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Publisher Correction: Systemic inflammation is associated with incident stroke and heart disease in East Asians.

Mohd A Karim, Christiana Kartsonaki, Derrick A Bennett, Iona Y Millwood, Michael R Hill, Daniel Avery, Zheng Bian, Huaidong Du, Yu Guo, Yijian Qian, Chan Qu, Iain Turnbull, Dan Schmidt-Valle, Chunmei Wang, Canqing Yu, Jun Lv, Junshi Chen, Robert Clarke, Liming Li, Zhengming Chen, Michael V Holmes, Robin G Walters, ,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):8084]

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Association between adiposity measures and COPD risk in Chinese adults.

Jiachen Li, Lu Zhu, Yuxia Wei, Jun Lv, Yu Guo, Zheng Bian, Huaidong Du, Ling Yang, Yiping Chen, Yonglin Zhou, Ruqin Gao, Junshi Chen, Zhengming Chen, Weihua Cao, Canqing Yu, Liming Li, ,

Bodyweight and fat distribution may be related to COPD risk. Limited prospective evidence linked COPD to abdominal adiposity. We investigated the association of body mass index (BMI) and measures of abdominal adiposity with COPD risk in a prospective cohort study.The China Kadoorie Biobank recruited participants aged 30-79 years from 10 areas ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2020, 55(4):]

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Factors associated with negative conversion of viral RNA in patients hospitalized with COVID-19.

Xiaowen Hu, Yuhan Xing, Jing Jia, Wei Ni, Jiwei Liang, Dan Zhao, Xin Song, Ruqin Gao, Fachun Jiang,

Factors associated with negative conversion of SARS-CoV-2 RNA in hospitalized patients have not yet been systematically determined. We conducted a retrospective cohort study of COVID-19 patients in Qingdao, China. Both univariate and multivariate analysis were performed to identify independent factors for time to viral RNA negative conversion. Data on patients ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 728:138812]

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Epidemiological characteristics and spatial-temporal clusters of hand, foot, and mouth disease in Qingdao City, China, 2013-2018.

Zengqiang Kou, Jing Jia, Xiaohui Liu, Tingting Luo, Xueling Xin, Jinling Gong, Jingfei Zhang, Dapeng Sun, Fachun Jiang, Ruqin Gao,

BACKGROUND:Hand, foot, and mouth disease (HFMD) has become one of the most important infectious diseases recent years. Qingdao City has suffered from serious HFMD epidemic. This study aimed to describe epidemiological characteristics and investigate spatial-temporal distribution at town level in Qingdao City. METHOD:The surveillance data of HFMD during 2013-2018 were ... Read more >>

PLoS ONE (PloS one)
[2020, 15(6):e0233914]

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Detection of SARS-CoV-2 in Different Types of Clinical Specimens.

Wenling Wang, Yanli Xu, Ruqin Gao, Roujian Lu, Kai Han, Guizhen Wu, Wenjie Tan,

JAMA (JAMA)
[2020, :]

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Systemic inflammation is associated with incident stroke and heart disease in East Asians.

Mohd A Karim, Christiana Kartsonaki, Derrick A Bennett, Iona Y Millwood, Michael R Hill, Daniel Avery, Zheng Bian, Huaidong Du, Yu Guo, Yijian Qian, Chan Qu, Iain Turnbull, Dan Schmidt-Valle, Chunmei Wang, Canqing Yu, Jun Lv, Junshi Chen, Robert Clarke, Liming Li, Zhengming Chen, Michael V Holmes, Robin G Walters, ,

Systemic inflammation, reflected by increased plasma concentrations of C-reactive protein (CRP) and fibrinogen, is associated with increased risk of coronary heart disease, but its relevance for stroke types remains unclear. Moreover, evidence is limited in non-European populations. We investigated associations of CRP and fibrinogen with risks of incident major coronary ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5605]

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Mortality and recurrent vascular events after first incident stroke: a 9-year community-based study of 0·5 million Chinese adults.

Yiping Chen, Neil Wright, Yu Guo, Iain Turnbull, Christiana Kartsonaki, Ling Yang, Zheng Bian, Pei Pei, Dongxia Pan, Yidan Zhang, Haiqiang Qin, Yilong Wang, Jun Lv, Ming Liu, Zilong Hao, Yongjun Wang, Canqing Yu, Richard Peto, Rory Collins, Liming Li, Robert Clarke, Zhengming Chen, ,

BACKGROUND:Stroke is a leading cause of death and disability worldwide. Despite considerable improvements in diagnosis and treatment, little is known about the short-term and long-term prognosis after a first stroke in low-income and middle-income countries, including China. We aimed to assess the short-term and long-term risk of recurrent stroke and ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2020, 8(4):e580-e590]

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Epidemiological Characteristics on the Clustering Nature of COVID-19 in Qingdao City, 2020: A Descriptive Analysis.

