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Zebrafish Trak proteins 1a and 2 localize to the mitochondria.

Kelsey A Oonk, Lauren B Bienvenu, Paxton S Sickler, Christine Martin, Emily Nickoloff-Bybel, Albert Matthew Volk, Douglas C Weiser, Susan Walsh,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Oral Fecal Microbiota Transplant Capsules Are Safe and Effective for Recurrent Clostridioides difficile Infection: A Systematic Review and Meta-Analysis.

Charles Du, Yuying Luo, Samantha Walsh, Ari Grinspan,

<h4>Goals</h4>We performed a systematic review with meta-analysis to examine the efficacy and safety of oral fecal microbiota transplantation (FMT) capsules for recurrent Clostridioides difficile infection (rCDI).<h4>Background</h4>FMT through colonoscopy is established as effective and safe in treating multiple recurrences of CDI, but consensus has not been established on delivery through oral ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2021, :]

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Evaluation of Alitretinoin for the Treatment of Mycosis Fungoides and Sézary Syndrome.

Raed Alhusayen, Trang Tuyet Vu, Nouf Almuhanna, Iris Wohlmuth-Wieser, Jori Hardin, John-Douglas Matthew Hughes, Justin Chia, Leslie Street, Neil Hartley Shear, Scott Richard Walsh, Robert Gniadecki,

<h4>Background</h4>Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of cutaneous T-cell lymphoma (CTCL). There is currently no cure for CTCL, and treatment is aimed at limiting disease progression. This study evaluated the efficacy and tolerability of alitretinoin in CTCL management.<h4>Methods</h4>A retrospective, multicenter study was conducted on ... Read more >>

Dermatology (Dermatology (Basel, Switzerland))
[2021, :1-7]

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Is there a dose-response relationship between musical instrument playing and later-life cognition? A cohort study using EPIC-Norfolk data.

Sebastian Walsh, Robert Luben, Shabina Hayat, Carol Brayne,

<h4>Introduction</h4>Musical instrument playing provides intellectual stimulation, which is hypothesised to generate cognitive reserve that protects against cognitive impairment. Studies to date have classified musicianship as a binary entity. This investigation draws on the dataset of the European Prospective Investigation of Cancer Norfolk study to examine the effect of frequency of ... Read more >>

Age Ageing (Age and ageing)
[2021, 50(1):220-226]

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Development and Validation of an Automated Radiomic CT Signature for Detecting COVID-19.

Julien Guiot, Akshayaa Vaidyanathan, Louis Deprez, Fadila Zerka, Denis Danthine, Anne-Noëlle Frix, Marie Thys, Monique Henket, Gregory Canivet, Stephane Mathieu, Evanthia Eftaxia, Philippe Lambin, Nathan Tsoutzidis, Benjamin Miraglio, Sean Walsh, Michel Moutschen, Renaud Louis, Paul Meunier, Wim Vos, Ralph T H Leijenaar, Pierre Lovinfosse,

The coronavirus disease 2019 (COVID-19) outbreak has reached pandemic status. Drastic measures of social distancing are enforced in society and healthcare systems are being pushed to and beyond their limits. To help in the fight against this threat on human health, a fully automated AI framework was developed to extract ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 11(1):]

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Do school closures reduce community transmission of COVID-19? A systematic review of observational studies

Sebastian Walsh, Avirup Chowdhury, Simon Russell, Vickie Braithwaite, Joseph Ward, Claire Waddington, Carol Brayne, Chris Bonell, Russell Viner, Oliver Mytton,

<h4>Introduction</h4> School closures are associated with significant negative consequences and may exacerbate inequalities. They were implemented worldwide to control SARS-CoV-2 in the first half of 2020, but their effectiveness remains uncertain. This review summarises the empirical evidence of their effect on SARS-CoV-2 community transmission. <h4>Methods</h4> The study protocol was registered ... Read more >>

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Sexually transmitted disease clinics in the United States: Understanding the needs of patients and the capabilities of providers.

William S Pearson, Sagar Kumar, Melissa A Habel, Sara Walsh, Michael Meit, Roxanne Y Barrow, Gretchen Weiss, Thomas L Gift,

Reports of bacterial sexually transmitted infections are at the highest levels ever reported in the United States, and state and local budgetary issues are placing specialized sexually transmitted disease (STD) care at risk. This study collected information from 4138 patients seeking care at 26 STD clinics in large metropolitan areas ... Read more >>

Prev Med (Preventive medicine)
[2020, 145:106411]

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Treatment and long-term outcome in primary nephrogenic diabetes insipidus.

