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Author Salvatore Gueli Alletti

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Laparoscopic vs. robotic-assisted laparoscopy in endometrial cancer staging: large retrospective single-institution study.

Emanuele Perrone, Ilaria Capasso, Tina Pasciuto, Alessandro Gioè, Salvatore Gueli Alletti, Stefano Restaino, Giovanni Scambia, Francesco Fanfani,

<h4>Objective</h4>The aim of this study is to analyze and draw the potential differences between the robotic-assisted surgery (RS) and the laparoscopy (LPS) in endometrial cancer staging.<h4>Methods</h4>In this single-institution retrospective study we enrolled 1,221 consecutive clinical stage I-III endometrial cancer patients undergone minimally invasive surgical staging. We compared patients treated by ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e45]

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Update on new imaging technologies in sentinel node detection.

Silvia Pelligra, Giuseppe Scaletta, Stefano Cianci, Salvatore Gueli Alletti, Stefano Restaino, Anna Fagotti, Giovanni Scambia, Francesco Fanfani,

In most cancers, lymph node status is the most critical factor impacting the evolution of the disease and the overall survival. Identifying potential nodal metastasis allows the oncologist to adjust the stage and, consequently, the patient's treatment. For this reason, a precise evaluation of the regional nodes is mandatory. In ... Read more >>

Minerva Ginecol (Minerva ginecologica)
[2020, 72(6):404-412]

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Peritoneal HPV-DNA test in cervical cancer (PIONEER study): A proof of concept.

Nicolò Bizzarri, Luigi Pedone Anchora, Paola Cattani, Rosa De Vincenzo, Simona Marchetti, Carmine Conte, Vito Chiantera, Valerio Gallotta, Salvatore Gueli Alletti, Giuseppe Vizzielli, Barbara Costantini, Anna Fagotti, Francesco Fanfani, Giovanni Scambia, Gabriella Ferrandina,

The aim of this study was to investigate the prevalence of peritoneal human papillomavirus (HPV) infection in different clinical cervical cancer (CC) settings, and its association with potential clinical and/or histological factors. This is a single-center, prospective, observational study. Consecutive patients with newly diagnosed or recurrent/persistent CC, between March 2019 ... Read more >>

Int J Cancer (International journal of cancer)
[2021, 148(5):1197-1207]

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Uterine manipulator in endometrial cancer: we are still far from the answer.

Stefano Uccella, Stefano Cianci, Salvatore Gueli Alletti,

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, 224(3):332]

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Laparotomy vs. minimally invasive surgery for ovarian cancer recurrence: a systematic review.

Stefano Uccella, Massimo P Franchi, Stefano Cianci, Pier Carlo Zorzato, Francesca Bertoli, Salvatore Gueli Alletti, Fabio Ghezzi, Giovanni Scambia,

The objective of the present review is to thoroughly investigate the role of minimally invasive surgery (MIS) in the setting of secondary cytoreduction for ovarian cancer recurrence, comparing this approach to traditional open surgery. PubMed, ClinicalTrials.gov, Scopus and Web of Science databases (between 1st January 1989 and 1st January 2020), ... Read more >>

Gland Surg (Gland surgery)
[2020, 9(4):1130-1139]

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Sentinel lymph node mapping with indocyanine green in cervical cancer patients undergoing open radical hysterectomy: a single-institution series.

Nicolò Bizzarri, Pedone Anchora Luigi, Gabriella Ferrandina, Gian Franco Zannoni, Maria Vittoria Carbone, Camilla Fedele, Elena Teodorico, Valerio Gallotta, Salvatore Gueli Alletti, Vito Chiantera, Anna Fagotti, Giovanni Scambia, Francesco Fanfani,

<h4>Purpose</h4>To assess the rate of bilateral sentinel lymph node (SLN) detection with indocyanine green (ICG), to evaluate the sensitivity and the negative predictive value of cervical cancer patients undergoing open radical hysterectomy; to compare open versus minimally invasive SLN biopsy performance and to assess factors related to no/unilateral SLN mapping.<h4>Methods</h4>We ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2021, 147(3):649-659]

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Randomized trial of primary debulking surgery versus neoadjuvant chemotherapy for advanced epithelial ovarian cancer (SCORPION-NCT01461850).

