Full Text Journal Articles by
Author S Chew

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Leptomeningeal Relapse of Embryonal Rhabdomyosarcoma after 15 years.

S Chew, J P Gleeson, A McCarthy, G A Watson, R O'Dwyer, S Nicholson, M Capra, C Owens, M McDermott, P Daly, C Grant,

Aim Rhabdomyosarcoma (RMS) is the most common malignant soft tissue tumour of childhood. We present the case of a late relapse of RMS to the leptomeninges after 15 years. Methods A 20 year old male presented with a 3 week history of headaches and nausea. He previously had RMS of ... Read more >>

Ir Med J (Irish medical journal)
[2020, 112(10):1026]

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Disease specific alterations in the olfactory mucosa of patients with Alzheimer’s disease

Riikka Lampinen, Mohammad Feroze Fazaludeen, Simone Avesani, Tiit Örd, Elina Penttilä, Juha-Matti Lehtola, Toni Saari, Sanna Hannonen, Liudmila Saveleva, Emma Kaartinen, Francisco Fernandes Acosta, Marcela Cruz-Haces, Heikki Löppönen, Alan Mackay-Sim, Tarja Malm, Minna Kaikkonen-Määttä, Anne Koivisto, Anthony White, Rosalba Giugno, Sweelin Chew, Katja Kanninen,

ABSTRACT Olfactory dysfunction manifests in early stages of neurodegeneration in several disorders of the central nervous system. The sense of smell is orchestrated by the cells of the olfactory mucosa located in the upper nasal cavity, however, it is unclear how this tissue reflects key neurodegenerative features in Alzheimer’s disease ... Read more >>

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Nutritional Biomarkers and Associated Factors in Community-Dwelling Older Adults: Findings from the SHIELD Study.

Magdalin Cheong, Samuel Teong Huang Chew, Jeffery Oliver, Geraldine Baggs, Yen Ling Low, Choon How How, Ngiap Chuan Tan, Dieu Thi Thu Huynh, Siew Ling Tey,

Aging is associated with intrinsic and extrinsic changes which affect the nutrient intake and nutritional status of an older individual. Suboptimal nutritional status is linked with adverse health outcomes. There are limited data in this area for community-dwelling older adults who are not at risk of malnutrition. The objective of ... Read more >>

Nutrients (Nutrients)
[2020, 12(11):]

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Associations between socio-demographics, nutrition knowledge, nutrition competencies and attitudes in community-dwelling healthy older adults in Singapore: Findings from the SHIELD study

Rebecca Hui Shan Ong, Wai Leng Chow, Magdalin Cheong, Gladys Huiyun Lim, Weiyi Xie, Geraldine Baggs, Dieu Thi Thu Huynh, Hong Choon Oh, Choon How How, Ngiap-Chuan Tan, Siew Ling Tey, Samuel Teong Huang Chew,

Abstract Background Nutrition literacy refers to an individual’s knowledge, motivation and competencies to access, process, and understand nutrition information to make nutrition-related decisions. It is known to influence dietary habits of individuals including older adults. This cross-sectional study was designed to: (1) understand the nutrition knowledge, competencies and attitudes of ... Read more >>

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Impact of Probiotic B. Infantis EVC001 Feeding in Premature Infants on the Gut Microbiome, Nosocomially Acquired Antibiotic Resistance, and Enteric Inflammation

Marielle Nguyen, Heaven Holdbrooks, Prasanthi Mishra, Maria Abrantes, Sherri Eskew, MariaJamiela Garma, Cyr-Geraurd Oca, Carrie McGuckin, Cynthia Hein, Ryan Mitchell, Sufyan Kazi, Stephanie Chew, Giorgio Casaburi, Heather Brown, Steve Frese, Bethany Michele Henrick,

Abstract BackgroundPreterm birth is a major determinant of neonatal survival and morbidity, but the gut microbiome and associated enteric inflammation are also key factors in neonatal development and the risk of associated morbidities. We prospectively and longitudinally followed two cohorts of preterm infants, one of which was fed Bifidobacterium longum ... Read more >>

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Comparative Genomic and Phenotypic Analyses of Pathogenic Fungi Neoscytalidium Dimidiatum and Bipolaris Papendorfii, Isolated From Human Skin Scraping

Chee Sian Kuan, Kee Peng Ng, Su Mei Yew, Hadiza Umar Meleh, Heng Fong Seow, Kang Nien How, Siok Koon Yeo, Jap Meng Jee, Yung-Chie Tan, Wai-Yan Yee, Chee-Choong Hoh, Rukumani Devi Velayuthan, Shiang Ling Na, Siti Norbaya Masri, Shu Yih Chew, Leslie Thian Lung Than,

