Full Text Journal Articles by
Author Sagheer Ahmed

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Genetic variations in the drug metabolizing enzyme, CYP2E1, among various ethnic populations of Pakistan.

Sagheer Ahmed, Nadeem Altaf, Mahnoor Ejaz, Zaira Zulfiqar, Kholood Janjua, Dana Festila, Nicula Cristina,

Genetic polymorphism in cytochrome P450 (CYP) monooxygenase genes is an important source of interindividual variability of drug response. CYP enzyme activities may change as a result of such polymorphisms which then, may affect drug metabolism. This would result in a change in the severity and frequency of adverse effects in ... Read more >>

PeerJ (PeerJ)
[2020, 8:e9721]

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Lack of Association of CYP2C9 genetic polymorphism with oral squamous cell carcinoma

Sagheer Ahmed, Saeed Khan, Syeda Uzma Naqvi, Kholood Janjua, Zaira Zulfiqar, hanadi ahmedah, Marius Moga, Anca Ilea,

Abstract Background: There is increasing evidence for the role of polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines (HCAs) in carcinogenesis, including oral squamous cell carcinoma (OSCC). Several of these mutagenic substances are cytochrome (CYP)2C9 enzyme substrates. Methods: In this study, we examined the association of CYP2C9*2 and *3 genetic ... Read more >>

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Prevalence of EBV, CMV, and HPV in oral squamous cell carcinoma patients in the Pakistani population.

Syeda Uzma Naqvi, Saeed Khan, Ayaz Ahmed, Amanullah Lail, Saima Gul, Sagheer Ahmed,

Many studies have proposed an important role of viruses in the pathogenesis of oral cancer. The present study aimed to find out the prevalence of Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human papillomavirus (HPV) among patients with oral squamous cell carcinoma (OSCC) in a Pakistani cohort. We investigated tissue samples ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, :]

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Genetic variations in drug-metabolizing enzyme CYP2C9 among major ethnic groups of Pakistani population.

Hizbullah, Sagheer Ahmed, Mah Noor Mumtaz, Zaira Zulfiqar, Sheikh Amir Hamza, Sami Siraj, Musharraf Jelani, Imran Imran, Asifullah Khan,

The genetic polymorphism of cytochrome P450 (CYPs)drug-metabolizing enzymes are well studied in human populations for drug safety and efficacy. CYP2C9 is a highly polymorphic CYP enzyme that oxidizing the indigenous compounds and xenobiotics. The present study was pursued to evaluate the genetic variation across the CYP2C9 gene among major groups ... Read more >>

Gene (Gene)
[2020, 746:144659]

Cited: 1 time

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Synthesis, characterization, molecular docking evaluation, antiplatelet and anticoagulant actions of 1,2,4 triazole hydrazone and sulphonamide novel derivatives.

Waseem Khalid, Amir Badshah, Arif-Ullah Khan, Humaira Nadeem, Sagheer Ahmed,

In the present study, a series of new hydrazone and sulfonamide derivatives of 1,2,4-triazole were synthesized. Initially three 4-substituted-5-(2-pyridyl)-1,2,4-triazole-3-thiones ZE-1(a-c) were treated with ethyl chloroacetate to get the corresponding thioesters ZE-2(a-c), which were reacted with hydrazine hydrate to the respective hydrazides ZE-3(a-c). The synthesized hydrazides were condensed with different aldehydes ... Read more >>

(Chemistry Central journal)
[2018, 12(1):11]

Cited: 1 time

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Development of fixed dose combination tablets of aripiprazole plus divalproex sodium and their simultaneous determination using HPLC-UV.

Zia Ahmed, Fazal Subhan, Saba Ahmed, Qazi Abdur Rasheed, Sagheer Ahmed, Muhammad Shahid, Saeed Farooq,

A vast majority of psychiatric patients are effectively treated with combination of drugs to improve efficacy and adherence, but due to limited research and development in fixed dose combination (FDC) in psychiatry, these products are not commonly available. The aim of this study is to prepare cost effective FDC tablets ... Read more >>

Drug Dev Ind Pharm (Drug development and industrial pharmacy)
[2016, 42(9):1393-1405]

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Anti-platelet effects of nimesulide in isoproterenol-induced myocardial ischaemia and infarction in rabbits.

Sagheer Ahmed, Saima Gul, Hawa Ze Jaafar, Marius Moga, Muhammad Zia-Ul-Haq, Lorena Dima,

BACKGROUND:The present study was designed to determine the effects of cyclooxygenase-2 (COX-2) inhibitor-nimesulide on platelet activating factor (PAF) and arachidonic acid (AA)-induced platelet aggregation during myocardial infarction (Ml) and ischaemia in rabbits. METHODS:Rabbits were divided into three groups; group I served as control and contains normal rabbits that received saline, ... Read more >>

Acta Cardiol (Acta cardiologica)
[2015, 70(4):401-408]

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Hypolipidemic effects of nimesulide and celecoxib in experimentally induced hypercholesterolemia in rabbits.

