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Author Saeed Mirsadraee

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Suveer Singh, Diana A Gorog, Ciara F Mahon, Bhavin Rawal, Thomas R Semple, Edward D Nicol, Deepa R J Arachchillage, Susanna Price, Sujal Desai, Carole A Ridge, Simon P G Padley, Saeed Mirsadraee,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1190-e1191]

Cited: 0 times

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Imaging of Cardiac Infections: A Comprehensive Review and Investigation Flowchart for Diagnostic Workup.

Rachael R Kirkbride, Bhavin Rawal, Saeed Mirsadraee, Maya Galperin-Aizenberg, Kshama Wechalekar, Carole A Ridge, Diana E Litmanovich,

Infections of the cardiovascular system may present with nonspecific symptoms, and it is common for patients to undergo multiple investigations to arrive at the diagnosis. Echocardiography is central to the diagnosis of endocarditis and pericarditis. However, cardiac computed tomography (CT) and magnetic resonance imaging also play an additive role in ... Read more >>

J Thorac Imaging (Journal of thoracic imaging)
[2021, 36(5):W70-W88]

Cited: 1 time

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Implications of incidental findings from lung screening for primary care: data from a UK pilot.

Emily C Bartlett, Jonathan Belsey, Jane Derbyshire, Katie Morris, Michelle Chen, James Addis, Maria Martins, Carole A Ridge, Sujal R Desai, Saeed Mirsadraee, Simon Padley, Sarah Whiteside, Pritti Vaghani, Jaymin B Morjaria, Samuel V Kemp, Anand Devaraj,

Regional lung cancer screening (LCS) is underway in England, involving a "lung health check" (LHC) and low-dose CT scan for those at high risk of cancer. Incidental findings from LHCs or CTs are usually referred to primary care. We describe the proportion of participants referred from the West London LCS ... Read more >>

NPJ Prim Care Respir Med (NPJ primary care respiratory medicine)
[2021, 31(1):36]

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Prevalence of Thrombotic Complications in ICU-Treated Patients With Coronavirus Disease 2019 Detected With Systematic CT Scanning.

Saeed Mirsadraee, Diana A Gorog, Ciara F Mahon, Bhavin Rawal, Thomas R Semple, Edward D Nicol, Deepa R J Arachchillage, Anand Devaraj, Susanna Price, Sujal R Desai, Carole A Ridge, Suveer Singh, Simon P G Padley,

<h4>Objectives</h4>Severe coronavirus disease 2019 is associated with an extensive pneumonitis and frequent coagulopathy. We sought the true prevalence of thrombotic complications in critically ill patients with severe coronavirus disease 2019 on the ICU, with or without extracorporeal membrane oxygenation.<h4>Design</h4>We undertook a single-center, retrospective analysis of 72 critically ill patients with ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(5):804-815]

Cited: 4 times

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Association of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair.

Yu Zhu, Saeed Mirsadraee, George Asimakopoulos, Alessia Gambaro, Ulrich Rosendahl, John Pepper, Xiao Yun Xu,

Type A aortic dissection (TAAD) involves the ascending aorta or the arch. Acute TAAD usually requires urgent replacement of the ascending aorta. However, a subset of these patients develops aortic rupture due to further dilatation of the residual dissected aorta. There is currently no reliable means to predict the risk ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):11521]

Cited: 1 time

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Can dynamic imaging, using 18F-FDG PET/CT and CT perfusion differentiate between benign and malignant pulmonary nodules?

Aleksander Marin, John T Murchison, Kristopher M Skwarski, Adriana A S Tavares, Alison Fletcher, William A Wallace, Vladka Salapura, Edwin J R van Beek, Saeed Mirsadraee,

<h4>Background</h4>The aim of the study was to derive and compare metabolic parameters relating to benign and malignant pulmonary nodules using dynamic 2-deoxy-2-[fluorine-18]fluoro-D-glucose (<sup>18</sup>F-FDG) PET/CT, and nodule perfusion parameters derived through perfusion computed tomography (CT).<h4>Patients and methods</h4>Twenty patients with 21 pulmonary nodules incidentally detected on CT underwent a dynamic <sup>18</sup>F-FDG PET/CT ... Read more >>

Radiol Oncol (Radiology and oncology)
[2021, 55(3):259-267]

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Association of individual aortic leaflet calcification on paravalvular regurgitation and conduction abnormalities with self-expanding trans-catheter aortic valve insertion.

