Full Text Journal Articles by
Author Rupesh Raina

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Establishing core outcome domains in pediatric kidney disease: report of the Standardized Outcomes in Nephrology-Children and Adolescents (SONG-KIDS) consensus workshops.

Camilla S Hanson, Jonathan C Craig, Charlotte Logeman, Aditi Sinha, Allison Dart, Allison A Eddy, Chandana Guha, Debbie S Gipson, Detlef Bockenhauer, Hui-Kim Yap, Jaap Groothoff, Michael Zappitelli, Nicholas J A Webb, Stephen I Alexander, Susan L Furth, Susan Samuel, Alicia Neu, Andrea K Viecelli, Angela Ju, Ankit Sharma, Eric H Au, Hailey Desmond, Jenny I Shen, Karine E Manera, Karolis Azukaitis, Louese Dunn, Simon A Carter, Talia Gutman, Yeoungjee Cho, Amanda Walker, Anna Francis, Cheryl Sanchez-Kazi, Joshua Kausman, Meghan Pearl, Nadine Benador, Shobha Sahney, Allison Tong, ,

Trials in children with chronic kidney disease do not consistently report outcomes that are critically important to patients and caregivers. This can diminish the relevance and reliability of evidence for decision making, limiting the implementation of results into practice and policy. As part of the Standardized Outcomes in Nephrology-Children and ... Read more >>

Kidney Int. (Kidney international)
[2020, :]

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Uncommon cause of fever in a child with steroid-dependent nephrotic syndrome.

Sidharth Kumar Sethi, Shyam Bansal, Ronith Chakraborty, Rahul Jain, Nikita Wadhwani, Rupesh Raina,

BACKGROUND:Children with nephrotic syndrome are vulnerable to developing infections due to a state of relative immunodeficiency, malnourishment, and use of immunosuppression. Case characteristics: We herein report the case of a 3-year-old child with steroid-dependent nephrotic syndrome who presented to us with fever of unknown origin. OBSERVATION:The child was found to ... Read more >>

Clin Nephrol Case Stud (Clinical nephrology. Case studies)
[2020, 8:49-52]

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Kidney Replacement Therapy in COVID-19 Induced Kidney Failure and Septic Shock: A Pediatric Continuous Renal Replacement Therapy [PCRRT] Position on Emergency Preparedness With Resource Allocation.

Rupesh Raina, Ronith Chakraborty, Sidharth Kumar Sethi, Timothy Bunchman,

The recent worldwide pandemic of COVID-19 has had a detrimental worldwide impact on people of all ages. Although data from China and the United States indicate that pediatric cases often have a mild course and are less severe in comparison to adults, there have been several cases of kidney failure ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:413]

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ACTH Treatment for Management of Nephrotic Syndrome: A Systematic Review and Reappraisal.

Ronith Chakraborty, Arul Mehta, Nikhil Nair, Lena Nemer, Rahul Jain, Hirva Joshi, Rupesh Raina,

Background:In recent years, the use of adrenocorticotropic hormone (ACTH) therapy for treatment of proteinuria due to nephrotic syndrome (NS) has been heavily explored. ACTH therapy, which comes in the natural (H. P. Acthar Gel) or synthetic (tetracosactide) form, has resulted in remission in patients with immunosuppressive and steroid-resistant NS. However, ... Read more >>

Int J Nephrol (International journal of nephrology)
[2020, 2020:2597079]

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Mystery of black urine: alkaptonuria.

Sidharth Kumar Sethi, Rupesh Raina, Ronith Chakraborty, Vijay Kher,

Kidney Int. (Kidney international)
[2020, 97(6):1303]

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Association of pulse pressure, pulse pressure index, and ambulatory arterial stiffness index with kidney function in a cross-sectional pediatric chronic kidney disease cohort from the CKiD study.

Rupesh Raina, Shyam Polaconda, Nikhil Nair, Ronith Chakraborty, Sidharth Sethi, Vinod Krishnappa, Gaurav Kapur, Maroun Mhanna, Kirsten Kusumi,

The morbidity and mortality of adult and pediatric chronic kidney disease (CKD) and end-stage renal disease (ESRD) populations are mainly driven by cardiovascular disease (CVD). Improving CVD outcomes focuses on risk assessment of factors including diastolic blood pressure (DBP), systolic blood pressure (SBP), left ventricular mass index (LVMI), pulse pressure ... Read more >>

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2020, 22(6):1059-1069]

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Low hemoglobin levels are independently associated with neonatal acute kidney injury: a report from the AWAKEN Study Group.

