Full Text Journal Articles by
Author Ryota Tsunekuni

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Highly Pathogenic Avian Influenza A(H5N8) Virus Clade 2.3.4.4b, Western Siberia, Russia, 2020.

Ivan Sobolev, Kirill Sharshov, Nikita Dubovitskiy, Olga Kurskaya, Alexander Alekseev, Sergey Leonov, Yuriy Yushkov, Victor Irza, Andrey Komissarov, Artem Fadeev, Daria Danilenko, Junki Mine, Ryota Tsunekuni, Yuko Uchida, Takehiko Saito, Alexander Shestopalov,

Two variants of highly pathogenic avian influenza A(H5N8) virus were detected in dead poultry in Western Siberia, Russia, during August and September 2020. One variant was represented by viruses of clade 2.3.4.4b and the other by a novel reassortant between clade 2.3.4.4b and Eurasian low pathogenicity avian influenza viruses circulating ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(8):2224-2227]

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First Outbreak of an H5N8 Highly Pathogenic Avian Influenza Virus on a Chicken Farm in Japan in 2020.

Saki Sakuma, Yuko Uchida, Momoyo Kajita, Taichiro Tanikawa, Junki Mine, Ryota Tsunekuni, Takehiko Saito,

On 5 November 2020, a confirmed outbreak due to an H5N8 highly pathogenic avian influenza virus (HPAIV) occurred at an egg-hen farm in Kagawa prefecture (western Japan). This virus, A/chicken/Kagawa/11C/2020 (Kagawa11C2020), was the first HPAI poultry isolate in Japan in 2020 and had multiple basic amino acids-a motif conferring high ... Read more >>

Viruses (Viruses)
[2021, 13(3):]

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Improvement of a recombinant avian avulavirus serotype 10 vectored vaccine by the addition of untranslated regions.

Ryota Tsunekuni, Taichiro Tanikawa, Takaaki Nakaya, Takehiko Saito,

<h4>Background</h4>We have previously developed a recombinant avian avulavirus serotype 10 (rAAvV-10/HA) expressing the hemagglutinin (HA) gene of a highly pathogenic avian influenza virus (HPAIV) as an emergency vaccine for poultry. rAAvV-10/HA can overcome the activity of the anti-AAvV-1 (Newcastle disease virus) antibody acquired by commercial chickens upon routine vaccination. Most ... Read more >>

Vaccine (Vaccine)
[2020, 38(4):822-829]

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Isolation of highly pathogenic H5N6 avian influenza virus in Southern Vietnam with genetic similarity to those infecting humans in China.

Ryota Tsunekuni, Kasumi Sudo, Phuong Thanh Nguyen, Bach Duc Luu, Thai Duy Phuong, Tran Minh Tan, Tung Nguyen, Junki Mine, Momoko Nakayama, Taichiro Tanikawa, Kirill Sharshov, Nobuhiro Takemae, Takehiko Saito,

Since 2013, H5N6 highly pathogenic avian influenza viruses (HPAIVs) have been responsible for outbreaks in poultry and wild birds around Asia. H5N6 HPAIV is also a public concern due to sporadic human infections being reported in China. In the current study, we isolated an H5N6 HPAIV strain (A/Muscovy duck/Long An/AI470/2018; ... Read more >>

Transbound Emerg Dis (Transboundary and emerging diseases)
[2019, 66(6):2209-2217]

Cited: 3 times

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A novel H7N3 reassortant originating from the zoonotic H7N9 highly pathogenic avian influenza viruses that has adapted to ducks.

Momoko Nakayama, Yuko Uchida, Akihiro Shibata, Yoshifumi Kobayashi, Junki Mine, Nobuhiro Takemae, Ryota Tsunekuni, Taichiro Tanikawa, Rieko Harada, Hiroyuki Osaka, Takehiko Saito,

The first human case of zoonotic H7N9 avian influenza virus (AIV) infection was reported in March 2013 in China. This virus continues to circulate in poultry in China while mutating to highly pathogenic AIVs (HPAIVs). Through monitoring at airports in Japan, a novel H7N3 reassortant of the zoonotic H7N9 HPAIVs, ... Read more >>

Transbound Emerg Dis (Transboundary and emerging diseases)
[2019, 66(6):2342-2352]

Cited: 3 times

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Pathogenicity of two novel human-origin H7N9 highly pathogenic avian influenza viruses in chickens and ducks.