Ciara Mahon, Allan Davies, Alessia Gambaro, Francesca Musella, Ana Luisa Costa, Vasileios Panoulas, Edward Nicol, Alison Duncan, Simon Davies, Saeed Mirsadraee,

<h4>Background</h4>Complication rates of paravalvular aortic regurgitation (PVR) and permanent pacemaker insertion remain high in patients undergoing trans-catheter aortic valve insertion for severe aortic stenosis. The spatial distribution of calcium between individual aortic valve leaflets, and its potential role in these complications is gaining interest. We aimed to assess the accuracy ... Read more >>

Quant Imaging Med Surg (Quantitative imaging in medicine and surgery)
[2021, 11(5):1970-1982]

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Percutaneous devices for the treatment of complex native valve mitral leaflet and aortomitral continuity defects: Review and case series.

Richard J Jabbour, Bushra Rana, Nilesh Sutaria, Angela Frame, Henry Seligman, Deepa Gopalan, Ben Ariff, Saeed Mirsadraee, Edward Barden, Neil Ruparelia, Iqbal S Malik,

Percutaneous closure of paravalvar leaks (PVLs) was once only performed in extreme or non-surgical risk cases not suitable for redo-surgery with tissue or mechanical valves. This technique is now the treatment of choice with long term outcomes that are better than redo operations.<sup>123</sup> As interventionalists become more familiar with using ... Read more >>

Cardiovasc Revasc Med (Cardiovascular revascularization medicine : including molecular interventions)
[2021, :]

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Cardiac Energetics Before, During, and After Anthracycline-Based Chemotherapy in Breast Cancer Patients Using 31P Magnetic Resonance Spectroscopy: A Pilot Study.

Gillian Macnaught, Olga Oikonomidou, Christopher T Rodgers, William Clarke, Annette Cooper, Heather McVicars, Larry Hayward, Saeed Mirsadraee, Scott Semple, Martin A Denvir,

<b>Purpose:</b> To explore the utility of phosphorus magnetic resonance spectroscopy (<sup>31</sup>P MRS) in identifying anthracycline-induced cardiac toxicity in patients with breast cancer. <b>Methods:</b> Twenty patients with newly diagnosed breast cancer receiving anthracycline-based chemotherapy had cardiac magnetic resonance assessment of left ventricular ejection fraction (LVEF) and <sup>31</sup>P MRS to determine myocardial ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2021, 8:653648]

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Thrombotic complications in 2928 patients with COVID-19 treated in intensive care: a systematic review.

William J Jenner, Rahim Kanji, Saeed Mirsadraee, Ying X Gue, Susanna Price, Sanjay Prasad, Diana A Gorog,

A prothrombotic state is reported with severe COVID-19 infection, which can manifest in venous and arterial thrombotic events. Coagulopathy is reflective of more severe disease and anticoagulant thromboprophylaxis is recommended in hospitalized patients. However, the prevalence of thrombosis on the intensive care unit (ICU) remains unclear, including whether this is ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, 51(3):595-607]

Cited: 14 times

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Cardiac Energetics Before, During and After Anthracycline-based Chemotherapy in Breast Cancer Patients Using 31P Magnetic Resonance Spectroscopy: A Pilot Study

Gillian Macnaught, Olga Oikonomidou, Christopher Rodgers, William Clarke, Annette Cooper, Heather McVicars, Larry Hayward, Saeed Mirsadraee, Scott Semple, Martin Denvir,

PURPOSETo explore the utility of phosphorus magnetic resonance spectroscopy ( 31 P MRS) in identifying anthracycline-induced cardiac toxicity in patients with breast cancer.METHODS20 patients with newly diagnosed breast cancer receiving anthracycline-based chemotherapy had cardiac magnetic resonance assessment of left ventricular ejection fraction (LVEF) and 31 P MRS to determine myocardial ... Read more >>

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Corona Virus Disease 2019 in situ arterial and venous thrombosis in critically ill patients: a case series.

