is evident in chronic HIV-infected individuals and may underlie inflammation that persists even during antiretroviral therapy (ART). It remains unclear, however, how early after HIV infection gut dysbiosis emerges and how it is affected by early ART.<h4>Methods</h4>Fecal microbiota were studied by 16s rDNA sequencing in 52 Thai ... Read more >>
Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(12):ofz367]
Cited: 0 times
EBioMedicine (EBioMedicine)
[2019, 44:18-19]
Cited: 0 times
Trevor A Crowell, Donn J Colby, Suteeraporn Pinyakorn, Carlo Sacdalan, Amélie Pagliuzza, Jintana Intasan, Khunthalee Benjapornpong, Kamonkan Tangnaree, Nitiya Chomchey, Eugène Kroon, Mark S de Souza, Sodsai Tovanabutra, Morgane Rolland, Michael A Eller, Dominic Paquin-Proulx, Diane L Bolton, Andrey Tokarev, Rasmi Thomas, Hiroshi Takata, Lydie Trautmann, Shelly J Krebs, Kayvon Modjarrad, Adrian B McDermott, Robert T Bailer, Nicole Doria-Rose, Bijal Patel, Robert J Gorelick, Brandie A Fullmer, Alexandra Schuetz, Pornsuk V Grandin, Robert J O'Connell, Julie E Ledgerwood, Barney S Graham, Randall Tressler, John R Mascola, Nicolas Chomont, Nelson L Michael, Merlin L Robb, Nittaya Phanuphak, Jintanat Ananworanich, ,
<h4>Background</h4>HIV-1-specific broadly neutralising antibodies such as VRC01 could promote HIV remission by halting viral replication and clearing infected cells. We investigated whether VRC01 could promote sustained viral control off antiretroviral therapy (ART) in adults who initiated ART during acute HIV infection.<h4>Methods</h4>We did a randomised, double-blind, placebo-controlled trial at the Thai ... Read more >>
Lancet HIV (The lancet. HIV)
[2019, 6(5):e297-e306]
Cited: 12 times
David Easterhoff, Justin Pollara, Kan Luo, William Tolbert, Brianna Young, Dieter Mielke, Shalini Jha, Robert O’Connell, Sandhya Vasan, Jerome Kim, Nelson Michael, Jean-Louis Excler, Merlin Robb, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Sorachai Nitayaphan, Faruk Sinangil, James Tartaglia, Sanjay Phogat, Thomas Kepler, Munir Alam, Kevin Wiehe, Kevin Saunders, David Montefiori, Georgia Tomaras, Anthony Moody, Marzena Pazgier, Barton Haynes, Guido Ferrari,
Induction of protective antibodies is a critical goal of HIV-1 vaccine development. One strategy is to induce non-neutralizing antibodies that kill virus-infected cells as these antibody specificities have been implicated in slowing HIV-1 disease progression and in protection. HIV-1 Env constant region 1 and 2 (C1C2) antibodies frequently contain potent ... Read more >>
Cited: 0 times
Denise C Hsu, Piyanate Sunyakumthorn, Matthew Wegner, Alexandra Schuetz, Decha Silsorn, Jacob D Estes, Claire Deleage, Khamis Tomusange, Samir K Lakhashe, Ruth M Ruprecht, Eric Lombardini, Rawiwan Im-Erbsin, Yanin Kuncharin, Yuwadee Phuang-Ngern, Dutsadee Inthawong, Weerawan Chuenarom, Robin Burke, Merlin L Robb, Lishomwa C Ndhlovu, Jintanat Ananworanich, Victor Valcour, Robert J O'Connell, Serena Spudich, Nelson L Michael, Sandhya Vasan,
Studies utilizing highly pathogenic simian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV) have largely focused on the immunopathology of the central nervous system (CNS) during end-stage neurological AIDS and SIV encephalitis. However, this may not model pathophysiology in earlier stages of infection. In this nonaccelerated SHIV model, plasma SHIV ... Read more >>
J Virol (Journal of virology)
[2018, 92(11):]
Cited: 3 times
Elizabeth Heger, Alexandra Schuetz, Sandhya Vasan,
Despite progress in antiretroviral therapy, pre-exposure prophylaxis, microbicides, and other preventive strategies, a vaccine to prevent HIV-1 infection remains desperately needed. Development of an effective vaccine is challenged by several immunologic features of HIV-1 evidenced by the failure of five of the six HIV-1 candidate vaccine efficacy trials to date. ... Read more >>
Adv Exp Med Biol (Advances in experimental medicine and biology)
[2018, 1075:3-30]
Cited: 1 time
Denise C Hsu, Matthew D Wegner, Piyanate Sunyakumthorn, Decha Silsorn, Sujitra Tayamun, Dutsadee Inthawong, Yanin Kuncharin, Rawiwan Im-Erbsin, Christine Ege, Robert J O'Connell, Nelson L Michael, Lishomwa C Ndhlovu, Sandhya Vasan,
Limited longitudinal data exist on the effect of HIV on adipose tissue (AT). We found an increase in CD4+ cells and detectable SHIV-RNA in AT during acute SHIV infection. SHIV-RNA+ cells were rare, suggesting that AT is unlikely to be a major source of productively infected cells in SHIV infection. ... Read more >>
J Med Primatol (Journal of medical primatology)
[2017, 46(4):154-157]
Cited: 5 times
Sandhya Vasan, Tanyaporn Wansom, Alexandra Schuetz, Shelly Krebs, Rasmi Thomas, Gustavao Kijak, Christina Polyak,
J Virus Erad (Journal of virus eradication)
[2017, 3(2):92-96]
Cited: 0 times