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Improving Diagnosis of Hepatitis C Virus Infection Using Hepatitis C Core Antigen Testing in a Resource-Poor Setting.

Ayswarya Kannan, Lalitha Biswas, Anil Kumar, Jessy Kurian, Anjaly S Nair, Parasmal Suresh, Shine Sadasivan, Raja Biswas,

<h4>Introduction</h4>We compared the hepatitis C virus (HCV) core antigen test with the HCV RNA assay to confirm anti-HCV results to determine whether the HCV core antigen test could be used as an alternative confirmatory test to the HCV RNA test.<h4>Methods</h4>Sera from 156 patients were analyzed for anti-HCV and HCV core ... Read more >>

Rev Soc Bras Med Trop (Revista da Sociedade Brasileira de Medicina Tropical)
[2021, 54:e02532020]

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Correction to: Phosphodiesterase 10A Inhibition Leads to Brain Region-Specific Recovery Based on Stroke Type.

Shirin Z Birjandi, Nora Abduljawad, Shyama Nair, Morteza Dehghani, Kazunori Suzuki, Haruhide Kimura, S Thomas Carmichael,

Transl Stroke Res (Translational stroke research)
[2021, 12(4):691]

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Prevention of Cardiac Surgery-Associated Acute Kidney Injury by Implementing the KDIGO Guidelines in High-Risk Patients Identified by Biomarkers: The PrevAKI-Multicenter Randomized Controlled Trial.

Alexander Zarbock, Mira Küllmar, Marlies Ostermann, Gianluca Lucchese, Kamran Baig, Armando Cennamo, Ronak Rajani, Stuart McCorkell, Christian Arndt, Hinnerk Wulf, Marc Irqsusi, Fabrizio Monaco, Ambra Licia Di Prima, Mercedes García Alvarez, Stefano Italiano, Jordi Miralles Bagan, Gudrun Kunst, Shrijit Nair, Camilla L'Acqua, Eric Hoste, Wim Vandenberghe, Patrick M Honore, John A Kellum, Lui G Forni, Philippe Grieshaber, Christina Massoth, Raphael Weiss, Joachim Gerss, Carola Wempe, Melanie Meersch,

<h4>Background</h4>Prospective, single-center trials have shown that the implementation of the Kidney Disease: Improving Global Outcomes (KDIGO) recommendations in high-risk patients significantly reduced the development of acute kidney injury (AKI) after surgery. We sought to evaluate the feasibility of implementing a bundle of supportive measures based on the KDIGO guideline in ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 133(2):292-302]

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Intraoperative posterior polar cortical disc defect: sign of intact posterior capsule.

Jeewan S Titiyal, Sridevi Nair, Manpreet Kaur, Jyoti Rawat, Saima Ahsan Mazumdar,

<h4>Purpose</h4>To describe the incidence and morphological characteristics of posterior polar cortical disc defect (PPCDD) sign observed during phacoemulsification in posterior polar cataract (PPC).<h4>Setting</h4>Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.<h4>Design</h4>Prospective case series.<h4>Methods</h4>Sixty-seven eyes of 56 patients with PPC undergoing phacoemulsification were evaluated. Outcome ... Read more >>

J Cataract Refract Surg (Journal of cataract and refractive surgery)
[2021, 47(8):1039-1043]

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Efficacy and Safety of Corticosteroids in Acute Respiratory Distress Syndrome: An overview of Meta-analyses.

Muhammed Rashid, Sohil Khan, Divya Datta, Girish Thunga, Viji Pulikkel Chandran, Athira Balakrishnan, Vishal Shanbhag, Raviraja V Acharya, Sreedharan Nair,

<h4>Background</h4>Evidence-based recommendations on efficacy and safety of corticosteroids in acute respiratory distress syndrome (ARDS) remains a therapeutic challenge. Findings from several systematic reviews and meta-analyses are inconsistent. We aimed to assess the published meta-analyses through a systematic review approach and provide further insight into the current uncertainty.<h4>Methodology</h4>We followed the Preferred ... Read more >>

Int J Clin Pract (International journal of clinical practice)
[2021, :e14645]

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Wilms tumor with Mulibrey Nanism: A case report and review of literature.

