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Author Samuel J Asirvatham

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Anatomy and Pathology of the Cardiac Conduction System.

Roshan Karki, Anvi Raina, Fatima M Ezzeddine, Melanie C Bois, Samuel J Asirvatham,

The cardiac conduction system is formed of histologically and electrophysiologically distinct specialized tissues uniquely located in the human heart. Understanding the anatomy and pathology of the cardiac conduction system is imperative to an interventional electrophysiologist to perform safe ablation and device therapy for the management of cardiac arrhythmias and heart ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):569-584]

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Electrocardiography-Based Artificial Intelligence Algorithm Aids in Prediction of Long-term Mortality After Cardiac Surgery.

Abdulah A Mahayni, Zachi I Attia, Jose R Medina-Inojosa, Mohamed F A Elsisy, Peter A Noseworthy, Francisco Lopez-Jimenez, Suraj Kapa, Samuel J Asirvatham, Paul A Friedman, Juan A Crestenallo, Mohamad Alkhouli,

To assess whether an electrocardiography-based artificial intelligence (AI) algorithm developed to detect severe ventricular dysfunction (left ventricular ejection fraction [LVEF] of 35% or below) independently predicts long-term mortality after cardiac surgery among patients without severe ventricular dysfunction (LVEF>35%). Patients who underwent valve or coronary bypass surgery at Mayo Clinic (1993-2019) ... Read more >>

Mayo Clin Proc (Mayo Clinic proceedings)
[2021, 96(12):3062-3070]

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Catheter ablation of ventricular tachycardia in patients with postinfarction left ventricular aneurysm.

Mustapha Amin, Medhat Farwati, Emilie Hilaire, Konstantinos C Siontis, Malini Madhavan, Suraj Kapa, Siva K Mulpuru, Abhishek J Deshmukh, Yong-Mei Cha, Paul A Friedman, Thomas Munger, Samuel J Asirvatham, Ammar M Killu,

<h4>Background</h4>While ventricular tachycardia (VT) in the setting of postmyocardial infarction left ventricular aneurysms (LVA) is not uncommonly encountered, there is a scarcity of data regarding the safety, efficacy, and outcomes of ablation of VT in this subset of patients.<h4>Methods</h4>Our study included consecutive patients aged 18 years or older with postmyocardial ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, :]

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Outcomes of Direct Oral Anticoagulants Co-Prescribed with Common Interacting Medications.

David Sanborn, Alan Sugrue, Mustapha Amin, Ramila Mehta, Medhat Farwati, Abhishek J Deshmukh, Haarini Sridhar, Azza Ahmed, Samuel J Asirvatham, Narith N Ou, Peter A Noseworthy, Ammar M Killu, Siva K Mulpuru, Malini Madhavan,

Direct oral anticoagulants (DOACs) can potentially interact with multiple prescription medications. We examined the prevalence of co-prescription of DOACs with interacting medications and its impact on outcomes in patients with atrial fibrillation (AF). Patients with AF treated with a DOAC from 2010 to 2017 at the Mayo Clinic and co-prescribed ... Read more >>

Am J Cardiol (The American journal of cardiology)
[2021, :]

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Single-Dose Intraprocedural Steroid Administration Does Not Impact Early Atrial Fibrillation Recurrence.

Kolade M Agboola, Michael Dietrich, Roshan Karki, Fahad Lodhi, Trevon McGill, Samuel J Asirvatham, Abhishek J Deshmukh, Christopher V DeSimone,

<h4>Purpose</h4>To evaluate the effect of single-dose intravenous dexamethasone on atrial fibrillation (AF) recurrence following radiofrequency catheter ablation.<h4>Methods</h4>A cohort of 84 adult patients (> 18 years) underwent catheter ablation at Mayo Clinic Rochester from January to March 2019. Only first-time ablation patients were included, with all re-do ablations excluded to minimize heterogeneity. Administration ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2021, :]

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Regional and Temporal Variation of Ventricular and Conduction Tissue Activity During Ventricular Fibrillation in Canines.