Jing Jia, Xiaowen Hu, Feng Yang, Xin Song, Liyan Dong, Jingfei Zhang, Fachun Jiang, Ruqin Gao,

OBJECTIVES:As an emerging infectious disease, COVID-19 has involved many countries and regions. With the further development of the epidemic, the proportion of clusters has increased. METHODS:In our study, we collected information on COVID-19 clusters in Qingdao City. The epidemiological characteristics and clinical manifestations were analyzed. RESULTS:Eleven clusters of COVID-19 were ... Read more >>

Disaster Med Public Health Prep (Disaster medicine and public health preparedness)
[2020, :1-5]

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Precautions are Needed for COVID-19 Patients with Coinfection of Common Respiratory Pathogens

Quansheng Xing, Guoju Li, Yuhan Xing, Ting Chen, Wenjie Li, Wei Ni, Kai Deng, Ruqin Gao, Changzheng Chen, Yang Gao, Qiang Li, Guiling Yu, Jianning Tong, Wei Li, Guiliang Hao, Yue Sun, Ai Zhang, Qin Wu, Zipu Li, Silin Pan,

Background: With the ongoing outbreak of Coronavirus Disease 2019 (COVID-19), infected patients within and beyond the epidemic area, Wuhan, China, showed different epidemiological and clinical characteristics. There is a paucity of data concerning coinfection with other common respiratory pathogens in COVID-19 patients outside of Wuhan. Methods: We conducted a double-centre ... Read more >>

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Habitual snoring, adiposity measures and risk of type 2 diabetes in 0.5 million Chinese adults: a 10-year cohort.

Yuxia Wei, Bang Zheng, Junning Fan, Jun Lv, Yu Guo, Zheng Bian, Huaidong Du, Ling Yang, Yiping Chen, Jianxin Chen, Xunfu Zhong, Junshi Chen, Zhengming Chen, Canqing Yu, Liming Li, ,

OBJECTIVES:The present study aimed to examine whether habitual snoring was independently associated with risk of type 2 diabetes among Chinese adults, and to assess the role that adiposity measures play in the snoring-diabetes association, as well as to evaluate the joint influence of snoring and adiposity measures on diabetes. RESEARCH ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(1):]

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Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City.

Yong Zhang, Yuehua Yang, Qian Zhang, Jing Cui, Abdul Rahaman, Xiao-Rong Huang, Ya Su, Ruqin Gao, Bingling Wang, Zulqarnain Baloch,

Introduction:The study was designed to explore the possible adverse effects of prenatal polycyclic aromatic hydrocarbons (PAHs) on the neurodevelopment of the infants at the age of 12 months in a birth cohort in Qingdao of China. Benzo[a]pyrene (BaP)-DNA adduct level in umbilical cord blood was measured by enzyme immunoassay. Methods:Child ... Read more >>

Neuropsychiatr Dis Treat (Neuropsychiatric disease and treatment)
[2019, 15:3351-3357]

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Early famine exposure and adult disease risk based on a 10-year prospective study of Chinese adults.

Ruogu Meng, Canqing Yu, Yu Guo, Zheng Bian, Jiahui Si, Jia Nie, Ling Yang, Yiping Chen, Huaidong Du, Liyuan Zhou, Yun Liu, Junshi Chen, Zhengming Chen, Liming Li, Jun Lv, ,

OBJECTIVE:To comprehensively examine the potential impacts of prenatal experience of the Chinese Great Famine on chronic disease risks in the middle age. METHODS:This study included 92 284 participants aged 39-51 years from China Kadoorie Biobank born around the famine period and without major chronic diseases at baseline. We categorised participants ... Read more >>

Heart (Heart (British Cardiac Society))
[2020, 106(3):213-220]

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Pregnancy, pregnancy loss and the risk of diabetes in Chinese women: findings from the China Kadoorie Biobank.

Sanne A E Peters, Ling Yang, Yu Guo, Yiping Chen, Zheng Bian, Huarong Sun, Yanjie Li, Liming Li, Mark Woodward, Zhengming Chen, ,

Pregnancy and pregnancy loss may be associated with increased risk of diabetes in later life. However, the evidence is inconsistent and sparse, especially among East Asians where reproductive patterns differ importantly from those in the West. We examined the associations of pregnancy and pregnancy loss (miscarriage, induced abortion, and still ... Read more >>

Eur. J. Epidemiol. (European journal of epidemiology)
[2020, 35(3):295-303]

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Soy intake and breast cancer risk: a prospective study of 300,000 Chinese women and a dose-response meta-analysis.