Anna Fagotti, Maria Gabriella Ferrandina, Giuseppe Vizzielli, Tina Pasciuto, Francesco Fanfani, Valerio Gallotta, Pasquale Alessandro Margariti, Vito Chiantera, Barbara Costantini, Salvatore Gueli Alletti, Francesco Cosentino, Giovanni Scambia,

<h4>Objective</h4>To investigate whether neoadjuvant chemotherapy followed by interval debulking surgery is superior to primary debulking surgery in terms of perioperative complications and progression-free survival, in advanced epithelial ovarian, fallopian tube or primary peritoneal cancer patients with high tumor load.<h4>Methods</h4>Patients with advanced epithelial ovarian, fallopian tube or primary peritoneal cancer (stage ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(11):1657-1664]

Cited: 3 times

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Percutaneous-assisted vs mini-laparoscopic hysterectomy: comparison of ultra-minimally invasive approaches.

Stefano Cianci, Emanuele Perrone, Cristiano Rossitto, Francesco Fanfani, Alessandro Tropea, Antonio Biondi, Giovanni Scambia, Salvatore Gueli Alletti,

To assess the feasibility and the safety of the ultra-minimally invasive (U-MIS) approaches in gynecology, we compared our experience in percutaneous assisted hysterectomy (PSS-H) with a series of 3 mm mini-laparoscopy hysterectomy (m-LPS-H). 126 patients affected by benign and malignant gynecological conditions were considered eligible for minimally invasive hysterectomy: 80 patients ... Read more >>

Updates Surg (Updates in surgery)
[2020, :]

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Percutaneous-Assisted versus Laparoscopic Hysterectomy: A Prospective Comparison.

Emanuele Perrone, Cristiano Rossitto, Francesco Fanfani, Stefano Cianci, Anna Fagotti, Stefano Uccella, Giuseppe Vizzielli, Carmine Vascone, Stefano Restaino, Camilla Fedele, Farrah Layla Saleh, Giovanni Scambia, Salvatore Gueli Alletti,

<h4>Objective</h4>To evaluate the feasibility of percutaneous approach, we prospectively compared our experience in percutaneous-assisted hysterectomy (PSS-H) with that in a series of laparoscopic hysterectomies (LPS-Hs).<h4>Methods</h4>In this multicentric cohort study, from May 2015 to October 2017, 160 patients affected by benign and malignant gynecological conditions were considered eligible for minimally invasive ... Read more >>

Gynecol Obstet Invest (Gynecologic and obstetric investigation)
[2020, 85(4):318-326]

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Role of ultrasound in the detection of recurrent ovarian cancer: a review of the literature.

Andrea Rosati, Salvatore Gueli Alletti, Vito Andrea Capozzi, Mariateresa Mirandola, Virginia Vargiu, Camilla Fedele, Stefano Uccella, Carmine Vascone,

Nowadays, no standard approaches for follow up in ovarian cancer (OC) patients exist. While the role of ultrasound (US) is well defined in primary diagnosis of OC, it is still controversial during follow-up of surgically treated OC. The aim of this narrative review is to evaluate the role described in ... Read more >>

Gland Surg (Gland surgery)
[2020, 9(4):1092-1101]

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Feasibility and perioperative outcomes of percutaneous-assisted laparoscopic hysterectomy: A multicentric Italian experience.

Salvatore Gueli Alletti, Emanuele Perrone, Antonio Cretì, Stefano Cianci, Stefano Uccella, Camilla Fedele, Francesco Fanfani, Stefano Palmieri, Anna Fagotti, Giovanni Scambia, Cristiano Rossitto,

OBJECTIVE:This multicentric prospective phase II study aimed to investigate the feasibility, safety, and efficacy of percutaneous-assisted laparoscopic hysterectomy in terms of perioperative outcomes, feasibility, VAS score, and cosmetic outcomes. STUDY DESIGN:Between May 2015 and October 2017, 382 patients were considered eligible for minimally invasive percutaneous-assisted laparoscopic hysterectomy using Percuvance™, Percutaneous ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2020, 245:181-185]

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Laparoscopy vs. laparotomy for advanced ovarian cancer: a systematic review of the literature.

