Full Text Journal Articles by
Author Sadrettin Pence

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Role of mir-33a, mir-203b, mir361-3p, and mir-424 in hepatocellular carcinoma

Burhanettin Yalçınkaya, Esra Güzel, Didem Taştekin, Sadrettin Pençe,

<h4>Background/aim</h4>Hepatocellular carcinoma (HCC) is one of the most aggressive cancer types. MicroRNAs (miRNAs) are small noncoding regulatory RNAs that function posttranscriptionally. miRNA deregulation was observed in the development and progression of HCC. In this study, we aimed to investigate the expression levels of four miRNAs (mir-33a, mir-203b, mir361-3p, and mir-424) ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2021, 51(2):638-643]

Cited: 0 times

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A novel insight into differential expression profiles of sporadic cerebral cavernous malformation patients with different symptoms.

Hilal Eren Gozel, Kıvanç Kök, Fatma Ozlen, Cihan Isler, Sadrettin Pence,

Cerebral cavernous malformation (CCM) is a vascular lesion of the central nervous system that may lead to distinct symptoms among patients including cerebral hemorrhages, epileptic seizures, focal neurologic deficits, and/or headaches. Disease-related mutations were identified previously in one of the three CCM genes: CCM1, CCM2, and CCM3. However, the rate ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):19351]

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SARS-CoV-2 Presence in the Saliva, Tears, and Cerumen of COVID-19 Patients.

Fatih M Hanege, Esra Kocoglu, Mahmut T Kalcioglu, Serdal Celik, Yasemin Cag, Fehim Esen, Eray Bayindir, Sadrettin Pence, Emine Alp Mese, Canan Agalar,

<h4>Objectives/hypothesis</h4>The emergence of a new coronavirus strain (SARS-CoV-2) in December 2019 from China led to a global pandemic. The lack of herd immunity against this virus and the possibility of viral spread from asymptomatic individuals is still a major challenge for the prevention of viral transmission. The aim of this ... Read more >>

Laryngoscope (The Laryngoscope)
[2021, 131(5):E1677-E1682]

Cited: 9 times

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The role of the serum exosomal and endometrial microRNAs in recurrent implantation failure.

Fatemeh Azhari, Sadrettin Pence, Mohammad Kazem Hosseini, Burcin Karamustafaoglu Balci, Nazife Cevik, Ercan Bastu, Tuba Gunel,

<h4>Objective</h4>It has been identified that endometrium specific microRNAs have different expression levels in endometrial tissues and maternal serum during endometrial cycle. The aim of this study was to analyze microRNA expression levels in recurrent implantation failure patients and healthy controls endometrial samples for enlightening the aetiopathogenesis of the disease. The ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-11]

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Effects of ECE-1b rs213045 and rs2038089 polymorphisms on the development of contrast-induced acute kidney injury in patients with acute coronary syndrome.

Sadiye Nur Dalgic, Hulya Yilmaz Aydogan, Oguz Ozturk, Sadrettin Pence, Deniz Kanca Demirci, Okay Abaci, Cuneyt Kocas, Yalcin Dalgic, Cem Bostan, Ahmet Yildiz,

<h4>Objective</h4>Endothelin-1 (ET-1) promotes the progression and induction of sclerotic renal changes in end-stage kidney disease. Membrane-bound endothelin-converting enzyme 1 (ECE-1) is involved in the production of ET-1. The aim of this study was to assess the effects of <i>ECE-1b</i> rs213045 and rs2038089 polymorphisms, which have been shown to be involved ... Read more >>

J Int Med Res (The Journal of international medical research)
[2020, 48(3):300060519886987]

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Examination of the expression levels of MACC1, Filamin A and FBXW7 genes in colorectal cancer patients.

Funda Yesilkaya, Didem Tastekin, Hani Al Saadoni, Arzu Ergen, Sadrettin Pence,

<h4>Objective</h4>Colorectal cancer (CRC) is the third most common type of cancer observed in cancer-related mortality because it has a high metastasis ratio. This study aims to investigate the expression levels of several genes, including metastasis-related colon cancer 1 (MACC1), Filamin A (FLNA), F-box/WD repeat-containing protein 7 (FBXW7), which has an ... Read more >>

North Clin Istanb (Northern clinics of Istanbul)
[2020, 7(1):1-5]

Cited: 0 times

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Investigation of JAM-A (rs790056) and LFA-1 (rs8058823) gene variants in Turkish colorectal cancer patients.

