Full Text Journal Articles by
Author Sadia Zafar

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Molecular Dynamic Simulations to Probe Stereoselectivity of Tiagabine Binding with Human GAT1.

Sadia Zafar, Ishrat Jabeen,

The human gamma aminobutyric acid transporter subtype 1 (hGAT1) located in the nerve terminals is known to catalyze the neuronal function by the electrogenic reuptake of γ-aminobutyric acid (GABA) with the co-transport of Na+ and Cl- ions. In the past, there has been a major research drive focused on the ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(20):]

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Oncolytic adenovirus type 3 coding for CD40L facilitates dendritic cell therapy of prostate cancer in humanized mice and patient samples.

Sadia Zafar, Saru Basnet, Inga-Maria Launonen, Dafne Carolina Alves Quixabeira, Joao Santos, Otto Hemminki, Minna Malmstedt, Victor Cervera-Carrascon, Pasi Aronen, Riikka Kalliokoski, Riikka Havunen, Antti Rannikko, Tuomas Mirtti, Mika Matikainen, Anna Kanerva, Akseli Hemminki,

Dendritic cell (DC) based vaccines have shown some degree of success for the treatment of prostate cancer. However, the highly immunosuppressive tumor microenvironment leads to DC dysfunction, which has limited the effectiveness of these vaccines. We hypothesised that use of a fully serotype 3 oncolytic adenovirus (Ad3-hTERT-CMV-hCD40L; TILT-234) could stimulate ... Read more >>

Hum Gene Ther (Human gene therapy)
[2020, :]

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Ad5/3 is able to avoid neutralization by binding to erythrocytes and lymphocytes.

Sadia Zafar, Dafne Carolina Alves Quixabeira, Tatiana Viktorovna Kudling, Victor Cervera-Carrascon, Joao Manuel Santos, Susanna Grönberg-Vähä-Koskela, Fang Zhao, Pasi Aronen, Camilla Heiniö, Riikka Havunen, Suvi Sorsa, Anna Kanerva, Akseli Hemminki,

Oncolytic adenoviruses are promising cancer therapeutic agents. Clinical data have shown adenoviruses' ability to transduce tumors after systemic delivery in human cancer patients, despite antibodies. In the present work, we have focused on the interaction of a chimeric adenovirus Ad5/3 with human lymphocytes and human erythrocytes. Ad5/3 binding with human ... Read more >>

Cancer Gene Ther. (Cancer gene therapy)
[2020, :]

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Chemical constituents, experimental and clinical pharmacology of Rosa damascena: a literature review.

Muhammad Akram, Muhammad Riaz, Naveed Munir, Naheed Akhter, Sadia Zafar, Farhat Jabeen, Mohammad Ali Shariati, Naheed Akhtar, Zarfishan Riaz, Syed Hassan Altaf, Muhammad Daniyal, Muhammad Daniyal, Rabia Zahid, Fahad Said Khan,

CONTEXT:Rosa damascena Mill. is prescribed for the management of chest and abdominal pain, constipation, digestive disorders, menstrual bleeding and liver ailments. OBJECTIVE:The current review compiles up to date and complete information of whole plant of R. damascena with particular emphasis on its numerous scientifically proved pharmacological effects, traditional and folk medicinal ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, 72(2):161-174]

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Eel fish bite: an impending emergency in Arabian sea.

Sadia Zafar, Zafar Fatmi,

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2019, 69(12):1928]

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Therapeutic potential of medicinal plants for the management of scabies.

Muhammad Akram, Muhammad Riaz, Sarwat Noreen, Mohammad A Shariati, Ghazala Shaheen, Naheed Akhter, Farzana Parveen, Naheed Akhtar, Sadia Zafar, Aymen Owais Ghauri, Zerfishan Riaz, Fahad S Khan, Shamaila Kausar, Rida Zainab,

Sarcoptes scabiei (S. scabiei), a parasite mite which causes scabies disease resulting in serious public health concern. The long-term scabies disease can lead to complications such as septicemia, acute post-streptococcal glomerulonephritis, heart disease, and secondary infections. Timely treatment to the affected patients is required to control the disease and get ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2020, 33(1):e13186]

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Ex-vivo abortifacient activity of Androsace foliosa n-hexane leaves extract on isolated rabbit uterus.

