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Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank.

Jonathan R I Coleman, Wouter J Peyrot, Kirstin L Purves, Katrina A S Davis, Christopher Rayner, Shing Wan Choi, Christopher Hübel, Héléna A Gaspar, Carol Kan, Sandra Van der Auwera, Mark James Adams, Donald M Lyall, Karmel W Choi, , Erin C Dunn, Evangelos Vassos, Andrea Danese, Barbara Maughan, Hans J Grabe, Cathryn M Lewis, Paul F O'Reilly, Andrew M McIntosh, Daniel J Smith, Naomi R Wray, Matthew Hotopf, Thalia C Eley, Gerome Breen,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2020, :]

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A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.

Xueyi Shen, David M Howard, Mark J Adams, W David Hill, Toni-Kim Clarke, , Ian J Deary, Heather C Whalley, Andrew M McIntosh,

Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):2301]

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Poster Presentations at the 10th Canadian Conference on Dementia (CCD), Québec City, October 3, 2019.

(Canadian geriatrics journal : CGJ)
[2020, 23(1):4-87]

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Association of polygenic score for major depression with response to lithium in patients with bipolar disorder.

Azmeraw T Amare, Klaus Oliver Schubert, Liping Hou, Scott R Clark, Sergi Papiol, Micah Cearns, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M Czerski, Nina Dalkner, Alexandre Dayer, Maria Del Zompo, J Raymond DePaulo, Bruno Étain, Stephane Jamain, Peter Falkai, Andreas J Forstner, Louise Frisen, Mark A Frye, Janice M Fullerton, Sébastien Gard, Julie S Garnham, Fernando S Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Andrea Hofmann, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John R Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J McCarthy, Susan L McElroy, Francesc Colom, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Markus M Nöthen, Tomas Novák, Claire O'Donovan, Norio Ozaki, Urban Ösby, Andrea Pfennig, James B Potash, Andreas Reif, , Eva Reininghaus, Guy A Rouleau, Janusz K Rybakowski, Martin Schalling, Peter R Schofield, Barbara W Schweizer, Giovanni Severino, Paul D Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H Witt, Adam Wright, Peter P Zandi, Philip B Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J McMahon, Thomas G Schulze, Bernhard T Baune,

Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2020, :]

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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank.

Jonathan R I Coleman, Wouter J Peyrot, Kirstin L Purves, Katrina A S Davis, Christopher Rayner, Shing Wan Choi, Christopher Hübel, Héléna A Gaspar, Carol Kan, Sandra Van der Auwera, Mark James Adams, Donald M Lyall, Karmel W Choi, , Erin C Dunn, Evangelos Vassos, Andrea Danese, Barbara Maughan, Hans J Grabe, Cathryn M Lewis, Paul F O'Reilly, Andrew M McIntosh, Daniel J Smith, Naomi R Wray, Matthew Hotopf, Thalia C Eley, Gerome Breen,

Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2020, 25(7):1430-1446]

Cited: 3 times

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Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.

Till F M Andlauer, Jose Guzman-Parra, Fabian Streit, Jana Strohmaier, Maria José González, Susana Gil Flores, Francisco J Cabaleiro Fabeiro, Francisco Del Río Noriega, Fermin Perez Perez, Jesus Haro González, Guillermo Orozco Diaz, Yolanda de Diego-Otero, Berta Moreno-Küstner, Georg Auburger, Franziska Degenhardt, Stefanie Heilmann-Heimbach, Stefan Herms, Per Hoffmann, Josef Frank, Jerome C Foo, Jens Treutlein, Stephanie H Witt, Sven Cichon, Manolis Kogevinas, , , Fabio Rivas, Fermín Mayoral, Bertram Müller-Myhsok, Andreas J Forstner, Markus M Nöthen, Marcella Rietschel,

Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2019, :]

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The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.

Jonathan R I Coleman, Héléna A Gaspar, Julien Bryois, , , Gerome Breen,

BACKGROUND:Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Multiple approaches have shown considerable sharing of risk factors across mood disorders despite their diagnostic distinction. METHODS:To clarify the shared ... Read more >>

Biol Psychiatry (Biological psychiatry)
[2020, 88(2):169-184]

Cited: 5 times

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APOE ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia.

