Full Text Journal Articles by
Author S Murphy

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Reply to Wenzel and Kubiak: Neuroticism is best defined by mean levels of negative emotion, not emotional variability.

Elise K Kalokerinos, Sean C Murphy, Peter Koval, Merijn Mestdagh, Brock Bastian, Peter Kuppens,

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, :]

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NICE community-acquired pneumonia guideline review.

Sarah Murphy, Louise Thomson,

Arch Dis Child Educ Pract Ed (Archives of disease in childhood. Education and practice edition)
[2020, :]

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Co-production as an Emerging Methodology for Developing School-Based Health Interventions with Students Aged 11-16: Systematic Review of Intervention Types, Theories and Processes and Thematic Synthesis of Stakeholders' Experiences.

Hayley Reed, Danielle Couturiaux, Marianne Davis, Amy Edwards, Edward Janes, Hyun Sue Kim, G J Melendez-Torres, Simon Murphy, Torill Alise Rotevatn, Jesse Smith, Rhiannon Evans,

Co-production affords an intervention's target population the opportunity to participate in intervention theory decision-making during the development process. This addresses the over-reliance on developing interventions through academic theories which can be devoid of contextual understanding and result in challenges to implementing school-based health programmes. There is an emergent empirical literature ... Read more >>

Prev Sci (Prevention science : the official journal of the Society for Prevention Research)
[2020, :]

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Author Correction: Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction.

Goodwell Nzou, Robert T Wicks, Nicole R VanOstrand, Gehad A Mekky, Stephanie A Seale, Aya El-Taibany, Elizabeth E Wicks, Carl M Nechtman, Eric J Marrotte, Vishruti S Makani, Sean V Murphy, M C Seeds, John D Jackson, Anthony J Atala,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):20384]

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Consulting with young people: informing guidelines for children's palliative care.

Johanna Taylor, Sarah Murphy, Lizzie Chambers, Jan Aldridge,

OBJECTIVE:Increasingly the views of young people are sought when improving healthcare; however, it is unclear how they shape policy or practice. This paper presents a consultation with young people commissioned by the National Institute for Health and Care Excellence (NICE) to inform clinical guidelines for paediatric palliative care (end-of-life care ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, :]

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Digital Care Transformation: Interim Report From the First 5000 Patients Enrolled in a Remote Algorithm-Based Cardiovascular Risk Management Program to Improve Lipid and Hypertension Control.

Benjamin M Scirica, Christopher P Cannon, Naomi D L Fisher, Thomas A Gaziano, David Zelle, Kira Chaney, Angela Miller, Hunter Nichols, Lina Matta, William J Gordon, Shawn Murphy, Kavi B Wagholikar, Jorge Plutzky, Calum A MacRae,

Circulation (Circulation)
[2020, :]

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Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis.

Alexander Neumann, Esther Walton, Silvia Alemany, Charlotte Cecil, Juan Ramon González, Dereje D Jima, Jari Lahti, Samuli T Tuominen, Edward D Barker, Elisabeth Binder, Doretta Caramaschi, Ángel Carracedo, Darina Czamara, Jorunn Evandt, Janine F Felix, Bernard F Fuemmeler, Kristine B Gutzkow, Cathrine Hoyo, Jordi Julvez, Eero Kajantie, Hannele Laivuori, Rachel Maguire, Léa Maitre, Susan K Murphy, Mario Murcia, Pia M Villa, Gemma Sharp, Jordi Sunyer, Katri Raikkönen, Marian Bakermans-Kranenburg, Marinus van IJzendoorn, Mònica Guxens, Caroline L Relton, Henning Tiemeier,

Attention-deficit and hyperactivity disorder (ADHD) is a common childhood disorder with a substantial genetic component. However, the extent to which epigenetic mechanisms play a role in the etiology of the disorder is unknown. We performed epigenome-wide association studies (EWAS) within the Pregnancy And Childhood Epigenetics (PACE) Consortium to identify DNA ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2020, 10(1):398]

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Insights From Rapid Deployment of a "Virtual Hospital" as Standard Care During the COVID-19 Pandemic.

