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Author Saeed Ahmad

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Toward a Practical, Two-Step Process for Molnupiravir from Cytidine

Dinesh J. Paymode, Natarajan Vasudevan, Saeed Ahmad, Appasaheb Kadam, Flavio S. Cardoso, Justina Burns, Daniel Cook, Rodger Stringham, David Snead,

<p>A two-step synthesis of molnupiravir (<b>1</b>) is presented. This work focuses on the development of practical reaction and purification conditions toward a manufacturing route. The sequence commences from highly available cytidine (<b>2</b>), and molnupiravir is formed through direct hydroxamination of the cytosine ring and esterification of the sugar’s primary alcohol ... Read more >>

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A Phenomenological Analysis of Adoption of Coping Strategies Among Survivors of Acid Violence in Pakistan.

Hadia Batool, Mudasir Mustafa, Saeed Ahmad,

The primary objective of the current study was to explore the adoption of different coping strategies among survivors of acid violence in Pakistan. The data were collected from survivors of acid violence till saturation point was reached with the help of four key informants through a semi-structured interview guide from ... Read more >>

J Interpers Violence (Journal of interpersonal violence)
[2020, :886260520975863]

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Mathematical analysis of COVID-19 via new mathematical model.

Abdullah, Saeed Ahmad, Saud Owyed, Abdel-Haleem Abdel-Aty, Emad E Mahmoud, Kamal Shah, Hussam Alrabaiah,

We develop a new mathematical model by including the resistive class together with quarantine class and use it to investigate the transmission dynamics of the novel corona virus disease (COVID-19). Our developed model consists of four compartments, namely the susceptible class, S(t), the healthy (resistive) class, H(t), the infected class, ... Read more >>

Chaos Solitons Fractals (Chaos, solitons, and fractals)
[2021, 143:110585]

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Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases.

Abu Hazafa, Ammara Batool, Saeed Ahmad, Muhammad Amjad, Sundas Nasir Chaudhry, Jamal Asad, Hasham Feroz Ghuman, Hafiza Madeeha Khan, Muhammad Naeem, Usman Ghani,

Humanin (HN) is a small mitochondrial-derived cytoprotective polypeptide encoded by mtDNA. HN exhibits protective effects in several cell types, including leukocytes, germ cells, neurons, tissues against cellular stress conditions and apoptosis through regulating various signaling mechanisms, such as JAK/STAT pathway and interaction of BCL-2 family of protein. HN is an ... Read more >>

Life Sci (Life sciences)
[2021, 264:118679]

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Multi-Method Determination of Antioxidant Capacity, Phytochemical and Biological Investigation of Four Different Solvent Extractives of Leucophyllum frutescens (cenizo)

Imtiaz Ahmad, Saeed Ahmad, Huma Rao, Umer Shaukat, Muhammad Nadeem Shahzad, Sajid-ur- Rehman, Abdul Basit, Adeel Arshad, Bilal Ahmad,

The four solvent extractives obtained from aerial parts of Leucophyllum frutescens were evaluated for their Total Antioxidant Activity (TAA) by ammonium molybdate method, scavenging potential by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Trolox-Equivalent Antioxidant Capacity (TEAC) assays, metal-reducing potential by Cupric Reducing Antioxidant Capacity (CUPRAC) and Ferric Reducing Antioxidant Power (FRAP) assays, Total ... Read more >>

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Therapeutic Efficacy of Urinile Against Gouty Arthritis.

Saeed Ahmad, Ejaz Mohiuddin, Syed Muhammad Ali Shah, Muhammad Akram, Muhammad Amjad, Jaweria Nisar, Muhammad Riaz, Naveed Munir, Ghulam Rasool,

Gout is arthritis caused due to Monosodium urate (MSU) crystals deposition occurring particularly in patients with associated comorbidities limiting the use of conventional therapies. This study was planned to evaluate the therapeutic efficacy of urinile (a herbal drug) for the treatment of gouty arthritis. Allopurinol was used as standard drug ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820946934]

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Correction to: Synthesis, spectroscopic characterization and in vitro anticancer activity of new platinum(II) complexes with some thione ligands in the presence of triethylphosphine.

Mohammed Yagoub Jomaa, Muhammed Altaf, Saeed Ahmad, Gaurav Bhatia, Jatinder Singh, Saleh Altuwaijri, Anvarhusein A Isab,

Due to an unfortunate turn of events, the main affiliation of Dr. Saleh Altuwaijri was omitted from the above mentioned three articles. The complete affiliations are published below and should be treated as definitive. ... Read more >>

Biometals (Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine)
[2020, 33(4-5):283]

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Single-step extraction for simultaneous quantification of desvenlafaxine and alprazolam in human spiked plasma by RP-HPLC.

