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Personalized tumor-specific DNA junctions to detect circulating tumor in patients with endometrial cancer.

Tommaso Grassi, Faye R Harris, James B Smadbeck, Stephen J Murphy, Matthew S Block, Francesco Multinu, Janet L Schaefer Klein, Piyan Zhang, Giannoula Karagouga, Minetta C Liu, Alyssa Larish, Maureen A Lemens, Marla Kay S Sommerfield, Serena Cappuccio, John C Cheville, George Vasmatzis, Andrea Mariani,

<h4>Introduction</h4>There are no reliable blood biomarkers for monitoring endometrial cancer patients in the current clinical practice. Circulating tumor DNA (ctDNA) is emerging as a promising non-invasive method to measure tumor burden, define prognosis and monitor disease status in many solid cancers. In this pilot study, we investigated if unique tumor-specific ... Read more >>

PLoS One (PloS one)
[2021, 16(6):e0252390]

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Distortion product otoacoustic mapping measured pre- and post-loud sound exposures.

Chris A Brooks, Odile H Clavier, Abigail M Fellows, Catherine C Rieke, Christopher E Niemczak, Jiang Gui, Nina J Pryor, Hilary L Gallagher, Sara A Murphy, Sean R Wise, Claire Healy-Leavitt, Lindsay V Allen, Jay C Buckey,

<h4>Objective</h4>Sampling distortion product otoacoustic emissions (DPOAEs) at multiple f<sub>2</sub>/f<sub>1</sub> ratios and f<sub>2</sub> frequency values produces a DPOAE "map." This study examined the efficacy of DPOAE mapping compared with pure tone audiometry and standard DPOAEs for detecting noise effects in subjects exposed to loud sound.<h4>Design</h4>A map significance score was developed as ... Read more >>

Int J Audiol (International journal of audiology)
[2021, :1-10]

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HSV-1 ICP22 is a selective viral repressor of cellular RNA polymerase II-mediated transcription elongation

Nur Isa, Olivier Bensaude, Nadiah Aziz, Shona Murphy,

The Herpes Simplex Virus (HSV-1) immediate early protein ICP22 interacts with cellular proteins to inhibit host cell gene expression and promote viral gene expression. ICP22 inhibits phosphorylation of Ser2 of the RNA polymerase II (pol II) carboxyl-terminal domain (CTD) and productive elongation of pol II. Here we show that ICP22 ... Read more >>

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Deep learning connects DNA traces to transcription to reveal predictive features beyond enhancer-promoter contact.

Aparna R Rajpurkar, Leslie J Mateo, Sedona E Murphy, Alistair N Boettiger,

Chromatin architecture plays an important role in gene regulation. Recent advances in super-resolution microscopy have made it possible to measure chromatin 3D structure and transcription in thousands of single cells. However, leveraging these complex data sets with a computationally unbiased method has been challenging. Here, we present a deep learning-based ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):3423]

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Imprecisely georeferenced specimen data provide unique information on species' distributions and environmental tolerances: Don't let the perfect be the enemy of the good

Adam Smith, Stephen Murphy, David Henderson, Kelley Erickson,

Conservation assessments frequently use occurrence records to estimate species' geographic distributions and environmental tolerances. Typically, records with imprecise geolocality information are discarded before analysis because they cannot be matched confidently to environmental conditions. However, removing records can artificially truncate species' environmental and geographic distributions. Here we evaluate the trade-offs between ... Read more >>

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Hand sanitiser-fuelled fire performance and thermal injury: case report.

Samantha T Murphy, Leopoldo C Cancio,

A 23-year-old man presented to our burn center after sustaining a 62.5% total body surface area burn during a fire performance, in which he applied alcohol-based hand sanitiser to his body and ignited it. The patient underwent 6 operations at this facility and was discharged after 41 days. Fire-performance art ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(6):]

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Protocol for a two-arm pragmatic stepped-wedge hybrid effectiveness-implementation trial evaluating Engagement and Collaborative Management to Proactively Advance Sepsis Survivorship (ENCOMPASS).

Marc Kowalkowski, Tara Eaton, Andrew McWilliams, Hazel Tapp, Aleta Rios, Stephanie Murphy, Ryan Burns, Bella Gutnik, Katherine O'Hare, Lewis McCurdy, Michael Dulin, Christopher Blanchette, Shih-Hsiung Chou, Scott Halpern, Derek C Angus, Stephanie P Taylor,

<h4>Background</h4>Sepsis survivors experience high morbidity and mortality, and healthcare systems lack effective strategies to address patient needs after hospital discharge. The Sepsis Transition and Recovery (STAR) program is a navigator-led, telehealth-based multicomponent strategy to provide proactive care coordination and monitoring of high-risk patients using evidence-driven, post-sepsis care tasks. The purpose ... Read more >>

BMC Health Serv Res (BMC health services research)
[2021, 21(1):544]

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Identifying the Best Questions for Rapid Screening of Secondhand Smoke Exposure Among Children.