Burcu Çaykara, Hani Alsaadoni, Halime Hanım Pençe, Sadrettin Pençe, Hülya Yılmaz Aydoğan, Didem Taştekin,

BACKGROUND/AIMS:Lymphocyte function-associated antigen 1 (LFA-1) is a transmembrane glycoprotein expressed on the surface of leukocytes and containing the binding domain for junctional adhesion molecule-A (JAM-A). The aim of the present study was to evaluate the effects of JAM-A and LFA-1 variants on the formation of colorectal cancer and metastasis. MATERIALS ... Read more >>

Turk J Gastroenterol (The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology)
[2019, 30(10):872-876]

Cited: 0 times

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Myophosphorylase (PYGM) mutations determined by next generation sequencing in a cohort from Turkey with McArdle disease.

Güldal Inal-Gültekin, Bahar Toptaş-Hekimoğlu, Zeliha Görmez, Özlem Gelişin, Hacer Durmuş, Bekir Ergüner, Hüseyin Demirci, Mahmut Ş Sağıroğlu, Yeşim Parman, Feza Deymeer, Hülya Yılmaz-Aydoğan, Sadrettin Pençe, Can Ebru Bekircan-Kurt, Ersin Tan, Sevim Erdem-Özdamar, Duran Üstek, Urs Giger, Oğuz Öztürk, Piraye Serdaroğlu-Oflazer,

This study aimed to identify PYGM mutations in patients with McArdle disease from Turkey by next generation sequencing (NGS). Genomic DNA was extracted from the blood of the McArdle patients (n = 67) and unrelated healthy volunteers (n = 53). The PYGM gene was sequenced with NGS and the observed mutations were validated by ... Read more >>

Neuromuscul Disord (Neuromuscular disorders : NMD)
[2017, 27(11):997-1008]

Cited: 7 times

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Low Oxalobacter Formigenes Colonization is Associated with Reduced Bone Mineral Density in Urinary Stone Forming Patients.

Sadrettin Pence, Ibrahim Ikizceli, Emin Ozbek, Necip Ozan Tiryakioglu, Hilal Eren, Emre Can Polat, Halime Hanım Pence,

<h4>Introduction</h4>Lower bone mineral density (BMD) and reduced <i>Oxalobacter formigenes</i> colonization are common findings in urolithiasis patients. But none of the studies conducted investigated the relationship between decreased bone mineral density and reduced Oxalobacter colonization. Here we evaluated the relation between BMD and <i>O. formigenes</i> colonization in urolithiasis patients.<h4>Materials and methods</h4>50 ... Read more >>

Curr Urol (Current urology)
[2015, 8(4):189-193]

Cited: 0 times

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Analysis of CASP8 D302H Gene Variants in Patients with Primary Brain Tumors.

Canan Cacina, Sadrettin Pence, Saime Turan, Feyza Genc, Hulya Ozdemir, Ali Kafadar, Mehmet Yasar Kaynar, Ilhan Yaylim,

<h4>Background</h4>Alteration in cell-cycle control and apoptosis pathways play important roles in tumorigenesis. Caspase-8 (CASP8) is a member of the cysteine protease family, that is implicated in apoptosis regulation. The present study was designed to investigate the possible role of CASP8 D302H gene polymorphism in the tumor development.<h4>Materials and methods</h4>A total ... Read more >>

In Vivo (In vivo (Athens, Greece))
[2015, 29(5):601-604]

Cited: 2 times

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Effect of Ramadan fasting on maternal oxidative stress during the second trimester: a preliminary study.

Ebru Ozturk, Ozcan Balat, Mete Gurol Ugur, Caglar Yazıcıoglu, Sadrettin Pence, Özcan Erel, Seval Kul,

<h4>Aim</h4>To evaluate whether fasting during Ramadan has any significant effects on maternal oxidative stress or fetal health in healthy, pregnant women with an uncomplicated, second-trimester, singleton pregnancy.<h4>Methods</h4>During the month of Ramadan, 1-29 September 2008, 42 fasting and 30 non-fasting pregnant women were enrolled in this prospective controlled study. Total antioxidant ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2011, 37(7):729-733]

Cited: 12 times

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Homocysteine, folic acid and vitamin B12 levels in maternal and umbilical cord plasma and homocysteine levels in placenta in pregnant women with pre-eclampsia.

