Full Text Journal Articles by
Author Ryan W Haines

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Return to Work After Coronavirus Disease 2019 Acute Respiratory Distress Syndrome and Intensive Care Admission: Prospective, Case Series at 6 Months From Hospital Discharge.

Luca Carenzo, Francesca Dalla Corte, Ryan W Haines, Chiara Palandri, Angelo Milani, Alessio Aghemo, Daniela Pini, Alessandro Protti, Maurizio Cecconi,

<h4>Objectives</h4>Joblessness is common in survivors from critical care. Our aim was to describe rates of return to work versus unemployment following coronavirus disease 2019 acute respiratory distress syndrome requiring intensive care admission.<h4>Design</h4>Single-center, prospective case series.<h4>Setting</h4>Critical Care Follow-Up Clinic, Humanitas Clinical and Research Center-IRCCS, Rozzano, Italy.<h4>Patients</h4>One hundred and one consecutive laboratory-confirmed ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):e1157-e1162]

Cited: 1 time

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Effect of intermittent or continuous feeding and amino acid concentration on urea-to-creatinine ratio in critical illness.

Luke Flower, Ryan W Haines, Angela McNelly, Danielle E Bear, Kiran Koelfat, Steven Olde Damink, Nicholas Hart, Hugh Montgomery, John R Prowle, Zudin Puthucheary,

<h4>Background</h4>We sought to determine whether peaks in essential amino acid (EAA) concentration associated with intermittent feeding may provide anabolic advantages when compared with continuous feeding regimens in critical care.<h4>Methods</h4>We performed a secondary analysis of data from a multicenter trial of UK intensive care patients randomly assigned to intermittent or continuous ... Read more >>

JPEN J Parenter Enteral Nutr (JPEN. Journal of parenteral and enteral nutrition)
[2021, :]

Cited: 0 times

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Admission serum myoglobin and the development of acute kidney injury after major trauma.

Virginie Tarazona, Samy Figueiredo, Sophie Hamada, Jonas Pochard, Ryan W Haines, John R Prowle, Jacques Duranteau, Bernard Vigué, Anatole Harrois,

<h4>Background</h4>Myoglobin and creatine kinase (CK) are both established markers of muscle injury but their hospital admission values have never been compared to predict post-traumatic acute kidney injury (AKI).<h4>Methods</h4>An observational registry study of consecutive trauma patients admitted to a major regional trauma centre. The primary outcome was stage 1 or more ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2021, 11(1):140]

Cited: 0 times

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Emergency hospital admissions associated with non-communicable diseases 1998-2018 in England, Wales and Scotland: an ecological study.

Alexander J Robbins, Alex J Fowler, Ryan W Haines, Rupert M Pearse, John R Prowle, Zudin Puthucheary,

<h4>Background</h4>Non-communicable diseases (NCDs) are increasingly prevalent and were responsible for 40.5 million deaths (71%) globally in 2016. We examined the number of NCD-related emergency hospital admissions during the years 1998 to 2018 in the UK.<h4>Methods</h4>Demographic features for those admitted as an emergency with NCDs as their primary diagnosis were collated ... Read more >>

Clin Med (Lond) (Clinical medicine (London, England))
[2021, 21(2):e179-e185]

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Long-term kidney function of patients discharged from hospital after an intensive care admission: observational cohort study.

Ryan W Haines, Jonah Powell-Tuck, Hugh Leonard, Siobhan Crichton, Marlies Ostermann,

The long-term trajectory of kidney function recovery or decline for survivors of critical illness is incompletely understood. Characterising changes in kidney function after critical illness and associated episodes of acute kidney injury (AKI), could inform strategies to monitor and treat new or progressive chronic kidney disease. We assessed changes in ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):9928]

Cited: 1 time

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Individualized acute kidney injury after care.

Jay L Koyner, Ryan W Haines, Josee Bouchard,

<h4>Purpose of review</h4>The aim of this study was to summarize the current evidence around the impact of individualizing patient care following an episode of acute kidney injury (AKI) in the ICU.<h4>Recent findings</h4>Over the last years, evidence has demonstrated that the follow-up care after episodes of AKI is lacking and standardization ... Read more >>

Curr Opin Crit Care (Current opinion in critical care)
[2020, 26(6):581-589]

Cited: 1 time

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Prognostic association of routinely measured biomarkers in patients admitted to critical care: a systematic review.

Yize I Wan, Adam B Brayne, Ryan W Haines, Zudin A Puthucheary, John R Prowle,

<h4>Purpose</h4>To examine reported prognostic associations of routine blood measurements in the intensive care unit.<h4>Materials and methods</h4>We searched PubMed, EMBASE through 28<sup>th</sup> May 2020 to identify all studies in adult critical care investigating associations between parameters measured routinely in whole blood, plasma or serum, and length of stay or mortality. Registration: ... Read more >>

Biomarkers (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals)
[2021, 26(1):1-12]

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COVID-19 Phenotypes and Potential Harm of Conventional Treatments: How to Prove the Hypothesis.