Karthik Upasana, Dhwanee Thakkar, Dheeraj Gautam, Manvinder Singh Sachdev, Anjali Yadav, Rohit Kapoor, Veena Raghunathan, Maninder Singh Dhaliwal, Kartikeya Bhargava, Sandhya Nair, Jaiprakash Sharma, Neha Rastogi, Satya Prakash Yadav,

<h4>Background</h4>Mulibrey-Nanism (Muscle-liver-brain-eye Nanism = dwarfism; MUL) is a rare genetic syndrome. The underlying TRIM37 mutation predisposes these children to develop tumors frequently. In the largest published series of MUL, 8% patients were reported to develop Wilms tumor (WT). The published literature lacks data regarding the best treatment protocol and outcome of this ... Read more >>

Cancer Rep (Hoboken) (Cancer reports (Hoboken, N.J.))
[2021, :e1512]

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Single-cell atlas reveals meningeal leukocyte heterogeneity in the developing mouse brain.

Aura Zelco, Vanja Börjesson, Jurrian K de Kanter, Cristina Lebrero-Fernandez, Volker M Lauschke, Eridan Rocha-Ferreira, Gisela Nilsson, Syam Nair, Pernilla Svedin, Mats Bemark, Henrik Hagberg, Carina Mallard, Frank C P Holstege, Xiaoyang Wang,

The meninges are important for brain development and pathology. Using single-cell RNA sequencing, we have generated the first comprehensive transcriptional atlas of neonatal mouse meningeal leukocytes under normal conditions and after perinatal brain injury. We identified almost all known leukocyte subtypes and found differences between neonatal and adult border-associated macrophages, ... Read more >>

Genes Dev (Genes & development)
[2021, :]

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Development and validation of an LC-MS/MS method to quantify the bromodomain and extra-terminal (BET) inhibitor JQ1 in mouse plasma and brain microdialysate: Application to cerebral microdialysis study.

Sreenath Nair, Abigail Davis, Olivia Campagne, John D Schuetz, Clinton F Stewart,

JQ1, is a cell-permeable small-molecule inhibitor of bromodomain and extra-terminal protein (BET) function with reportedly good CNS penetration, however, unbound and pharmacologically active CNS JQ1 exposures have not been characterized. Additionally, no quantitative bioanalytical methods for JQ1 have been described in the literature to support the CNS penetration studies. In ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 204:114274]

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Fibromatoses of Head and Neck: Case Series and Literature Review.

Muddasir Bhati, Gurukeerthi Balakrishna, Kamaldeep Joshi, Kajari Bhattacharya, Munita Bal, Sarbani Ghosh Laskar, Shwetabh Sinha, Amit Joshi, Poonam Joshi, Sudhir Nair, Pankaj Chaturvedi,

<h4>Objective</h4>The objective of this study was to retrospectively review clinical data, management protocols, and clinical outcomes of patients with fibromatoses of head and neck region treated at our tertiary care center.<h4>Methods</h4>We retrospectively reviewed the medical records of 11 patients with confirmed histopathological diagnosis of fibromatosis registered in the Department of ... Read more >>

Rambam Maimonides Med J (Rambam Maimonides medical journal)
[2021, 12(3):]

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Mental Health in the Times of Corona: A model for Positive Mental Health During the Global Pandemic.

Jain Mathew, Roseline Florence Gomes, Sheeba Bhaskar, Preksha Yadav, Sridevi Nair,

As the world comes to terms with the changes brought on by the appearance and spread of Covid-19, there is an increase in fear and anxiety levels. The World Health Organization has stressed on the need to focus on mental health, as the epidemic affects both young and old. One ... Read more >>

Psychol Stud (Mysore) (Psychological studies)
[2021, :1-7]

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Randomised, Double-blind, Comparative Clinical Study of New Ranibizumab Biosimilar in Neovascular (Wet) Age-Related Macular Degeneration.

Prasad Apsangikar, Pravin Ghadge, Manoj Naik, Santosh Nair, Ravikiran Payghan,

<h4>Purpose</h4>The study was undertaken for regulatory purposes to establish clinical biosimilarity and interchangeability of a ranibizumab biosimilar with reference product.<h4>Patients and methods</h4>A total of 159 subjects with neovascular (wet) age-related macular degeneration (AMD) were dosed with ranibizumab. Initial double blind period of 16 weeks was followed by open-label phase till ... Read more >>

Clin Ophthalmol (Clinical ophthalmology (Auckland, N.Z.))
[2021, 15:3087-3095]

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Structural and mechanistic investigations of protein S-glycosyltransferases.

