Full Text Journal Articles by
Author Salwa Elkazaz


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Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.

Ehab D AlFadly, Perihan A Elzahhar, Anna Tramarin, Salwa Elkazaz, Hossam Shaltout, Marwa M Abu-Serie, Jana Janockova, Ondrej Soukup, Doaa A Ghareeb, Ahmed F El-Yazbi, Rim W Rafeh, Nour-Mounira Z Bakkar, Firas Kobeissy, Isabel Iriepa, Ignacio Moraleda, Manal N S Saudi, Manuela Bartolini, Ahmed S F Belal,

Neuroinflammation and cholinergic deficit are key detrimental processes involved in Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the multi-target-directed ligand paradigm was applied to the rational design of two series of new hybrids endowed with anti-inflammatory and anticholinesterase activity via triple targeting properties, namely able ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2019, 167:161-186]

Cited: 7 times

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Design and synthesis of some new 2,3'-bipyridine-5-carbonitriles as potential anti-inflammatory/antimicrobial agents.

Perihan A Elzahhar, Salwa Elkazaz, Raafat Soliman, Alaa A El-Tombary, Hossam A Shaltout, Ibrahim M El-Ashmawy, Abeer E Abdel Wahab, Soad A El-Hawash,

<h4>Aim</h4>Inflammation may cause accumulation of fluid in the injured area, which may promote bacterial growth. Other reports disclosed that non-steroidal anti-inflammatory drugs may enhance progression of bacterial infection.<h4>Results</h4>This work describes synthesis of new series of 2,3'-bipyridine-5-carbonitriles as structural analogs of etoricoxib, linked at position-6 to variously substituted thio or oxo ... Read more >>

Future Med Chem (Future medicinal chemistry)
[2017, 9(12):1413-1450]

Cited: 1 time

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Photochemical hydroxylation of 1-methyl-9,10-anthraquinones: synthesis of 9'-hydroxyaloesaponarin II.

Salwa Elkazaz, Paul B Jones,

Photolysis of 1-methyl-9,10-anthraquinones in the presence of oxygen yields endoperoxides that can be reduced to produce 1-hydroxymethyl-9,10-anthraquinones. The reaction proceeds in a fashion similar to that of other o-alkylphenones which yield either a 1,4-diradical or a "photoenol" upon irradiation. Anthraquinones undergo photochemistry at a wavelength where the endoperoxide is transparent, ... Read more >>

J Org Chem (The Journal of organic chemistry)
[2010, 75(2):412-416]

Cited: 3 times

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Observation of heavy atom effects in the development of water soluble caged 4-hydroxy-trans-2-nonenal.

Paul B Jones, Robert G Brinson, Saurav J Sarma, Salwa Elkazaz,

During the course of our study on the photochemistry of 1-alkoxy-9,10-anthraquinones, we have developed a second generation of a caged 4-hydroxy-trans-2-nonenal (4-HNE). As we optimized the anthraquinonyl chromophore to achieve water solubility, we studied the photochemistry of various substituents to understand their effect on the photochemistry. We observed a significant ... Read more >>

Org Biomol Chem (Organic & biomolecular chemistry)
[2008, 6(22):4204-4211]

Cited: 6 times

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