Nicholas Y Tan, Georgios Christopoulos, Thomas P Ladas, Zhi Jiang, Alan M Sugrue, Jason A Tri, Elena G Tolkacheva, Freddy Del-Carpio Munoz, Christopher J McLeod, Samuel J Asirvatham, Christopher V DeSimone,

[Figure: see text]. ... Read more >>

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2021, 14(10):e010281]

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Automatic wide complex tachycardia differentiation using mathematically synthesized vectorcardiogram signals.

Anthony H Kashou, Sarah LoCoco, Trevon D McGill, Christopher M Evenson, Abhishek J Deshmukh, David O Hodge, Daniel H Cooper, Sandeep S Sodhi, Phillip S Cuculich, Samuel J Asirvatham, Peter A Noseworthy, Christopher V DeSimone, Adam M May,

<h4>Background</h4>Automated wide complex tachycardia (WCT) differentiation into ventricular tachycardia (VT) and supraventricular wide complex tachycardia (SWCT) may be accomplished using novel calculations that quantify the extent of mean electrical vector changes between the WCT and baseline electrocardiogram (ECG). At present, it is unknown whether quantifying mean electrical vector changes within ... Read more >>

Ann Noninvasive Electrocardiol (Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc)
[2021, :e12890]

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Doppler Mean Gradient Is Discordant to Aortic Valve Calcium Scores in Patients with Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement.

Adham K Alkurashi, Sorin V Pislaru, Jeremy J Thaden, Jeremy D Collins, Thomas A Foley, Kevin L Greason, Mackram F Eleid, Gurpreet S Sandhu, Mohamad A Alkhouli, Samuel J Asirvatham, Yong-Mei Cha, Eric E Williamson, Juan A Crestanello, Patricia A Pellikka, Jae K Oh, Vuyisile T Nkomo,

<h4>Background</h4>Doppler mean gradient (MG) may underestimate aortic stenosis (AS) severity when obtained during atrial fibrillation (AF) because of lower forward flow compared with sinus rhythm (SR). Whether AS is more advanced at the time of referral for aortic valve intervention in AF compared with SR is unknown. The aim of ... Read more >>

J Am Soc Echocardiogr (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography)
[2021, :]

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Outcomes and periprocedural management of cardiac implantable electronic devices in patients with carcinoid heart disease.

Robert C Ward, Sushil Allen Luis, Samuel A Shabtaie, Patricia A Pellikka, Heidi M Connolly, William Miranda, Hartzell Schaff, Win-Kuen Shen, Ammar M Killu, Yong-Mei Cha, Samuel J Asirvatham, Abhishek J Deshumkh, Christopher V DeSimone,

<h4>Background</h4>Carcinoid heart disease (CHD) is a rare complication of hormonally active neuroendocrine tumors that often requires surgical intervention. Data on cardiac implantable electronic device (CIED) implantation in patients with CHD are limited.<h4>Objective</h4>The purpose of this study was to evaluate the experience of CIED implantation in patients with CHD.<h4>Methods</h4>Patients with a ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, 18(12):2094-2100]

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Electrogram-guided endomyocardial biopsy yield in patients with suspected cardiac sarcoidosis and relation to outcomes.

Fatima M Ezzeddine, Suraj Kapa, Andrew Rosenbaum, Lori Blauwet, Abhishek J Deshmukh, Omar F AbouEzzeddine, Joseph J Maleszewski, Samuel J Asirvatham, John P Bois, John A Schirger, Panithaya Chareonthaitawee, Konstantinos C Siontis,

<h4>Objective</h4>Endomyocardial biopsy (EMB) is a useful diagnostic tool though the yield may be limited in many myocardial diseases. Data on the diagnostic yield and prognostic significance of EMB guided by abnormal electrograms (EGM-Bx) in suspected cardiac sarcoidosis (CS) are scarce.<h4>Methods</h4>Seventy-nine patients (mean age: 56 ± 12 years; 61% men) with suspected CS ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(9):2486-2495]

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Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model.

Eyal Heller, Tomas Garcia-Sanchez, Yonatan Moshkovits, Raul Rabinovici, Dvora Grynberg, Amit Segev, Samuel J Asirvatham, Antoni Ivorra, Elad Maor,

This study compared monophasic 100-μs pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, 7(8):959-964]

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Sub-mitral valve aneurysm ventricular tachycardia masquerading as arrhythmogenic right ventricular cardiomyopathy.