Huma Rao, Saeed Ahmad, Asadullah Madni, Imtiaz Ahmad, Muhammad Nadeem Shahzad,

Desvenlafaxine (DES) and Alprazolam (ALP) are the drugs commonly prescribed together for the treatment of Major Depressive Disorders (MDD). A literature survey revealed, there is no method for the simultaneous determination of these two drugs. The purpose of this research was to develop and validate a simple, accurate, precise, robust, ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0238954]

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Chronic neck sinus secondary to retained polyglactin 910 suture following sub-total thyroidectomy: a case study.

Nasiru A Ibrahim, Saeed Ahmad, Iloba Njokanma, Mobolaji Oludara, Akinwunmi Akanji, Ishola T Ibrahim,

OBJECTIVE:Reaction to sutures is a rare cause of non-healing in clean wounds. Cases of severe reaction to silk sutures have been reported, causing chronic infection and failure of thyroidectomy wound healing. We report a case of retained polyglactin 910 suture presenting with a chronically discharging sinus of the neck after ... Read more >>

J Wound Care (Journal of wound care)
[2020, 29(Sup8):S8-S10]

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Multidirectional insights into the phytochemical, biological, and multivariate analysis of the famine food plant (Calligonum polygonoides L).: A novel source of bioactive phytocompounds.

Irfan Pervaiz, Hammad Saleem, Muhammad Sarfraz, Muhammad Imran Tousif, Umair Khurshid, Saeed Ahmad, Gokhan Zengin, Kouadio Ibrahime Sinan, Marcello Locatelli, Fawzi M Mahomoodally, Syafiq Asnawi Zainal Abidin, Nafees Ahemad,

Calligonum polygonoides L. also known as famine food plant, is normally consumed in times of food scarcity in India and Pakistan and also used traditionally in the management of common diseases. The present design aims to provide an insight into the medicinal potential of four solvent extracts of C. polygonoides ... Read more >>

Food Res Int (Food research international (Ottawa, Ont.))
[2020, 137:109606]

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Antibacterial and Toxicity Evaluation of Eastern Medicine Formulation Eczegone for the Management of Eczema.

Muhammad Amjad Chishti, Ejaz Mohi-Ud-Din, Shahbaz Ahmad Zakki, Muhammad Rahil Aslam, Sheraz Siddiqui, Saeed Ahmad, Abdul Hayee,

The present study was conducted to evaluate the antibacterial activity, <i>in vit</i>ro and <i>in vivo</i> cytotoxicity, cell viability and safety of Eastern Medicine coded medicinal formulation Eczegone comprising extracts of <i>Azadirachta indica</i> (Azin)<i>, Fumaria indica</i> (Fuin)<i>, Sphaeranthus indicus</i> (Spin) and <i>Lawsonia inermis</i> (Lain). This work also evaluated antibacterial activity of ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820956798]

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Scalable growth of single-walled carbon nanotubes with a highly uniform structure.

Aqeel Hussain, Er-Xiong Ding, Ben Mclean, Kimmo Mustonen, Saeed Ahmad, Mohammad Tavakkoli, Alister J Page, Qiang Zhang, Jani Kotakoski, Esko I Kauppinen,

Here, a scalable floating catalyst chemical vapor deposition (FCCVD) method is developed for the production of single-walled carbon nanotubes (SWCNTs) with a controlled structure. For the first time, water is used as the growth promoter in the FCCVD process to modulate the growth of SWCNTs. At an optimum water concentration ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(23):12263-12267]

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An Economical Route to Lamivudine Featuring a Novel Strategy for Stereospecific Assembly.

David R Snead, D Tyler McQuade, Saeed Ahmad, Rudy Krack, Rodger W Stringham, Justina M Burns, Irini Abdiaj, Vijayagopal Gopalsamuthiram, Ryan C Nelson, B Frank Gupton,

An economical synthesis of lamivudine was developed by employing a new method to establish the stereochemistry about the heterocyclic oxathiolane ring. Toward this end, an inexpensive and readily accessible lactic acid derivative served the dual purpose of activating the carbohydrate's anomeric center for N-glycosylation and transferring stereochemical information to the ... Read more >>

Org Process Res Dev (Organic process research & development)
[2020, 24(6):1194-1198]

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TargetCPP: accurate prediction of cell-penetrating peptides from optimized multi-scale features using gradient boost decision tree.

