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Kisspeptin-54 accurately identifies hypothalamic GnRH neuronal dysfunction in men with congenital hypogonadotropic hypogonadism.

Ali Abbara, Pei Chia Eng, Maria Phylactou, Sophie A Clarke, Edouard Mills, Germaine Chia, Lisa Yang, Chioma Izzi-Engbeaya, Neil Smith, Channa N Jayasena, Alexander N Comninos, Ravinder Anand-Ivell, Jesse Rademaker, Cheng Xu, Richard Quinton, Nelly Pitteloud, Waljit S Dhillo,

BACKGROUND:Hypogonadotropic hypogonadism is hypogonadism due to either hypothalamic or pituitary dysfunction. Whilst gonadotropin releasing hormone (GnRH) can directly test pituitary function, no specific test of hypothalamic function exists. Kisspeptin-54 (KP54) is a neuropeptide that directly stimulates hypothalamic GnRH-release and thus could be used to specifically interrogate hypothalamic function. Congenital Hypogonadotropic ... Read more >>

Neuroendocrinology (Neuroendocrinology)
[2020, :]

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Pattern of cognitive deficits in severe COVID-19.

Valérie Beaud, Sonia Crottaz-Herbette, Vincent Dunet, Julien Vaucher, Raphaël Bernard-Valnet, Renaud Du Pasquier, Pierre-Alexandre Bart, Stephanie Clarke,

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, :]

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Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders.

Ali Abbara, Pei Chia Eng, Maria Phylactou, Sophie A Clarke, Rachel Richardson, Charlene M Sykes, Chayarndorn Phumsatitpong, Edouard Mills, Manish Modi, Chioma Izzi-Engbeaya, Debbie Papadopoulou, Kate Purugganan, Channa N Jayasena, Lisa Webber, Rehan Salim, Bryn Owen, Paul Bech, Alexander N Comninos, Craig A McArdle, Margaritis Voliotis, Krasimira Tsaneva-Atanasova, Suzanne Moenter, Aylin Hanyaloglu, Waljit S Dhillo,

BACKGROUNDKisspeptin is a key regulator of hypothalamic gonadotropin-releasing hormone (GnRH) neurons and is essential for reproductive health. A specific kisspeptin receptor (KISS1R) agonist could significantly expand the potential clinical utility of therapeutics targeting the kisspeptin pathway. Herein, we investigate the effects of a KISS1R agonist, MVT-602, in healthy women and ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2020, :]

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CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels.

Claudia C S Chini, Thais R Peclat, Gina M Warner, Sonu Kashyap, Jair Machado Espindola-Netto, Guilherme C de Oliveira, Lilian S Gomez, Kelly A Hogan, Mariana G Tarragó, Amrutesh S Puranik, Guillermo Agorrody, Katie L Thompson, Kevin Dang, Starlynn Clarke, Bennett G Childs, Karina S Kanamori, Micaela A Witte, Paola Vidal, Anna L Kirkland, Marco De Cecco, Karthikeyani Chellappa, Melanie R McReynolds, Connor Jankowski, Tamara Tchkonia, James L Kirkland, John M Sedivy, Jan M van Deursen, Darren J Baker, Wim van Schooten, Joshua D Rabinowitz, Joseph A Baur, Eduardo N Chini,

Decreased NAD+ levels have been shown to contribute to metabolic dysfunction during aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However, it is not known how CD38 is regulated during aging, and how its ecto-enzymatic activity impacts NAD+ homeostasis. Here we show that an increase ... Read more >>

Nat Metab (Nature metabolism)
[2020, 2(11):1284-1304]

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Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Historical Cholesterol Exposure

Shoa Clarke, Catherine Tcheandjieu, Austin Hilliard, Kyung Min Lee, Julie Lynch, Kyong-Mi Chang, Donald Miller, Joshua Knowles, Christopher O’Donnell, Phil Tsao, Daniel Rader, Peter Wilson, Yan Sun, Michael Gaziano, Themistocles Assimes, ,

Abstract Aims Familial hypercholesterolemia (FH) genetic variants confer risk for coronary artery disease (CAD) even after adjusting for low-density lipoprotein cholesterol (LDL-C) levels, using a single measurement. This study evaluated whether multiple historical measures of LDL-C observed in the electronic health record (EHR) can account for the risk associated with ... Read more >>

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Evaluation of marine spatial planning requires fit for purpose monitoring strategies.