Robert Ward, Roshan Karki, Samuel J Asirvatham, Abhishek J Deshmukh, Christopher V DeSimone,

HeartRhythm Case Rep (HeartRhythm case reports)
[2021, 7(9):588-592]

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Arrhythmia Recurrence After Atrial Fibrillation Ablation: Impact of Warfarin vs. Non-Vitamin K Antagonist Oral Anticoagulants.

Songnan Wen, Cristina Pislaru, Kristi H Monahan, Stephanie M Barnes, David O Hodge, Douglas L Packer, Sorin V Pislaru, Samuel J Asirvatham,

<h4>Purpose</h4>Both warfarin and non-vitamin K antagonist oral anticoagulants (NOACs) have pleiotropic effects including anti-inflammatory and anti-fibrotic properties. This study aims to explore whether arrhythmia recurrence after AF ablation is influenced by the choice of oral anticoagulant.<h4>Methods</h4>We retrospectively studied all patients who underwent primary AF ablation between 2011 and 2017 and ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2021, :]

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An under-recognized phenomenon: Myocardial volume change during the cardiac cycle.

Vinayak Kumar, Armando Manduca, Chaitanya Rao, Alexander J Ryu, Raymond J Gibbons, Bernard J Gersh, Krishnaswamy Chandrasekaran, Samuel J Asirvatham, Philip A Araoz, Jae K Oh, Alexander C Egbe, Atta Behfar, Barry A Borlaug, Nandan S Anavekar,

<h4>Background</h4>Myocardial volume is assumed to be constant over the cardiac cycle in the echocardiographic models used by professional guidelines, despite evidence that suggests otherwise. The aim of this paper is to use literature-derived myocardial strain values from healthy patients to determine if myocardial volume changes during the cardiac cycle.<h4>Methods</h4>A systematic ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2021, 38(8):1235-1244]

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Sound wave balloon-assisted device implantation: a novel approach that merits consideration.

Walid Barake, Malini Madhavan, Gurukripa N Kowlgi, Yong-Mei Cha, Samuel J Asirvatham, Paul A Friedman,

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, 23(5):747]

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Infection Rate and Outcomes of Watchman Devices: Results from a Single-Center 14-Year Experience.

Robert C Ward, Trevon McGill, Fadi Adel, Shiva Ponamgi, Samuel J Asirvatham, Larry M Baddour, David R Holmes, Daniel C DeSimone, Christopher V DeSimone,

The Watchman device (WD) is a commonly used alternative strategy to oral anticoagulation for stroke risk reduction in patients with atrial fibrillation who have an increased bleeding risk. There are rare case reports of WD-related infection. Currently, there is no formal study that has systematically evaluated the incidence and outcomes ... Read more >>

Biomed Hub (Biomedicine hub)
[2021, 6(2):59-62]

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Hemodynamic Benefits From Left Atrial Pacing to Treat Interatrial Conduction Delay Following Atrial Fibrillation Ablation.

Madeline K Mahowald, Yogesh N V Reddy, Juan A Crestanello, Samuel J Asirvatham, Rick A Nishimura,

Circ Heart Fail (Circulation. Heart failure)
[2021, 14(5):e008191]

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Reconstitution of native intrinsic conduction in patients with chronic conduction block with His bundle pacing.

Fatima M Ezzeddine, Rajeev Singh, Samuel J Asirvatham, Gopi Dandamudi, Subodh R Devabhaktuni,

HeartRhythm Case Rep (HeartRhythm case reports)
[2021, 7(6):364-368]

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Outcomes of cardiac resynchronization therapy in patients with chemotherapy-induced cardiomyopathy.

Fatima M Ezzeddine, Antoine N Saliba, Vaibhav Jain, Hector R Villarraga, Joerg Herrmann, Samuel J Asirvatham, Yong-Mei Cha,

<h4>Background</h4>Several chemotherapy agents are associated with the development of non-ischemic cardiomyopathy (NIC). When chemotherapy-induced cardiomyopathy (CHIC) is associated with left bundle branch block (LBBB) and a left ventricular ejection fraction (LVEF) 35% or lower, cardiac resynchronization therapy (CRT) is often utilized to improve cardiac function and relieve symptoms.<h4>Objective</h4>To determine the ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(4):625-632]

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Liposomal bupivacaine during subcutaneous implantable cardioverter defibrillator implantation for pain management.