Saira Saeed Mirza, Usman Saeed, Jo Knight, Joel Ramirez, Donald T Stuss, Julia Keith, Sean M Nestor, Di Yu, Walter Swardfager, Ekaterina Rogaeva, Peter St George Hyslop, Sandra E Black, Mario Masellis, ,

OBJECTIVE:To determine if APOE ε4 influences the association between white matter hyperintensities (WMH) and cognitive impairment in Alzheimer disease (AD) and dementia with Lewy bodies (DLB). METHODS:A total of 289 patients (AD = 239; DLB = 50) underwent volumetric MRI, neuropsychological testing, and APOE ε4 genotyping. Total WMH volumes were ... Read more >>

Neurology (Neurology)
[2019, 93(19):e1807-e1819]

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Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression.

Kylie P Glanville, Jonathan R I Coleman, Ken B Hanscombe, Jack Euesden, Shing Wan Choi, Kirstin L Purves, Gerome Breen, Tracy M Air, Till F M Andlauer, Bernhard T Baune, Elisabeth B Binder, Douglas H R Blackwood, Dorret I Boomsma, Henriette N Buttenschøn, Lucía Colodro-Conde, Udo Dannlowski, Nese Direk, Erin C Dunn, Andreas J Forstner, Eco J C de Geus, Hans J Grabe, Steven P Hamilton, Ian Jones, Lisa A Jones, James A Knowles, Zoltán Kutalik, Douglas F Levinson, Glyn Lewis, Penelope A Lind, Susanne Lucae, Patrik K Magnusson, Peter McGuffin, Andrew M McIntosh, Yuri Milaneschi, Ole Mors, Sara Mostafavi, Bertram Müller-Myhsok, Nancy L Pedersen, Brenda W J H Penninx, James B Potash, Martin Preisig, Stephan Ripke, Jianxin Shi, Stanley I Shyn, Jordan W Smoller, Fabian Streit, Patrick F Sullivan, Henning Tiemeier, Rudolf Uher, Sandra Van der Auwera, Myrna M Weissman, , Paul F O'Reilly, Cathryn M Lewis,

BACKGROUND:The prevalence of depression is higher in individuals with autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for the overlap, and in this study we tested whether genetic variation in the major histocompatibility complex (MHC), which is associated with risk ... Read more >>

Biol Psychiatry (Biological psychiatry)
[2020, 87(5):419-430]

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2018 Canadian Consortium on Neurodegeneration in Aging (CCNA) Science Day Abstracts (Montréal, Québec - October 1–2, 2018).

(Canadian geriatrics journal : CGJ)
[2019, 22(1):34-48]

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Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.

Darina Czamara, Gökçen Eraslan, Christian M Page, Jari Lahti, Marius Lahti-Pulkkinen, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Pia M Villa, Rebecca M Reynolds, Wenche Nystad, Siri E Håberg, Stephanie J London, Kieran J O'Donnell, Elika Garg, Michael J Meaney, Sonja Entringer, Pathik D Wadhwa, Claudia Buss, Meaghan J Jones, David T S Lin, Julie L MacIsaac, Michael S Kobor, Nastassja Koen, Heather J Zar, Karestan C Koenen, Shareefa Dalvie, Dan J Stein, Ivan Kondofersky, Nikola S Müller, Fabian J Theis, , Katri Räikkönen, Elisabeth B Binder,

Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):2548]

Cited: 7 times

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Identification of common genetic risk variants for autism spectrum disorder.