V Stelzenmüller, R Cormier, K Gee, R Shucksmith, M Gubbins, K L Yates, A Morf, C Nic Aonghusa, E Mikkelsen, J F Tweddle, E Peccu, A Kannen, S A Clarke,

Marine spatial planning (MSP) has rapidly become the most widely used integrated, place-based management approach in the marine environment. Monitoring and evaluation of MSP is key to inform best practices, adaptive management and plan iteration. While standardised evaluation frameworks cannot be readily applied, accounting for evaluation essentials such as the ... Read more >>

J Environ Manage (Journal of environmental management)
[2020, 278(Pt 2):111545]

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From Preproduction to Coproduction: COVID-19, whiteness, and making black mental health matter.

Colin King, Michael Bennett, Kenneth W M Fulford, Simon Clarke, Steve Gillard, Anna Bergqvist, John Richardson,

Lancet Psychiatry (The lancet. Psychiatry)
[2020, :]

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Thyroid function before, during and after COVID-19.

Bernard Khoo, Tricia Tan, Sophie A Clarke, Edouard G Mills, Bijal Patel, Manish Modi, Maria Phylactou, Pei Chia Eng, Layla Thurston, Emma C Alexander, Karim Meeran, Alexander N Comninos, Ali Abbara, Waljit S Dhillo,

CONTEXT:The effects of COVID-19 on the thyroid axis remain uncertain. Recent evidence has been conflicting, with both thyrotoxicosis and suppression of thyroid function reported. OBJECTIVE:We aimed to detail the acute effects of COVID-19 on thyroid function and determine if these effects persisted upon recovery from COVID-19. DESIGN:Cohort observational study. PARTICIPANTS ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2020, :]

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Effects of High-Fat Diet Induced Obesity and Fructooligosaccharide Supplementation on Cardiac Protein Expression.

Sidra Sarfaraz, Shamjeet Singh, Aileen Hawke, Sandra T Clarke, D Dan Ramdath,

The mechanism by which high fat-diet induced obesity affects cardiac protein expression is unclear, and the extent to which this is modulated by prebiotic treatment is not known. These outcomes were assessed in rats initially fed a high-fat diet, then the top 40% weight gain group were randomly allocated to ... Read more >>

Nutrients (Nutrients)
[2020, 12(11):]

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Outcomes at five to eight years of age for children with Hirschsprung's disease.

Benjamin Saul Raywood Allin, Charles Opondo, Timothy John Bradnock, Simon Edward Kenny, Jennifer J Kurinczuk, Gregor M Walker, Marian Knight, ,

OBJECTIVE:This study describes core outcomes of Hirschsprung's disease (HD) in a UK-wide cohort of primary school-aged children. DESIGN:A prospective cohort study conducted from 1 October 2010 to 30 September 2012. Outcomes data were collected from parents and clinicians when children were 5-8 years of age, and combined with data collected ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, :]

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British Association of Critical Care Nurses: Evidence-based consensus paper for oral care within adult critical care units.

Tim Collins, Catherine Plowright, Vanessa Gibson, Louise Stayt, Sarah Clarke, Jo Caisley, Claire Harcourt Watkins, Emily Hodges, Gillian Leaver, Sarah Leyland, Patricia McCready, Sara Millin, Julie Platten, Michelle Scallon, Patsy Tipene, Gabby Wilcox,

BACKGROUND:Patients who are critically ill are at increased risk of hospital acquired pneumonia and ventilator associated pneumonia. Effective evidence based oral care may reduce the incidence of such iatrogenic infection. AIM:To provide an evidence-based British Association of Critical Care Nurses endorsed consensus paper for best practice relating to implementing oral ... Read more >>

Nurs Crit Care (Nursing in critical care)
[2020, :]

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Pinto beans modulate the gut microbiome, augment MHC II protein, and antimicrobial peptide gene expression in mice fed a normal or western-style diet.

Babajide A Ojo, Peiran Lu, Sanmi E Alake, Bryant Keirns, Kendall Anderson, Grace Gallucci, Matthew D Hart, Guadalupe Davila El-Rassi, Jerry W Ritchey, Winyoo Chowanadisai, Dingbo Lin, Stephen Clarke, Brenda J Smith, Edralin A Lucas,

The onset of type 2 diabetes in obesity is associated with gut dysbiosis and a failure to confine commensal bacteria and toxins to the gut lumen while prebiotics may prevent these effects. This study evaluated the effects of pinto beans (PB) supplementation on cecal bacteria, short-chain fatty acids (SCFAs), distal ... Read more >>

J Nutr Biochem (The Journal of nutritional biochemistry)
[2020, 88:108543]

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Using Technology to Seek the Vulnerable and Marginalized Child's Voice in Hospital: Co-working with a 'Child Research Advisory Group' (CRAG).

Sonya Clarke,

This paper illustrates the development, value and outcome of co-working with a 'child research advisory group' (CRAG) within healthcare research. The UK qualitative study completed as part of a Doctorate in Education (EdD) primarily explored the child's experience of hospital in Northern Ireland from the perspective of the child (and ... Read more >>

Compr Child Adolesc Nurs (Comprehensive child and adolescent nursing)
[2020, :1-10]

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Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.