Mireya Castro-Verdes, Antonia Gkouma, John Wort, Carole Ridge, Saeed Mirsadraee, Simon Padley, Awais Sheikh, Suveer Singh,

<h4>Background</h4>Corona Virus Disease 2019 (COVID-19) pneumonitis associated with severe respiratory failure carries a high mortality. Coagulopathy has emerged as a significant contributor to thrombotic complications.<h4>Case summary</h4>We describe two cases of severe COVID-19 pneumonitis refractory to conventional mechanical ventilation and proning position, transferred to our specialist centre for cardiorespiratory failure. Cross-sectional ... Read more >>

Eur Heart J Case Rep (European heart journal. Case reports)
[2020, 4(6):1-7]

Cited: 1 time

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Dual-Energy CT Pulmonary Angiography (DECTPA) Quantifies Vasculopathy in Severe COVID-19 Pneumonia.

Carole A Ridge, Sujal R Desai, Nidhish Jeyin, Ciara Mahon, Dione L Lother, Saeed Mirsadraee, Tom Semple, Susanna Price, Caroline Bleakley, Deepa J Arachchillage, Elizabeth Shaw, Brijesh V Patel, Simon Pg Padley, Anand Devaraj,

<h4>Background</h4>The role of dual energy computed tomographic pulmonary angiography (DECTPA) in revealing vasculopathy in coronavirus disease 2019 (COVID-19) has not been fully explored.<h4>Purpose</h4>To evaluate the relationship between DECTPA and disease duration, right ventricular dysfunction (RVD), lung compliance, D-dimer and obstruction index in COVID-19 pneumonia.<h4>Materials and methods</h4>This institutional review board approved ... Read more >>

Radiol Cardiothorac Imaging (Radiology. Cardiothoracic imaging)
[2020, 2(5):e200428]

Cited: 8 times

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Radiological and Laboratory Findings of Patients with COVID-19 Infection at the Time of Admission.

Saeed Mirsadraee, Mihan Pourabrollah Toutkaboni, Mehrdad Bakhshayeshkaram, Mitrasadat Rezaei, Elham Askari, Sara Haseli, Nazanin Sadraee,

<h4>Background & objective</h4>Diagnosis of coronavirus disease 2019 (COVID-19) can be challenging, especially when the real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) is not available or it is negative. In this study, we evaluated imaging and laboratory findings in a group of patients with a multidisciplinary diagnosis of COVID-19 pneumonia.<h4>Methods</h4>A ... Read more >>

Iran J Pathol (Iranian journal of pathology)
[2021, 16(2):137-143]

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Leaflet thrombosis after valve-in-valve transcatheter aortic valve implantation: a case series.

Dincer Aktuerk, Saeed Mirsadraee, Cesare Quarto, Simon Davies, Alison Duncan,

<h4>Background</h4>Valve-in-valve transcatheter aortic valve implantation (ViV-TAVI) in degenerated surgical aortic valve replacement (SAVR) is an alternative to redo-SAVR. However, reports on leaflet thrombosis following ViV-TAVI are emerging and subclinical thrombosis has gained recent attention. Although the incidence of transcatheter heart valve (THV) thrombosis after TAVI for native aortic valve disease ... Read more >>

Eur Heart J Case Rep (European heart journal. Case reports)
[2020, 4(4):1-6]

Cited: 0 times

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Baseline Results of the West London lung cancer screening pilot study - Impact of mobile scanners and dual risk model utilisation.