Taichiro Tanikawa, Yuko Uchida, Nobuhiro Takemae, Ryota Tsunekuni, Junki Mine, Ming-Tsan Liu, Ji-Rong Yang, Masayuki Shirakura, Shinji Watanabe, Takato Odagiri, Takehiko Saito,

Human infection by low-pathogenic avian influenza viruses of the H7N9 subtype was first reported in March 2013 in China. Subsequently, these viruses caused five outbreaks through September 2017. In the fifth outbreak, H7N9 virus possessing a multiple basic amino acid insertion in the cleavage site of hemagglutinin emerged and caused ... Read more >>

Arch Virol (Archives of virology)
[2019, 164(2):535-545]

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Genetics and pathogenicity of H5N6 highly pathogenic avian influenza viruses isolated from wild birds and a chicken in Japan during winter 2017-2018.

Junki Mine, Yuko Uchida, Momoko Nakayama, Taichiro Tanikawa, Ryota Tsunekuni, Kirill Sharshov, Nobuhiro Takemae, Ivan Sobolev, Alexander Shestpalov, Takehiko Saito,

An H5N6 highly pathogenic avian influenza virus (HPAIV) outbreak occurred in poultry in Japan during January 2018, and H5N6 HPAIVs killed several wild birds in 3 prefectures during Winter 2017-2018. Time-measured phylogenetic analyses demonstrated that the Hemagglutinin (HA) and internal genes of these isolates were genetically similar to clade 2.3.4.4.B ... Read more >>

Virology (Virology)
[2019, 533:1-11]

Cited: 4 times

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Comparative pathogenicity of H5N6 subtype highly pathogenic avian influenza viruses in chicken, Pekin duck and Muscovy duck.

Yuko Uchida, Junki Mine, Nobuhiro Takemae, Taichiro Tanikawa, Ryota Tsunekuni, Takehiko Saito,

In Japan during the 2016-2017 winter season, clade 2.3.4.4 highly pathogenic avian influenza viruses (HPAIVs) of the H5N6 subtype caused 12 outbreaks in chicken and Muscovy duck farms. These viruses have been circulating in Vietnam and China since 2014. In this study, we evaluated the susceptibility of chicken, Pekin duck ... Read more >>

Transbound Emerg Dis (Transboundary and emerging diseases)
[2019, 66(3):1227-1251]

Cited: 8 times

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Genetic and antigenic dynamics of influenza A viruses of swine on pig farms in Thailand.

Junki Mine, Haruka Abe, Sujira Parchariyanon, Prakit Boonpornprasert, Namfon Ubonyaem, Bandit Nuansrichay, Nobuhiro Takemae, Taichiro Tanikawa, Ryota Tsunekuni, Yuko Uchida, Takehiko Saito,

Surveillance studies of influenza A virus of swine (IAV-S) have accumulated information regarding IAVs-S circulating in Thailand, but how IAVs-S evolve within a farm remains unclear. In the present study, we isolated 82 A(H1N1)pdm09 and 87 H3N2 viruses from four farms from 2011 through 2017. We then phylogenetically and antigenically ... Read more >>

Arch Virol (Archives of virology)
[2019, 164(2):457-472]

Cited: 5 times

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Neuraminidase inhibitor susceptibility and evolutionary analysis of human influenza B isolates from three Asian countries during 2012-2015.