Lei Wu, Xin Guo, Siau Yen Wong, Peiran Lu, Steven D Hartson, Denis M Medeiros, Weiqun Wang, Stephen L Clarke, Edralin A Lucas, Brenda J Smith, Winyoo Chowanadisai, Dingbo Lin,

Hypothalamic inflammation has been linked to various aspects of central metabolic dysfunction and diseases in humans, including hyperphagia, altered energy expenditure, and obesity. We previously reported that loss of β-carotene oxygenase 2 (BCO2), a mitochondrial inner membrane protein, causes the alteration of the hypothalamic metabolome, low-grade inflammation, and an increase ... Read more >>

J Nutr Biochem (The Journal of nutritional biochemistry)
[2020, 88:108542]

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Isotopic and microbotanical insights into Iron Age agricultural reliance in the Central African rainforest.

Madeleine Bleasdale, Hans-Peter Wotzka, Barbara Eichhorn, Julio Mercader, Amy Styring, Jana Zech, María Soto, Jamie Inwood, Siobhán Clarke, Sara Marzo, Bianca Fiedler, Veerle Linseele, Nicole Boivin, Patrick Roberts,

The emergence of agriculture in Central Africa has previously been associated with the migration of Bantu-speaking populations during an anthropogenic or climate-driven 'opening' of the rainforest. However, such models are based on assumptions of environmental requirements of key crops (e.g. Pennisetum glaucum) and direct insights into human dietary reliance remain ... Read more >>

Commun Biol (Communications biology)
[2020, 3(1):619]

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The Value and Development of Postgraduate Pre-registration Children and Young People's Nursing Using Co-production.

Sonya Clarke, Christine Brown Wilson,

Compr Child Adolesc Nurs (Comprehensive child and adolescent nursing)
[2020, :1-5]

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Global Analysis of Transcription Start Sites in the New Ovine Reference Genome (Oar rambouillet v1.0).

Mazdak Salavati, Alex Caulton, Richard Clark, Iveta Gazova, Timothy P L Smith, Kim C Worley, Noelle E Cockett, Alan L Archibald, Shannon M Clarke, Brenda M Murdoch, Emily L Clark,

The overall aim of the Ovine FAANG project is to provide a comprehensive annotation of the new highly contiguous sheep reference genome sequence (Oar rambouillet v1.0). Mapping of transcription start sites (TSS) is a key first step in understanding transcript regulation and diversity. Using 56 tissue samples collected from the ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:580580]

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Preventive malaria treatment among school-aged children in sub-Saharan Africa: a systematic review and meta-analyses.

Lauren M Cohee, Charles Opondo, Siân E Clarke, Katherine E Halliday, Jorge Cano, Andrea G Shipper, Breanna Barger-Kamate, Abdoulaye Djimde, Seybou Diarra, Aditi Dokras, Moses R Kamya, Pascal Lutumba, Alioune Badara Ly, Joaniter I Nankabirwa, J Kiambo Njagi, Hamma Maiga, Catherine Maiteki-Sebuguzi, Junior Matangila, George Okello, Fabian Rohner, Natalie Roschnik, Saba Rouhani, Mahamadou S Sissoko, Sarah G Staedke, Mahamadou A Thera, Elizabeth L Turner, J P Van Geertruyden, Michael B Zimmerman, Matthew C H Jukes, Simon J Brooker, Elizabeth Allen, Miriam K Laufer, R Matthew Chico,

BACKGROUND:The burden of malaria infection in sub-Saharan Africa among school-aged children aged 5-15 years is underappreciated and represents an important source of human-to-mosquito transmission of Plasmodium falciparum. Additional interventions are needed to control and eliminate malaria. We aimed to assess whether preventive treatment of malaria might be an effective means ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2020, 8(12):e1499-e1511]

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Potential Impact of COVID-19 on Recently Resettled Refugee Populations in the United States and Canada: Perspectives of Refugee Healthcare Providers.

Sarah K Clarke, Gayathri S Kumar, James Sutton, Jacob Atem, Anna Banerji, Mahli Brindamour, Paul Geltman, Najah Zaaeed,

Recently resettled refugee populations may be at greater risk for exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a virus that causes coronavirus 2019 (COVID-19), and face unique challenges in following recommendations to protect their health. Several factors place resettled refugees at elevated risk for exposure to persons with ... Read more >>

J Immigr Minor Health (Journal of immigrant and minority health)
[2020, :]

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Accuracy of Placement of Pedicle Screws in the Lumbosacral Region of Dogs Using 3D-Printed Patient-Specific Drill Guides.