Emily C Bartlett, Samuel V Kemp, Carole A Ridge, Sujal R Desai, Saeed Mirsadraee, Jaymin B Morjaria, Pallav L Shah, Sanjay Popat, Andrew G Nicholson, Alexandra J Rice, Simon Jordan, Sofina Begum, Aleksander Mani, Jane Derbyshire, Katie Morris, Michelle Chen, Christine Peacock, James Addis, Maria Martins, Stan B Kaye, Simon P G Padley, Anand Devaraj, ,

<h4>Objectives</h4>The West London lung screening pilot aimed to identify early-stage lung cancer by targeting low-dose CT (LDCT) to high risk participants. Successful implementation of screening requires maximising participant uptake and identifying those at highest risk. As well as reporting pre-specified baseline screening metrics, additional objectives were to 1) compare participant ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2020, 148:12-19]

Cited: 3 times

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Successful Conservative Treatment of a Type A Aortic Intramural Hematoma.

Dimitrios Vlastos, Francisco Fernandes, Ishaansinh Chauhan, Saeed Mirsadraee, George Asimakopoulos,

Type A intramural hematoma (IMH) constitutes a variant of acute aortic syndrome. Western guidelines support an aggressive surgical approach, whereas Asian centers propose initial conservative treatment. Further expanding on this notion, we present a case of conservative subacute type A IMH management, resulting in radical hematoma resorption within 4 weeks. (<b>Level ... Read more >>

JACC Case Rep (JACC. Case reports)
[2020, 2(8):1143-1147]

Cited: 0 times

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Rapid deployment aortic valve replacement through anterior right thoracotomy: Clinical outcomes and haemodynamic performance.

Haytham Sabry, Aigul Baltabaeva, Andreas Gkikas, Oswaldo Valencia, Georgia Sarri, Saeed Mirsadraee, Tarun Mittal, Toufan Bahrami,

<h4>Background</h4>The ease of implantation of the rapid deployment (RD) and sutureless valves has contributed to the adoption of anterior right thoracotomy (ART) approach for aortic valve replacement (AVR).<h4>Aim of the study</h4>This study evaluates the safety and haemodynamic performance of minimally invasive AVR through ART using the RD valves.<h4>Methods</h4>This is a ... Read more >>

J Card Surg (Journal of cardiac surgery)
[2020, 35(7):1420-1424]

Cited: 1 time

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In vivo alpha-V beta-3 integrin expression in human aortic atherosclerosis.

William S Jenkins, Alex T Vesey, Anna Vickers, Anoushka Neale, Catriona Moles, Martin Connell, Nikhil Vilas Joshi, Christophe Lucatelli, Alison M Fletcher, James C Spratt, Saeed Mirsadraee, Edwin Jr van Beek, James Hf Rudd, David E Newby, Marc R Dweck,

<h4>Objectives</h4>Intraplaque angiogenesis and inflammation are key promoters of atherosclerosis and are mediated by the alpha-V beta-3 (α<sub>v</sub>β<sub>3</sub>) integrin pathway. We investigated the applicability of the α<sub>v</sub>β<sub>3</sub>-integrin receptor-selective positron emission tomography (PET) radiotracer 18F-fluciclatide in assessing human aortic atherosclerosis.<h4>Methods</h4>Vascular 18F-fluciclatide binding was evaluated using ex vivo analysis of carotid endarterectomy samples ... Read more >>

Heart (Heart (British Cardiac Society))
[2019, 105(24):1868-1875]

Cited: 4 times

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Inconsistency in aortic stenosis severity between CT and echocardiography: prevalence and insights into mechanistic differences using computational fluid dynamics.

Tarun Kumar Mittal, Luise Reichmuth, Sanjeev Bhattacharyya, Manish Jain, Aigul Baltabaeva, Shelley Rahman Haley, Saeed Mirsadraee, Vasileios Panoulas, Tito Kabir, Edward David Nicol, Miles Dalby, Miles Dalby, Quan Long,

<h4>Objectives</h4>The aims of this study were to evaluate the inconsistency of aortic stenosis (AS) severity between CT aortic valve area (CT-AVA) and echocardiographic Doppler parameters, and to investigate potential underlying mechanisms using computational fluid dynamics (CFD).<h4>Methods</h4>A total of 450 consecutive eligible patients undergoing transcatheter AV implantation assessment underwent CT cardiac ... Read more >>

Open Heart (Open heart)
[2019, 6(2):e001044]

Cited: 0 times

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Real-world comparison of the new 34 mm self-expandable transcatheter aortic prosthesis Evolut R to its 31 mm core valve predecessor.