Sagheer Ahmed, Saima Gul, Muhammad Zia-ul-Haq, Muhammad Riaz,

BACKGROUND/AIM:Hypercholesterolemia plays an important role in the development of atherosclerotic disease, which is one of the leading causes of mortality in the world. Previous studies showed that cyclooxygenase (COX) inhibitors could be used in treating hypercholesterolemia. Thepresentstudywas designed to testwhether COX-2 inhibition can improve lipid profiles inhypercholesterolemia. MATERIALS AND METHODS:Rabbits ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2015, 45(2):277-283]

Cited: 2 times

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Multiple pathways are responsible for anti-inflammatory and cardiovascular activities of Hordeum vulgare L.

Saima Gul, Sagheer Ahmed, Nurolaini Kifli, Qazi Tahir Uddin, Nafisa Batool Tahir, Abrar Hussain, Hawa Z E Jaafar, Marius Moga, Muhammad Zia-Ul-Haq,

Hordeum vulgare L. (HV or barley) is used by traditional healers to treat various inflammatory and cardiovascular diseases, without the knowledge of pharmacologic rationale behind its actions. This study was designed to explore the potential scientific mechanism(s) that could explain the use of Hordeum vulgare in traditional medicine as a ... Read more >>

J Transl Med (Journal of translational medicine)
[2014, 12:316]

Cited: 5 times

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Anti-inflammatory and antiplatelet activities of plasma are conserved across twelve mammalian species.

Sagheer Ahmed, Saima Gul, Fazean Idris, Abrar Hussain, Muhammad Zia-Ul-Haq, Hawa Z E Jaafar, Marius Moga,

Human plasma inhibits arachidonic acid metabolism and platelet aggregation. This helps human form a haemostatic control system that prevents the progress of certain aggregatory or inflammatory reactions. Whether this property of plasma is unique to human or extends to other species is not well known. It is speculated that this ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2014, 19(8):11385-11394]

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Cyclooxygenase-2 inhibition improves antioxidative defense during experimental hypercholesterolemia.

Sagheer Ahmed, Saima Gul, Humera Gul, Muhammad Zia-Ul-Haq, Sezai Ercisli,

Scientific literature shows that inflammation and oxidative stress contribute in the pathogenesis of atherosclerosis. The oxidative stress is the consequence of an imbalance between the free radical generation and elimination. One source of free oxygen radicals is cyclooxygenase (COX)-2 and, therefore, inhibiting the activity of this enzyme is likely to ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2014, 14(2):63-69]

Cited: 6 times

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Status of serum adiponectin related to insulin resistance in prediabetics.

Shahid Ahsan, Sagheer Ahmed, Syed Danish Haseen Ahmed, Kiran Nauman,

OBEJCTIVE: To find the status of serum adiponectin in individuals progressing towards Type 2 diabetes mellitus and compare it with normal glucose tolerant subjects to determine the stage where alteration of adiponectin occurred.The cross-sectional study was carried out at the Department of Biochemistry, Jinnah Postgraduate Medical Centre, Karachi, during January ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2014, 64(2):184-188]

Cited: 0 times

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Report: Platelet aggregation inhibition activity of selected legumes of Pakistan.

Muhammad Zia-Ul-Haq, Sagheer Ahmed, Ghazala Hafeez Rizwani, Mughal Qayum, Shakeel Ahmad, Muhammad Hanif,

The current study was designed to explore the platelet aggregation activity of methanolic extracts of green gram, lentil, mash bean and soya bean. The extracts dose-dependently inhibited platelet aggregation initiated by arachidonic acid (AA) and platelet activating factor (PAF). Extract of green gram was effective only against AA mediated activity ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2012, 25(4):863-865]

Cited: 4 times

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Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea.

M Zia-ul-Haq, Barkat Ali Khan, Premysl Landa, Zsófia Kutil, Sagheer Ahmed, Mughal Qayum, Shakeel Ahmad,

Inflammation is the natural body defense mechanism for the removal of injurious agents, necrosed cells and tissues from the body. This study was aimed to evaluate the anti-inflammatory and platelet aggregation effects of three medicinal plants of Pakistan. Methanolic extract of garden pea inhibited arachidonic acid (AA)-induced platelet aggregation (IC50 ... Read more >>

Acta Pol Pharm (Acta poloniae pharmaceutica)
[2012, 69(4):707-711]

Cited: 2 times

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Analgesic, anti-inflammatory and anti-platelet activities of the methanolic extract of Acacia modesta leaves.