Albert J Ksinan, Yaou Sheng, Elizabeth K Do, Julia C Schechter, Junfeng Jim Zhang, Rachel L Maguire, Cathrine Hoyo, Susan K Murphy, Scott H Kollins, Bruce Rubin, Bernard F Fuemmeler,

<h4>Introduction</h4>Many children suffer from secondhand smoke exposure (SHSe), which leads to a variety of negative health consequences. However, there is no consensus on how clinicians can best query parents for possible SHSe among children. We employed a data-driven approach to create an efficient screening tool for clinicians to quickly and ... Read more >>

Nicotine Tob Res (Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco)
[2021, 23(7):1217-1223]

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The Digital Analytic Patient Reviewer (DAPR) for COVID-19 Data Mart Validation

Heekyong Park, Taowei David Wang, Nich Wattanasin, Victor Castro, Vivian Gainer, Sergey Goryachev, Shawn Murphy,

<h4>Objective</h4> To provide high-quality data for COVID-19 research, we validated COVID-19 clinical indicators and 22 associated computed phenotypes, which were derived by machine learning algorithms, in the Mass General Brigham (MGB) COVID-19 Data Mart. <h4>Materials and Methods</h4> Fifteen reviewers performed a manual chart review for 150 COVID-19 positive patients in ... Read more >>

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Measurement invariance of the short Warwick-Edinburgh Mental Wellbeing Scale and latent mean differences (SWEMWBS) in young people by current care status.

Rebecca Anthony, Graham Moore, Nicholas Page, Gillian Hewitt, Simon Murphy, G J Melendez-Torres,

<h4>Purpose</h4>Studying mental wellbeing requires the use of reliable, valid, and practical assessment tools, such as the Short version of the Warwick-Edinburgh Mental Wellbeing Scale (SWEMWBS). Research on the mental wellbeing of children in care is sparse. The current study aims to: (1) examine the unidimensionality of SWEMWBS; (2) assess measurement ... Read more >>

Qual Life Res (Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation)
[2021, :]

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PfSPZ-CVac efficacy against malaria increases from 0% to 75% when administered in the absence of erythrocyte stage parasitemia: A randomized, placebo-controlled trial with controlled human malaria infection.

Sean C Murphy, Gregory A Deye, B Kim Lee Sim, Shirley Galbiati, Jessie K Kennedy, Kristen W Cohen, Sumana Chakravarty, Natasha Kc, Yonas Abebe, Eric R James, James G Kublin, Stephen L Hoffman, Thomas L Richie, Lisa A Jackson,

PfSPZ-CVac combines 'PfSPZ Challenge', which consists of infectious Plasmodium falciparum sporozoites (PfSPZ), with concurrent antimalarial chemoprophylaxis. In a previously-published PfSPZ-CVac study, three doses of 5.12x104 PfSPZ-CVac given 28 days apart had 100% vaccine efficacy (VE) against controlled human malaria infection (CHMI) 10 weeks after the last immunization, while the same ... Read more >>

PLoS Pathog (PLoS pathogens)
[2021, 17(5):e1009594]

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Patient Activation, Depressive Symptoms, and Self-Rated Health: Care Management Intervention Effects among High-Need, Medically Complex Adults.

Cynthia F Corbett, Kenn B Daratha, Sterling McPherson, Crystal L Smith, Michael S Wiser, Brenda K Vogrig, Sean M Murphy, Roy Cantu, Dennis G Dyck,

The purpose of this randomized controlled trial (<i>n</i> = 268) at a Federally Qualified Health Center was to evaluate the outcomes of a care management intervention versus an attention control telephone intervention on changes in patient activation, depressive symptoms and self-rated health among a population of high-need, medically complex adults. ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(11):]

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A taxonomy of risk-associated alternative health practices: A Delphi study.

Bernie Garrett, Timothy Caulfield, Blake Murdoch, Matt Brignall, Atul Kumar Kapur, Susan Murphy, Erin Nelson, Jillian Reardon, Mark Harrison, Jonathan Hislop, Barbara J Wilson-Keates, Joseph Anthony, Peter S Loewen, Richard M Musoke, Joan Braun,

Defining alternative health care and the recording of associated adverse events and harm remains problematic. This Canadian study aimed to establish and classify risk-associated alternative health practices in a Delphi study undertaken with an interdisciplinary panel of 17 health experts in 2020. It provides a new functional definition of alternative ... Read more >>

Health Soc Care Community (Health & social care in the community)
[2021, :]

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A Dietary Supplement Frequency Questionnaire Correctly Ranks Nutrient Intakes in US Older Adults When Compared to a Comprehensive Dietary Supplement Inventory.