Justin Z Lee, Amy E Glasgow, Elizabeth B Habermann, Luis Scott, Win-Kuang Shen, Fred M Kusumoto, Christopher J McLeod, Vasudha Goel, Pranita Kaginele, Yong-Mei Cha, Paul A Friedman, Samuel J Asirvatham, Siva K Mulpuru,

<h4>Background</h4>The subcutaneous implantable cardioverter-defibrillator (S-ICD) has a larger generator and its implantation involves more dissection and tunneling compared to traditional transvenous defibrillator system. Liposomal bupivacaine, an extended-release bupivacaine with 72 h of duration has been used for postoperative pain management in patients undergoing S-ICD implantation. Our aim was to compare postoperative ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(3):513-518]

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Sinus rhythm heart rate increase after atrial fibrillation ablation is associated with lower risk of arrhythmia recurrence.

Ammar M Killu, Chance M Witt, Alan M Sugrue, Vaibhav Vaidya, Kristi H Monahan, Stephanie Barnes, Charles J Lenz, Vidhushei Yogeswaran, Philip Y Sun, David O Hodge, Paul A Friedman, Douglas L Packer, Samuel J Asirvatham,

<h4>Background</h4>Pulmonary vein isolation (PVI) with autonomic modulation may be more successful than PVI alone for atrial fibrillation (AF) ablation and may be signaled by changes in sinus rhythm heart rate (HR) post ablation. We sought to determine if a change in sinus rhythm HR predicted AF recurrence post PVI.<h4>Methods</h4>Patients who ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2021, 44(4):651-656]

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Efficacy of medical and ablation therapy for inappropriate sinus tachycardia: A single-center experience.

Samuel A Shabtaie, Chance M Witt, Samuel J Asirvatham,

<h4>Background</h4>Effective therapy for inappropriate sinus tachycardia (IST) remains challenging with high rates of treatment failure and symptom recurrence. It is uncertain how effective pharmacotherapy and procedural therapy are long-term, with poor response to medical therapy in general.<h4>Methods</h4>We retrospectively reviewed all patients with the diagnosis of IST at a tertiary academic ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(4):1053-1061]

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Reversible Atrioventricular Conduction Impairment Following Bipolar Nanosecond Electroporation of the Interventricular Septum.

Martin van Zyl, Adetola O Ladejobi, Jason A Tri, Omar Z Yasin, Richard J Connolly, David J Danitz, Christopher V DeSimone, Ammar M Killu, Elad Maor, Samuel J Asirvatham,

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, 7(2):255-257]

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Gastric ablation as a novel technique for modulating electrical conduction in the in vivo stomach.

Zahra Aghababaie, Niranchan Paskaranandavadivel, Satya Amirapu, Chih-Hsiang Alexander Chan, Peng Du, Samuel J Asirvatham, Gianrico Farrugia, Arthur Beyder, Gregory O'Grady, Leo K Cheng, Timothy R Angeli-Gordon,

Gastric motility is coordinated by underlying bioelectrical "slow wave" activity. Slow wave dysrhythmias are associated with motility disorders, including gastroparesis, offering an underexplored potential therapeutic target. Although ablation is widely used to treat cardiac arrhythmias, this approach has not yet been trialed for gastric electrical abnormalities. We hypothesized that ablation ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2021, 320(4):G573-G585]

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Sustained Improvement in Diastolic Reserve Following Percutaneous Pericardiotomy in a Porcine Model of Heart Failure With Preserved Ejection Fraction.

C Charles Jain, Dawn Pedrotty, Philip A Araoz, Alan Sugrue, Vaibhav R Vaidya, Deepak Padmanabhan, Shivaram P Arunachalam, Lilach O Lerman, Samuel J Asirvatham, Barry A Borlaug,

<h4>Background</h4>Heart failure with preserved ejection fraction is increasing in prevalence, but few effective treatments are available. Elevated left ventricular (LV) diastolic filling pressures represent a key therapeutic target. Pericardial restraint contributes to elevated LV end-diastolic pressure, and acute studies have shown that pericardiotomy attenuates the rise in LV end-diastolic pressure ... Read more >>

Circ Heart Fail (Circulation. Heart failure)
[2021, 14(2):e007530]

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