Full Text Journal Articles by
Author Samantha Schrecke

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Selective regulation of human TRAAK channels by biologically active phospholipids.

Samantha Schrecke, Yun Zhu, Jacob W McCabe, Mariah Bartz, Charles Packianathan, Minglei Zhao, Ming Zhou, David Russell, Arthur Laganowsky,

TRAAK is an ion channel from the two-pore domain potassium (K2P) channel family with roles in maintaining the resting membrane potential and fast action potential conduction. Regulated by a wide range of physical and chemical stimuli, the affinity and selectivity of K2P4.1 toward lipids remains poorly understood. Here we show ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Discovery of Potent Charge-Reducing Molecules for Native Ion Mobility Mass Spectrometry Studies.

Jixing Lyu, Yang Liu, Jacob W McCabe, Samantha Schrecke, Lei Fang, David H Russell, Arthur Laganowsky,

There is growing interest in the characterization of protein complexes and their interactions with ligands using native ion mobility mass spectrometry. A particular challenge, especially for membrane proteins, is preserving noncovalent interactions and maintaining native-like structures. Different approaches have been developed to minimize activation of protein complexes by manipulating charge ... Read more >>

Anal. Chem. (Analytical chemistry)
[2020, 92(16):11242-11249]

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Amphiphile self-assembly dynamics at the solution-solid interface reveal asymmetry in head/tail desorption.

Henry D Castillo, John M Espinosa-Duran, James R Dobscha, Daniel C Ashley, Sibali Debnath, Brandon E Hirsch, Samantha R Schrecke, Mu-Hyun Baik, Peter J Ortoleva, Krishnan Raghavachari, Amar H Flood, Steven L Tait,

Amphiphilic alkoxybenzonitriles (ABNs) of varying chain length are studied at the solution/graphite interface to analyze dynamics of assembly. Competitive self-assembly between ABNs and alkanoic acid solvent is shown by scanning tunneling microscopy (STM) to be controlled by concentration and molecular size. Molecular dynamics (MD) simulations reveal key roles of the ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2018, 54(72):10076-10079]

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