Arwa Nada, David Askenazi, Louis J Boohaker, Linzi Li, John D Mahan, Jennifer Charlton, Russell L Griffin, ,

BACKGROUND:Studies in adults showed a relationship between low hemoglobin (Hb) and acute kidney injury (AKI). We performed this study to evaluate this association in newborns. METHODS:We evaluated 1891 newborns from the Assessment of Worldwide AKI Epidemiology in Neonates (AWAKEN) database. We evaluated the associations for the entire cohort and 3 ... Read more >>

Pediatr. Res. (Pediatric research)
[2020, :]

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Autosomal-dominant polycystic kidney disease: tolvaptan use in adolescents and young adults with rapid progression.

Rupesh Raina, Ronith Chakraborty, Meredith E DeCoy, Timothy Kline,

BACKGROUND:The phase 3 Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes (TEMPO 3:4) clinical trial demonstrated the beneficial effect of tolvaptan on kidney growth and function in subjects aged 18-50 years over a 3-year period. However, it did not specifically assess the use ... Read more >>

Pediatr. Res. (Pediatric research)
[2020, :]

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Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy.

Rupesh Raina, Jirair K Bedoyan, Uta Lichter-Konecki, Philippe Jouvet, Stefano Picca, Nicholas Ah Mew, Marcel C Machado, Ronith Chakraborty, Meghana Vemuganti, Manpreet K Grewal, Timothy Bunchman, Sidharth Kumar Sethi, Vinod Krishnappa, Mignon McCulloch, Khalid Alhasan, Arvind Bagga, Rajit K Basu, Franz Schaefer, Guido Filler, Bradley A Warady,

Hyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea cycle disorders or organic acidaemias. Few studies have assessed the role of extracorporeal therapies in the management of hyperammonaemia in ... Read more >>

Nat Rev Nephrol (Nature reviews. Nephrology)
[2020, 16(8):471-482]

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An Overview of Rickets in Children.

Rahul Chanchlani, Paul Nemer, Rajiv Sinha, Lena Nemer, Vinod Krishnappa, Etienne Sochett, Fayez Safadi, Rupesh Raina,

Rickets is a common bone disease worldwide that is associated with disturbances in calcium and phosphate homeostasis and can lead to short stature and joint deformities. Rickets can be diagnosed based on history and physical examination, radiological features, and biochemical tests. It can be classified into 2 major groups based ... Read more >>

Kidney Int Rep (Kidney International Reports)
[2020, 5(7):980-990]

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Bone mineral density in adolescent urinary stone formers: is sex important?

Kirsten Kusumi, Andrew L Schwaderer, Curtis Clark, Kevin Budge, Nazar Hussein, Rupesh Raina, Michelle Denburg, Fayez Safadi,

Urinary stone disease (USD) is affecting a greater number of children and low bone mineral density (BMD) and increased skeletal fractures have been demonstrated in stone patients; however, the mechanism(s) driving bone disease remain unclear. This pilot study was undertaken to assess an adolescent kidney stone cohort's BMD and evaluate ... Read more >>

Urolithiasis (Urolithiasis)
[2020, 48(4):329-335]

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An Update on the Pathophysiology and Treatment of Cardiorenal Syndrome.

Rupesh Raina, Nikhil Nair, Ronith Chakraborty, Lena Nemer, Rahul Dasgupta, Kenneth Varian,

Cardiorenal syndrome (CRS) encompasses various disorders of the heart and kidneys; dysfunction of one organ leads to acute or chronic dysfunction of the other. It incorporates the intersection of heart-kidney interactions across several mediums, hemodynamically, through the alterations in neurohormonal markers, and increased venous and renal pressure, all of which ... Read more >>

Cardiol Res (Cardiology research)
[2020, 11(2):76-88]

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Nocturnal home hemodialysis in children: Advantages, implementation, and barriers.