Jakob Grove, Stephan Ripke, Thomas D Als, Manuel Mattheisen, Raymond K Walters, Hyejung Won, Jonatan Pallesen, Esben Agerbo, Ole A Andreassen, Richard Anney, Swapnil Awashti, Rich Belliveau, Francesco Bettella, Joseph D Buxbaum, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Felecia Cerrato, Kimberly Chambert, Jane H Christensen, Claire Churchhouse, Karin Dellenvall, Ditte Demontis, Silvia De Rubeis, Bernie Devlin, Srdjan Djurovic, Ashley L Dumont, Jacqueline I Goldstein, Christine S Hansen, Mads Engel Hauberg, Mads V Hollegaard, Sigrun Hope, Daniel P Howrigan, Hailiang Huang, Christina M Hultman, Lambertus Klei, Julian Maller, Joanna Martin, Alicia R Martin, Jennifer L Moran, Mette Nyegaard, Mette Nyegaard, Terje Nærland, Duncan S Palmer, Aarno Palotie, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Timothy dPoterba, Jesper Buchhave Poulsen, Beate St Pourcain, Per Qvist, Karola Rehnström, Abraham Reichenberg, Jennifer Reichert, Elise B Robinson, Kathryn Roeder, Panos Roussos, Evald Saemundsen, Sven Sandin, F Kyle Satterstrom, George Davey Smith, Hreinn Stefansson, Stacy Steinberg, Christine R Stevens, Patrick F Sullivan, Patrick Turley, G Bragi Walters, Xinyi Xu, , , , , Kari Stefansson, Daniel H Geschwind, Merete Nordentoft, David M Hougaard, Thomas Werge, Ole Mors, Preben Bo Mortensen, Benjamin M Neale, Mark J Daly, Anders D Børglum,

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish ... Read more >>

Nat Genet (Nature genetics)
[2019, 51(3):431-444]

Cited: 87 times

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Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder.

Simone de Jong, Mateus Jose Abdalla Diniz, Andiara Saloma, Ary Gadelha, Marcos L Santoro, Vanessa K Ota, Cristiano Noto, , Charles Curtis, Stephen J Newhouse, Hamel Patel, Lynsey S Hall, Paul F O Reilly, Sintia I Belangero, Rodrigo A Bressan, Gerome Breen,

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic ... Read more >>

Commun Biol (Communications biology)
[2018, 1:163]

Cited: 2 times

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Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank.

Miruna C Barbu, Yanni Zeng, Xueyi Shen, Simon R Cox, Toni-Kim Clarke, Jude Gibson, Mark J Adams, Mandy Johnstone, Chris S Haley, Stephen M Lawrie, Ian J Deary, , , Andrew M McIntosh, Heather C Whalley,

BACKGROUND:Major depressive disorder is a clinically heterogeneous psychiatric disorder with a polygenic architecture. Genome-wide association studies have identified a number of risk-associated variants across the genome and have reported growing evidence of NETRIN1 pathway involvement. Stratifying disease risk by genetic variation within the NETRIN1 pathway may provide important routes for ... Read more >>

Biol Psychiatry Cogn Neurosci Neuroimaging (Biological psychiatry. Cognitive neuroscience and neuroimaging)
[2019, 4(1):91-100]

Cited: 4 times

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12 Year Trajectories of Depressive Symptoms in Community-Dwelling Older Adults and the Subsequent Risk of Death Over 13 Years.

Saira Saeed Mirza, M Arfan Ikram, Rosanne Freak-Poli, Albert Hofman, Dimitris Rizopoulos, Henning Tiemeier,

Background:Populations of depressed persons are typically comprised of individuals with different courses of depression and thus might carry different risks of death. This study aimed to identify different trajectories of depressive symptoms in community-dwelling older adults and study the risk of death across these trajectories. Methods:In the population-based Rotterdam Study, ... Read more >>

J. Gerontol. A Biol. Sci. Med. Sci. (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2018, 73(6):820-827]

Cited: 1 time

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.