Cristina Toni, Bill Oxley, Stephen Clarke, Sebastien Behr,

OBJECTIVE: The aim of this study was to report the accuracy of pedicle screw placement using three-dimensional (3D)-printed, patient-specific drill guides in the lumbosacral region of dogs. STUDY DESIGN: This was a retrospective study. Thirty-two pedicle screws were placed in five dogs. Medical records were reviewed between November 2015 and November 2018 ... Read more >>

Vet Comp Orthop Traumatol (Veterinary and comparative orthopaedics and traumatology : V.C.O.T)
[2020, :]

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A Critical Assessment of Postneoadjuvant Therapy Pancreatic Cancer Regression Grading Schemes With a Proposal for a Novel Approach.

Angela Chou, Mahsa Ahadi, Jennifer Arena, Loretta Sioson, Amy Sheen, Talia L Fuchs, Nick Pavlakis, Stephen Clarke, Andrew Kneebone, George Hruby, Sumit Sahni, Anubhav Mittal, Jaswinder Samra, Anthony J Gill,

Currently, there is no consensus on the optimal tumor response score (TRS) system to assess regression in pancreatic cancers resected after neoadjuvant therapy. We developed a novel TRS (Royal North Shore [RNS] system) based on estimating the percentage of tumor bed occupied by viable cancer and categorized into 3 tiers: ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, :]

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Magnetic Ordering in the Layered Cr(II) Oxide Arsenides Sr2CrO2Cr2As2 and Ba2CrO2Cr2As2.

Xiaoyu Xu, Michael A Jones, Simon J Cassidy, Pascal Manuel, Fabio Orlandi, Maria Batuk, Joke Hadermann, Simon J Clarke,

Sr2CrO2Cr2As2 and Ba2CrO2Cr2As2 with Cr2+ ions in CrO2 sheets and in CrAs layers crystallize with the Sr2Mn3Sb2O2 structure (space group I4/mmm, Z = 2) and lattice parameters a = 4.00800(2) Å, c = 18.8214(1) Å (Sr2CrO2Cr2As2) and a = 4.05506(2) Å, c = 20.5637(1) Å (Ba2CrO2Cr2As2) at room temperature. Powder ... Read more >>

Inorg Chem (Inorganic chemistry)
[2020, 59(21):15898-15912]

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Platelet glycoprotein Ib alpha chain as a putative therapeutic target for juvenile idiopathic arthritis: a Mendelian randomization study.

Shan Luo, Sarah Clarke, Athimalaipet Ramanan, Susan D Thompson, Carl D Langefeld, Miranda C Marion, Alexei A Grom, C Mary Schooling, Tom R Gaunt, Shiu Lun Au Yeung, Jie Zheng,

OBJECTIVE:To ascertain the role of platelet glycoprotein Ib alpha chain (GPIbα) plasma protein levels in cardiovascular, autoimmune and autoinflammatory diseases and whether its effects are mediated by platelet count. METHODS:We performed a two-sample Mendelian randomization (MR) study, using both cis and trans-acting protein expression quantitative trait loci (pQTL) near GP1BA ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2020, :]

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Impact of COVID-19 on cardiac procedure activity in England and associated 30-day mortality.

Mohamed O Mohamed, Amitava Banerjee, Sarah Clarke, Mark de Belder, Ashish Patwala, Andrew T Goodwin, Chun Shing Kwok, Muhammad Rashid, Chris P Gale, Nick Curzen, Mamas A Mamas,

BACKGROUND:Limited data exists on the impact of COVID-19 on national changes in cardiac procedure activity, including patient characteristics and clinical outcomes before and during the COVID-19 pandemic. METHODS AND RESULTS:All major cardiac procedures (n = 374,899) performed between 1st January and 31st May for the years 2018, 2019 and 2020 were analysed, ... Read more >>

Eur Heart J Qual Care Clin Outcomes (European heart journal. Quality of care & clinical outcomes)
[2020, :]

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White matter microstructural differences in underweight adolescents with anorexia nervosa and a preliminary longitudinal investigation of change following short-term weight restoration.

Kristi R Griffiths, Beatriz Martin Monzon, Sloane Madden, Michael R Kohn, Stephen Touyz, Perminder S Sachdev, Simon Clarke, Nasim Foroughi, Phillipa Hay,

PURPOSE:Anorexia nervosa (AN) affects approximately 2.9% of females and has the highest mortality rate among all psychiatric disorders. Despite several advances, the neurobiology of this disorder is still not well understood. Several studies have reported abnormalities in the white matter, but it is not know if these are disease-related or ... Read more >>

Eat Weight Disord (Eating and weight disorders : EWD)
[2020, :]

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