Kranthi Sitammagari, Stephanie Murphy, Marc Kowalkowski, Shih-Hsiung Chou, Matthew Sullivan, Stephanie Taylor, James Kearns, Thomas Batchelor, Carly Rivet, Colleen Hole, Tony Hinson, Pamela McCreary, Ryan Brown, Todd Dunn, Zeev Neuwirth, Andrew McWilliams,

BACKGROUND:Pandemics disrupt traditional health care operations by overwhelming system resource capacity but also create opportunities for care innovation. OBJECTIVE:To describe the development and rapid deployment of a virtual hospital program, Atrium Health hospital at home (AH-HaH), within a large health care system. DESIGN:Prospective case series. SETTING:Atrium Health, a large integrated ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2020, :]

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Pharmacotherapy for Hospitalized Patients with COVID-19: Treatment Patterns by Disease Severity.

Kueiyu Joshua Lin, Sebastian Schneeweiss, Helen Tesfaye, Elvira D'Andrea, Jun Liu, Joyce Lii, Shawn N Murphy, Joshua J Gagne,

BACKGROUND:Treatment decisions for Coronavirus Disease 2019 (COVID-19) depend on disease severity, but the prescribing pattern by severity and drivers of therapeutic choices remain unclear. OBJECTIVES:The objectives of the study were to evaluate pharmacological treatment patterns by COVID-19 severity and identify the determinants of prescribing for COVID-19. METHODS:Using electronic health record ... Read more >>

Drugs (Drugs)
[2020, :]

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Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression.

Liliana P Capitão, Robert Chapman, Nicola Filippini, Lucy Wright, Susannah E Murphy, Anthony James, Phil J Cowen, Catherine J Harmer,

Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the effects of a single dose of fluoxetine vs. placebo in adolescents with major depressive disorder. In contrast with previous studies in adults ... Read more >>

J Psychopharmacol (Journal of psychopharmacology (Oxford, England))
[2020, :269881120959608]

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Cardiologist Evaluation of Patients with Type 2 Myocardial Infarction.

Cian P McCarthy, David S Olshan, Saad Rehman, Maeve Jones-O'Connor, Sean Murphy, Joshua A Cohen, Avinainder Singh, Muthiah Vaduganathan, James L Januzzi, Jason H Wasfy,

Circ Cardiovasc Qual Outcomes (Circulation. Cardiovascular quality and outcomes)
[2020, :]

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Time to surgery and composite graft survival in paediatric fingertip amputations: A systematic literature review.

O Abbassi, S Murphy, Q Young Sing,

J Plast Reconstr Aesthet Surg (Journal of plastic, reconstructive & aesthetic surgery : JPRAS)
[2020, :]

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Effect of Evolocumab on Complex Coronary Disease Requiring Revascularization.

Kazuma Oyama, Remo H M Furtado, Antonio Fagundes, Thomas A Zelniker, Minao Tang, Julia Kuder, Sabina A Murphy, Andrew Hamer, Huei Wang, Anthony C Keech, Robert P Giugliano, Marc S Sabatine, Brian A Bergmark,

BACKGROUND:Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors induce plaque regression and reduce the risk of coronary revascularization overall. OBJECTIVES:To evaluate the ability of PCSK9 inhibitors to reduce the risk of complex coronary atherosclerosis requiring revascularization. METHODS:FOURIER was a randomized trial of the PCSK9 inhibitor evolocumab vs. placebo in 27,564 patients ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2020, :]

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Neuronal/astrocytic expression of chemokine (C-C motif) ligand 2 is associated with monocyte/macrophage recruitment in male chronic pelvic pain.

Zhiqiang Liu, Stephen F Murphy, Larry Wong, Anthony J Schaeffer, Praveen Thumbikat,

Chronic pelvic pain syndrome is a multisymptom syndrome with unknown etiology. The experimental autoimmune prostatitis (EAP) mouse model of chronic pelvic pain syndrome is associated with immune cell infiltration into the prostate, expression of C-C chemokine ligand 2 (CCL2), and neuroinflammation in the spinal cord. Here, we studied CCL2 expression ... Read more >>

Pain (Pain)
[2020, 161(11):2581-2591]

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c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis.

