Full Text Journal Articles by
Author S Morris

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The association between use of chemsex drugs and HIV clinic attendance among gay and bisexual men living with HIV in London.

A R Howarth, V Apea, S Michie, S Morris, M Sachikonye, C H Mercer, A Evans, V C Delpech, C Sabin, F M Burns,

<h4>Objectives</h4>To investigate the association between chemsex drug use and HIV clinic attendance among gay and bisexual men in London.<h4>Methods</h4>A cross-sectional survey of adults (> 18 years) diagnosed with HIV for > 4 months, attending seven London HIV clinics (May 2014 to August 2015). Participants self-completed an anonymous questionnaire linked to clinical data. Sub-optimal clinic ... Read more >>

HIV Med (HIV medicine)
[2021, :]

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Could COVID-19 Reverse the Modest Gains Made in Newborn Health in Ethiopia?

Abiy Seifu Estifanos, Kescha Kazmi, Shaun K Morris,

<h4>Introduction</h4>Ethiopia has made remarkable progress in reducing childhood and neonatal mortality in the last two decades. However, with the spread of the COVID-19 pandemic in Ethiopia, disruptions in routine health care pose a significant risk in reversing the gains made in neonatal mortality reduction.<h4>Methods</h4>Using the World Health Organization's health systems ... Read more >>

Matern Child Health J (Maternal and child health journal)
[2021, :]

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Mortality and AIDS-defining events among young people following transition from paediatric to adult HIV care in the UK.

H Asad, I J Collins, R L Goodall, S Crichton, T Hill, K Doerholt, C Foster, H Lyall, F A Post, S Welch, A Winston, C A Sabin, A Judd, ,

<h4>Objectives</h4>To investigate risk of AIDS and mortality after transition from paediatric to adult care in a UK cohort of young people with perinatally acquired HIV.<h4>Methods</h4>Records of people aged ≥ 13 years on 31 December 2015 in the UK paediatric HIV cohort (Collaborative HIV Paediatric Study) were linked to those of adults in the ... Read more >>

HIV Med (HIV medicine)
[2021, :]

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Publisher Correction: Ferroelastic-switching-driven large shear strain and piezoelectricity in a hybrid ferroelectric.

Yuzhong Hu, Lu You, Bin Xu, Tao Li, Samuel Alexander Morris, Yongxin Li, Yehui Zhang, Xin Wang, Pooi See Lee, Hong Jin Fan, Junling Wang,

Nat Mater (Nature materials)
[2021, 20(5):711]

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Determining the Impact of Hogget Breeding Performance on Profitability under a Fixed Feed Supply Scenario in New Zealand.

Lydia J Farrell, Paul R Kenyon, Peter R Tozer, Stephen T Morris,

Hoggets (ewe lambs aged 4 to 16 months) can be bred from approximately 8 months of age for potentially increased flock production and profit, however most New Zealand hoggets are not presented for breeding and their reproductive success is highly variable. Bio-economic modelling was used to analyse flock productivity and ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2021, 11(5):]

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The effect of care provided by paediatric critical care transport teams on mortality of children transported to paediatric intensive care units in England and Wales: a retrospective cohort study.

Sarah E Seaton, Elizabeth S Draper, Christina Pagel, Fatemah Rajah, Jo Wray, Padmanabhan Ramnarayan, ,

<h4>Background</h4>Centralisation of paediatric intensive care units (PICUs) has the increased the need for specialist paediatric critical care transport teams (PCCT) to transport critically ill children to PICU. We investigated the impact of care provided by PCCTs for children on mortality and other clinically important outcomes.<h4>Methods</h4>We analysed linked national data from ... Read more >>

BMC Pediatr (BMC pediatrics)
[2021, 21(1):217]

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Loss of growth hormone signaling in the mouse germline or in adulthood reduces islet mass and alters islet function with notable sex differences.

Silvana Duran-Ortiz, Kathryn L Corbin, Ishrat Jahan, Nicholas B Whitticar, Sarah E Morris, Ania N Bartholomew, Kira G Slepchenko, Hannah L West, Ibiagbani M Max-Harry, Edward O List, John J Kopchick, Craig S Nunemaker,

In the endocrine pancreas, growth hormone (GH) is known to promote pancreatic islet growth and insulin secretion. In this study, we show that GH receptor (GHR) loss in the germline and in adulthood impacts islet mass in general but more profoundly in male mice. GHR knockout (GHRKO) mice have enhanced ... Read more >>

Am J Physiol Endocrinol Metab (American journal of physiology. Endocrinology and metabolism)
[2021, :]

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Yersinia enterocolitica Outbreak Associated with Pasteurized Milk.

