Full Text Journal Articles by
Author Sadaf Saleem

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Targeted Delivery of Natural Bioactives and Lipid-nanocargos against Signaling Pathways Involved in Skin Cancer.

Mohammad Kashif Iqubal, Aiswarya Chaudhuri, Ashif Iqubal, Sadaf Saleem, Madan Mohan Gupta, Alka Ahuja, Javed Ali, Sanjula Baboota,

At present, skin cancer is a widespread malignancy in human beings. Among diverse population types, Caucasian populations are much more prone in comparison to darker skin populations due to the comparative lack of skin pigmentation. Skin cancer is divided into malignant and non-melanoma skin cancer, which is additionally categorized as ... Read more >>

Curr Med Chem (Current medicinal chemistry)
[2020, :]

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Trends in nanotechnology-based delivery systems for dermal targeting of drugs: an enticing approach to offset psoriasis.

Sadaf Saleem, Mohammad Kashif Iqubal, Sanjay Garg, Javed Ali, Sanjula Baboota,

INTRODUCTION:Psoriasis is identified as an inflammatory, chronic, auto-immune disease requiring long-term treatment, imposing an unnecessary burden on the patient. A significant impediment for the treatment of dermatological disorders via transdermal route is the inability of drug molecules to cross the stratum corneum (SC), as the larger size of drug molecules ... Read more >>

Expert Opin Drug Deliv (Expert opinion on drug delivery)
[2020, 17(6):817-838]

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Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting.

Mohammad Kashif Iqubal, Sadaf Saleem, Ashif Iqubal, Aiswarya Chaudhuri, Faheem Hyder Pottoo, Javed Ali, Sanjula Baboota,

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and ... Read more >>

Curr Pharm Des (Current pharmaceutical design)
[2020, 26(36):4551-4568]

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Choline Transporter in α/β core neurons of Drosophila mushroom body non-canonically regulates pupal eclosion and maintains neuromuscular junction integrity

Runa Hamid, Nikhil Hajirnis, Shikha Kushwaha, Sadaf Saleem, Vimlesh Kumar, Rakesh Mishra,

Abstract Insect mushroom bodies (MB) have an ensemble of synaptic connections well-studied for their role in experience-dependent learning and several higher cognitive functions. MB requires neurotransmission for an efficient flow of information across synapses with the different flexibility to meet the demand of the dynamically changing environment of an insect. ... Read more >>

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Drosophila Choline transporter non-canonically regulates pupal eclosion and NMJ integrity through a neuronal subset of mushroom body.

Runa Hamid, Nikhil Hajirnis, Shikha Kushwaha, Sadaf Saleem, Vimlesh Kumar, Rakesh K Mishra,

Insect mushroom bodies (MB) have an ensemble of synaptic connections well-studied for their role in experience-dependent learning and several higher cognitive functions. MB requires neurotransmission for an efficient flow of information across synapses with different flexibility to meet the demand of the dynamically changing environment of an insect. Neurotransmitter transporters ... Read more >>

Dev Biol (Developmental biology)
[2019, 446(1):80-93]

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Discordant interpretation of serial bone mineral density measurements by dual-energy X-ray absorptiometry using vendor's and institutional least significant changes: Serious impact on decision-making.

Nosheen Fatima, Maseeh Uz Zaman, Sadaf Saleem, Noureen Hameed, Jamila Bano,

Meaningful change in bone mineral density (BMD) should be equal or higher than institutional least significant change (LSC). But some facilities use vendor's LSC which is discouraged by International Society for Clinical Densitometry (ISCD). The aim of this study was to find the impact of scan interpretation upon interval BMD ... Read more >>

World J Nucl Med (World journal of nuclear medicine)
[2018, 17(4):236-240]

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Effects of methanolic and aqueous extracts of Ipomoea batatas L on mineral contents level (calcium and magnesium) in alloxan-induced diabetic rats.

Imtiaz Mahmood Tahir, Naheed Akhter, Abida Parveen, Huma Mehboob, Sadaf Saleem, Naveed Munir, Syed Muhammad-Ali Shah, Jawad Zaheer, Fahad Said Khan, Sabira Sultana, Muhammad Akram,

In diabetic patients, electrolyte disorders frequently occur with the characteristic changes in minerals like calcium and magnesium etc. Several medicines are used to manage diabetes mellitus but they exert adverse effects. Plants are a valuable alternative to synthetic medicines because they are easily available, economical and have fewer side effects. ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(5(Supplementary)):2077-2083]

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Diagnostic accuracy study of internal assessment using receiver operator characteristic curve analysis.

Khadija Qamar, Muhammad Alamgir Khan, Sadaf Saleem,

OBJECTIVE:To assess whether internal assessment as a part of continuous assessment links to the outcome of the final summative assessment. METHODS:The diagnostic accuracy study was conducted at Army Medical College, Rawalpindi, Pakistan, from November 2015 to July 2016, and comprised medical students of 2nd year. Different teaching methods used were ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2018, 68(5):721-724]

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Effect of UDP-Glucuronosyltransferase (UGT) 1A Polymorphism (rs8330 and rs10929303) on Glucuronidation Status of Acetaminophen.

Huma Mehboob, Imtiaz Mahmood Tahir, Tahira Iqbal, Sadaf Saleem, Sofia Perveen, Aboubakker Farooqi,

Interindividual variability in polymorphic uridine diphosphate-glucuronosyltransferase 1A1 (UGT1A1) ascribed to genetic diversity is associated with relative glucuronidation level among individuals. The present research was aimed to study the effect of 2 important single nucleotide polymorphisms (SNPs; rs8330 and rs10929303) of UGT1A1 gene on glucuronidation status of acetaminophen in healthy volunteers ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2017, 15(3):1559325817723731]

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