Salvatore Gueli Alletti, Vito A Capozzi, Andrea Rosati, Ilaria De Blasis, Stefano Cianci, Giuseppe Vizzielli, Stefano Uccella, Valerio Gallotta, Francesco Fanfani, Anna Fagotti, Giovanni Scambia,

<h4>Introduction</h4>In the last decade, laparoscopy has been progressively introduced in the management of advanced-stage ovarian cancer (AOC) to evaluate tumor resectability, avoiding an explorative laparotomy, to identify non-responders to submit to second-line chemotherapy and to perform primary or interval minimally invasive debulking surgery in selected patients. This review aims to ... Read more >>

Minerva Med (Minerva medica)
[2019, 110(4):341-357]

Cited: 5 times

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Clinical Impact of a Surgical Energy Device in Advanced Ovarian Cancer Surgery Including Bowel Resection.

Giuseppe Vizzielli, Carmine Conte, Massimo Romano, Anna Fagotti, Barbara Costantini, Claudio Lodoli, Salvatore Gueli Alletti, Khaled Gaballah, Fabio Pacelli, Alfredo Ercoli, Giovanni Scambia, Valerio Gallotta,

To evaluate the clinical impact of the use of the Caiman® articulating energy device in advanced ovarian cancer (AOC) including rectosigmoid resection [e.g. modified posterior exenteration (MPE)].This was a prospective single-institution observational study with women undergoing MPE where all soft-tissue dissections and vessel ligations were performed using the Caiman® device. ... Read more >>

In Vivo (In vivo (Athens, Greece))
[2018, 32(2):359-364]

Cited: 1 time

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Sexual Function following Laparoscopic versus Transvaginal Closure of the Vaginal Vault after Laparoscopic Hysterectomy: Secondary Analysis of a Randomized Trial by the Italian Society of Gynecological Endoscopy Using a Validated Questionnaire.

Stefano Uccella, Vito Andrea Capozzi, Matteo Ricco', Emanuele Perrone, Margherita Zanello, Stefania Ferrari, Pier Carlo Zorzato, Renato Seracchioli, Antonella Cromi, Maurizio Serati, Raffaella Ergasti, Francesco Fanfani, Roberto Berretta, Mario Malzoni, Stefano Cianci, Enrico Vizza, Maurizio Guido, Francesco Legge, Giuseppe Ciravolo, Salvatore Gueli Alletti, Fabio Ghezzi, Massimo Candiani, Giovanni Scambia,

<h4>Study objective</h4>The effect of the different types of vaginal cuff closures on posthysterectomy sexual function has not been investigated in depth. We evaluated if there is a difference between transvaginal versus a laparoscopic closure after total laparoscopic hysterectomy (TLH) on female sexual function, using a validated questionnaire.<h4>Design</h4>Secondary analysis of a ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2020, 27(1):186-194]

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Step by Step Total Laparoscopic Hysterectomy with Uterine Arteries Ligation at the Origin.

Salvatore Gueli Alletti, Stefano Restaino, Angelo Finelli, Carlo Ronsini, Alessandro Lucidi, Giovanni Scambia, Francesco Fanfani,

<h4>Study objective</h4>To reveal principles and the feasibility of a total laparoscopic hysterectomy (TLH) with uterine artery ligation at the origin.<h4>Design</h4>Step-by-step demonstration and explanation of technique using videos from patients.<h4>Setting</h4>Gynecologic oncology unit at a university hospital.<h4>Patient</h4>A 54-year-old woman with uterine fibromatosis and metrorrhagia.<h4>Intervention</h4>TLH has 7 common components. First, round ligaments are ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2020, 27(1):22-23]

Cited: 1 time

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The role of sentinel node in early ovarian cancer: a systematic review.