Sergio C Lopez-Garcia, Mallory L Downie, Ji Soo Kim, Olivia Boyer, Stephen B Walsh, Tom Nijenhuis, Svetlana Papizh, Pallavi Yadav, Ben C Reynolds, Stéphane Decramer, Martine Besouw, Manel Perelló Carrascosa, Claudio La Scola, Francesco Trepiccione, Gema Ariceta, Aurélie Hummel, Claire Dossier, John A Sayer, Martin Konrad, Mandy G Keijzer-Veen, Atif Awan, Biswanath Basu, Dominique Chauveau, Leire Madariaga, Linda Koster-Kamphuis, Mónica Furlano, Miriam Zacchia, Pierluigi Marzuillo, Yincent Tse, Ismail Dursun, Ayse Seda Pinarbasi, Despoina Tramma, Ewout J Hoorn, Ibrahim Gokce, Kathleen Nicholls, Loai A Eid, Lisa Sartz, Michael Riordan, Nakysa Hooman, Nikoleta Printza, Olivier Bonny, Pedro Arango Sancho, Raphael Schild, Rajiv Sinha, Stefano Guarino, Victor Martinez Jimenez, Lidia Rodríguez Peña, Hendrica Belge, Olivier Devuyst, Tanja Wlodkowski, Francesco Emma, Elena Levtchenko, Nine V A M Knoers, Daniel G Bichet, Franz Schaefer, Robert Kleta, , Detlef Bockenhauer,

<h4>Background</h4>Primary nephrogenic diabetes insipidus (NDI) is a rare disorder and little is known about treatment practices and long-term outcome.<h4>Methods</h4>Paediatric and adult nephrologists contacted through European professional organizations entered data in an online form.<h4>Results</h4>Data were collected on 315 patients (22 countries, male 84%, adults 35%). Mutation testing had been performed in ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2020, :]

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An overview of the Scientific Advisory Committee on Nutrition's position statement on nutrition and older adults living in the community.

Margie van Dijk, Adrienne Cullum, Gillian Swan, Emma Peacock, Gill Fine, Siân Robinson, Harry McArdle, Angus Walls, Stella Walsh, ,

Br J Nutr (The British journal of nutrition)
[2020, :1-4]

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OXTR rs53576 Variation with Breast and Nipple Pain in Breastfeeding Women.

Ruth Lucas, Yiming Zhang, Stephen J Walsh, Angela Starkweather, Erin Young,

<h4>Background</h4>Thirty percent of women who seek professional breastfeeding support require assistance with ongoing breast and nipple pain and < 50% of women report resolution of their pain. It is unknown if there is a molecular risk for ongoing breast and nipple pain during breastfeeding. Aim -To evaluate associations among breast ... Read more >>

Pain Manag Nurs (Pain management nursing : official journal of the American Society of Pain Management Nurses)
[2020, :]

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The management of Sjögren's syndrome: British Society for Rheumatology guideline scope.

Elizabeth Price, Alexander Allen, Saaeha Rauz, Anwar Tappuni, Nurhan Sutcliffe, Michele Bombardieri, Sara Carty, Coziana Ciurtin, Bridget Crampton, Lisa Duncalfe, Benjamin Fisher, Peter Glennon, Katie L Hackett, Genevieve Larkin, Fai Ng, Athimalaipet V Ramanan, Saad Rassam, Stephen B Walsh, Simon Bowman,

The guideline will be developed using the methods and processes outlined in Creating Clinical Guidelines: Our Protocol (1). This development process to produce guidance, advice and recommendations for practice has National Institute for Health and Care Excellence (NICE) accreditation. ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, :]

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Beyond the black stump: rapid reviews of health research issues affecting regional, rural and remote Australia.

Sonya R Osborne, Laura V Alston, Kristy A Bolton, Jill Whelan, Erica Reeve, Anna Wong Shee, Jennifer Browne, Troy Walker, Vincent L Versace, Steven Allender, Melanie Nichols, Kathryn Backholer, Nicholas Goodwin, Suzanne Lewis, Hazel Dalton, Grace Prael, Michael Curtin, Robert Brooks, Sarah Verdon, Judith Crockett, Gene Hodgins, Sandra Walsh, David M Lyle, Sandra C Thompson, Leanne J Browne, Sabina Knight, Sabrina W Pit, Martin Jones, Marianne H Gillam, Matthew J Leach, David A Gonzalez-Chica, Kuda Muyambi, Tesfahun Eshetie, Kham Tran, Esther May, Gena Lieschke, Vicki Parker, Angela Smith, Christopher Hayes, Adrian J Dunlop, Hema Rajappa, Ruth White, Patrick Oakley, Simon Holliday,

CHAPTER 1: RETAIL INITIATIVES TO IMPROVE THE HEALTHINESS OF FOOD ENVIRONMENTS IN RURAL, REGIONAL AND REMOTE COMMUNITIES: Objective: To synthesise the evidence for effectiveness of initiatives aimed at improving food retail environments and consumer dietary behaviour in rural, regional and remote populations in Australia and comparable countries, and to discuss ... Read more >>

Med J Aust (The Medical journal of Australia)
[2020, 213 Suppl 11:S3-S32.e1]

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Site-selective modification strategies in antibody-drug conjugates.