Joann F Gruber, Sheri Morris, Kimberly A Warren, Kelly E Kline, Betsy Schroeder, Lisa Dettinger, Brigitte Husband, Kerry Pollard, Carina Davis, Judith Miller, Andre Weltman, Mia Mattioli, Logan Ray, Cheryl Tarr, Allison H Longenberger,

In July 2019, we investigated a cluster of <i>Yersinia enterocolitica</i> cases affecting a youth summer camp and nearby community in northeastern Pennsylvania. After initial telephone interviews with camp owners and community members, we identified pasteurized milk from a small dairy conducting on-site pasteurization, Dairy A, as a shared exposure. We ... Read more >>

Foodborne Pathog Dis (Foodborne pathogens and disease)
[2021, :]

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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

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<h4>Background</h4>In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.<h4>Methods</h4>This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10285):1637-1645]

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Transplantation of high fat fed mouse microbiota into zebrafish embryos identifies pathobiont species

Pradeep Manuneedhi Cholan, Simone Morris, Kaiming Luo, Jinbiao Chen, Jade Boland, Geoff McCaughan, Warwick Britton, Stefan Oehlers,

Gut dysbiosis is an important modifier of pathologies including cardiovascular disease but our understanding of the role of individual microbes is limited. Here, we have used transplantation of mouse microbiota into microbiota-deficient zebrafish embryos to study the interaction between members of a mammalian high fat diet-associated gut microbiota with a ... Read more >>

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A combined experimental and computational study of mechanical properties after balloon kyphoplasty.

Philip Purcell, Fiona McEvoy, Stephen Tiernan, Derek Sweeney, Seamus Morris,

Vertebral compression fractures rank among the most frequent injuries to the musculoskeletal system, with more than 1 million fractures per annum worldwide. The past decade has seen a considerable increase in the utilisation of surgical procedures such as balloon kyphoplasty to treat these injuries. While many kyphoplasty studies have examined the ... Read more >>

Proc Inst Mech Eng H (Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine)
[2021, :9544119211013927]

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The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care: a randomised clinical controlled trial.

Aikaterini Kassavou, Venus Mirzaei, Sonia Shpendi, James Brimicombe, Jagmohan Chauhan, Debi Bhattacharya, Felix Naughton, Wendy Hardeman, Helen Eborall, Miranda Van Emmenis, Anna De Simoni, Amrit Takhar, Pankaj Gupta, Prashanth Patel, Cecilia Mascolo, Andrew Toby Prevost, Stephen Morris, Simon Griffin, Richard J McManus, Jonathan Mant, Stephen Sutton,

The PAM intervention is a behavioural intervention to support adherence to anti-hypertensive medications and therefore to lower blood pressure. This feasibility trial recruited 101 nonadherent patients (54% male, mean age 65.8 years) with hypertension and high blood pressure from nine general practices in the UK. The trial had 15.5% uptake and ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):8897]

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Temperature dependence and histological correlation of inhomogeneous magnetization transfer and myelin water imaging in ex vivo brain.

Valentin H Prevost, Andrew Yung, Sarah R Morris, Irene M Vavasour, Zahra Samadi-Bahrami, G R Wayne Moore, Cornelia Laule, Alex Mackay, Piotr Kozlowski,

<h4>Purpose</h4>The promise of inhomogeneous magnetization transfer (ihMT) as a new myelin imaging method was studied in ex vivo human brain tissue and in relation to myelin water fraction (MWF). The temperature dependence of both methods was characterized, as well as their correspondence with a histological measure of myelin content. Unfiltered ... Read more >>

Neuroimage (NeuroImage)
[2021, 236:118046]

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Dental attendance and behavioural pathways to adult oral health inequalities.

Carol C Guarnizo-Herreño, Shaun Scholes, Anja Heilmann, Rhiannon O'Connor, Elizabeth Fuller, Jing Shen, Richard G Watt, Steve Morris, John Wildman, Georgios Tsakos,

<h4>Background</h4>While inequalities in oral health are documented, little is known about the extent to which they are attributable to potentially modifiable factors. We examined the role of behavioural and dental attendance pathways in explaining oral health inequalities among adults in England, Wales and Northern Ireland.<h4>Methods</h4>Using nationally representative data, we analysed ... Read more >>

J Epidemiol Community Health (Journal of epidemiology and community health)
[2021, :]

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Results from a PrEP Demonstration Project for At-Risk Cisgender Women in the United States.