Jack Leslie, Marina García Macia, Saimir Luli, Julie C Worrell, William J Reilly, Hannah L Paish, Amber Knox, Ben S Barksby, Lucy M Gee, Marco Y W Zaki, Amy L Collins, Rachel A Burgoyne, Rainie Cameron, Charlotte Bragg, Xin Xu, Git W Chung, Colin D A Brown, Andrew D Blanchard, Carmel B Nanthakumar, Morten Karsdal, Stuart M Robinson, Derek M Manas, Gourab Sen, Jeremy French, Steven A White, Sandra Murphy, Matthias Trost, Johannes L Zakrzewski, Ulf Klein, Robert F Schwabe, Ingmar Mederacke, Colin Nixon, Tom Bird, Laure-Anne Teuwen, Luc Schoonjans, Peter Carmeliet, Jelena Mann, Andrew J Fisher, Neil S Sheerin, Lee A Borthwick, Derek A Mann, Fiona Oakley,

Fibrosis is a common pathological feature of chronic disease. Deletion of the NF-κB subunit c-Rel limits fibrosis in multiple organs, although the mechanistic nature of this protection is unresolved. Using cell-specific gene-targeting manipulations in mice undergoing liver damage, we elucidate a critical role for c-Rel in controlling metabolic changes required ... Read more >>

Nat Metab (Nature metabolism)
[2020, 2(11):1350-1367]

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Optimizing clinical cytology touch preparations for next generation sequencing.

Stephen J Murphy, Faye R Harris, James B Smadbeck, Vishnu Serla, Giannoula Karagouga, Sarah H Johnson, Farhad Kosari, Karlyn E Pierson, Aaron O Bungum, Eric S Edell, Aaron S Mansfield, Dennis A Wigle, Benjamin R Kipp, George Vasmatzis, Marie Christine Aubry,

Intraoperative diagnosis is routinely performed on cytology touch preparations (TPs) from core needle biopsies (CNBs). Current interest promotes their utility as an important source of patient tissue for clinical genomic testing. Herein we present whole genome structural variant analysis (SVA) from mate-pair sequencing (MPseq) and whole exome sequencing (WES) mutation ... Read more >>

Genomics (Genomics)
[2020, :]

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Developing whole-school mental health and wellbeing intervention through pragmatic formative process evaluation: A case-study of innovative local practice within the School Health Research Network

Nina Gobat, Hannah Littlecott, Andy Williams, Kirsten McEwan, Helen Stanton, Michael Robling, Stephen Rollnick, Simon Murphy, Rhiannon Evans,

Abstract Background: The evidence-base for whole school approaches aimed at improving student mental health and wellbeing remains limited. This may be due to a focus on developing and evaluating de-novo, research-led interventions, while neglecting the potential of local, contextually-relevant innovation that has demonstrated acceptability and feasibility. This study reports a ... Read more >>

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Ethical frameworks for quality improvement activities: an analysis of international practice.

Corina Naughton, Elaine Meehan, Elaine Lehane, Ciara Landers, Sarah Jane Flaherty, Aoife Lane, Margaret Landers, Caroline Kilty, Mohamad Saab, John Goodwin, Nuala Walshe, Teresa Wills, Vera Mccarthy, Siobhan Murphy, Joan Mccarthy, Helen Cummins, Deirdre Madden, Josephine Hegarty,

PURPOSE:To examine international approaches to the ethical oversight and regulation of quality improvement and clinical audit in healthcare systems. DATA SOURCES:We searched grey literature including websites of national research and ethics regulatory bodies and health departments of selected countries. STUDY SELECTION:National guidance documents were included from six countries: Ireland, England, ... Read more >>

Int J Qual Health Care (International journal for quality in health care : journal of the International Society for Quality in Health Care)
[2020, 32(8):558-566]

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Atrial Natriuretic Peptide and Treatment With Sacubitril/Valsartan in Heart Failure With Reduced Ejection Fraction.