Jawad Zaheer, Qazi Najam-Us-Saqib, Asif Mehmmod Hashmi, Muhammad Mukhtiar, Sadia Zafar, Muhammad Riaz, Ghulam Rasool, Muhammad Akram, Syed Muhammad-Ali Shah, Saher Rahat, Faid Said Khan,

Androsace foliosa is a medicinal herb utilized in different areas of Pakistan for abortifacient, diabetic and liver complications. In the current research, the possible action of the n-hexane leaves extract of the Androsace foliosa on isolated rabbit uterus was examined. Abortifacient activity was examined in the existence of standard antagonist ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(5(Supplementary)):2333-2339]

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Effect of Genetic Modifications on Physical and Functional Titers of Adenoviral Cancer Gene Therapy Constructs.

Camilla Heiniö, Suvi Sorsa, Mikko Siurala, Susanna Grönberg-Vähä-Koskela, Riikka Havunen, Elina Haavisto, Anniina Koski, Otto Hemminki, Sadia Zafar, Víctor Cervera-Carrascon, Eleonora Munaro, Anna Kanerva, Akseli Hemminki,

After the discovery and characterization of the adenovirus in the 1950s, this prevalent cause of the common cold and other usually mild diseases has been modified and utilized in biomedicine in several ways. To date, adenoviruses are the most frequently used vectors and therapeutic (e.g., oncolytic) agents with a number ... Read more >>

Hum. Gene Ther. (Human gene therapy)
[2019, 30(6):740-752]

Cited: 1 time

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GRID-independent molecular descriptor analysis and molecular docking studies to mimic the binding hypothesis of γ-aminobutyric acid transporter 1 (GAT1) inhibitors.

Sadia Zafar, Ishrat Jabeen,

Background:The γ-aminobutyric acid (GABA) transporter GAT1 is involved in GABA transport across the biological membrane in and out of the synaptic cleft. The efficiency of this Na+ coupled GABA transport is regulated by an electrochemical gradient, which is directed inward under normal conditions. However, in certain pathophysiological situations, including strong ... Read more >>

(PeerJ)
[2019, 7:e6283]

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Modeling and Simulation of hGAT1: A Mechanistic Investigation of the GABA Transport Process.

Sadia Zafar, Megin E Nguyen, Ramaiah Muthyala, Ishrat Jabeen, Yuk Y Sham,

Human γ-Aminobutyric acid transporter 1 (hGAT1) is a Na+/Cl- dependent co-transporter that plays a key role in the inhibitory neurotransmission of GABA in the brain. Due to the lack of structural data, the exact co-transport mechanism of GABA reuptake by hGAT1 remains unclear. To examine the roles of the co-transport ... Read more >>

(Computational and structural biotechnology journal)
[2019, 17:61-69]

Cited: 1 time

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Structure, Function, and Modulation of γ-Aminobutyric Acid Transporter 1 (GAT1) in Neurological Disorders: A Pharmacoinformatic Prospective.

Sadia Zafar, Ishrat Jabeen,

γ-Aminobutyric acid (GABA) Transporters (GATs) belong to sodium and chloride dependent-transporter family and are widely expressed throughout the brain. Notably, GAT1 is accountable for sustaining 75% of the synaptic GABA concentration and entails its transport to the GABAA receptors to initiate the receptor-mediated inhibition of post-synaptic neurons. Imbalance in ion ... Read more >>

(Frontiers in chemistry)
[2018, 6:397]

Cited: 3 times

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Evidence of cognitive flexibility deficits and impaired emotion regulation in childhood survivors of acute lymphoblastic leukaemia: Findings from task switching study.

Amara Gul, Sadia Zafar,

The objective of the current study was to compare cognitive flexibility and emotion regulation between childhood survivors of Acute Lymphoblastic Leukaemia (ALL) and healthy control subjects. Twenty-five childhood survivors of ALL treated with intrathecal chemotherapy between 2013 to 2016 from Shaukat Khanum Memorial Cancer Hospital, Children Hospital and Jinnah Hospital ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2018, 68(3):848-486]

Cited: 0 times

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Assessment of Titanium Dioxide Nanoparticles (TiO2-NPs) Induced Hepatotoxicity and Ameliorative Effects of Cinnamomum cassia in Sprague-Dawley Rats.