Jill Blumenthal, Sonia Jain, Feng He, K Rivet Amico, Ryan Kofron, Eric Ellorin, Jamila K Stockman, Christina Psaros, Gifty M Ntim, Karen Chow, Peter L Anderson, Richard Haubrich, Katya Corado, David J Moore, Sheldon Morris, Raphael J Landovitz,

<h4>Background</h4>Daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) is effective for reducing HIV acquisition among cisgender women. We report results from the first United States observational open-label demonstration project of PrEP among at-risk cisgender women.<h4>Methods</h4>Adherence Enhancement Guided by Individualized Texting and Drug Levels (AEGiS) was a 48-week single-arm open-label demonstration study of ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

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Demographic, clinical, and epidemiologic characteristics of persons under investigation for Coronavirus Disease 2019-United States, January 17-February 29, 2020.

Olivia L McGovern, Mark Stenger, Sara E Oliver, Tara C Anderson, Cheryl Isenhour, Matthew R Mauldin, Nia Williams, Eric Griggs, Tonny Bogere, Chris Edens, Aaron T Curns, Joana Y Lively, Yingtao Zhou, Songli Xu, Maureen H Diaz, Jessica L Waller, Kevin R Clarke, Mary E Evans, Elisabeth M Hesse, Sapna Bamrah Morris, Robert P McClung, Laura A Cooley, Naeemah Logan, Andrew T Boyd, Allan W Taylor, Kristina L Bajema, Stephen Lindstrom, Christopher A Elkins, Christopher Jones, Aron J Hall, Samuel Graitcer, Alexandra M Oster, Alicia M Fry, Marc Fischer, Laura Conklin, Runa H Gokhale,

<h4>Background</h4>The Coronavirus Disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), evolved rapidly in the United States. This report describes the demographic, clinical, and epidemiologic characteristics of 544 U.S. persons under investigation (PUI) for COVID-19 with complete SARS-CoV-2 testing in the beginning stages of the pandemic ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0249901]

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Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - A high risk community-hospital interface.

Kathy K Li, Y Mun Woo, Oliver Stirrup, Joseph Hughes, Antonia Ho, Ana Da Silva Filipe, Natasha Johnson, Katherine Smollett, Daniel Mair, Stephen Carmichael, Lily Tong, Jenna Nichols, Elihu Aranday-Cortes, Kirstyn Brunker, Yasmin A Parr, Kyriaki Nomikou, Sarah E McDonald, Marc Niebel, Patawee Asamaphan, Vattipally B Sreenu, David L Robertson, Aislynn Taggart, Natasha Jesudason, Rajiv Shah, James Shepherd, Josh Singer, Alison H M Taylor, Zoe Cousland, Jonathan Price, Jennifer S Lees, Timothy P W Jones, Carlos Varon Lopez, Alasdair MacLean, Igor Starinskij, Rory Gunson, Scott T W Morris, Peter C Thomson, Colin C Geddes, Jamie P Traynor, Judith Breuer, Emma C Thomson, Patrick B Mark, ,

<h4>Objectives</h4>Patients requiring haemodialysis are at increased risk of serious illness with SARS-CoV-2 infection. To improve the understanding of transmission risks in six Scottish renal dialysis units, we utilised the rapid whole-genome sequencing data generated by the COG-UK consortium.<h4>Methods</h4>We combined geographical, temporal and genomic sequence data from the community and hospital ... Read more >>

J Infect (The Journal of infection)
[2021, :]

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The impact of the COVID-19 pandemic on influenza, respiratory syncytial virus, and other seasonal respiratory virus circulation in Canada

HE Groves, Piché-Renaud, Peci, DS Farrar, Buckrell, Bancej, Sevenhuysen, Campigotto, JB Gubbay, SK Morris,

<h4>Background</h4> The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in implementation of public health measures worldwide to mitigate disease spread, including; travel restrictions, lockdowns, messaging on handwashing, use of face coverings and physical distancing. As the pandemic progresses, exceptional decreases in seasonal respiratory viruses are increasingly reported. We aimed ... Read more >>

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ER stress protein PERK promotes inappropriate innate immune responses and pathogenesis during RSV infection.