Stefano Uccella, Pier Carlo Zorzato, Gabriele Lanzo, Anna Fagotti, Stefano Cianci, Davide Gallina, Salvatore Gueli Alletti, Giorgia Monterossi, Massimo Franchi, Fabio Ghezzi, Gian Franco Zannoni, Giovanni Scambia,

<h4>Introduction</h4>Early ovarian cancer (EOC) is defined as ovarian cancer macroscopically limited to the ovaries at the time of initial diagnosis. Approximately only 25% of patients with ovarian cancer are affected by EOC. This condition requires complete surgical staging, including systematic lymphadenectomy up to the level of the renal vessels, with ... Read more >>

Minerva Med (Minerva medica)
[2019, 110(4):358-366]

Cited: 1 time

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Sexual function and quality of life of patients affected by ovarian cancer.

Stefano Cianci, Mattia Tarascio, Andrea Rosati, Salvatore Caruso, Stefano Uccella, Francesco Cosentino, Giuseppe Scaletta, Salvatore Gueli Alletti, Giovanni Scambia,

<h4>Introduction</h4>The sexual function (SF) in patients affected by malignancies represents an important aspect influencing the quality of life (QoL). The most frequent symptoms reported are the decreased sexual desire, dyspareunia, and/or problems with arousal or achieving orgasm. The present study is aimed at analyzing the available scientific evidence regarding the ... Read more >>

Minerva Med (Minerva medica)
[2019, 110(4):320-329]

Cited: 4 times

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Role of ultrasound in advanced peritoneal malignancies.

Ilaria De Blasis, Maria C Moruzzi, Francesca Moro, Floriana Mascilini, Stefano Cianci, Salvatore Gueli Alletti, Luigi C Turco, Giorgia Garganese, Giovanni Scambia, Antonia C Testa,

<h4>Introduction</h4>Ovarian cancer is the seventh most common cancer among women in the developed world, and most women with ovarian cancer are diagnosed at an advanced stage of disease, when large intraperitoneal dissemination has already occurred. An accurate preoperative assessment of the tumor dissemination is pivotal for adequate counseling among risks ... Read more >>

Minerva Med (Minerva medica)
[2019, 110(4):292-300]

Cited: 2 times

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Sarcopenia in Ovarian Cancer Patients, Oncologic Outcomes Revealing the Importance of Clinical Nutrition: Review of Literature.

Stefano Cianci, Valerio Rumolo, Andrea Rosati, Giuseppe Scaletta, Salvatore Gueli Alletti, Taís Marques Cerentini, Zaki Sleiman, Patricia Lordelo, Daniela Angerame, Giorgia Garganese, Stefano Uccella, Mattia Tarascio, Giovanni Scambia,

<h4>Introduction</h4>Ovarian cancer is the leading cause of death among gynecological malignancies. Its usual clinical manifestation is at advanced stages, with nutritional impairment, weight loss, and a consequent decline in skeletal muscle mass and strength (defined as sarcopenia). The relationship between sarcopenia and decreased survival was demonstrated not only in ovarian ... Read more >>

Curr Pharm Des (Current pharmaceutical design)
[2019, 25(22):2480-2490]

Cited: 5 times

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Upfront HIPEC and bevacizumab-containing adjuvant chemotherapy in advanced epithelial ovarian cancer.

Ida Paris, Stefano Cianci, Giuseppe Vizzielli, Anna Fagotti, Gabriella Ferrandina, Salvatore Gueli Alletti, Barbara Costantini, Francesco Cosentino, Ettore Capoluongo, Mariangela Pasqualoni, Giovanni Scambia,

<h4>Introduction</h4>In advanced epithelial ovarian cancer patients, the standard of care is primary debulking surgery, followed by first-line chemotherapy often with bevacizumab addiction. In this context, some experiences have shown that a comprehensive treatment approach to surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) could improve the prognosis.<h4>Objective</h4>This is a study aimed ... Read more >>

Int J Hyperthermia (International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group)
[2018, 35(1):370-374]

Cited: 5 times

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Minimally invasive salvage lymphadenectomy in gynecological cancer patients: A single institution series.