Sean P Murphy, Margaret F Prescott, Alexander Camacho, Seethalakshmi R Iyer, Alan S Maisel, G Michael Felker, Javed Butler, Ileana L Piña, Nasrien E Ibrahim, Cheryl Abbas, John C Burnett, Scott D Solomon, James L Januzzi,

OBJECTIVES:This study sought to assess associations between longitudinal change in atrial natriuretic peptide (ANP) and reverse cardiac remodeling following initiation of sacubitril/valsartan in patients with heart failure with reduced ejection fraction (HFrEF). BACKGROUND:Neprilysin inhibition results in an increase of several vasoactive peptides that may mediate the beneficial effects of sacubitril/valsartan, ... Read more >>

JACC Heart Fail (JACC. Heart failure)
[2020, :]

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Collecting genetic samples and linked mental health data from adolescents in schools: Protocol co-production and a mixed-methods pilot of feasibility and acceptability

Naomi Warne, Sarah Rook, Rhys Bevan-Jones, Rachel Brown, Lesley Bates, Lucinda Hopkins-Jones, Alexandra Evans, Jeremy Hall, Kate Langley, Anita Thapar, James Walters, Simon Murphy, Graham Moore, Frances Rice, Stephan Collishaw,

Abstract Objectives To co-produce a school-based protocol and examine acceptability and feasibility of collecting saliva samples for genetic studies from young adolescent students in schools for the purpose of mental health research. Design Protocol co-production and mixed-methods feasibility pilot. Setting: Secondary schools in Wales, UK. Participants Year 7 and 8 ... Read more >>

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Effect of Sand on Knee Load During a Single-Leg Jump Task: Implications for Injury Prevention and Rehabilitation Programs.

Mark C Richardson, Sinead Murphy, Tom Macpherson, Bryan English, Iain Spears, Paul Chesterton,

Richardson, MC, Murphy, S, Macpherson, T, English, B, Spears, I, and Chesterton, P. Effect of sand on knee load during a single-leg jump task: implications for injury prevention and rehabilitation programs. J Strength Cond Res 34(11): 3164-3172, 2020-The purpose of the study was to determine potential differences in landing strategies ... Read more >>

J Strength Cond Res (Journal of strength and conditioning research)
[2020, 34(11):3164-3172]

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The cost of opioid use disorder and the value of aversion.

Sean M Murphy,

BACKGROUND:The objective of this study was twofold. First, to update and estimate the economic burden of opioid use disorder (OUD) to the U.S. from the perspectives of the healthcare sector, taxpayer, and society, overall and by age. Second, to estimate the mean present value of averting an OUD, overall and ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2020, :108382]

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Oculomotor, vestibular, reaction time and cognitive eye-tracking mild traumatic brain injury assessment.

Alex Kiderman, Michael Hoffer, Mikhaylo Szczupak, Hillary Snapp, Sara Murphy, Kate Marshall, James Crawford, Aura Kullmann, Robin Ashmore, Jane Chung, Carey Balaban,

OBJECTIVE:Can oculomotor, vestibular, reaction time and cognitive eye-tracking tests (OVRT-C) assess mild traumatic brain injury? BACKGROUND:OVRT-C tests using eye tracking technology have been employed in our previous studies for assessing mild traumatic brain injury (mTBI). Here we present a composite Concussion Assessment algorithm that incorporates these findings. DESIGN/METHODS:Concussion Assessment algorithm ... Read more >>

Neurology (Neurology)
[2020, 95(20 Supplement 1):S2]

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Lipocalin-2 Expression in Pancreas Adenocarcinoma Tumor Microenvironment Via Endoscopic Ultrasound Fine Needle Biopsy Is Feasible and May Reveal a Therapeutic Target.

Ferga C Gleeson, Michael J Levy, Rory A Jackson, Stephen J Murphy, Kevin C Halling, Benjamin R Kipp, Rondell P Graham, Lizhi Zhang,

Pancreas (Pancreas)
[2020, 49(10):e98-e99]

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Healthcare utilization patterns among persons who use drugs during the COVID-19 pandemic.

Sean M Murphy, James Yoder, Jyotishman Pathak, Jonathan Avery,

Persons with drug use disorders are an underserved and stigmatized population, and the COVID-19 pandemic could exacerbate these issues. The discussion around those with drug use disorders in the midst of the pandemic has focused on the need to ensure uninterrupted treatment access; however, very few in this population actually ... Read more >>

J Subst Abuse Treat (Journal of substance abuse treatment)
[2020, :108177]

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