Yuxia Wei, Jun Lv, Yu Guo, Zheng Bian, Meng Gao, Huaidong Du, Ling Yang, Yiping Chen, Xi Zhang, Tao Wang, Junshi Chen, Zhengming Chen, Canqing Yu, Dezheng Huo, Liming Li, ,

Epidemiological evidence on the association of soy intake with breast cancer risk is still inconsistent due to different soy intake levels across previous studies and small number of breast cancer cases. We aimed to investigate this issue by analyzing data from the China Kadoorie Biobank (CKB) study and conducting a ... Read more >>

Eur. J. Epidemiol. (European journal of epidemiology)
[2020, 35(6):567-578]

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Adherence to a healthy lifestyle and all-cause and cause-specific mortality in Chinese adults: a 10-year prospective study of 0.5 million people.

Nanbo Zhu, Canqing Yu, Yu Guo, Zheng Bian, Yuting Han, Ling Yang, Yiping Chen, Huaidong Du, Huimei Li, Fang Liu, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li, ,

BACKGROUND:Adherence to a healthy lifestyle is associated with substantially lower risks of mortality from all causes, cardiovascular diseases, and cancer in white populations. However, little is known about the health benefits among non-white populations. Also, no previous studies have focused on respiratory disease mortality in both white and non-white populations. ... Read more >>

Int J Behav Nutr Phys Act (The international journal of behavioral nutrition and physical activity)
[2019, 16(1):98]

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Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults.

Tao Huang, Shoaib Afzal, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Iona Y Millwood, Robin G Walters, Yiping Chen, Ningyu Chen, Ruqin Gao, Junshi Chen, Robert Clarke, Zhengming Chen, Christina Ellervik, Børge G Nordestgaard, Jun Lv, Liming Li, ,

BACKGROUND:Randomised control trials and genetic analyses have demonstrated that vitamin D or 25-hydroxyvitamin D (25[OH]D) levels may not play a causal role in the development of cardiovascular disease. However, it is unclear if 25(OH)D is causally associated with cause-specific vascular disease and lipids. Therefore, we examined the causal association of ... Read more >>

BMC Med (BMC medicine)
[2019, 17(1):160]

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Genetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese Adults.

Wei Gan, Fiona Bragg, Robin G Walters, Iona Y Millwood, Kuang Lin, Yiping Chen, Yu Guo, Julien Vaucher, Zheng Bian, Derrick Bennett, Jun Lv, Canqing Yu, Anubha Mahajan, Robert J Clarke, Liming Li, Michael V Holmes, Mark I McCarthy, Zhengming Chen, ,

In observational studies, type 2 diabetes is associated with two- to fourfold higher risk of cardiovascular diseases (CVD). Using data from the China Kadoorie Biobank (CKB), we examined associations of genetically predicted type 2 diabetes with CVD among ∼160,000 participants to assess whether these relationships are causal. A type 2 ... Read more >>

Diabetes (Diabetes)
[2019, 68(11):2155-2164]

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Synergistic effects of depression and obesity on type 2 diabetes incidence in Chinese adults.

Feng Ning, Dong Zhang, Bai Xue, Lei Zhang, Jintai Zhang, Zhigang Zhu, Dongfeng Zhang, Ruqin Gao, Zengchang Pang, Qing Qiao, ,

BACKGROUND:Cross-sectional studies have supported the association among depression, obesity, and type 2 diabetes, but the causality remains controversial in Chinese adults. In this longitudinal study, we evaluated the synergistic effect of depression and obesity on the risk of type 2 diabetes. METHODS:This study included 2809 participants randomly selected from the ... Read more >>

J Diabetes (Journal of diabetes)
[2020, 12(2):142-150]

Cited: 1 time

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Association between tea consumption and risk of cancer: a prospective cohort study of 0.5 million Chinese adults.

Xinyi Li, Canqing Yu, Yu Guo, Zheng Bian, Zewei Shen, Ling Yang, Yiping Chen, Yongyue Wei, Hao Zhang, Zhe Qiu, Junshi Chen, Feng Chen, Zhengming Chen, Jun Lv, Liming Li, ,

Current experimental and epidemiological studies provide inconsistent evidence toward the association between tea consumption and cancer incidence. We investigated whether tea consumption was associated with the incidence of all cancers and six leading types of cancer (lung cancer, stomach cancer, colorectal cancer, liver cancer, female breast cancer and cervix uteri ... Read more >>

Eur. J. Epidemiol. (European journal of epidemiology)
[2019, 34(8):753-763]

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Cancer incidence in relation to body fatness among 0.5 million men and women: Findings from the China Kadoorie Biobank.