Samanthi Narayanan, Srikanth Elesela, Andrew J Rasky, Susan H Morris, Surinder Kumar, David Lombard, Nicholas W Lukacs,

The activation of dendritic cells (DC) during respiratory viral infections is central to directing the immune response and the pathologic outcome. In these studies, the effect of RSV infection on development of ER stress responses and the impact on innate immunity was examined. The upregulation of ER stress was closely ... Read more >>

J Leukoc Biol (Journal of leukocyte biology)
[2021, :]

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Responses to Navon tasks differ across development and between tasks with differing attentional demands.

Su Morris, Iroise Dumontheil, Emily K Farran,

Navon hierarchical stimuli are designed to measure responses to the global level (grouped local elements, e.g. a forest) and the local level (individuated local elements, e.g. trees) of a visual scene. Cross-sectional evidence suggests that there are developmental changes in global and local processing. We examined global and local processing ... Read more >>

Vision Res (Vision research)
[2021, 185:17-28]

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Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids.

Kyaw Thu Minn, Sabine Dietmann, Sarah E Waye, Samantha A Morris, Lilianna Solnica-Krezel,

Human embryonic stem cells cultured in 2D micropatterns with BMP4 differentiate into a radial arrangement of germ layers and extraembryonic cells. Single-cell transcriptomes demonstrate generation of cell types transcriptionally similar to their in vivo counterparts in Carnegie stage 7 human gastrula. Time-course analyses indicate sequential differentiation, where the epiblast arises by ... Read more >>

Stem Cell Reports (Stem cell reports)
[2021, :]

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Reply to Comment on: Data sources that enumerate people experiencing homelessness in the United States: Opportunities and challenges for epidemiological research.

Emily Mosites, Sapna Bamrah Morris, Julie Self, Jay Butler,

Am J Epidemiol (American journal of epidemiology)
[2021, :]

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Evaluating bowel movements, self-initiations, and problem behavior with the emergence of urinary continence.

Brandon C Perez, Samuel L Morris, Janelle K Bacotti, Timothy R Vollmer,

Much of the research evaluating toilet training interventions for children with ASD has focused on urinations as the primary dependent variable. As a result, the effects that toilet training interventions targeting urinations may have on other related dependent variables remains unclear. We conducted a retrospective analysis of data obtained by ... Read more >>

J Appl Behav Anal (Journal of applied behavior analysis)
[2021, :]

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CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition

David Gallo, Jordan T.F. Young, Jimmy Fourtounis, Giovanni Martino, Alejandro Álvarez-Quilón, Cynthia Bernier, Nicole Duffy, Robert Papp, Anne Roulston, Rino Stocco, Janek Szychowski, Artur Veloso, Hunain Alam, Prasamit Baruah, Alexanne Bonneau Fortin, Julian Bowlan, Natasha Chaudhary, Jessica Desjardins, Evelyne Dietrich, Sara Fournier, Chloe Fugère-Desjardins, Theo Goullet de Rugy, Marie-Eve Leclaire, Bingcan Liu, Henrique Melo, Olivier Nicolas, Akul Singhania, Rachel Szilard, Ján Tkáč, Shou Yun Yin, Stephen Morris, Michael Zinda, Gary Marshall, Daniel Durocher,

Amplification of the gene encoding cyclin E ( CCNE1 ) is an oncogenic driver in several malignancies and is associated with chemoresistance and poor prognosis. To uncover therapeutic targets for CCNE1 -amplified tumors, we undertook genome-scale CRISPR/Cas9-based synthetic lethality screens in cellular models of CCNE1 amplification. Here, we report that ... Read more >>

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Processes of care and survival associated with treatment in specialist teenage and young adult cancer centres: results from the BRIGHTLIGHT cohort study.

Lorna A Fern, Rachel M Taylor, Julie Barber, Javier Alvarez-Galvez, Richard Feltbower, Sarah Lea, Ana Martins, Stephen Morris, Louise Hooker, Faith Gibson, Rosalind Raine, Dan P Stark, Jeremy Whelan,

<h4>Objective</h4>Survival gains in teenagers and young adults (TYA) are reported to be lower than children and adults for some cancers. Place of care is implicated, influencing access to specialist TYA professionals and research.Consequently, age-appropriate specialist cancer care is advocated for TYA although systematic investigation of associated outcomes is lacking. In ... Read more >>

BMJ Open (BMJ open)
[2021, 11(4):e044854]

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