Yurdanur G Acilmis, Ebru Dikensoy, Ali I Kutlar, Ozcan Balat, Fatma B Cebesoy, Ebru Ozturk, Hulya Cicek, Sadrettin Pence,

<h4>Aim</h4>The aim of this study was to evaluate maternal and fetal serum levels of homocysteine, folic acid, vitamin B12 and placental tissue levels of homocysteine and their association with severity of pre-eclampsia.<h4>Material & methods</h4>A case-control study, performed by a single center, included 26 pregnant women with mild pre-eclampsia, 26 pregnant ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2011, 37(1):45-50]

Cited: 24 times

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Measurement of the placental total antioxidant status in preeclamptic women using a novel automated method.

Ebru Ozturk, Ozcan Balat, Yurdanur Gurcay Acılmıs, Caglayan Ozcan, Sadrettin Pence, Özcan Erel,

<h4>Aim</h4>We aimed to measure the levels of total antioxidant status (TAS) in placental samples from preeclamptic pregnant women and evaluate the relation of placental TAS, total oxidant status (TOS) and oxidative stress index (OSI) with fetomaternal compartments using the more recently designated Erel method.<h4>Material and methods</h4>Thirty four preeclamptic and 27 ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2011, 37(4):337-342]

Cited: 10 times

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The effects of exogenous melatonin on peripheral nerve regeneration and collagen formation in rats.

Bekir Atik, Ibrahim Erkutlu, Mustafa Tercan, Hakan Buyukhatipoglu, Mehmet Bekerecioglu, Sadrettin Pence,

<h4>Background</h4>Peripheral nerve damage that requires surgical repair does not result in complete recovery because of collagen scar formation, ischemia, free oxygen radical damage, and other factors. To date, the best treatment method has not yet been determined. In this study, we designed an experimental peripheral nerve injury model, and researched ... Read more >>

J Surg Res (The Journal of surgical research)
[2011, 166(2):330-336]

Cited: 23 times

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The changes of plasma malondialdehyde, nitric oxide, and adrenomedullin levels in patients with preeclampsia.

Ebru Dikensoy, Ozcan Balat, Sadrettin Pence, Ayse Balat, Mustafa Cekmen, Muhuttin Yurekli,

<h4>Objective</h4>The aim of the study was to investigate the role of malondialdehyde, nitric oxide and adrenomedullin in the etiopathogenesis of preeclampsia.<h4>Material and methods</h4>Forty-two pregnant women with preeclampsia and 30 healthy pregnant women were involved. The plasma concentrations of malondialdehyde, nitric oxide, and adrenomedullin were compared between the study group and ... Read more >>

Hypertens Pregnancy (Hypertension in pregnancy)
[2009, 28(4):383-389]

Cited: 14 times

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Antiepileptogenic effects of glutathione against increased brain ADA in PTZ-induced epilepsy.

Sadrettin Pence, Ibrahim Erkutlu, Naciye Kurtul, Mehmet Bosnak, Mehmet Alptekin, Uner Tan,

Adenosine has been shown to play a significant role as a modulator of neuronal activity in convulsive disorders, acting as an endogenous anticonvulsant agent. Any change in adenosine deaminase (ADA) levels will reflect to adenosine levels. In the present study, we have investigated the effect of glutathione on brain tissue ... Read more >>

Int J Neurosci (The International journal of neuroscience)
[2009, 119(5):616-629]

Cited: 3 times

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Effects of progesterone on total brain tissue adenosine deaminase activity in experimental epilepsy.

Sadrettin Pençe, Ibrahim Erkutlu, Naciye Kurtul, Mehmet Alptekin, Uner Tan,

Single seizure and epilepsy is one of the most commonly encountered neurologic disorders in elderly individuals, arising as a result of complex and often multiple acquired underlying pathologies. Adenosine, acting at A1 receptors, exhibits anticonvulsant effects in experimental epilepsy and inhibits progression to status epilepticus. Adenosine deaminase is the enzyme ... Read more >>

Int J Neurosci (The International journal of neuroscience)
[2009, 119(2):204-213]

Cited: 3 times

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Malondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrhea.

Ebru Dikensoy, Ozcan Balat, Sadrettin Pençe, Ayse Balat, Mustafa Cekmen, Muhuttin Yurekli,

<h4>Aim</h4>The aim of the study was to examine whether there was a relationship between primary dysmenorrhea and serum levels of malondialdehyde (MDA), nitric oxide (NO) and adrenomedullin (AM) in young women.<h4>Methods</h4>Sixty female subjects without serious medical problems, aged between 20 and 34, who had regular menses for at least six ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2008, 34(6):1049-1053]

Cited: 13 times

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The effect of progesterone on total brain tissue sialic acid levels in experimental epilepsy.