Stephen J Walsh, Jonathan D Bargh, Friederike M Dannheim, Abigail R Hanby, Hikaru Seki, Andrew J Counsell, Xiaoxu Ou, Elaine Fowler, Nicola Ashman, Yuri Takada, Albert Isidro-Llobet, Jeremy S Parker, Jason S Carroll, David R Spring,

Antibody-drug conjugates (ADCs) harness the highly specific targeting capabilities of an antibody to deliver a cytotoxic payload to specific cell types. They have garnered widespread interest in drug discovery, particularly in oncology, as discrimination between healthy and malignant tissues or cells can be achieved. Nine ADCs have received approval from ... Read more >>

Chem Soc Rev (Chemical Society reviews)
[2020, :]

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Transbronchial cryobiopsy increases diagnostic confidence in interstitial lung disease: a prospective multicentre trial.

Jürgen Hetzel, Athol U Wells, Ulrich Costabel, Thomas V Colby, Simon L F Walsh, Johny Verschakelen, Alberto Cavazza, Sara Tomassetti, Claudia Ravaglia, Michael Böckeler, Werner Spengler, Michael Kreuter, Ralf Eberhardt, Kaid Darwiche, Alfons Torrego, Virginia Pajares, Rainer Muche, Regina Musterle, Marius Horger, Falko Fend, Arne Warth, Claus Peter Heußel, Sara Piciucchi, Alessandra Dubini, Dirk Theegarten, Tomas Franquet, Enrique Lerma, Venerino Poletti, Maik Häntschel,

<h4>Introduction</h4>The accurate diagnosis of individual interstitial lung diseases (ILD) is often challenging, but is a critical determinant of appropriate management. If a diagnosis cannot be made after multidisciplinary team discussion (MDTD), surgical lung biopsy is the current recommended tissue sampling technique according to the most recent guidelines. Transbronchial lung cryobiopsy ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, 56(6):]

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Insights into the genetic architecture of the human face.

Julie D White, Karlijne Indencleef, Sahin Naqvi, Ryan J Eller, Hanne Hoskens, Jasmien Roosenboom, Myoung Keun Lee, Jiarui Li, Jaaved Mohammed, Stephen Richmond, Ellen E Quillen, Heather L Norton, Eleanor Feingold, Tomek Swigut, Mary L Marazita, Hilde Peeters, Greet Hens, John R Shaffer, Joanna Wysocka, Susan Walsh, Seth M Weinberg, Mark D Shriver, Peter Claes,

The human face is complex and multipartite, and characterization of its genetic architecture remains challenging. Using a multivariate genome-wide association study meta-analysis of 8,246 European individuals, we identified 203 genome-wide-significant signals (120 also study-wide significant) associated with normal-range facial variation. Follow-up analyses indicate that the regions surrounding these signals are ... Read more >>

Nat Genet (Nature genetics)
[2021, 53(1):45-53]

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Exposure Assessment Tools for Hypersensitivity Pneumonitis. An Official American Thoracic Society Workshop Report.

Kerri A Johannson, Hayley Barnes, Anne-Pauline Bellanger, Jean-Charles Dalphin, Evans R Fernández Pérez, Kevin R Flaherty, Yuh-Chin T Huang, Kirk D Jones, Leticia Kawano-Dourado, Kevin Kennedy, Melissa Millerick-May, Yasunari Miyazaki, Julie Morisset, Ferran Morell, Ganesh R Raghu, Coreen Robbins, Coralynn S Sack, Margaret L Salisbury, Moises Selman, Martina Vasakova, Simon L F Walsh, Cecile S Rose,

This report is based on proceedings from the Exposure Assessment Tools for Hypersensitivity Pneumonitis (HP) Workshop, sponsored by the American Thoracic Society, that took place on May 18, 2019, in Dallas, Texas. The workshop was initiated by members from the Environmental, Occupational, and Population Health and Clinical Problems Assemblies of ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2020, 17(12):1501-1509]

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Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications.

Andrew T Levin, William P Hanage, Nana Owusu-Boaitey, Kensington B Cochran, Seamus P Walsh, Gideon Meyerowitz-Katz,

Determine age-specific infection fatality rates for COVID-19 to inform public health policies and communications that help protect vulnerable age groups. Studies of COVID-19 prevalence were collected by conducting an online search of published articles, preprints, and government reports that were publicly disseminated prior to 18 September 2020. The systematic review ... Read more >>

Eur J Epidemiol (European journal of epidemiology)
[2020, 35(12):1123-1138]

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Lobular intraepithelial neoplasia: Outcomes and optimal management.