Alana D Steffen, Lynne R Wilkens, Kim M Yonemori, Cheryl L Albright, Suzanne P Murphy,

<h4>Background</h4>Dietary supplements are commonly taken by adults in the United States and can contribute substantially to daily nutrient intakes. Short supplement-use questionnaires are often used in dietary surveys, but their accuracy has not been well studied.<h4>Objectives</h4>The primary objective was to evaluate the accuracy of a short, self-administered supplement frequency questionnaire ... Read more >>

J Nutr (The Journal of nutrition)
[2021, :]

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The effect of the SARS-CoV-2 pandemic and civil unrest on massive transfusion protocol activations in Minneapolis 2020.

Alexander L Braun, Jed B Gorlin, Jessica Peters, Sherrie Murphy, Nancy L Van Buren,

<h4>Background</h4>The year 2020 presented the transfusion community with unprecedented events and challenges, including the ongoing SARS-CoV-2 (COVID-19) pandemic, and more recently by civil unrest, following the death of George Floyd in late May of 2020. As a level 1 trauma center located in Minneapolis, Minnesota, Hennepin Healthcare (HCMC) offers a ... Read more >>

Transfusion (Transfusion)
[2021, :]

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International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries.

Florence T Bourgeois, Alba Gutiérrez-Sacristán, Mark S Keller, Molei Liu, Chuan Hong, Clara-Lea Bonzel, Amelia L M Tan, Bruce J Aronow, Martin Boeker, John Booth, Jaime Cruz Rojo, Batsal Devkota, Noelia García Barrio, Nils Gehlenborg, Alon Geva, David A Hanauer, Meghan R Hutch, Richard W Issitt, Jeffrey G Klann, Yuan Luo, Kenneth D Mandl, Chengsheng Mao, Bertrand Moal, Karyn L Moshal, Shawn N Murphy, Antoine Neuraz, Kee Yuan Ngiam, Gilbert S Omenn, Lav P Patel, Miguel Pedrera Jiménez, Neil J Sebire, Pablo Serrano Balazote, Arnaud Serret-Larmande, Andrew M South, Anastasia Spiridou, Deanne M Taylor, Patric Tippmann, Shyam Visweswaran, Griffin M Weber, Isaac S Kohane, Tianxi Cai, Paul Avillach, ,

<h4>Importance</h4>Additional sources of pediatric epidemiological and clinical data are needed to efficiently study COVID-19 in children and youth and inform infection prevention and clinical treatment of pediatric patients.<h4>Objective</h4>To describe international hospitalization trends and key epidemiological and clinical features of children and youth with COVID-19.<h4>Design, setting, and participants</h4>This retrospective cohort study ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(6):e2112596]

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Nonhuman primate models for SARS-CoV-2 research: Infrastructure needs for pandemic preparedness.

Sheri Ann Hild, Michael C Chang, Stephanie J Murphy, Franziska B Grieder,

Lab Anim (NY) (Lab animal)
[2021, 50(6):140-141]

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Characterizing initiation, use, and discontinuation of extended-release buprenorphine in a nationally representative United States commercially insured cohort.

Jake R Morgan, Alexander Y Walley, Sean M Murphy, Avik Chatterjee, Scott E Hadland, Joshua Barocas, Benjamin P Linas, Sabrina A Assoumou,

<h4>Background and aims</h4>While the United States is in the midst of an overdose epidemic, effective treatments are underutilized and commonly discontinued. Innovations in medication delivery, including an extended-release formulations, have the potential to improve treatment access and reduce discontinuation. We sought to assess extended-release buprenorphine discontinuation among individuals with opioid ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2021, 225:108764]

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Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial.

Katie J Ewer, Jordan R Barrett, Sandra Belij-Rammerstorfer, Hannah Sharpe, Rebecca Makinson, Richard Morter, Amy Flaxman, Daniel Wright, Duncan Bellamy, Mustapha Bittaye, Christina Dold, Nicholas M Provine, Jeremy Aboagye, Jamie Fowler, Sarah E Silk, Jennifer Alderson, Parvinder K Aley, Brian Angus, Eleanor Berrie, Sagida Bibi, Paola Cicconi, Elizabeth A Clutterbuck, Irina Chelysheva, Pedro M Folegatti, Michelle Fuskova, Catherine M Green, Daniel Jenkin, Simon Kerridge, Alison Lawrie, Angela M Minassian, Maria Moore, Yama Mujadidi, Emma Plested, Ian Poulton, Maheshi N Ramasamy, Hannah Robinson, Rinn Song, Matthew D Snape, Richard Tarrant, Merryn Voysey, Marion E E Watson, Alexander D Douglas, Adrian V S Hill, Sarah C Gilbert, Andrew J Pollard, Teresa Lambe, ,

Nat Med (Nature medicine)
[2021, :]

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Focused ultrasound of the caudal vena cava in dogs with cavitary effusions or congestive heart failure: A prospective, observational study.