Abstract Background: Neoscytalidium dimidiatum and Bipolaris species are fungal plant pathogens that have been reported to cause human diseases. Recently, we have isolated numerous N. dimidiatum and Bipolaris species from the skin scrapings and nails of different patients. In this work, we have sequenced the genome of one strain of ... Read more >>

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Bifidobacteria-mediated immune system imprinting early in life

Bethany Henrick, Lucie Rodriguez, Tadepally Lakshmikanth, Christian Pou, Ewa Henckel, Axel Olin, Jun Wang, Jaromir Mikes, Ziyang Tan, Yang Chen, Amy Ehrlich, Anna Karin Bernhardsson, Constantin Habimana Mugabo, Ylva Ambrosiani, Anna Gustafsson, Stephanie Chew, Heather Brown, Johann Prambs, Kajsa Bohlin, Ryan Mitchell, Mark Underwood, Jennifer Smilowitz, Bruce German, Steven Frese, Petter Brodin,

SUMMARY Immune-microbe interactions early in life influence an individual’s risk of developing allergies, asthma and some autoimmune disorders. Breastfeeding helps guide the development of healthy immune-microbe relationships, in part by providing nutrients to specialized microbes that in turn benefit the host and its developing immune system. Such bacteria having co-evolved ... Read more >>

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Proficiencies of military medical officers in intubating difficult airways.

Jonathan Zm Lim, Shi Hao Chew, Benjamin Zb Chin, Raymond Ch Siew,

BACKGROUND:This study sheds light on the proficiency of military medical officers who had received between 2 and 3 years of post-graduate training, in the handling of the difficult airway in a trauma manikin simulator using direct and video laryngoscopes. METHOD:One hundred thirty-three doctors from the Singapore Armed Forces Medical Officer Cadet ... Read more >>

BMC Emerg Med (BMC emergency medicine)
[2020, 20(1):78]

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A laser microdissection-based axotomy model incorporating the use of biomimicking fiber scaffolds reveals that microRNAs promote axon regeneration over long injury distances.

Na Zhang, Junquan Lin, Jiah Shin Chin, Kunyu Zhang, Sing Yian Chew,

The regeneration of injured neurons over long injury distances remains suboptimal. In order to successfully stimulate nerve regrowth, potent biomolecules are necessary. Furthermore, reproducible and translatable methods to test the potency of candidate drugs for enhancing nerve regeneration over long axotomy distances are also needed. To address these issues, we ... Read more >>

Biomater Sci (Biomaterials science)
[2020, 8(22):6286-6300]

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The Role of Angiogenesis-Inducing microRNAs in Vascular Tissue Engineering.

May-Hui Ding, Eloy G Lozoya, Rene N Rico, Sue Anne Chew,

Angiogenesis is an important process in tissue repair and regeneration as blood vessels are integral to supply nutrients to a functioning tissue. In this review, the application of microRNAs (miRNAs) or anti-miRNAs that can induce angiogenesis to aid in blood vessel formation for vascular tissue engineering in ischemic diseases such ... Read more >>

Tissue Eng Part A (Tissue engineering. Part A)
[2020, :]

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Proficiencies of Military Medical Officers in Intubating Difficult Airways

Jonathan Zhao Min Lim, Shi Hao Chew, Benjamin Zhao Bin Chin, Raymond Chern Hwee Siew,

Abstract Background This study sheds light on the proficiency of military medical officers who had received between 2-3 years of post-graduate training, in the handling of the difficult airway in a trauma manikin simulator using direct and video laryngoscopes. Method 133 doctors from the Singapore Armed Forces Medical Officer Cadet ... Read more >>

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Illumination enhances the protein abundance of sarcoplasmic reticulum Ca2+-ATPases-like transporter in the ctenidium and whitish inner mantle of the giant clam, Tridacna squamosa, to augment exogenous Ca2+ uptake and shell formation, respectively.