Manpreet K Grewal, Arul Mehta, Ronith Chakraborty, Rupesh Raina,

Chronic kidney disease and end-stage renal disease (ESRD) in children are major health concerns worldwide with increasing incidence and prevalence. Renal replacement therapies and kidney transplants have remarkably improved the management of patients with ESRD in both adult and pediatric populations. Kidney transplant has the best patient outcomes, but many ... Read more >>

Semin Dial (Seminars in dialysis)
[2020, 33(2):109-119]

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Pediatric Continuous Renal Replacement Therapy (PCRRT) expert committee recommendation on prescribing prolonged intermittent renal replacement therapy (PIRRT) in critically ill children.

Sidharth Kumar Sethi, Aliza Mittal, Nikhil Nair, Arvind Bagga, Arpana Iyenger, Uma Ali, Rajiv Sinha, Indira Agarwal, Marcelo de Sousa Tavares, Asiri Abeyagunawardena, Mohammed Hanif, Devender Shreshtha, Khemchand Moorani, Sadaf Asim, Vijay Kher, Khalid Alhasan, Chebl Mourani, Mohammed Al Riyami, Timothy E Bunchman, Mignon McCulloch, Rupesh Raina,

INTRODUCTION:Recently, prolonged intermittent renal replacement therapies (PIRRT) have emerged as cost-effective alternatives to conventional CRRT and their use in the pediatric population has started to become more prominent. However, there is a lack of consensus guidelines on the use of PIRRT in pediatric patients in an intensive care setting. METHODS:A ... Read more >>

Hemodial Int (Hemodialysis international. International Symposium on Home Hemodialysis)
[2020, 24(2):237-251]

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Extracorporeal Therapies in the Treatment of Focal Segmental Glomerulosclerosis.

Rupesh Raina, Joseph Wang, Aditya Sharma, Ronith Chakraborty,

Focal segmental glomerulosclerosis (FSGS) is one of the most frequent and severe glomerular kidney disease with frequent progression to end-stage renal disease and a high rate of recurrence in renal transplantations. Due to intolerance or resistance to the current immunomodulatory treatments, the management of FSGS is a therapeutic challenge. Over ... Read more >>

Blood Purif. (Blood purification)
[2020, :1-11]

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Renal Replacement Therapy in Pediatric Acute Kidney Injury.

Sidharth Kumar Sethi, Ronith Chakraborty, Hirva Joshi, Rupesh Raina,

Acute kidney injury (AKI) is common in critically ill children and affects nearly 30-40% of patients admitted to the pediatric intensive care unit (ICU). Even with technological advances in critical care and dialysis, there is a high mortality rate of 66.8% to 90% in ICU patients. Renal replacement therapy (RRT) ... Read more >>

Indian J Pediatr (Indian journal of pediatrics)
[2020, 87(8):608-617]

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The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease.

Rupesh Raina, Abigail Chauvin, Ronith Chakraborty, Nikhil Nair, Haikoo Shah, Vinod Krishnappa, Kirsten Kusumi,

Background:Endothelins (ET) are a family of peptides that act as potent vasoconstrictors and pro-fibrotic growth factors. ET-1 is integral to renal and cardiovascular pathophysiology and exerts effects via autocrine, paracrine and endocrine signaling pathways tied to regulation of aldosterone, catecholamines, and angiotensin. In the kidney, ET-1 is critical to maintaining ... Read more >>

Kidney Dis (Basel) (Kidney Diseases)
[2020, 6(1):22-34]

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Management of Intoxication via Extracorporeal Therapy in Pediatrics.

Rupesh Raina, Sidharth Kumar Sethi, Timothy Bunchman,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(5):913-914]

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A boy with IgA vasculitis and anuria: Answers.

Vivek Sharma, Sidharth Kumar Sethi, Rupesh Raina, Shyam Bansal, S S Baijal, Vijay Kher,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(3):401-402]

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Acute Kidney Injury is Associated with Poor Lung Outcomes in Infants Born ≥32 Weeks of Gestational Age.