Patrick A Boland, Emma C Dunne, Akvile Kovanaite, Maurice Stokes, Malcolm R Kell, John Mitchel Barry, Margaret Kennedy, Fidelma Flanagan, Siun M Walsh,

<h4>Introduction</h4>Lobular neoplasia is a term encompassing both atypical lobular hyperplasia and lobular carcinoma in situ. These pathological findings are of uncertain malignant potential and predispose to a higher lifetime risk of breast cancer. Debate surrounds the management of such lesions, with the rationale for diagnostic excision based on the possibility ... Read more >>

Breast J (The breast journal)
[2020, 26(12):2383-2390]

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Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes.

Calvin S Carter, Sunny C Huang, Charles C Searby, Benjamin Cassaidy, Michael J Miller, Wojciech J Grzesik, Ted B Piorczynski, Thomas K Pak, Susan A Walsh, Michael Acevedo, Qihong Zhang, Kranti A Mapuskar, Ginger L Milne, Antentor O Hinton, Deng-Fu Guo, Robert Weiss, Kyle Bradberry, Eric B Taylor, Adam J Rauckhorst, David W Dick, Vamsidhar Akurathi, Kelly C Falls-Hubert, Brett A Wagner, Walter A Carter, Kai Wang, Andrew W Norris, Kamal Rahmouni, Garry R Buettner, Jason M Hansen, Douglas R Spitz, E Dale Abel, Val C Sheffield,

Cell Metab (Cell metabolism)
[2020, 32(6):1076]

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Smoking behavior and symptoms of depression and anxiety among young adult backpackers: Results from a short longitudinal study.

Osnat C Melamed, Sophie D Walsh, Shmuel Shulman,

Levels of smoking and smoking initiation have been found to increase during the transition to adulthood. Symptoms of depression and anxiety may both precede or follow smoking behavior, yet there is equivocal evidence regarding the direction of this relationship. The aim of the current study was to examine the direction ... Read more >>

Scand J Psychol (Scandinavian journal of psychology)
[2020, :]

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Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population.

Sandra Walsh, Mercè Izquierdo-Serra, Sandra Acosta, Albert Edo, María Lloret, Roser Moret, Elena Bosch, Baldo Oliva, Jaume Bertranpetit, José Manuel Fernández-Fernández,

TRPP3 (also called PKD2L1) is a nonselective, cation-permeable channel activated by multiple stimuli, including extracellular pH changes. TRPP3 had been considered a candidate for sour sensor in humans, due to its high expression in a subset of tongue receptor cells detecting sour, along with its membership to the TRP channel ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):20999]

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The Role of Conservative Management in Treatment of Critical Limb Ischemia

Sara Mohamed, Deirdre Mc Dermott, Khalid Ahmed, Veronica McInerney, Linda Howard, Muhammad Tubassam, Timothy O'Brien, STEWART WALSH,

<h4>Background: </h4> Revascularization has been considered the gold standard treatment for critical limb ischemia (CLI). Due to the high morbidity and mortality associated with intervention, evidence has emerged recently supporting the suitability of conservative management as a primary option to achieve amputation-free survival (AFS) in CLI patients even when revascularization ... Read more >>

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Cannabidiol: pharmacology and therapeutic targets.

Stevie C Britch, Shanna Babalonis, Sharon L Walsh,

<h4>Rationale</h4>Cannabidiol (CBD) products lacking regulatory approval are being used to self-treat a myriad of conditions and for their unsubstantiated health benefits. The scientific evidence supporting these claims largely arises not from controlled clinical trials, but from the recognition that CBD has numerous biological targets. Yet, CBD is commonly consumed and ... Read more >>

Psychopharmacology (Berl) (Psychopharmacology)
[2021, 238(1):9-28]

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Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Erik Volz, Verity Hill, John T McCrone, Anna Price, David Jorgensen, Áine O'Toole, Joel Southgate, Robert Johnson, Ben Jackson, Fabricia F Nascimento, Sara M Rey, Samuel M Nicholls, Rachel M Colquhoun, Ana da Silva Filipe, James Shepherd, David J Pascall, Rajiv Shah, Natasha Jesudason, Kathy Li, Ruth Jarrett, Nicole Pacchiarini, Matthew Bull, Lily Geidelberg, Igor Siveroni, , Ian Goodfellow, Nicholas J Loman, Oliver G Pybus, David L Robertson, Emma C Thomson, Andrew Rambaut, Thomas R Connor,

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. ... Read more >>

Cell (Cell)
[2021, 184(1):64-75.e11]

Cited: 7 times

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Xanthoma disseminatum: rare normolipidaemic mucocutaneous xanthomatosis.

H Zaaroura, S Walsh,

Clin Exp Dermatol (Clinical and experimental dermatology)
[2020, :]

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