Daisuke Fujinami, Chantal V Garcia de Gonzalo, Subhanip Biswas, Yue Hao, Huan Wang, Neha Garg, Tiit Lukk, Satish K Nair, Wilfred A van der Donk,

Attachment of sugars to nitrogen and oxygen in peptides is ubiquitous in biology, but glycosylation of sulfur atoms has only been recently described. Here, we characterize two S-glycosyltransferases SunS and ThuS that selectively glycosylate one of five Cys residues in their substrate peptides; substitution of this Cys with Ser results ... Read more >>

Cell Chem Biol (Cell chemical biology)
[2021, :]

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Commentary: "Save the Nerve": Technical Nuances for Hearing Preservation and Restoration in Vestibular Schwannoma Surgery: 2-Dimensional Operative Video.

Adesh Shrivastava, Suresh Nair,

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2021, :]

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Warming of blood and intravenous fluids using low-power infra-red light-emitting diodes.

Sarath S Nair, V Sreedevi, D S Nagesh,

Non-contact warming of blood and intravenous (IV) fluids with temperature drop compensation is an unmet clinical need till now, for management of hypothermia in patients with urgent requirement of blood. Currently available technologies provide wet warming or dry warming with direct contact using hot water or with a hot plate, ... Read more >>

J Med Eng Technol (Journal of medical engineering & technology)
[2021, :1-13]

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Romidepsin and lenalidomide based regimens have efficacy in relapsed/refractory lymphoma: combined analysis of two phase I studies with expansion cohorts.

Neha Mehta-Shah, Matthew A Lunning, Alison J Moskowitz, Adam M Boruchov, Jia Ruan, Peggy Lynch, Paul A Hamlin, John Leonard, Matthew J Matasar, Patricia L Myskowski, Evan Marzouk, Sumithra Nair, Tamir Sholklapper, Veena Minnal, Maria L Palomba, James Vredenburgh, Anita Kumar, Ariela Noy, David J Straus, Andrew David Zelenetz, Heiko Schoder, Jurgen Rademaker, Wendy Schaffer, Natasha Galasso, Nivetha Ganesan, Steven M Horwitz,

Romidepsin (histone deacetylase inhibitor), lenalidomide (immunomodulatory agent), and carfilzomib (proteasome inhibitor), have efficacy and lack cumulative toxicity in relapsed/refractory lymphoma. We performed two investigator initiated sequential phase I studies to evaluate the maximum tolerated dose (MTD) of romidepsin and lenalidomide (regimen A) and romidepsin, lenalidomide, and carfilzomib (regimen B) in ... Read more >>

Am J Hematol (American journal of hematology)
[2021, :]

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Multiplexed technologies for sexually transmitted infections: global evidence on patient-centered and clinical health outcomes.

Faheel Naeem, Angela Karellis, Suma Nair, Jean-Pierre Routy, Cédric Philippe Yansouni, John Kim, Nitika Pai,

<h4>Introduction</h4>Conventional care packages around screening for sexually transmitted infections (STIs) entail multiple clinic visits and precipitate losses to follow-up. To prevent these losses, multiplexed technologies for STIs (immunochromatographic tests/devices/assays and molecular assays that can screen multiple pathogens or multiple strains of one STI) can yield same-day results in a single ... Read more >>

BMJ Glob Health (BMJ global health)
[2021, 6(7):]

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Postgraduate Physiotherapy Training in a Quandary - Ramifications of Corona virus pandemic Lockdown: A Survey-based Study.

Shailesh Gardas, Shruti Nair, Pothiraj Pitchai, Vrushali Panhale,

<h4>Introduction</h4>Coronavirus disease-2019 (COVID-19) has disrupted clinical services and postgraduate training across the world. Hence, this survey was conducted to understand the impact of pandemic on Physiotherapy post-graduate (PG) education.<h4>Methods</h4>It was a cross-sectional, observational study. A total of 254 Physiotherapy PG trainees were recruited through snowball sampling from Physiotherapy colleges across ... Read more >>

J Adv Med Educ Prof (Journal of advances in medical education & professionalism)
[2021, 9(3):144-153]

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1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long-sought-after mimetics for ortho/meta-substituted arenes.

Jin-Xin Zhao, Yu-Xuan Chang, Chi He, Benjamin J Burke, Michael R Collins, Matthew Del Bel, Jeff Elleraas, Gary M Gallego, T Patrick Montgomery, James J Mousseau, Sajiv K Nair, Matthew A Perry, Jillian E Spangler, Julien C Vantourout, Phil S Baran,

The development of a versatile platform for the synthesis of 1,2-difunctionalized bicyclo[1.1.1]pentanes to potentially mimic <i>ortho</i>/<i>meta</i>-substituted arenes is described. The syntheses of useful building blocks bearing alcohol, amine, and carboxylic acid functional handles have been achieved from a simple common intermediate. Several <i>ortho-</i> and <i>meta</i>-substituted benzene analogs, as well as ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(28):]

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Chronic Low Back Pain: The Therapeutic Benefits of Diagnostic Medial Branch Nerve Blocks.