Justin W J Chan, Mel V Boo, Wai P Wong, Shit F Chew, Yuen K Ip,

The fluted giant clam, Tridacna squamosa, can perform light-enhanced shell formation, aided by its symbiotic dinoflagellates (Symbiodinium, Cladocopium, Durusdinium), which are able to donate organic nutrients to the host. During light-enhanced shell formation, increased Ca2+ transport from the hemolymph through the shell-facing epithelium of the inner mantle to the extrapallial ... Read more >>

Comp Biochem Physiol A Mol Integr Physiol (Comparative biochemistry and physiology. Part A, Molecular & integrative physiology)
[2021, 251:110811]

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Early Epidemiological Features and Trends of the COVID-19 Outbreak in Southeast Asia: a Population-Level Observational Study

Mingjian Zhu, Kleepbua Jirapat, Jian Shen, Sien Ping Chew, Joanna Wei Hui Tan, Natthjija Latthitham, Lanjuan Li,

Abstract Background: The global outbreak of coronavirus disease 2019 (COVID-19) has been ongoing in Southeast Asia since 13 January 2020. We conducted an observational study to investigate underlying disease patterns of COVID-19 in Southeast Asia, and consequently to guide intervention strategies against the pandemic. Methods: In this population-level observational study ... Read more >>

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Targeting Gut Microbial Biofilms-A Key to Hinder Colon Carcinogenesis?

Siang-Siang Chew, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Priyia Pusparajah, Bey-Hing Goh, Nurul Syakima Ab Mutalib, Learn-Han Lee,

Colorectal cancer (CRC) is a global public health issue which poses a substantial humanistic and economic burden on patients, healthcare systems and society. In recent years, intestinal dysbiosis has been suggested to be involved in the pathogenesis of CRC, with specific pathogens exhibiting oncogenic potentials such as Fusobacterium nucleatum, Escherichia ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(8):]

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Validation of Saliva and Self-Administered Nasal Swabs for COVID-19 Testing

Alvin Kuo Jing Teo, Yukti Choudhury, Iain Beehuat Tan, Chae Yin Cher, Shi Hao Chew, Zi Yi Wan, Lionel Tim Ee Cheng, Lynette Lin Ean Oon, Min Han Tan, Kian Sing Chan, Li Yang Hsu,

Background Active cases of COVID-19 has primarily been diagnosed via RT-PCR of nasopharyngeal (NP) swabs. Saliva and self-administered nasal (SN) swabs can be collected safely without trained staff. We aimed to test the sensitivity of naso-oropharyngeal saliva and SN swabs compared to NP swabs in a large cohort of migrant ... Read more >>

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The fluted giant clam (Tridacna squamosa) increases the protein abundance of the host's copper-zinc superoxide dismutase in the colorful outer mantle, but not the whitish inner mantle, during light exposure.

Shit F Chew, Clarissa Z Y Koh, Kum C Hiong, Mel V Boo, Wai P Wong, Yuen K Ip,

The colorful outer mantle of giant clams contains abundance of symbiotic dinoflagellates (zooxanthellae) and iridocytes, and has direct exposure to light. In light, photosynthesizing dinoflagellates produce O2, and the host cells in the outer mantle would be confronted with hyperoxia-related oxidative stress. In comparison, the whitish inner mantle contains few ... Read more >>

Comp Biochem Physiol A Mol Integr Physiol (Comparative biochemistry and physiology. Part A, Molecular & integrative physiology)
[2020, 250:110791]

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Biomimicking Fiber Platform with Tunable Stiffness to Study Mechanotransduction Reveals Stiffness Enhances Oligodendrocyte Differentiation but Impedes Myelination through YAP-Dependent Regulation.

William Ong, Nicolas Marinval, Junquan Lin, Mui Hoon Nai, Yee-Song Chong, Coline Pinese, Sreedharan Sajikumar, Chwee Teck Lim, Charles Ffrench-Constant, Marie E Bechler, Sing Yian Chew,

A key hallmark of many diseases, especially those in the central nervous system (CNS), is the change in tissue stiffness due to inflammation and scarring. However, how such changes in microenvironment affect the regenerative process remains poorly understood. Here, a biomimicking fiber platform that provides independent variation of fiber structural ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2020, 16(37):e2003656]

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Proficiencies of Military Medical Officers in Intubating Difficult Airways

Jonathan Zhao Min Lim, Shi Hao Chew, Benjamin Zhao Bin Chin, Raymond Chern Hwee Siew,

Abstract Introduction This study shed light on the proficiency of military medical officers who had received between 2-3 years of post-graduate training, in the handling of the difficult airway in a trauma manikin simulator using direct and video laryngoscopes. Method 133 doctors from the Singapore Armed Forces Medical Officer Cadet ... Read more >>

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Building Global Nutrition Policies in Health Care: Insights for Tackling Malnutrition from the Academy of Nutrition and Dietetics 2019 Global Nutrition Research and Policy Forum.