Ishfaq A Bukhari, Rafeeq A Khan, Anwar H Gilani, Sagheer Ahmed, Sheikh Arshad Saeed,

The current study was aimed to evaluate Acacia modesta for analgesic, anti-inflammatory, and anti-platelet activities. The analgesic and anti-inflammatory effects were assessed in rodents using acetic acid and formalin-induced nociception, hot plate and carrageenan-induced rat paw oedema tests. The intraperitoneal (i.p.) administration of the methanolic extract (50 and 100 mg/kg) ... Read more >>

Inflammopharmacology (Inflammopharmacology)
[2010, 18(4):187-196]

Cited: 10 times

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Significance of an index of insulin resistance in non-diabetic patients with impaired fasting glucose with acute myocardial infarction and its correlation to short term outcome.

Dhurjati P Sinha, Sagheer Ahmed, Amal Kr Baneerjee, Munna Das, Haseeb Hassan,

AIMS AND OBJECTIVES: To investigate the potential role of a simple insulin resistance index i.e. Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) in identifying insulin resistance in patients admitted with an acute coronary syndrome without diabetes mellitus and its effect on short term outcome on cardiovascular morbidity and mortality. METHODS: Seventy non-diabetic ... Read more >>

Indian Heart J (Indian heart journal)
[2009, 61(1):40-43]

Cited: 6 times

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Inhibitors of phosphatidylinositide 3-kinase: effects on reactive oxygen species and platelet aggregation.

Sheikh Arshad Saeed, John Dennis Connor, Imran, Javeria Quadri, Shumaila Tasneem, Sagheer Ahmed, Muhammad Ahmed Mesaik, Muhammad Iqbal Choudhary,

Phosphoinositide 3-kinase (PI 3-kinase) exists in cells as a family of isoforms. The enzymes are important regulators of fundamental metabolic processes, such as energy utilization, growth, cell proliferation and survival. They are activated by cell surface receptors for hormones, and by G-protein coupled receptors. Enzyme p110 gamma, in particular, catalyzes ... Read more >>

Pharmacol Rep (Pharmacological reports : PR)
[2007, 59(2):238-243]

Cited: 11 times

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Lipoproteins inhibit platelet aggregation and arachidonic acid metabolism in experimental hypercholesterolaemia.

Rukhsana Aslam, Sheikh A Saeed, Sagheer Ahmed, John D Connor,

1. Human plasma contains unidentified components that inhibit arachidonic acid (AA) metabolism. In the present study, we investigated whether plasma from rabbits fed a normal or high-cholesterol diet for 16 weeks also inhibits AA metabolism. Specifically, we studied the effects of plasma on platelet aggregation and on the production of ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2008, 35(5-6):656-662]

Cited: 4 times

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Dual inhibition of cyclooxygenase and lipoxygenase by human haptoglobin: its polymorphism and relation to hemoglobin binding.

Sheikh Arshad Saeed, Nabeel Ahmad, Sagheer Ahmed,

Haptoglobin (Hp) binds hemoglobin (Hb) specifically and stoichiometrically. Since Hb stimulates prostaglandin (PG biosynthesis), we investigated if Hp effects arachidonic acid (AA) metabolism. The results showed that Hp (50-250 microg protein) inhibited the biosynthesis of PGs via cyclooxygenase (COX) and 12-HETE via lipoxygenase pathway in human platelets. Additional evidence was ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2007, 353(4):915-920]

Cited: 26 times

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Anti-ischemic effects of nimesulide, a cyclooxygenase-2 inhibitor on the ischemic model of rabbit induced by isoproterenol.

Sheikh Arshad Saeed, Sagheer Ahmed,

The objective was to devise an animal model of myocardial infarction (MI) against which cardioprotective drugs might be tested. We describe the effects of nimesulide, a COX experience with development and validation of such a model. The rabbit was chosen in preference to rodents because its heart and cardiac circulation ... Read more >>

Arch. Pharm. Res. (Archives of pharmacal research)
[2006, 29(11):977-983]

Cited: 7 times

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Role of cyclooxygenase-2 in myocardial infarction and ischaemia.

Sheikh Arshad Saeed, Sagheer Ahmed,

OBJECTIVE: To determine the role of cyclooxygenase-2 (COX-2), on coronary perfusion rate (CPR) in a rabbit heart model showing ischaemic damage and reperfusion injury to the myocardium. DESIGN: An experimental study. PLACE AND DURATION OF STUDY: The animal unit of the Dr. Panjwani Center for Molecular Medicine and Drug Research, ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2006, 16(5):324-328]

Cited: 13 times

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Mechanisms for platelet aggregation mediated by g-protein coupled receptors in human platelets.

Arshad Saeed, Afaq Motiwala, Zia-Ur-Rehman Qureshi, Raheela Khan, Ashique Ali, Javeria Quadri, Sagheer Ahmed,

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2006, 16(2):167]

Cited: 1 time

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