Muhammad Arif, Saeed Ahmad, Farman Ali, Ge Fang, Min Li, Dong-Jun Yu,

Cell-penetrating peptides (CPPs) are short length permeable proteins have emerged as drugs delivery tool of therapeutic agents including genetic materials and macromolecules into cells. Recently, CPP has become a hotspot avenue for life science research and paved a new way of disease treatment without harmful impact on cell viability due ... Read more >>

J Comput Aided Mol Des (Journal of computer-aided molecular design)
[2020, 34(8):841-856]

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Hepatitis-C Virus and Cirrhosis: An Overview from Khyber Pakhtunkhwa Province of Pakistan.

Amin Ullah, Irshad Ur Rehman, Jamshaid Ahmad, Maryam Gohar, Saeed Ahmad, Bashir Ahmad,

Hepatitis C virus (HCV) leads to liver cirrhosis and carcinoma worldwide. The data of HCV cirrhotic patients were collected from hospitals of Peshawar in the period from 2015 to 2018. A total sample of 267 patients, in the age limit (>19 and <87 years) were found to be cirrhotic and ... Read more >>

Viral Immunol (Viral immunology)
[2020, 33(5):396-403]

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Development of herbal formulation of medicinal plants and determination of its antihyperuricemic potential in vitro and in vivo rat's model.

Muhammad Bilal, Saeed Ahmad, Tayyeba Rehman, Waheed Mumtaz Abbasi, Aymen Owais Ghauri, Muhammad Adeel Arshad, Sultan Ayaz, Allah Nawaz,

Hyperuricemia is a common metabolic disorder and several herbal formulations are being used for its treatment. The study aimed to develop herbal formulation (Urinil B) and find its hypouricemic effects in vitro and in vivo. Urinil B was prepared by taking Trachyspermum ammi, Piper nigrum and Berberis vulgaris equally. In ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(2):641-649]

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The Role of Socio-demographics in Adoption of Religious-Spiritual and Other Coping Strategies Among Muslim Chronic Patients with Hepatitis C in Pakistan.

Malik Muhammad Sohail, Saeed Ahmad, Fauzia Maqsood,

Coping has emerged as a vital indicator among patients in the chronic conditions. The current study examined the role of demographic characteristics (such as age, education, gender, marital status, residential background, family type and number of children) in adoption of coping (emotion-focused, problem-solving, religious-spiritual) strategies for nursing among hepatitis patients. ... Read more >>

J Relig Health (Journal of religion and health)
[2020, 59(1):234-256]

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In vitro and in vivo anti-diabetic activity of Citrullus colocynthis pulpy flesh with seeds hydro-ethanolic extract.

Aymen Owais Ghauri, Saeed Ahmad, Tayyeba Rehman,

Background Diabetes is the one of the leading cause of morbidity and mortality. Traditionally phytotherapy is widely being used for diabetes treatment and highly valued. Citrus colocynthis has known anti-diabetic potential. However, anti-diabetic potential of hydro-ethanolic extract of C. colocynthis pulpy flesh with seeds is not reported yet. Methods The ... Read more >>

J Complement Integr Med (Journal of complementary & integrative medicine)
[2020, 17(2):]

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Awareness and current knowledge of epilepsy.

Asmat Ullah Khan, Muhammad Akram, Muhammad Daniyal, Naheed Akhter, Muhammad Riaz, Naheed Akhtar, Mohammad Ali Shariati, Fozia Anjum, Samreen Gul Khan, Abida Parveen, Saeed Ahmad,

Epilepsy is a severe neural disorder that affects approximately fifty million individuals globally. Despite the fact that for most of the people with epilepsy, convulsions are better controlled by current accessible antiepileptic medicines, yet there are more than 30% of individuals affected with medically intractable epilepsy and around 30-40% of ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, 35(1):45-63]

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Antidiabetic potential of flavonoids from Artemisia macrocephalla Jaquem in streptozotocin-induced diabetic rats: Pharmacological and biochemical approach.

Syed Wadood-Ali Shah, Mehreen Ghias, Mohammad Shoaib, Niaz Ali, Ismail Shah, Muhammad Naveed Umar, Syed Muhammad Mukarram Shah, Syed Muhammad Hassan Shah, Wali Khan, Shahzeb Khan, Tour Jan, Saeed Ahmad, Shakir Ullah, Shafi Ullah,

Plants belongs to Asteraceae family are reported to be rich in major phytochemical including flavonoids and are documented to acquire antidiabetic response. Antidiabetic effects of salvigenin, eupatilin and cirsilineol were screened on in-vitro enzyme inhibition and in-vivo streptozotocin animal models. Administration of salvigenin, eupatilin and cirsilineol (7.5 and 15mg/kg) produced ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(6(Supplementary)):2865-2871]

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Role of medicinal plants in HIV/AIDS therapy.