Naomi R Wray, Stephan Ripke, Manuel Mattheisen, Maciej Trzaskowski, Enda M Byrne, Abdel Abdellaoui, Mark J Adams, Esben Agerbo, Tracy M Air, Till M F Andlauer, Silviu-Alin Bacanu, Marie Bækvad-Hansen, Aartjan F T Beekman, Tim B Bigdeli, Elisabeth B Binder, Douglas R H Blackwood, Julien Bryois, Henriette N Buttenschøn, Jonas Bybjerg-Grauholm, Na Cai, Enrique Castelao, Jane Hvarregaard Christensen, Toni-Kim Clarke, Jonathan I R Coleman, Lucía Colodro-Conde, Baptiste Couvy-Duchesne, Nick Craddock, Gregory E Crawford, Cheynna A Crowley, Hassan S Dashti, Gail Davies, Ian J Deary, Franziska Degenhardt, Eske M Derks, Nese Direk, Conor V Dolan, Erin C Dunn, Thalia C Eley, Nicholas Eriksson, Valentina Escott-Price, Farnush Hassan Farhadi Kiadeh, Hilary K Finucane, Andreas J Forstner, Josef Frank, Héléna A Gaspar, Michael Gill, Paola Giusti-Rodríguez, Fernando S Goes, Scott D Gordon, Jakob Grove, Lynsey S Hall, Eilis Hannon, Christine Søholm Hansen, Thomas F Hansen, Stefan Herms, Ian B Hickie, Per Hoffmann, Georg Homuth, Carsten Horn, Jouke-Jan Hottenga, David M Hougaard, Ming Hu, Craig L Hyde, Marcus Ising, Rick Jansen, Rick Jansen, Fulai Jin, Eric Jorgenson, James A Knowles, Isaac S Kohane, Julia Kraft, Warren W Kretzschmar, Jesper Krogh, Zoltán Kutalik, Jacqueline M Lane, Yihan Li, Yun Li, Penelope A Lind, Xiaoxiao Liu, Leina Lu, Donald J MacIntyre, Dean F MacKinnon, Robert M Maier, Wolfgang Maier, Jonathan Marchini, Hamdi Mbarek, Patrick McGrath, Peter McGuffin, Sarah E Medland, Divya Mehta, Christel M Middeldorp, Evelin Mihailov, Yuri Milaneschi, Lili Milani, Jonathan Mill, Francis M Mondimore, Grant W Montgomery, Sara Mostafavi, Niamh Mullins, Matthias Nauck, Bernard Ng, Michel G Nivard, Dale R Nyholt, Paul F O'Reilly, Hogni Oskarsson, Michael J Owen, Jodie N Painter, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Roseann E Peterson, Erik Pettersson, Wouter J Peyrot, Giorgio Pistis, Danielle Posthuma, Shaun M Purcell, Jorge A Quiroz, Per Qvist, John P Rice, Brien P Riley, Margarita Rivera, Saira Saeed Mirza, Richa Saxena, Robert Schoevers, Eva C Schulte, Ling Shen, Jianxin Shi, Stanley I Shyn, Engilbert Sigurdsson, Grant B C Sinnamon, Johannes H Smit, Daniel J Smith, Hreinn Stefansson, Stacy Steinberg, Craig A Stockmeier, Fabian Streit, Jana Strohmaier, Katherine E Tansey, Henning Teismann, Alexander Teumer, Wesley Thompson, Pippa A Thomson, Thorgeir E Thorgeirsson, Chao Tian, Matthew Traylor, Jens Treutlein, Vassily Trubetskoy, André G Uitterlinden, Daniel Umbricht, Sandra Van der Auwera, Albert M van Hemert, Alexander Viktorin, Peter M Visscher, Yunpeng Wang, Bradley T Webb, Shantel Marie Weinsheimer, Jürgen Wellmann, Gonneke Willemsen, Stephanie H Witt, Yang Wu, Hualin S Xi, Jian Yang, Futao Zhang, , , Volker Arolt, Bernhard T Baune, Klaus Berger, Dorret I Boomsma, Sven Cichon, Udo Dannlowski, E C J de Geus, J Raymond DePaulo, Enrico Domenici, Katharina Domschke, Tõnu Esko, Hans J Grabe, Steven P Hamilton, Caroline Hayward, Andrew C Heath, David A Hinds, Kenneth S Kendler, Stefan Kloiber, Glyn Lewis, Qingqin S Li, Susanne Lucae, Pamela F A Madden, Patrik K Magnusson, Nicholas G Martin, Andrew M McIntosh, Andres Metspalu, Ole Mors, Preben Bo Mortensen, Bertram Müller-Myhsok, Merete Nordentoft, Markus M Nöthen, Michael C O'Donovan, Sara A Paciga, Nancy L Pedersen, Brenda W J H Penninx, Roy H Perlis, David J Porteous, James B Potash, Martin Preisig, Marcella Rietschel, Catherine Schaefer, Thomas G Schulze, Jordan W Smoller, Kari Stefansson, Henning Tiemeier, Rudolf Uher, Henry Völzke, Myrna M Weissman, Thomas Werge, Ashley R Winslow, Cathryn M Lewis, Douglas F Levinson, Gerome Breen, Anders D Børglum, Patrick F Sullivan, ,

Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression ... Read more >>

Nat Genet (Nature genetics)
[2018, 50(5):668-681]

Cited: 252 times

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Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations.

Yuri Milaneschi, Femke Lamers, Wouter J Peyrot, Bernhard T Baune, Gerome Breen, Abbas Dehghan, Andreas J Forstner, Hans J Grabe, Georg Homuth, Carol Kan, Cathryn Lewis, Niamh Mullins, Matthias Nauck, Giorgio Pistis, Martin Preisig, Margarita Rivera, Marcella Rietschel, Fabian Streit, Jana Strohmaier, Alexander Teumer, Sandra Van der Auwera, Naomi R Wray, Dorret I Boomsma, Brenda W J H Penninx, ,

Importance:The association between major depressive disorder (MDD) and obesity may stem from shared immunometabolic mechanisms particularly evident in MDD with atypical features, characterized by increased appetite and/or weight (A/W) during an active episode. Objective:To determine whether subgroups of patients with MDD stratified according to the A/W criterion had a different ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2017, 74(12):1214-1225]

Cited: 24 times

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Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes.

Liz Rietschel, Fabian Streit, Gu Zhu, Kerrie McAloney, Josef Frank, Baptiste Couvy-Duchesne, Stephanie H Witt, Tina M Binz, , , John McGrath, Ian B Hickie, Narelle K Hansell, Margaret J Wright, Nathan A Gillespie, Andreas J Forstner, Thomas G Schulze, Stefan Wüst, Markus M Nöthen, Markus R Baumgartner, Brian R Walker, Andrew A Crawford, Lucía Colodro-Conde, Sarah E Medland, Nicholas G Martin, Marcella Rietschel,

Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):15351]

Cited: 2 times

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Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium.

Wouter J Peyrot, Sandra Van der Auwera, Yuri Milaneschi, Conor V Dolan, Pamela A F Madden, Patrick F Sullivan, Jana Strohmaier, Stephan Ripke, Marcella Rietschel, Michel G Nivard, Niamh Mullins, Grant W Montgomery, Anjali K Henders, Andrew C Heat, Helen L Fisher, Erin C Dunn, Enda M Byrne, Tracy A Air, , Bernhard T Baune, Gerome Breen, Douglas F Levinson, Cathryn M Lewis, Nick G Martin, Elliot N Nelson, Dorret I Boomsma, Hans J Grabe, Naomi R Wray, Brenda W J H Penninx,

BACKGROUND:The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. ... Read more >>

Biol Psychiatry (Biological psychiatry)
[2018, 84(2):138-147]