Marianella Herrera Cuenca, Gabriela V Proaño, Jeanne Blankenship, Carlos Cano-Gutierrez, Samuel T H Chew, Patrizia Fracassi, Heather Keller, M G Venkatesh Mannar, Valeria Mastrilli, Magdalena Milewska, Alison Steiber,

Around the world, the burden of malnutrition remains high despite significant efforts to thwart both undernutrition and overnutrition. The links between food security, dietary choices, and health outcomes pose a dilemma: What can nutrition policymakers and health care professionals do to harness the benefits of nutrition to improve health outcomes ... Read more >>

J Acad Nutr Diet (Journal of the Academy of Nutrition and Dietetics)
[2020, 120(8):1407-1416]

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Symbiodiniaceae Dinoflagellates Express Urease in Three Subcellular Compartments and Upregulate its Expression Levels in situ in Three Organs of a Giant Clam (Tridacna squamosa) During Illumination1.

Yuen Kwong Ip, Germaine Ching Yun Teng, Mel Veen Boo, Jeslyn Shi Ting Poo, Kum Chew Hiong, Hyoju Kim, Wai Peng Wong, Shit Fun Chew,

Giant clams harbor three genera of symbiotic dinoflagellates (Symbiodinium, Cladocopium, and Durusdinium) as extracellular symbionts (zooxanthellae). While symbiotic dinoflagellates can synthesize amino acids to benefit the host, they are nitrogen-deficient. Hence, the host must supply them with nitrogen including urea, which can be degraded to ammonia and carbon dioxide by ... Read more >>

J Phycol (Journal of phycology)
[2020, :]

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Biofunctional scaffolds with high packing density of aligned electrospun fibers support neural regeneration.

Vanja Cnops, Jiah Shin Chin, Ulla Milbreta, Sing Yian Chew,

Neurons of the central nervous system do not regenerate spontaneously after injury. As such, biofunctional tissue scaffolds have been explored to provide a growth-promoting environment to enhance neural regeneration. In this regard, aligned electrospun fibers have proven invaluable for regeneration by offering guidance for axons to cross the injury site. ... Read more >>

J Biomed Mater Res A (Journal of biomedical materials research. Part A)
[2020, 108(12):2473-2483]

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Localized delivery of CRISPR/dCas9 via layer-by-layer self-assembling peptide coating on nanofibers for neural tissue engineering.

Kunyu Zhang, Wai Hon Chooi, Shuang Liu, Jiah Shin Chin, Aoife Murray, Dean Nizetic, Du Cheng, Sing Yian Chew,

The clustered regularly interspaced short palindromic repeat (CRISPR) systems have a wide variety of applications besides precise genome editing. In particular, the CRISPR/dCas9 system can be used to control specific gene expression by CRISPR activation (CRISPRa) or interference (CRISPRi). However, the safety concerns associated with viral vectors and the possible ... Read more >>

Biomaterials (Biomaterials)
[2020, 256:120225]

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Characteristics and Outcomes of COVID-19 Patients with Respiratory Failure Admitted to a "Pandemic Ready" Intensive Care Unit - Lessons from Singapore.

Si Yuan Chew, Yee Shay Lee, Deepak Ghimiray, Chee Keat Tan, Gerald Sw Chua,

INTRODUCTION:Singapore was one of the first countries affected by the coronavirus disease 2019 (COVID-19) pandemic but has been able to prevent its healthcare system and intensive care units (ICU) from being overwhelmed. We describe the clinical features, management and outcomes of COVID-19 patients with respiratory failure admitted to our ICU. ... Read more >>

Ann Acad Med Singap (Annals of the Academy of Medicine, Singapore)
[2020, 49(7):434-448]

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Non-Pharmacological and Pharmacological Management of Cardiac Dysautonomia Syndromes.

Lucy Y Lei, Derek S Chew, Roopinder K Sandhu, Robert S Sheldon, Satish R Raj,

Vasovagal syncope, postural orthostatic tachycardia syndrome, and inappropriate sinus tachycardia comprise a heterogenous group of common autonomic disorders that are associated with significant symptoms that impair quality of life. Clinical management of these disorders should prioritize conservative non-pharmacological therapies and consider incorporating pharmacological agents for recurrences. The selection and titration ... Read more >>

J Atr Fibrillation (Journal of atrial fibrillation)
[2020, 13(1):2395]

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Correction to: Association among dispositional mindfulness, self-compassion, and leukocyte telomere length in Chinese adults.

Shian-Ling Keng, Onn Siong Yim, Poh San Lai, Soo Hong Chew, Richard P Ebstein,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

BMC Psychol (BMC psychology)
[2020, 8(1):65]

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