Sadrettin Pence, Mehmet Bosnak, Naciye Kurtul, Mete Gurol Ugur, Ibrahim Erkutlu, Cahit Bagci, Uner Tan,

Epilepsy, the most common neurological disorder worldwide, changing cellular interactions and connectivity may have effects on sialic acid levels. A total of 80 mice were separated into 8 groups: the sham, control, pentylentetrazole (PTZ), PTZ plus progesterone, five dose progesterone, single dose progesterone, kindling, and kindling plus progesterone groups. Brains ... Read more >>

Int J Neurosci (The International journal of neuroscience)
[2008, 118(1):105-118]

Cited: 1 time

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The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism.

Ebru Dikensoy, Ozcan Balat, Sadrettin Pence, Cenk Akcali, Hulya Cicek,

Flutamide is an effective drug in treatment of hirsutism. Hepatotoxicity occasionally may occur with therapeutic doses (750-1500 mg/day), 3 months after initiation of treatment. Monitoring of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels is recommended to obviate serious hepatotoxicity.Two hundred and fourteen patients with mean age of 20.9+/-2.34 ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2009, 279(3):321-327]

Cited: 15 times

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"Unertan syndrome" in two Turkish families in relation to devolution and emergence of Homo erectus: neurological examination, MRI, and PET scans.

Uner Tan, Sadrettin Pençe, Mustafa Yilmaz, Ayhan Ozkur, Sibel Karaca, Meliha Tan, Mehmet Karataş,

"Unertan syndrome" consists of two main symptoms: quadrupedal gait and primitive cognitive abilities including language and conscious experience. To assess the central mechanisms involved in this syndrome, the authors performed MRI and PET scans on affected and unaffected individuals from both families. All affected individuals were also subjected to neurological ... Read more >>

Int J Neurosci (The International journal of neuroscience)
[2008, 118(3):313-336]

Cited: 6 times

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Unertan syndrome: a case series demonstrating human devolution.

Uner Tan, Sibel Karaca, Meliha Tan, Bekir Yilmaz, Namik Kemal Bagci, Ayhan Ozkur, Sadrettin Pence,

A large family with six individuals exhibiting the Unertan syndrome (UTS) was identified residing in southern Turkey. All of the individuals had mental impairments and walked on all four extremities. The practice of intra-familial marriages suggested that the UTS may be an autosomal recessive disorder, similar to previously described cases. ... Read more >>

Int J Neurosci (The International journal of neuroscience)
[2008, 118(1):1-25]

Cited: 7 times

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Total brain tissue sialic acid levels due to glutathione effect in experimental epilepsy.

Sadrettin Pence, Ibrahim Erkutlu, Naciye Kurtul, Mehmet Bosnak, Uner Tan,

Epilepsy can be described as a group of neurological disorders, characterized by recurrent episodes of convulsive seizures, loss of consciousness, sensory disturbances, abnormal behavior, or all of these. Altered glutathione metabolism in association with increased oxidative stress has been implicated in the pathogenesis of many diseases such as seizures. It ... Read more >>

Int J Neurosci (The International journal of neuroscience)
[2007, 117(11):1523-1535]

Cited: 3 times

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In vivo effects of caffeic acid phenethyl ester on myocardial ischemia-reperfusion injury and apoptotic changes in rats.

Kerim Cagli, Cahit Bagci, Mukaddes Gulec, Beyhan Cengiz, Omer Akyol, Ibrahim Sari, Sevgi Cavdar, Sadrettin Pence, Hakan Dinckan,

Ischemia/reperfusion (I/R) has been reported to induce apoptotic cellular death in myocardium. This study tested the hypothesis that caffeic acid phenethyl ester (CAPE), one of the active components of propolis, may ameliorate myocardial apoptosis and oxidative myocardial injury. Wistar rats were divided into 4 groups: (i) sham operated, (ii) I/R, ... Read more >>

Ann Clin Lab Sci (Annals of clinical and laboratory science)
[2005, 35(4):440-448]

Cited: 11 times

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Adenosine deaminase activity in the serum of type 2 diabetic patients.

Naciye Kurtul, Sadrettin Pence, Ersin Akarsu, Hasan Kocoglu, Yemliha Aksoy, Hülya Aksoy,

Adenosine deaminase (ADA) is suggested to be an important enzyme for modulating the bioactivity of insulin, but its clinical significance in diabetes mellitus (DM) is not yet characterized. We measured the serum level of ADA in healthy controls (C, n=29) and type 2 diabetic patients (n=42). The mean serum level ... Read more >>

Acta Medica (Hradec Kralove) (Acta medica (Hradec Kralove))
[2004, 47(1):33-35]

Cited: 18 times

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