Yen-Yu Chou, Jessica L Ward, Lara Z Barron, Shane D Murphy, Melissa A Tropf, Gregory R Lisciandro, Lingnan Yuan, Jonathan P Mochel, Teresa C DeFrancesco,

<h4>Introduction</h4>Ultrasonographic indices of the inferior vena cava are useful for predicting right heart filling pressures in people.<h4>Objectives</h4>To determine whether ultrasonographic indices of caudal vena cava (CVC) differ between dogs with right-sided CHF (R-CHF), left-sided CHF (L-CHF), and noncardiac causes of cavitary effusion (NC).<h4>Materials and methods</h4>113 dogs diagnosed with R-CHF (n ... Read more >>

PLoS One (PloS one)
[2021, 16(5):e0252544]

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Inflammatory cytokines, high-sensitivity C-reactive protein, and risk of one-year vascular events, death, and poor functional outcome after stroke and transient ischemic attack.

S Coveney, S Murphy, O Belton, T Cassidy, M Crowe, E Dolan, M de Gaetano, J Harbison, G Horgan, M Marnane, J J McCabe, A Merwick, I Noone, D Williams, P J Kelly,

<h4>Background</h4>Inflammation driven by pro-inflammatory cytokines is a new therapeutic target in coronary disease. Few data exist on the association of key upstream cytokines and post-stroke recurrence. In a prospective cohort study, we investigated the association between pivotal cytokines, high-sensitivity C-reactive protein (hsCRP) and one-year outcomes.<h4>Methods</h4>BIO-STROKETIA is a multi-center prospective cohort ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2021, :1747493021995595]

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Correction to: Neurophysiological and ophthalmological findings of SPG7-related spastic ataxia: a phenotype study in an Irish cohort.

Petya Bogdanova-Mihaylova, Hongying Chen, Helena Maria Plapp, Ciara Gorman, Michael D Alexander, John C McHugh, Sharon Moran, Anne Early, Lorraine Cassidy, Timothy Lynch, Sinéad M Murphy, Richard A Walsh,

J Neurol (Journal of neurology)
[2021, :]

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Paediatric neurosurgical implications of a ribosomopathy: illustrative case and literature review.

Suzanne Murphy, Gabriella Grima, Kshitij Mankad, Kristian Aquilina,

Ribosomopathies are rare, recently defined entities. One of these, Labrune syndrome, is recognisable radiologically by its distinctive triad of leukoencephalopathy, intracranial calcifications and cysts (LCC). These cysts may have neurosurgical implications at different ages because of their progressive expansion and local mass effect. The aetiology of LCC is related to ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2021, :]

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Association Between Angiotensin Receptor-Neprilysin Inhibition, Cardiovascular Biomarkers, and Cardiac Remodeling in Heart Failure with Reduced Ejection Fraction.

Sean P Murphy, Margaret F Prescott, Alan S Maisel, Javed Butler, Ileana L Piña, G Michael Felker, Jonathan H Ward, Kristin M Williamson, Alexander Camacho, Ritvik R Kandanelly, Scott D Solomon, James L Januzzi,

<b><i>Background</i></b>: Sacubitril/valsartan (S/V) treatment is associated with reverse cardiac remodeling and reductions in biomarkers reflecting ventricular wall stress and myocardial injury, such as N-terminal pro B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT) and soluble suppressor of tumorigenicity-2 (sST2). How longitudinal changes in these biomarkers analyzed collectively are associated ... Read more >>

Circ Heart Fail (Circulation. Heart failure)
[2021, :]

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IFN-alpha receptor deficiency enhances host resistance to oral Salmonella enterica serovar Typhimurium infection during murine pregnancy.

Gerard Agbayani, Kristina Clark, Jagdeep K Sandhu, Melissa Hewitt, Subash Sad, Shawn P Murphy, Lakshmi Krishnan,

<h4>Problem</h4>Maternal tolerance during pregnancy increases the risk of infection with certain intracellular pathogens. Systemic Salmonella enterica serovar Typhimurium (S.Tm) infection during pregnancy in normally resistant 129X1/SvJ mice leads to severe placental infection, as well as fetal and maternal deaths. However, the effect of oral infection with S.Tm in pregnant mice ... Read more >>

Am J Reprod Immunol (American journal of reproductive immunology (New York, N.Y. : 1989))
[2021, :e13454]

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