Valerio Gallotta, Maria Teresa Giudice, Carmine Conte, Alicia Vazquez Sarandeses, Marco D'Indinosante, Alex Federico, Lucia Tortorella, Maria Vittoria Carbone, Salvatore Gueli Alletti, Giuseppe Vizzielli, Barbara Costantini, Giovanni Scambia, Gabriella Ferrandina,

<h4>Background</h4>to assess the feasibility of minimally invasive surgery in the management of lymph-nodal recurrences of gynecological cancers, in terms of surgical and oncological outcomes.<h4>Methods</h4>we retrospectively collected patients with isolated lymph-nodal recurrent disease of gynecological malignancies who underwent to minimally invasive lymphadenectomy at Catholic University of the Sacred Hearth in Rome ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2018, 44(10):1568-1572]

Cited: 5 times

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One-Step Nucleic Acid Amplification (OSNA): A fast molecular test based on CK19 mRNA concentration for assessment of lymph-nodes metastases in early stage endometrial cancer.

Francesco Fanfani, Giorgia Monterossi, Viola Ghizzoni, Esther D Rossi, Giorgia Dinoi, Frediano Inzani, Anna Fagotti, Salvatore Gueli Alletti, Francesca Scarpellini, Camilla Nero, Angela Santoro, Giovanni Scambia, Gian F Zannoni,

<h4>Introduction</h4>The aim of the current study is to evaluate the detection rate of micro- and macro-metastases of the One-Step Nucleic Acid Amplification (OSNA) compared to frozen section examination and subsequent ultra-staging examination in early stage endometrial cancer (EC).<h4>Material and methods</h4>From March 2016 to June 2016, data of 40 consecutive FIGO ... Read more >>

PLoS One (PloS one)
[2018, 13(4):e0195877]

Cited: 5 times

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Robotic versus laparoscopic radical hysterectomy in early cervical cancer: A case matched control study.

Valerio Gallotta, Carmine Conte, Alex Federico, Giuseppe Vizzielli, Salvatore Gueli Alletti, Lucia Tortorella, Luigi Pedone Anchora, Francesco Cosentino, Vito Chiantera, Anna Fagotti, Marco D'Indinosante, Silvia Pelligra, Giovanni Scambia, Gabriella Ferrandina,

This study aims at evaluating the feasibility, surgical outcome and oncological results observed after robotic radical hysterectomy (RH) compared to laparoscopy for patients with early stage cervical cancer (ECC) patients.Between January 2010 and October 2016, 210 patients underwent RH for treatment of ECC: 70 underwent robotic approach (Cases), and 140 ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2018, 44(6):754-759]

Cited: 8 times

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Laparoscopic vs transvaginal cuff closure after total laparoscopic hysterectomy: a randomized trial by the Italian Society of Gynecologic Endoscopy.

Stefano Uccella, Mario Malzoni, Antonella Cromi, Renato Seracchioli, Giuseppe Ciravolo, Francesco Fanfani, Fevzi Shakir, Salvatore Gueli Alletti, Francesco Legge, Roberto Berretta, Giacomo Corrado, Lucia Casarella, Paolo Donarini, Margherita Zanello, Emanuele Perrone, Baldo Gisone, Enrico Vizza, Giovanni Scambia, Fabio Ghezzi,

BACKGROUND:Vaginal cuff dehiscence following hysterectomy is considered an infrequent but potentially devastating complication. Different possible techniques for cuff closure have been proposed to reduce this threatening adverse event. OBJECTIVE:The aim of the present randomized study was to compare laparoscopic and transvaginal suture of the vaginal vault at the end of ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2018, 218(5):500.e1-500.e13]

Cited: 7 times

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3 mm Senhance robotic hysterectomy: a step towards future perspectives.

Salvatore Gueli Alletti, Emanuele Perrone, Stefano Cianci, Cristiano Rossitto, Giorgia Monterossi, Federica Bernardini, Giovanni Scambia,

J Robot Surg (Journal of robotic surgery)
[2018, 12(3):575-577]

Cited: 3 times

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