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An Ex Vivo Acid Injury and Repair (AIR) Model Using Precision-Cut Lung Slices to Understand Lung Injury and Repair.

Sally Yunsun Kim, Róisín Mongey, Mark Griffiths, Matthew Hind, Charlotte H Dean,

Recent advances in cell culture models like air-liquid interface culture and ex vivo models such as organoids have advanced studies of lung biology; however, gaps exist between these models and tools that represent the complexity of the three-dimensional environment of the lung. Precision-cut lung slices (PCLS) mimic the in vivo ... Read more >>

Curr Protoc Mouse Biol (Current protocols in mouse biology)
[2020, 10(4):e85]

Cited: 0 times

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The acid injury and repair (AIR) model: A novel ex-vivo tool to understand lung repair.

Sally Yunsun Kim, Róisín Mongey, Peizhu Wang, Stephen Rothery, David C A Gaboriau, Matthew Hind, Mark Griffiths, Charlotte H Dean,

Research into mechanisms underlying lung injury and subsequent repair responses is currently of paramount importance. There is a paucity of models that bridge the gap between in vitro and in vivo research. Such intermediate models are critical for researchers to decipher the mechanisms that drive repair and to test potential ... Read more >>

Biomaterials (Biomaterials)
[2020, 267:120480]

Cited: 0 times

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Can Stem Cells Beat COVID-19: Advancing Stem Cells and Extracellular Vesicles Toward Mainstream Medicine for Lung Injuries Associated With SARS-CoV-2 Infections.

Wojciech Chrzanowski, Sally Yunsun Kim, Lana McClements,

A number of medicines are currently under investigation for the treatment of COVID-19 disease including anti-viral, anti-malarial, and anti-inflammatory agents. While these treatments can improve patient's recovery and survival, these therapeutic strategies do not lead to unequivocal restoration of the lung damage inflicted by this disease. Stem cell therapies and, ... Read more >>

Front Bioeng Biotechnol (Frontiers in bioengineering and biotechnology)
[2020, 8:554]

Cited: 4 times

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Placenta Stem/Stromal Cell-Derived Extracellular Vesicles for Potential Use in Lung Repair.

Sally Yunsun Kim, Mugdha V Joglekar, Anandwardhan A Hardikar, Thanh Huyen Phan, Dipesh Khanal, Priyanka Tharkar, Christina Limantoro, Jancy Johnson, Bill Kalionis, Wojciech Chrzanowski,

Many acute and chronic lung injuries are incurable and rank as the fourth leading cause of death globally. While stem cell treatment for lung injuries is a promising approach, there is growing evidence that the therapeutic efficacy of stem cells originates from secreted extracellular vesicles (EVs). Consequently, EVs are emerging ... Read more >>

Proteomics (Proteomics)
[2019, 19(17):e1800166]

Cited: 5 times

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Isolation and Characterization of Extracellular Vesicles from Mesenchymal Stromal Cells.

Sally Yunsun Kim, Thanh Huyen Phan, Christina Limantoro, Bill Kalionis, Wojciech Chrzanowski,

Extracellular vesicles (EVs) have received immense attention in the past decade for their diverse use in diagnosis and therapeutics. Enhancing our understanding of EVs and increasing the reliability and reproducibility of EV research demands the use of standard isolation procedures and multiple characterization methods. Here we describe the most commonly ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2019, 2029:15-23]

Cited: 1 time

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High-fidelity probing of the structure and heterogeneity of extracellular vesicles by resonance-enhanced atomic force microscopy infrared spectroscopy.

Sally Yunsun Kim, Dipesh Khanal, Bill Kalionis, Wojciech Chrzanowski,

Extracellular vesicles (EVs) are highly specialized nanoscale assemblies that deliver complex biological cargos to mediate intercellular communication. EVs are heterogeneous, and characterization of this heterogeneity is paramount to understanding EV biogenesis and activity, as well as to associating them with biological responses and pathologies. Traditional approaches to studying EV composition ... Read more >>

Nat Protoc (Nature protocols)
[2019, 14(2):576-593]

Cited: 4 times

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None of us is the same as all of us: resolving the heterogeneity of extracellular vesicles using single-vesicle, nanoscale characterization with resonance enhanced atomic force microscope infrared spectroscopy (AFM-IR).

Sally Yunsun Kim, Dipesh Khanal, Priyanka Tharkar, Bill Kalionis, Wojciech Chrzanowski,

Extracellular vesicles (EVs) are highly specialized, nanoscale messengers that deliver biological signals and in doing so mediate intercellular communication. Increasing evidence shows that within populations of EVs, important properties including morphology, membrane composition, and content vary substantially. This heterogeneity arises in response to the nature, state, and environmental conditions of ... Read more >>

Nanoscale Horiz (Nanoscale horizons)
[2018, 3(4):430-438]

Cited: 1 time

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Animal models of smoke inhalation injury and related acute and chronic lung diseases.

Katarzyna Reczyńska, Priyanka Tharkar, Sally Yunsun Kim, Yiwei Wang, Elżbieta Pamuła, Hak-Kim Chan, Wojciech Chrzanowski,

Smoke inhalation injury leads to various acute and chronic lung diseases and thus is the dominant cause of fire-related fatalities. In a search for an effective treatment and validation of therapies different classes of animal models have been developed, which include both small and large animals. These models have advanced ... Read more >>

Adv. Drug Deliv. Rev. (Advanced drug delivery reviews)
[2018, 123:107-134]

Cited: 2 times

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Greater cellular stiffness in fibroblasts from patients with idiopathic pulmonary fibrosis.

Jade Jaffar, Soung-Hee Yang, Sally Yunsun Kim, Hae-Won Kim, Alen Faiz, Wojciech Chrzanowski, Janette K Burgess,

Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease involving degenerative breathing capacity. Fibrotic disease is driven by dysregulation in mechanical forces at the organ, tissue, and cellular level. While it is known that, in certain pathologies, diseased cells are stiffer than healthy cells, it is not known if fibroblasts ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2018, 315(1):L59-L65]

Cited: 6 times

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Atomized Human Amniotic Mesenchymal Stromal Cells for Direct Delivery to the Airway for Treatment of Lung Injury.

Sally Yunsun Kim, Janette K Burgess, Yiwei Wang, Eleanor P W Kable, Daniel J Weiss, Hak-Kim Chan, Wojciech Chrzanowski,

Current treatment regimens for inhalation injury are mainly supportive and rely on self-regeneration processes for recovery. Cell therapy with mesenchymal stromal cells (MSCs) is increasingly being investigated for the treatment of inhalation injury. Human amniotic MSCs (hAMSCs) were used in this study due to their potential use in inflammatory and ... Read more >>

J Aerosol Med Pulm Drug Deliv (Journal of aerosol medicine and pulmonary drug delivery)
[2016, 29(6):514-524]

Cited: 5 times

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The future perspectives of natural materials for pulmonary drug delivery and lung tissue engineering.

Sally Yunsun Kim, Alice Hai May Wong, Ensanya Ali Abou Neel, Wojciech Chrzanowski, Hak-Kim Chan,

Search for new, functional biomaterials that can be used to synergistically deliver a drug, enhance its adsorption and stimulate the post-injury recovery of tissue function, is one of the priorities in biomedicine. Currently used materials for drug delivery fail to satisfy one or more of these functionalities, thus they have ... Read more >>

Expert Opin Drug Deliv (Expert opinion on drug delivery)
[2015, 12(6):869-887]

Cited: 5 times

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