Michelle Liu, Naum Shaparin, Singh Nair, Ryung S Kim, Jacob R Hascalovici,

<h4>Background</h4>Chronic low back pain (CLBP) is an extremely prevalent disease, whose etiology is often multifactorial. Facet joint arthropathy is one of the most common causes of CLBP. Facet joints are innervated by the medial branches of the primary and adjacent level dorsal rami and are, therefore, key potential targets for ... Read more >>

Pain Physician (Pain physician)
[2021, 24(4):E521-E528]

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Commentary - Should immediate sequential bilateral cataract surgery be the norm in the COVID-19 era?

Sridevi Nair, Manpreet Kaur, Jeewan Singh Titiyal,

Indian J Ophthalmol (Indian journal of ophthalmology)
[2021, 69(7):1961-1962]

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Aurolab aqueous drainage implant in the vitreous cavity: Our modifications over the conventional technique of glaucoma implant surgery.

Vinit J Shah, Syed Mohideen Abdul Khadar, Y C Venugopal Reddy, Syed Saifuddin Adeel, Mohideen Abdul Kader, Rengappa Ramakrishnan, Shobita Nair,

Glaucoma drainage devices (GDDs) are used for managing refractory glaucoma due to failed trabeculectomy, neovascular glaucoma, traumatic glaucoma, and secondary glaucoma post keratoplasty. Aurolab aqueous drainage implant (AADI) is a nonvalved drainage implant conventionally implanted with the tube placed in the anterior chamber. Studies about the outcome of the various ... Read more >>

Indian J Ophthalmol (Indian journal of ophthalmology)
[2021, 69(7):1950-1952]

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Utility of serial optic nerve sheath diameter measurements in patients undergoing cerebral spinal fluid diversion procedures for hydrocephalus.

Susanth Subramanian, Shalini Nair, Ranjith K Moorthy, Grace Rebekah, R Krishnaprabhu, Baylis Vivek Joseph, Vedantam Rajshekhar,

<h4>Background</h4>Functional status of cerebrospinal fluid (CSF) diversion procedure for hydrocephalus is difficult to assess on several occasions. We report the use of serial ultrasonographic measurement of optic nerve sheath diameter (ONSD) to assess the functional status of CSF diversion procedures in patients with hydrocephalus.<h4>Methods</h4>In this prospective observational study, ultrasonographic ONSD ... Read more >>

World Neurosurg (World neurosurgery)
[2021, :]

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Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels.

Sharon R Stevens, Colleen M Longley, Yuki Ogawa, Lindsay H Teliska, Anithachristy S Arumanayagam, Supna Nair, Juan A Oses-Prieto, Alma L Burlingame, Matthew D Cykowski, Mingshan Xue, Matthew N Rasband,

Neuronal ankyrins cluster and link membrane proteins to the actin and spectrin-based cytoskeleton. Among the three vertebrate ankyrins, little is known about neuronal Ankyrin-R (AnkR). We report AnkR is highly enriched in Pv<sup>+</sup> fast-spiking interneurons in mouse and human. We identify AnkR-associated protein complexes including cytoskeletal proteins, cell adhesion molecules ... Read more >>

Elife (eLife)
[2021, 10:]

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Comparison of efficacy of two different doses of tranexamic acid in prevention of post operative blood loss in patients with congenital cyanotic heart disease undergoing cardiac surgery.

Thushara Madathil, Rakhi Balachandran, Brijesh P Kottayil, K R Sundaram, Suresh G Nair,

<h4>Background</h4>The optimal dose of tranexamic acid in minimizing perioperative bleeding is uncertain. We compared efficacy of two different doses of tranexamic acid in reducing post-operative blood loss and its side effects in patients with congenital cyanotic heart disease undergoing cardiac surgery.<h4>Settings and design</h4>Prospective observational study at a pediatric cardiac center ... Read more >>

Ann Card Anaesth (Annals of cardiac anaesthesia)
[2021, 24(3):339-344]

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Intraoperative Optical Coherence Tomography Guided Imaging of Incision-Site Descemet Membrane Dynamics During Phacoemulsification.

Sridevi Nair, Manpreet Kaur, Jeewan Singh Titiyal,

JAMA Ophthalmol (JAMA ophthalmology)
[2021, :]

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