Full Text Journal Articles by
Author Sameh Amara

Advertisement

Find full text journal articles








Stromal cell derived factor-1 and CXCR4 expression in colorectal cancer promote liver metastasis.

Sameh Amara, Ines Chaar, Meriem Khiari, Donia Ounissi, Marwa Weslati, Rahma Boughriba, Abdelmajid B Hmida, Saadia Bouraoui,

Recent studies suggest that SDF-1 and CXCR4 are expressed in certain cancer cells, and malignant cells use this chemokine/receptor system to promote tumor progression and metastasis. However, the pathophysiological significance of their expression in colorectal cancer (CRC) tissue has not been fully elucidated.The purpose of this study was to assess ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2015, 15(6):869-879]

Cited: 12 times

View full text PDF listing >>



Relationship between SDF-1G801A polymorphism and its expression in Tunisian patients with colorectal cancer.

Sameh Amara, Ines Chaar, Meriem Khiari, Donia Ounissi, Abdelmajid B Hmida, Sabeh Regaya Mzabi, Saadia Bouraoui,

The aim was to evaluate the relationship between SDF-1G801A polymorphism and its immunohistochemical expression in colorectal cancer tissues in the Tunisian cohort. The molecular and immunohistochemical analysis showed that SDF-1G801A polymorphic variant was higher in CRC patients with TNM stage II and III, the SDF-1 expression was significantly increased from ... Read more >>

J Immunoassay Immunochem (Journal of immunoassay & immunochemistry)
[2015, 36(2):182-194]

Cited: 4 times

View full text PDF listing >>



Advertisement

Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort.

Chaar Ines, Ounissi Donia, Boughriba Rahma, Azza Ben Ammar, Amara Sameh, Taher Khalfallah, Ben Hmida Abdelmajid, Mzabi Sabeh, Bouraoui Saadia,

According to the multistep route of genetic alterations in the colorectal adenoma-carcinoma sequence, the complex K-ras/p53 mutation is one of the first alterations to occur and represent an important genetic event in colorectal cancer (CRC). An evaluation of the mutation spectra in K-ras and p53 gene was effected in 167 ... Read more >>

Tumour Biol. (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine)
[2014, 35(7):7163-7175]

Cited: 5 times

View full text PDF listing >>



Biological significance of promoter hypermethylation of p14/ARF gene: relationships to p53 mutational status in Tunisian population with colorectal carcinoma.

Ines Chaar, Sameh Amara, Olfa Elhadj Elamine, Mariem Khiari, Donia Ounissi, Taher Khalfallah, Abdelmajid Ben Hmida, Sabeh Mzabi, Saadia Bouraoui,

One of the most important pathways which are frequently affected in colorectal cancer is p53/ (MDM2)/p14ARF pathway. We aim to determine the methylation pattern of p14/ARF in relation to mutation of p53. This correlation was studied to investigate whether their alterations could be considered as a predictor factor of prognosis ... Read more >>

Tumour Biol. (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine)
[2014, 35(2):1439-1449]

Cited: 13 times

View full text PDF listing >>



Relationship between MDM2 and p53 alterations in colorectal cancer and their involvement and prognostic value in the Tunisian population.

Ines Chaar, Sameh Amara, Mariem Khiari, Donia Ounissi, Monia Dhraif, Abd E M Ben Hamida, Lassad Gharbi, Sabeh Mzabi, Saadia Bouraoui,

The prevalence of p53 mutations in colorectal cancer could reach 90%. The most important regulator of this protein that was identified originally was the Murine Double Minute2 (MDM2) oncoprotein, by which the levels of p53 were fixed through an autoregulatory feedback loop. In cancer cases, the overexpression of MDM2 deregulates ... Read more >>

Appl Immunohistochem Mol Morphol (Applied immunohistochemistry & molecular morphology : AIMM)
[2013, 21(3):228-236]

Cited: 2 times

View full text PDF listing >>



The prognostic value of the immunohistochemical expression and mutational pattern of the key mediator of Wnt signaling: beta-catenin in Tunisian patients with colorectal carcinoma.

Meriem Khiari, Amira Arfaoui, Lilia Kriaa, Inés Chaar, Sameh Amara, Med Amine Lounis, Souraya Sammoud, Monia Dhraeif, Lassaad Gharbi, Sabeh Mzabi-Regaya, Saadia Bouraoui,

Beta-catenin plays a critical role with E-cadherin in cell-cell adhesion and is also a key molecule of the highly conserved Wnt signaling pathway that regulates cell proliferation and differentiation. Abrogation of this pathway is implicated in the carcinogenesis of several malignancies, especially colorectal cancer. The objective of this study was ... Read more >>

Appl Immunohistochem Mol Morphol (Applied immunohistochemistry & molecular morphology : AIMM)
[2012, 20(1):62-70]

Cited: 5 times

View full text PDF listing >>



Stromal cell-derived factor 1 polymorphism in patients infected with HIV and implications for AIDS progression in Tunisia.

Sameh Amara, Jorge Domenech, Faouzi Jenhani,

BACKGROUND:An interesting finding in the epidemiology of human immunodeficiency virus (HIV) infection is that certain mutations in genes coding for chemokines, and their receptors and ligands, may confer resistance or susceptibility to HIV-1 infection and acquired immunodeficiency syndrome (AIDS) progression. The mutation most frequently studied is stromal cell-derived factor (SDF)1-3'A, ... Read more >>

HIV AIDS (Auckl) (HIV/AIDS (Auckland, N.Z.))
[2010, 2:203-209]

Cited: 2 times

View full text PDF listing >>





Advertisement

Disclaimer
1.7066 s