Akinobu Hibino, Elie Massaad, Hiroki Kondo, Reiko Saito, Takashi Odagiri, Nobuhiro Takemae, Ryota Tsunekuni, Takehiko Saito, , Yadanar Kyaw, Nay Lin, Yi Yi Myint, Htay Htay Tin, Nguyen Le Khanh Hang, Le Quynh Mai, Ren Yagami, Yugo Shobugawa, Tommy Lam, Hassan Zaraket,

Influenza B viruses of both the Yamagata and the Victoria lineages are implicated in a large proportion of the morbidity and mortality associated with influenza outbreaks. In this study, we characterized the full genomes of 53 influenza B viruses isolated during 2012-2015 in three Asian countries: Japan, Myanmar, and Vietnam. ... Read more >>

Infect Genet Evol (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2018, 62:27-33]

Cited: 0 times

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Spatial transmission of H5N6 highly pathogenic avian influenza viruses among wild birds in Ibaraki Prefecture, Japan, 2016-2017.

Ryota Tsunekuni, Yuji Yaguchi, Yuki Kashima, Kaoru Yamashita, Nobuhiro Takemae, Junki Mine, Taichiro Tanikawa, Yuko Uchida, Takehiko Saito,

From 29 November 2016 to 24 January 2017, sixty-three cases of H5N6 highly pathogenic avian influenza virus (HPAIV) infections were detected in wild birds in Ibaraki Prefecture, Japan. Here, we analyzed the genetic, temporal, and geographic correlations of these 63 HPAIVs to elucidate their dissemination throughout the prefecture. Full-genome sequence ... Read more >>

Arch Virol (Archives of virology)
[2018, 163(5):1195-1207]

Cited: 5 times

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Five distinct reassortants of H5N6 highly pathogenic avian influenza A viruses affected Japan during the winter of 2016-2017.

Nobuhiro Takemae, Ryota Tsunekuni, Kirill Sharshov, Taichiro Tanikawa, Yuko Uchida, Hiroshi Ito, Kosuke Soda, Tatsufumi Usui, Ivan Sobolev, Alexander Shestopalov, Tsuyoshi Yamaguchi, Junki Mine, Toshihiro Ito, Takehiko Saito,

To elucidate the evolutionary pathway, we sequenced the entire genomes of 89 H5N6 highly pathogenic avian influenza viruses (HPAIVs) isolated in Japan during winter 2016-2017 and 117 AIV/HPAIVs isolated in Japan and Russia. Phylogenetic analysis showed that at least 5 distinct genotypes of H5N6 HPAIVs affected poultry and wild birds ... Read more >>

Virology (Virology)
[2017, 512:8-20]

Cited: 18 times

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Recombinant Avian Paramyxovirus Serotypes 2, 6, and 10 as Vaccine Vectors for Highly Pathogenic Avian Influenza in Chickens with Antibodies Against Newcastle Disease Virus.

Ryota Tsunekuni, Hirokazu Hikono, Taichiro Tanikawa, Riho Kurata, Takaaki Nakaya, Takehiko Saito,

Recombinant Newcastle disease virus (rNDV) expressing the hemagglutinin of highly pathogenic avian influenza virus (HPAIV HA) induces protective immunity against HPAIV in chickens. However, the efficacy of rNDV vectors is hampered when chickens are pre-immune to NDV, and most commercial chickens are routinely vaccinated against NDV. We recently showed that ... Read more >>

Avian Dis (Avian diseases)
[2017, 61(3):296-306]

Cited: 4 times

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Pathogenicity of H5N8 highly pathogenic avian influenza viruses isolated from a wild bird fecal specimen and a chicken in Japan in 2014.

Taichiro Tanikawa, Katsushi Kanehira, Ryota Tsunekuni, Yuko Uchida, Nobuhiro Takemae, Takehiko Saito,

Poultry outbreaks caused by H5N8 highly pathogenic avian influenza viruses (HPAIVs) occurred in Japan between December 2014 and January 2015. During the same period; H5N8 HPAIVs were isolated from wild birds and the environment in Japan. The hemagglutinin (HA) genes of these isolates were found to belong to clade 2.3.4.4 ... Read more >>

Microbiol Immunol (Microbiology and immunology)
[2016, 60(4):243-252]

Cited: 11 times

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Full Genome Characterization of Human Influenza A/H3N2 Isolates from Asian Countries Reveals a Rare Amantadine Resistance-Conferring Mutation and Novel PB1-F2 Polymorphisms.