Lu Wang, Guangfu Jin, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhibin Hu, Feng Chen, Zhengming Chen, Liming Li, Hongbing Shen, ,

High body mass index (BMI) has been associated with an increased risk of several cancers. Evidence relating body fatness, especially based on different anthropometric measures, to risk of major cancers in China from prospective cohort studies is lacking. The prospective China Kadoorie Biobank study recruited 0.5 million adults aged 30-79 years ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, 146(4):987-998]

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Solid Fuel Use and Risks of Respiratory Diseases. A Cohort Study of 280,000 Chinese Never-Smokers.

Ka Hung Chan, Om P Kurmi, Derrick A Bennett, Ling Yang, Yiping Chen, Yunlong Tan, Pei Pei, Xunfu Zhong, Jianxin Chen, Jun Zhang, Haidong Kan, Richard Peto, Kin Bong Hubert Lam, Zhengming Chen, ,

RATIONALE:Little evidence from large-scale cohort studies exists about the relationship of solid fuel use with hospitalization and mortality from major respiratory diseases. OBJECTIVES:To examine the associations of solid fuel use and risks of acute and chronic respiratory diseases. METHODS:A cohort study of 277,838 Chinese never-smokers with no prior major chronic ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2019, 199(3):352-361]

Cited: 3 times

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Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults.

Luanluan Sun, Robert Clarke, Derrick Bennett, Yu Guo, Robin G Walters, Michael Hill, Sarah Parish, Iona Y Millwood, Zheng Bian, Yiping Chen, Canqing Yu, Jun Lv, Rory Collins, Junshi Chen, Richard Peto, Liming Li, Zhengming Chen, , , , , ,

Stroke is the second leading cause of death worldwide and accounts for >2 million deaths annually in China1,2. Ischemic stroke (IS) and intracerebral hemorrhage (ICH) account for an equal number of deaths in China, despite a fourfold greater incidence of IS1,2. Stroke incidence and ICH proportion are higher in China than ... Read more >>

Nat. Med. (Nature medicine)
[2019, 25(4):569-574]

Cited: 7 times

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Age-specific association between blood pressure and vascular and non-vascular chronic diseases in 0·5 million adults in China: a prospective cohort study.

Ben Lacey, Sarah Lewington, Robert Clarke, Xiang Ling Kong, Yiping Chen, Yu Guo, Ling Yang, Derrick Bennett, Fiona Bragg, Zheng Bian, Shaojie Wang, Hua Zhang, Junshi Chen, Robin G Walters, Rory Collins, Richard Peto, Liming Li, Zhengming Chen, ,

BACKGROUND:The age-specific association between blood pressure and vascular disease has been studied mostly in high-income countries, and before the widespread use of brain imaging for diagnosis of the main stroke types (ischaemic stroke and intracerebral haemorrhage). We aimed to investigate this relationship among adults in China. METHODS:512 891 adults (59% women) ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2018, 6(6):e641-e649]

Cited: 13 times

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Association between multiple comorbidities and self-rated health status in middle-aged and elderly Chinese: the China Kadoorie Biobank study.

Xingyue Song, Jing Wu, Canqing Yu, Wenhong Dong, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhengming Chen, An Pan, Liming Li, ,

BACKGROUND:Understanding the correlates of self-rated health (SRH) can help public health professionals prioritize health-promotion and disease-prevention interventions. This study aimed to investigate the association between multiple comorbidities and global SRH and age-comparative SRH. METHODS:A total of 512,891 participants aged 30-79 years old were recruited into the China Kadoorie Biobank study from ... Read more >>

BMC Public Health (BMC public health)
[2018, 18(1):744]

Cited: 2 times

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Adiposity and risk of ischaemic and haemorrhagic stroke in 0·5 million Chinese men and women: a prospective cohort study.

Zhengming Chen, Andri Iona, Sarah Parish, Yiping Chen, Yu Guo, Fiona Bragg, Ling Yang, Zheng Bian, Michael V Holmes, Sarah Lewington, Ben Lacey, Ruqin Gao, Fang Liu, Zengzhi Zhang, Junshi Chen, Robin G Walters, Rory Collins, Robert Clarke, Richard Peto, Liming Li, ,

BACKGROUND:China has high stroke rates despite the population being relatively lean. Uncertainty persists about the relevance of adiposity to risk of stroke types. We aimed to assess the associations of adiposity with incidence of stroke types and effect mediation by blood pressure in Chinese men and women. METHODS:The China Kadoorie ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2018, 6(6):e630-e640]

Cited: 4 times

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