Cited: 10 times

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depressive disorder

Naomi Wray, Stephan Ripke, Manuel Mattheisen, Maciej Trzaskowski, Enda Byrne, Abdel Abdellaoui, Mark Adams, Esben Agerbo, Tracy Air, Till Andlauer, Silviu-Alin Bacanu, Marie Bækvad-Hansen, Aartjan Beekman, Tim Bigdeli, Elisabeth Binder, Douglas Blackwood, Julien Bryois, Henriette Buttenschøn, Jonas Bybjerg-Grauholm, Na Cai, Enrique Castelao, Jane Hvarregaard Christensen, Toni-Kim Clarke, Jonathan Coleman, Lucía Colodro-Conde, Baptiste Couvy-Duchesne, Nick Craddock, Gregory Crawford, Cheynna Crowley, Hassan Dashti, Gail Davies, Ian Deary, Franziska Degenhardt, Eske Derks, Nese Direk, Conor Dolan, Erin Dunn, Thalia Eley, Nicholas Eriksson, Valentina Escott-Price, Farnush Farhadi Hassan Kiadeh, Hilary Finucane, Andreas Forstner, Josef Frank, Héléna Gaspar, Michael Gill, Paola Giusti-Rorínguez, Fernando Goes, Scott Gordon, Jakob Grove, Lynsey Hall, Christine Søholm Hansen, Thomas Hansen, Stefan Herms, Ian Hickie, Per Hoffmann, Georg Homuth, Carsten Horn, Jouke-Jan Hottenga, David Hougaard, Ming Hu, Craig Hyde, Marcus Ising, Rick Jansen, Fulai Jin, Eric Jorgenson, James Knowles, Isaac Kohane, Julia Kraft, Warren Kretzschmar, Jesper Krogh, Zoltan Kutalik, Jacqueline Lane, Yihan Li, Yun Li, Penelope Lind, Xiaoxiao Liu, Leina Lu, Donald MacIntyre, Dean MacKinnon, Robert Maier, Wolfgang Maier, Jonathan Marchini, Hamdi Mbarek, Patrick McGrath, Peter McGuffin, Sarah Medland, Divya Mehta, Christel Middeldorp, Evelin Mihailov, Yuri Milaneschi, Lili Milani, Francis Mondimore, Grant Montgomery, Sara Mostafavi, Niamh Mullins, Matthias Nauck, Bernard Ng, Michel Nivard, Dale Nyholt, Paul O’Reilly, Hogni Oskarsson, Michael Owen, Jodie Painter, Carsten Bøcker, Marianne Giørtz Pedersen, Roseann Peterson, Erik Pettersson, Wouter Peyrot, Giorgio Pistis, Danielle Posthuma, Shaun Purcell, Jorge Quiroz, Per Qvist, John Rice, Brien Riley, Margarita Rivera, Saira Saeed Mirza, Richa Saxena, Robert Schoevers, Eva Schulte, Ling Shen, Jianxin Shi, Stanley Shyn, Engilbert Sigurdsson, Grant Sinnamon, Johannes Smit, Daniel Smith, Hreinn Stefansson, Stacy Steinberg, Craig Stockmeier, Fabian Streit, Jana Strohmaier, Katherine Tansey, Henning Teismann, Alexander Teumer, Wesley Thompson, Pippa Thomson, Thorgeir Thorgeirsson, Chao Tian, Matthew Traylor, Jens Treutlein, Vassily Trubetskoy, André Uitterlinden, Daniel Umbricht, Sandra Van der Auwera, Albert van Hemert, Alexander Viktorin, Peter Visscher, Yunpeng Wang, Bradley Webb, Shantel Marie Weinsheimer, Jürgen Wellmann, Gonneke Willemsen, Stephanie Witt, Yang Wu, Hualin Xi, Jian Yang, Futao Zhang, Volker Arolt, Bernhard Baune, Klaus Berger, Dorret Boomsma, Sven Cichon, udo Dannlowski, EJC de Geus, Raymond DePaulo, Enrico Domenici, Katharina Domschke, Tönu Esko, Hans Grabe, Steven Hamilton, Caroline Hayward, Andrew Heath, David Hinds, Kenneth Kendler, Stefan Kloiber, Glyn Lewis, Qingqin Li, Susanne Lucae, Pamela AF Madden, Patrik Magnusson, Nicholas Martin, Andrew McIntosh, Andres Metspalu, Ole Mors, Preben Bo Mortensen, Bertram Müller-Myhsok, Merete Nordentoft, Markus Nöthen, Michael O’Donovan, Sara Paciga, Nancy Pedersen, Brenda WJH Penninx, Roy Perlis, David Porteous, James Potash, Martin Preisig, Marcella Rietschel, Catherine Schaefer, Thomas Schulze, Jordan Smoller, Kari Stefansson, Henning Tiemeier, Rudolf Uher, Henry Völzke, Myrna Weissman, Thomas Werge, Ashley Winslow, Cathryn Lewis, Douglas Levinson, Gerome Breen, Anders Børglum, Patrick Sullivan, , , ,