Hassan Zaraket, Hiroki Kondo, Akinobu Hibino, Ren Yagami, Takashi Odagiri, Nobuhiro Takemae, Ryota Tsunekuni, Takehiko Saito, , Yi Yi Myint, Yadanar Kyaw, Khin Yi Oo, Htay Htay Tin, Nay Lin, Nguyen Phuong Anh, Nguyen Le Khanh Hang, Le Quynh Mai, Mohd R Hassan, Yugo Shobugawa, Julian Tang, Ghassan Dbaibo, Reiko Saito,

Influenza A viruses evolve at a high rate requiring continuous monitoring to maintain the efficacy of vaccines and antiviral drugs. We performed next generation sequencing analysis of 100 influenza A/H3N2 isolates collected in four Asian countries (Japan, Lebanon, Myanmar, and Vietnam) during 2012-2015. Phylogenetic analysis revealed several reassortment events leading ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2016, 7:262]

Cited: 11 times

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Intracontinental and intercontinental dissemination of Asian H5 highly pathogenic avian influenza virus (clade 2.3.4.4) in the winter of 2014-2015.

Takehiko Saito, Taichiro Tanikawa, Yuko Uchida, Nobuhiro Takemae, Katsushi Kanehira, Ryota Tsunekuni,

Asian H5 highly pathogenic avian influenza viruses (HPAIVs) that possess the clade 2.3.4.4 HA gene have been identified in wild birds and poultry since late 2014 in both Europe and North America (N. America). Clade 2.3.4.4 H5 HPAIVs of the H5N8 subtype have been isolated in both regions, whereas reassortment ... Read more >>

Rev Med Virol (Reviews in medical virology)
[2015, 25(6):388-405]

Cited: 32 times

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Co-infection of influenza A viruses of swine contributes to effective shuffling of gene segments in a naturally reared pig.

Haruka Abe, Junki Mine, Sujira Parchariyanon, Nobuhiro Takemae, Prakit Boonpornprasert, Namfon Ubonyaem, Phornnachat Patcharasinghawut, Bandit Nuansrichay, Taichiro Tanikawa, Ryota Tsunekuni, Takehiko Saito,

Following the 2009 H1N1 pandemic, surveillance activities have been accelerated globally to monitor the emergence of novel reassortant viruses. However, the mechanism by which influenza A viruses of swine (IAV-S) acquire novel gene constellations through reassortment events in natural settings remains poorly understood. To explore the mechanism, we collected 785 ... Read more >>

Virology (Virology)
[2015, 484:203-212]

Cited: 6 times

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Characterization of an H5N8 influenza A virus isolated from chickens during an outbreak of severe avian influenza in Japan in April 2014.

Katsushi Kanehira, Yuko Uchida, Nobuhiro Takemae, Hirokazu Hikono, Ryota Tsunekuni, Takehiko Saito,

A highly pathogenic avian influenza virus (HPAIV) of subtype H5N8, A/chicken/Kumamoto/1-7/2014, was isolated from a Japanese chicken farm during an outbreak in April 2014. Phylogenetic analysis revealed that this virus belonged to HA clade 2.3.4.4. All eight genomic segments showed high sequence similarity to those of the H5N8 subtype HPAIVs ... Read more >>

Arch Virol (Archives of virology)
[2015, 160(7):1629-1643]

Cited: 31 times

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Evaluation of avian paramyxovirus serotypes 2 to 10 as vaccine vectors in chickens previously immunized against Newcastle disease virus.

Ryota Tsunekuni, Hirokazu Hikono, Takehiko Saito,

Newcastle disease virus (NDV), also known as avian paramyxovirus (APMV) serotype 1, is used as a vaccine vector to express the hemagglutinin protein of avian influenza (AI) virus. However, use of live NDV recombinant vaccines expressing AI virus hemagglutinin is not desirable in emergency vaccination programs to control severe AI ... Read more >>

Vet Immunol Immunopathol (Veterinary immunology and immunopathology)
[2014, 160(3-4):184-191]

Cited: 5 times

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The characterization of low pathogenic avian influenza viruses isolated from wild birds in northern Vietnam from 2006 to 2009.