Alexander J Fowler, Yize I Wan, Luca Carenzo, Ryan W Haines,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(4):619-621]

Cited: 1 time

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Trauma-associated acute kidney injury.

Zane B Perkins, Ryan W Haines, John R Prowle,

<h4>Purpose of review</h4>A summary of recent research into the epidemiology, cause, management and outcomes of trauma-associated acute kidney injury (AKI). There is an increasing focus on subtypes of AKI to better target clinical management and future research.<h4>Recent findings</h4>AKI associated with trauma occurs in 20-24% of patients admitted to ICU. On ... Read more >>

Curr Opin Crit Care (Current opinion in critical care)
[2019, 25(6):565-572]

Cited: 1 time

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Managing Chloride and Bicarbonate in the Prevention and Treatment of Acute Kidney Injury.

Ryan W Haines, Christopher J Kirwan, John R Prowle,

Intravenous crystalloid therapy is one of the most ubiquitous aspects of hospital and critical care medicine. In recent years, there has been increasing focus on the electrolyte composition, and particularly chloride content, of crystalloid solutions. This has led to increasing clinical adoption of balanced solutions, containing substrates for bicarbonate generation ... Read more >>

Semin Nephrol (Seminars in nephrology)
[2019, 39(5):473-483]

Cited: 2 times

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Acute kidney injury and adverse outcomes of critical illness: correlation or causation?

Benedict J Girling, Samuel W Channon, Ryan W Haines, John R Prowle,

Critically ill patients who develop acute kidney injury (AKI) are more than twice as likely to die in hospital. However, it is not clear to what extent AKI is the cause of excess mortality, or merely a correlate of illness severity. The Bradford Hill criteria for causality (plausibility, temporality, magnitude, ... Read more >>

Clin Kidney J (Clinical kidney journal)
[2020, 13(2):133-141]

Cited: 6 times

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Elevated urea-to-creatinine ratio provides a biochemical signature of muscle catabolism and persistent critical illness after major trauma.

Ryan W Haines, Parjam Zolfaghari, Yize Wan, Rupert M Pearse, Zudin Puthucheary, John R Prowle,

<h4>Purpose</h4>Muscle wasting is common amongst patients with persistent critical illness and associated with increased urea production, but reduced creatinine production. We hypothesised that elevated urea:creatinine ratio would provide a biochemical signature of muscle catabolism and characterise prolonged intensive care (ICU) admissions after major trauma.<h4>Methods</h4>Using pre-specified hypotheses, we analysed two existing ... Read more >>

Intensive Care Med (Intensive care medicine)
[2019, 45(12):1718-1731]

Cited: 13 times

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Deserved attention for acute kidney injury after major trauma.

Ryan W Haines, Anatole Harrois, John R Prowle, Signe Søvik, Sigrid Beitland,

Intensive Care Med (Intensive care medicine)
[2019, 45(6):907-908]

Cited: 0 times

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Continuous renal replacement therapy: individualization of the prescription.

Ryan W Haines, Christopher J Kirwan, John R Prowle,

<h4>Purpose of review</h4>Continuous renal replacement therapy (CRRT) is now the mainstay of renal organ support in the critically ill. As our understanding of CRRT delivery and its impact on patient outcomes improves there is a focus on researching the potential benefits of tailored, patient-specific treatments to meet dynamic needs.<h4>Recent findings</h4>The ... Read more >>

Curr Opin Crit Care (Current opinion in critical care)
[2018, 24(6):443-449]

Cited: 2 times

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The incidence and associations of acute kidney injury in trauma patients admitted to critical care: A systematic review and meta-analysis.

Ryan W Haines, Alex J Fowler, Christopher J Kirwan, John R Prowle,

<h4>Background</h4>As more patients are surviving the initial effects of traumatic injury clinicians are faced with managing the systemic complications of severe tissue injury. Of these, acute kidney injury (AKI) may be a sentinel complication contributing to adverse outcomes.<h4>Objective</h4>To establish the incidence of AKI in patients admitted to critical care after ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2019, 86(1):141-147]

Cited: 9 times

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Acute Kidney Injury in Trauma Patients Admitted to Critical Care: Development and Validation of a Diagnostic Prediction Model.

Ryan W Haines, Shih-Pin Lin, Russell Hewson, Christopher J Kirwan, Hew D Torrance, Michael J O'Dwyer, Anita West, Karim Brohi, Rupert M Pearse, Parjam Zolfaghari, John R Prowle,

Acute Kidney Injury (AKI) complicating major trauma is associated with increased mortality and morbidity. Traumatic AKI has specific risk factors and predictable time-course facilitating diagnostic modelling. In a single centre, retrospective observational study we developed risk prediction models for AKI after trauma based on data around intensive care admission. Models ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):3665]

Cited: 13 times

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