Full Text Journal Articles by
Author Sahil C Aggarwal

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Development of Hydropersulfide Donors to Study Their Chemical Biology.

Vinayak S Khodade, Sahil C Aggarwal, Alexander Eremiev, Eric Bao, Sarah Porche, John P Toscano,

<b><i>Significance:</i></b> Hydropersulfides (RSSH) are ubiquitous in prokaryotes, eukaryotic cells, and mammalian tissues. The unique chemical properties and prevalent nature of these species suggest a crucial role of RSSH in cell regulatory processes, yet little is known about their physiological functions. <b><i>Recent Advances:</i></b> Examining the biological roles of RSSH species is ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2021, :]

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Alkylsulfenyl thiocarbonates: precursors to hydropersulfides potently attenuate oxidative stress.

Vinayak S Khodade, Sahil C Aggarwal, Blaze M Pharoah, Nazareno Paolocci, John P Toscano,

The recent discovery of the prevalence of hydropersulfides (RSSH) species in biological systems suggests their potential roles in cell regulatory processes. However, the reactive and transient nature of RSSH makes their study difficult, and dependent on the use of donor molecules. Herein, we report alkylsulfenyl thiocarbonates as a new class ... Read more >>

Chem Sci (Chemical science)
[2021, 12(23):8252-8259]

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