Hiroki Takakuwa, Tetsu Yamashiro, Mai Q Le, Lien S Phuong, Hiroichi Ozaki, Ryota Tsunekuni, Tatsufumi Usui, Hiroshi Ito, Tsuyoshi Yamaguchi, Toshihiro Ito, Toshiyuki Murase, Etsuro Ono, Koichi Otsuki,

Due to concerns that wild birds could possibly spread H5N1 viruses, surveillance was conducted to monitor the types of avian influenza viruses circulating among the wild birds migrating to or inhabiting in northern Vietnam from 2006 to 2009. An H5N2 virus isolated from a Eurasian woodcock had a close phylogenetic ... Read more >>

Comp Immunol Microbiol Infect Dis (Comparative immunology, microbiology and infectious diseases)
[2013, 36(6):581-590]

Cited: 4 times

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Molecular epidemiology of avian influenza viruses circulating among healthy poultry flocks in farms in northern Vietnam.

Hiroki Takakuwa, Tetsu Yamashiro, Mai Q Le, Lien S Phuong, Hiroichi Ozaki, Ryota Tsunekuni, Tatsufumi Usui, Hiroshi Ito, Masami Morimatsu, Yukiko Tomioka, Tsuyoshi Yamaguchi, Toshihiro Ito, Toshiyuki Murase, Etsuro Ono, Koichi Otsuki,

Repeated epizootics of highly pathogenic avian influenza (HPAI) virus subtype H5N1 were reported from 2003 to 2005 among poultry in Vietnam. More than 200 million birds were killed to control the spread of the disease. Human cases of H5N1 infection have been sporadically reported in an area where repeated H5N1 ... Read more >>

Prev Vet Med (Preventive veterinary medicine)
[2012, 103(2-3):192-200]

Cited: 7 times

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Possible circulation of H5N1 avian influenza viruses in healthy ducks on farms in northern Vietnam.

Hiroki Takakuwa, Tetsu Yamashiro, Mai Q Le, Lien S Phuong, Hiroichi Ozaki, Ryota Tsunekuni, Tatsufumi Usui, Hiroshi Ito, Tsuyoshi Yamaguchi, Toshihiro Ito, Toshiyuki Murase, Etsuro Ono, Koichi Otsuki,

To estimate the prevalence of influenza A subtype H5N1 viruses among domestic ducks in the period between October and November 2006 when H5N1 outbreaks had been absent, 1106 healthy ducks raised in northern Vietnam were collected. Inoculation of all throat and cloacae samples into embryonated eggs resulted in the isolation ... Read more >>

Microbiol Immunol (Microbiology and immunology)
[2010, 54(1):58-62]

Cited: 3 times

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Avian influenza virus and paramyxovirus isolation from migratory waterfowl and shorebirds in San-in district of western Japan from 2001 to 2008.

Yoshikazu Fujimoto, Hiroshi Ito, Sakar Shivakoti, Jyunya Nakamori, Ryota Tsunekuni, Koichi Otsuki, Toshihiro Ito,

Surveillance of avian influenza virus and paramyxovirus in migratory waterfowl and shorebirds was conducted in the San-in district of western Japan from the winter of 2001 to 2008. From 4,335 fecal samples from wild birds, 41 avian influenza viruses of 12 different HA and NA combinations, including two H5N3 strains, ... Read more >>

J Vet Med Sci (The Journal of veterinary medical science)
[2010, 72(7):963-967]

Cited: 9 times

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Genetic comparisons between lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants.

Ryota Tsunekuni, Hiroshi Ito, Koichi Otsuki, Hiroshi Kida, Toshihiro Ito,

Avirulent Newcastle disease viruses (NDV) harbored by waterfowl have the potential to become virulent after transmission to and circulation within chicken populations. In order to investigate how virulent viruses are selected from an avirulent background, we compared the complete sequences of the avirulent NDV isolate Goose/Alaska/415/91 and its virulent variant ... Read more >>

Virus Genes (Virus genes)
[2010, 40(2):252-255]

Cited: 17 times

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