Michelle C Starr, Louis Boohaker, Laurie C Eldredge, Shina Menon, Russell Griffin, Dennis Mayock, David Askenazi, Sangeeta Hingorani, ,

OBJECTIVE:This study aimed to evaluate the association between acute kidney injury (AKI) and lung outcomes in infants born ≥32 weeks of gestational age (GA). STUDY DESIGN:Secondary analysis of infants ≥32 weeks of GA in the assessment of worldwide acute kidney injury epidemiology in neonates (AWAKEN) retrospective cohort (n = 1,348). We used ... Read more >>

Am J Perinatol (American journal of perinatology)
[2020, 37(2):231-240]

Cited: 1 time

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A boy with IgA vasculitis and anuria: Questions.

Vivek Sharma, Sidharth Kumar Sethi, Rupesh Raina, Shyam Bansal, S S Baijal, Vijay Kher,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(3):399-400]

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Dextran-Sulfate Plasma Adsorption Lipoprotein Apheresis in Drug Resistant Primary Focal Segmental Glomerulosclerosis Patients: Results From a Prospective, Multicenter, Single-Arm Intervention Study.

Rupesh Raina, Vinod Krishnappa, Cheryl Sanchez-Kazi, Alejandro Quiroga, Katherine E Twombley, Robert Mathias, Megan Lo, Ronith Chakraborty, Shefali Mahesh, Julia Steinke, Timothy Bunchman, Joshua Zaritsky,

Background: Focal segmental glomerulosclerosis (FSGS) causes end stage renal disease (ESRD) in significant proportion of patients worldwide. Primary FSGS carries poor prognosis and management of FSGS patients, refractory to standard treatments or resistant to steroids, remains a major challenge. Lipoprotein apheresis is a therapeutic approach for drug resistant primary FSGS ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:454]

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Predictors of time to first cannulation for arteriovenous fistula in pediatric hemodialysis patients: Midwest Pediatric Nephrology Consortium study.

Ali Mirza Onder, Joseph T Flynn, Anthony A Billings, Fang Deng, Marissa DeFreitas, Chryso Katsoufis, Matthew M Grinsell, Larry Patterson, Jennifer Jetton, Sahar Fathallah-Shaykh, Daniel Ranch, Diego Aviles, Lawrence Copelovitch, Eileen Ellis, Vimal Chadha, Ayah Elmaghrabi, Jen-Jar Lin, Lavjay Butani, Maha Haddad, Olivera Marsenic, Paul Brakeman, Raymond Quigley, H Stella Shin, Rouba Garro, Hui Liu, Javad Rahimikollu, Rupesh Raina, Craig B Langman, Ellen Wood, ,

BACKGROUND:Permanent vascular access (PVA) is preferred for long-term hemodialysis. Arteriovenous fistulae (AVF) have the best patency and the lowest complication rates compared to arteriovenous grafts (AVG) and tunneled cuffed catheters (TCC). However, AVF need time to mature. This study aimed to investigate predictors of time to first cannulation for AVF ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(2):287-295]

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Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation.

Michelle C Starr, Louis Boohaker, Laurie C Eldredge, Shina Menon, Russell Griffin, Dennis E Mayock, Linzi Li, David Askenazi, Sangeeta Hingorani, ,

OBJECTIVE:This study aimed to evaluate the association between acute kidney injury (AKI) and bronchopulmonary dysplasia (BPD) in infants born <32 weeks of gestational age (GA). STUDY DESIGN:Present study is a secondary analysis of premature infants born at <32 weeks of GA in the Assessment of Worldwide Acute Kidney Injury Epidemiology ... Read more >>

Am J Perinatol (American journal of perinatology)
[2020, 37(3):341-348]

Cited: 3 times

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Design and Baseline Characteristics of the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease Trial.

George L Bakris, Rajiv Agarwal, Stefan D Anker, Bertram Pitt, Luis M Ruilope, Christina Nowack, Peter Kolkhof, Anna C Ferreira, Patrick Schloemer, Gerasimos Filippatos, , ,

BACKGROUND:Among diabetics, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality, and progression of their underlying disease. Finerenone is a novel, non-steroidal, selective mineralocorticoid-receptor antagonist which has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD), while revealing only ... Read more >>

Am. J. Nephrol. (American journal of nephrology)
[2019, 50(5):333-344]

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