Umme Laila, Muhammad Akram, Mohammad Ali Shariati, Asif Mehmmod Hashmi, Naheed Akhtar, Imtiaz Mahmood Tahir, Aymen Owais Ghauri, Naveed Munir, Muhammad Riaz, Naheed Akhter, Ghazala Shaheen, Qamar Ullah, Rabia Zahid, Saeed Ahmad,

Human immunodeficiency virus (HIV) causes the potentially life-threatening and chronic disease called acquired immune deficiency syndrome (AIDS). The main target of this viral disease is to suppress the immune system and make the body unresponsive to external stimuli. According to global health observatory data since epidemic, more than 78 million ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2019, 46(12):1063-1073]

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Nardostachys chinensis Batalin: A review of traditional uses, phytochemistry, and pharmacology.

Tayyeba Rehman, Saeed Ahmad,

Nardostachys chinensis Batalin (Valerianaceae) has been widely used in different traditional systems of medicine, including Islamic, Ayurvedic, Chinese, and Korean folk medicine. It has been used in traditional medicine as a tranquilizer, hepatotonic, cardiotonic, diuretic, and analgesic. Preliminary in vitro and in vivo studies have provided valuable scientific evidence for ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2019, 33(10):2622-2648]

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Antihyperglycemic Activity of Hydroalcoholic Extracts of Selective Medicinal Plants Curcuma longa, Lavandula stoechas, Aegle marmelos, and Glycyrrhiza glabra and Their Polyherbal Preparation in Alloxan-Induced Diabetic Mice.

Sodah Bint Mustafa, Muhammad Akram, Hafiz Muhammad Asif, Imran Qayyum, Asif Mehmood Hashmi, Naveed Munir, Fahad Said Khan, Muhammad Riaz, Saeed Ahmad,

<h4>Background</h4>Diabetes mellitus is a metabolic disorder associated with relative or absolute insulin deficiency or resistance, characterized by hyperglycemia. Modern prescriptions such as pioglitazone have better therapeutic potential, but its side effects and financial burden for developing countries have motivated the researchers to find alternative natural drugs to compete hyperglycemia in ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2019, 17(2):1559325819852503]

Cited: 1 time

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Metal-Based Scaffolds of Schiff Bases Derived from Naproxen: Synthesis, Antibacterial Activities, and Molecular Docking Studies.

Muhammad Ashraf Shaheen, Shanshan Feng, Mehwish Anthony, Muhammad Nawaz Tahir, Mubashir Hassan, Sung-Yum Seo, Saeed Ahmad, Mudassir Iqbal, Muhammad Saleem, Changrui Lu,

We report here the synthesis, characterization, and antibacterial evaluation of transition metal complexes of Ni, Cu, Co, Mn, Zn, and Cd (6a⁻f), using a Schiff base ligand (5) derived from naproxen (an anti-inflammatory drug) and 5-bromosalicylaldehyde by a series of reactions. The ligand and the synthesized complexes were characterized by ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2019, 24(7):]

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Periodic DFT modeling and vibrational analysis of silver(I) cyanide complexes of thioureas.

Saeed Ahmad, Ivelina Georgieva, Muhammad Hanif, Muhammad Monim-Ul-Mehboob, Shaukat Munir, Ahsan Sohail, Anvarhusein A Isab,

The structures of non-ionic [Ag(Tu)(CN)] (1) and ionic [Ag(Dmtu)<sub>2</sub>]<sup>+</sup>[Ag(CN)<sub>2</sub>]<sup>-</sup> (2) and [Ag(Imt)<sub>2</sub>]<sup>+</sup>[Ag(CN)<sub>2</sub>]<sup>-</sup> (3) silver(I) complexes, where Tu = thiourea, Dmtu = N,N'-dimethylthiourea and Imt = imidazoline-2-thione), were modeled by periodic DFT/PAW-PBE calculations; results were in good agreement with experiments. The bonding ability of the thiourea ligands (Tu, Dmtu and Imt) and the rival Ag-C, Ag-S, Ag-N and Ag-Ag bonds ... Read more >>

J Mol Model (Journal of molecular modeling)
[2019, 25(4):90]

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