Konstantinos Kalogeras, Tito Kabir, Tarun Mittal, Saeed Mirsadraee, Evangelos Skondras, Shelley Rahman Haley, Mohamed Zuhair, Manolis Vavuranakis, Dimitrios Tousoulis, Miles Dalby, Vasileios Panoulas,

<h4>Objectives</h4>The aim of the present study was to compare the incidence of periprocedural complications and short-term outcomes between the second-generation recapturable 34 mm Evolut-R and its first-generation 31 mm predecessor.<h4>Background</h4>Although already in extensive clinical use in real world patients, the periprocedural complications and clinical outcomes of the new 34 mm device have not ... Read more >>

Catheter Cardiovasc Interv (Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions)
[2019, 93(4):685-691]

Cited: 1 time

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Coronary CT Angiography and 5-Year Risk of Myocardial Infarction.

, David E Newby, Philip D Adamson, Colin Berry, Nicholas A Boon, Marc R Dweck, Marcus Flather, John Forbes, Amanda Hunter, Stephanie Lewis, Scott MacLean, Nicholas L Mills, John Norrie, Giles Roditi, Anoop S V Shah, Adam D Timmis, Edwin J R van Beek, Michelle C Williams,

<h4>Background</h4>Although coronary computed tomographic angiography (CTA) improves diagnostic certainty in the assessment of patients with stable chest pain, its effect on 5-year clinical outcomes is unknown.<h4>Methods</h4>In an open-label, multicenter, parallel-group trial, we randomly assigned 4146 patients with stable chest pain who had been referred to a cardiology clinic for evaluation ... Read more >>

N Engl J Med (The New England journal of medicine)
[2018, 379(10):924-933]

Cited: 166 times

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The 8th lung cancer TNM classification and clinical staging system: review of the changes and clinical implications.

Wanyin Lim, Carole A Ridge, Andrew G Nicholson, Saeed Mirsadraee,

Lung cancer is the leading cause of cancer death in both men and women. Clinical staging plays a crucial role in predicting survivor as well as influencing management option in lung cancer patients. Guidelines are constantly being reviewed as more data becomes available to provide the most accurate prognostic markers, ... Read more >>

Quant Imaging Med Surg (Quantitative imaging in medicine and surgery)
[2018, 8(7):709-718]

Cited: 42 times

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A slowly growing mass in the left chest wall: additive value of real time myocardial contrast echocardiography.

Ramasamy Manivarmane, Rajdeep S Khattar, Saeed Mirsadraee, Neil Moat, Roxy Senior,

Eur Heart J Cardiovasc Imaging (European heart journal. Cardiovascular Imaging)
[2018, 19(8):956]

Cited: 0 times

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Adverse prognosis associated with asymmetric myocardial thickening in aortic stenosis.

Jacek Kwiecinski, Calvin W L Chin, Russell J Everett, Audrey C White, Scott Semple, Emily Yeung, William J Jenkins, Anoop S V Shah, Maria Koo, Saeed Mirsadraee, Chim C Lang, Nicholas Mills, Sanjay K Prasad, Maurits A Jansen, Alan G Japp, David E Newby, Marc R Dweck,

<h4>Aims</h4>Asymmetric wall thickening has been described in patients with aortic stenosis. However, it remains poorly characterized and its prognostic implications are unclear. We hypothesized this pattern of adaptation is associated with advanced remodelling, left ventricular decompenzation, and a poor prognosis.<h4>Methods and results</h4>In a prospective observational cohort study, 166 patients with ... Read more >>

Eur Heart J Cardiovasc Imaging (European heart journal. Cardiovascular Imaging)
[2018, 19(3):347-356]

Cited: 6 times

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