Major depressive disorder (MDD) is a notably complex illness with a lifetime prevalence of 14%. 1 It is often chronic or recurrent and is thus accompanied by considerable morbidity, excess mortality, substantial costs, and heightened risk of suicide. 2-7 MDD is a major cause of disability worldwide. 8 We conducted ... Read more >>

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Cited: 6 times

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Mild cognitive impairment and risk of depression and anxiety: A population-based study.

Saira Saeed Mirza, M Arfan Ikram, Daniel Bos, Raluca Mihaescu, Albert Hofman, Henning Tiemeier,

Many people with mild cognitive impairment (MCI) suffer from concomitant depression or anxiety. Whether MCI increases the risk of future depression or anxiety is unknown.In the Rotterdam Study, cross-sectional (n = 4168) and longitudinal associations (n = 2967) of MCI with Diagnostic and Statistical Manual of Mental Disorders-depressive and anxiety disorders-were assessed (2002-2005 to ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2017, 13(2):130-139]

Cited: 13 times

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Mid- to Late-Life Trajectories of Blood Pressure and the Risk of Stroke: The Rotterdam Study.

Marileen L P Portegies, Saira Saeed Mirza, Vincentius J A Verlinden, Albert Hofman, Peter J Koudstaal, Sonja A Swanson, M Arfan Ikram,

Hypertension is a major modifiable risk factor for stroke. Associations of blood pressure with incident stroke are mostly based on single or average blood pressure levels. However, this approach does not take into account long-term trajectories of blood pressure, which can vary considerably in the elderly. Within the population-based Rotterdam ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2016, 67(6):1126-1132]

Cited: 11 times

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Association of Coffee Consumption with MRI Markers and Cognitive Function: A Population-Based Study.

Larissa Fortunato Araújo, Saira Saeed Mirza, Daniel Bos, Wiro J Niessen, Sandhi Maria Barreto, Aad van der Lugt, Meike W Vernooij, Albert Hofman, Henning Tiemeier, M Arfan Ikram,

Coffee is one of the most widely consumed beverages worldwide and has been of considerable interest in research on cognition and dementia.To investigate the effect of coffee on preclinical brain MRI markers of dementia and cognitive performance.In 2,914 participants from the population-based Rotterdam Study (mean age: 59.3±7.2 years, 55% females), ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2016, 53(2):451-461]

Cited: 7 times

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10-year trajectories of depressive symptoms and risk of dementia: a population-based study.

Saira Saeed Mirza, Frank J Wolters, Sonja A Swanson, Peter J Koudstaal, Albert Hofman, Henning Tiemeier, M Arfan Ikram,

BACKGROUND:Late-life depressive symptoms have been extensively studied for their relationship with incident dementia, but have been typically assessed at a single timepoint. Such an approach neglects the course of depression, which, given its remitting and relapsing nature, might provide further insights into the complex association of depression with dementia. We ... Read more >>

Lancet Psychiatry (The lancet. Psychiatry)
[2016, 3(7):628-635]

Cited: 42 times

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Higher Education Is Associated with a Lower Risk of Dementia after a Stroke or TIA. The Rotterdam Study.

Saira Saeed Mirza, Marileen L P Portegies, Frank J Wolters, Albert Hofman, Peter J Koudstaal, Henning Tiemeier, M Arfan Ikram,

Higher education is associated with a lower risk of dementia, possibly because of a higher tolerance to subclinical neurodegenerative pathology. Whether higher education also protects against dementia after clinical stroke or transient ischemic attack (TIA) remains unknown.Within the population-based Rotterdam Study, 12,561 participants free of stroke, TIA and dementia were ... Read more >>

Neuroepidemiology (Neuroepidemiology)
[2016, 46(2):120-127]

Cited: 5 times

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