Muhammad Shakeel, Farhat Jabeen, Rehana Iqbal, Abdul Shakoor Chaudhry, Sadia Zafar, Muhammad Ali, Muhammad Saleem Khan, Adeel Khalid, Samina Shabbir, Muhammad Saleem Asghar,

This study assessed the protective effects of Cinnamomum cassia (cinnamon) bark extract in rats exposed to titanium dioxide nanoparticles or titanium dioxide bulk salt. For in vivo evaluation of the ameliorative role of the cinnamon extract, the experimental groups were orally administered with the cinnamon extract at different dose levels ... Read more >>

Biol Trace Elem Res (Biological trace element research)
[2018, 182(1):57-69]

Cited: 5 times

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Intravenously usable fully serotype 3 oncolytic adenovirus coding for CD40L as an enabler of dendritic cell therapy.

Sadia Zafar, Suvi Parviainen, Mikko Siurala, Otto Hemminki, Riikka Havunen, Siri Tähtinen, Simona Bramante, Lotta Vassilev, Hongjie Wang, Andre Lieber, Silvio Hemmi, Tanja de Gruijl, Anna Kanerva, Akseli Hemminki,

Vaccination with dendritic cells (DCs), the most potent professional antigen-presenting cells in the body, is a promising approach in cancer immunotherapy. However, tumors induce immunosuppression in their microenvironment that suppresses and impairs the function of DCs. Therefore, human clinical trials with DC therapy have often been disappointing. To improve the ... Read more >>

(Oncoimmunology)
[2017, 6(2):e1265717]

Cited: 12 times

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Perceptions of childhood sexual abuse survivors: development and initial validation of a new scale to measure stereotypes of adult survivors of childhood sexual abuse.

Sadia Zafar, Erin C Ross,

The Childhood Sexual Abuse Stereotypes Scale was developed to assess stereotypes of adult survivors of childhood sexual abuse. Scale items were derived from two studies that elicited cultural and personal beliefs about, and emotions experienced towards adult childhood sexual abuse survivors among university undergraduates. Two scales, Emotions and Characteristics, were ... Read more >>

J Child Sex Abus (Journal of child sexual abuse)
[2013, 22(3):358-378]

Cited: 1 time

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BapC autotransporter protein of Bordetella pertussis is an adhesion factor.

Habib Bokhari, Iram Bilal, Sadia Zafar,

Bordetella pertussis, the causative agent of whooping cough, attaches to mucosal surfaces in upper respiratory tract, where it produces, a variety of surface-associated and secreted molecules. Among various secreted products, some of the proteins belonging to autotransporter family; pertactin (Prn), bordetella resistance to killing (BrkA) and a newly identified member, ... Read more >>

J. Basic Microbiol. (Journal of basic microbiology)
[2012, 52(4):390-396]

Cited: 6 times

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Computational analysis reveals abundance of potential glycoproteins in Archaea, Bacteria and Eukarya.

Sadia Zafar, Arshan Nasir, Habib Bokhari,

Glycosylation is the most common type of post-translational modification (PTM) and is known to affect protein stability, folding and activity. Inactivity of enzymes mediating glycosylation can result in serious disorders including colon cancer and brain disorders. Out of five main types of glycosylation, N-linked glycosylation is most abundant and characterized ... Read more >>

(Bioinformation)
[2011, 6(9):352-355]

Cited: 4 times

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Analysis of glycosylation motifs and glycosyltransferases in Bacteria and Archaea.

Syed Tabish, Abbas Raza, Arshan Nasir, Sadia Zafar, Habib Bokhari,

The process of glycosylation has been studied extensively in prokaryotes but many questions still remain unanswered. Glycosyltransferase is the enzyme which mediates glycosylation and has its preference for the target glycosylation sites as well as for the type of glycosylation i.e. N-linked and O-linked glycosylation. In this study we carried ... Read more >>

(Bioinformation)
[2011, 6(5):191-195]

Cited: 1 time

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