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Author Rupesh Dash

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Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host factors having implication in the disease pathogenesis and severity.

Voddu Suresh, Varshasnata Mohanty, Kiran Avula, Arup Ghosh, Bharati Singh, Rajendra Kumar Reddy, Deepti Parida, Amol Ratnakar Suryawanshi, Sunil Kumar Raghav, Soma Chattopadhyay, Punit Prasad, Rajeeb Kumar Swain, Rupesh Dash, Ajay Parida, Gulam Hussain Syed, Shantibhusan Senapati,

Syrian golden hamsters (Mesocricetus auratus) infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manifests lung pathology. In this study, efforts were made to check the infectivity of a local SARS-CoV-2 isolate in a self-limiting and non-lethal hamster model and evaluate the differential expression of lung proteins during acute infection ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21713]

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Correction: RRBP1 rewires cisplatin resistance in oral squamous cell carcinoma by regulating Hippo pathway.

Omprakash Shriwas, Rakesh Arya, Sibasish Mohanty, Pallavi Mohapatra, Sugandh Kumar, Rachna Rath, Sandeep Rai Kaushik, Falak Pahwa, Krushna Chandra Murmu, Saroj Kumar Das Majumdar, Dillip Kumar Muduly, Anshuman Dixit, Punit Prasad, Ranjan K Nanda, Rupesh Dash,

Br J Cancer (British journal of cancer)
[2021, 124(12):2039]

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Microtubule-targeting agents impair kinesin-2-dependent nuclear transport of β-catenin: Evidence of inhibition of Wnt/β-catenin signaling as an important antitumor mechanism of microtubule-targeting agents.

Anuradha Kumari, Omprakash Shriwas, Shailendra Sisodiya, Manas K Santra, Sankar K Guchhait, Rupesh Dash, Dulal Panda,

An aberrant accumulation of nuclear β-catenin is closely associated with the augmentation of cancer malignancy. In this work, we report that several microtubule-targeting agents (MTAs) such as vinblastine, taxol, and C12 (combretastatin-2-aminoimidazole analog) inhibit Wnt/β-catenin signaling in oral squamous cell carcinoma (OSCC). We showed that the inhibition of microtubule dynamics ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(4):e21539]

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RRBP1 rewires cisplatin resistance in oral squamous cell carcinoma by regulating Hippo pathway.

Omprakash Shriwas, Rakesh Arya, Sibasish Mohanty, Pallavi Mohapatra, Sugandh Kumar, Rachna Rath, Sandeep Rai Kaushik, Falak Pahwa, Krushna Chandra Murmu, Saroj Kumar Das Majumdar, Dillip Kumar Muduly, Anshuman Dixit, Punit Prasad, Ranjan K Nanda, Rupesh Dash,

<h4>Background</h4>Chemoresistance is one of the major factors for treatment failure in OSCC. Identifying key resistance triggering molecules will be useful strategy for developing novel treatment methods.<h4>Methods</h4>To identify the causative factors of chemoresistance, we performed RNA sequencing and global proteomic profiling of human OSCC lines presenting with sensitive, early and late ... Read more >>

Br J Cancer (British journal of cancer)
[2021, 124(12):2004-2016]

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DDX3 modulates cisplatin resistance in OSCC through ALKBH5-mediated m6A-demethylation of FOXM1 and NANOG.

Omprakash Shriwas, Manashi Priyadarshini, Sabindra K Samal, Rachna Rath, Sanjay Panda, Saroj Kumar Das Majumdar, Dillip Kumar Muduly, Mahendran Botlagunta, Rupesh Dash,

Platinum based drugs alone or in combination with 5FU and docetaxel are common regimen chemotherapeutics for the treatment of advanced OSCC. Chemoresistance is one of the major factors of treatment failure in OSCC. Human RNA helicase DDX3 plays an important role in cell proliferation, invasion, and metastasis in several neoplasms. ... Read more >>

Apoptosis (Apoptosis : an international journal on programmed cell death)
[2020, 25(3-4):233-246]

Cited: 12 times

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RRBP1 rewires cisplatin resistance in Oral Squamous Cell Carcinoma by regulating YAP-1

Omprakash Shriwas, Rakesh Arya, Sibasish Mohanty, Sugandh Kumar, Rachna Rath, Sandeep Rai Kaushik, Mukund Chandra Thakur, Falak Pahwa, Saroj Kumar Das Majumdar, Dillip Kumar Muduly, Ranjan Nanda, Rupesh Dash,

Cisplatin-based chemotherapy still remains as one of the primary treatment modalities for OSCC. Several OSCC patients experience relapse owing to development of chemoresistance. To identify key resistance triggering molecules, we performed global proteomic profiling of human OSCC lines presenting with sensitive, early and late cisplatin resistance patterns. From the proteomic ... Read more >>

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CMTM6 drives cisplatin resistance in OSCC by regulating AKT mediated Wnt signaling

Pallavi Mohapatra, Omprakash Shriwas, Sibasish Mohanty, Sandeep Rai Kaushik, Rakesh Arya, Rachna Rath, Saroj Kumar Das Majumdar, Dillip Kumar Muduly, Ranjan Nanda, Rupesh Dash,

Chemoresistance is one of the important factors for treatment failure in OSCC, which can culminate in progressive tumor growth and metastatic spread. Rewiring tumor cells to undergo drug-induced apoptosis is a promising way to overcome chemoresistance, which can be achieved by identifying the causative factors for acquired chemoresistance. In this ... Read more >>

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The Impact of m6A RNA Modification in Therapy Resistance of Cancer: Implication in Chemotherapy, Radiotherapy, and Immunotherapy.

Omprakash Shriwas, Pallavi Mohapatra, Sibasish Mohanty, Rupesh Dash,

m6A RNA methylation, which serves as a critical regulator of transcript expression, has gathered tremendous scientific interest in recent years. From RNA processing to nuclear export, RNA translation to decay, m6A modification has been studied to affect various aspects of RNA metabolism, and it is now considered as one of ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:612337]

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STAT3- and GSK3β-mediated Mcl-1 regulation modulates TPF resistance in oral squamous cell carcinoma.

Santanu Maji, Omprakash Shriwas, Sabindra K Samal, Manashi Priyadarshini, Rachna Rath, Sanjay Panda, Saroj Kumar Das Majumdar, Dillip Kumar Muduly, Rupesh Dash,

Cisplatin alone or in combination with 5FU (5-fluorouracil) and docetaxel (TPF) are common regimen chemotherapeutics for treatment of advanced oral squamous cell carcinoma (OSCC). Despite the initial positive response, several patients experience relapse due to chemoresistance. The potential role of Bcl-2 antiapoptotic members in acquired chemoresistance is yet to be ... Read more >>

Carcinogenesis (Carcinogenesis)
[2019, 40(1):173-183]

Cited: 8 times

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Publisher Correction: Identification of oral cancer related candidate genes by integrating protein-protein interactions, gene ontology, pathway analysis and immunohistochemistry.

Ravindra Kumar, Sabindra K Samal, Samapika Routray, Rupesh Dash, Anshuman Dixit,

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):8356]

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Author Correction: Identification of oral cancer related candidate genes by integrating protein-protein interactions, gene ontology, pathway analysis and immunohistochemistry.

Ravindra Kumar, Sabindra K Samal, Samapika Routray, Rupesh Dash, Anshuman Dixit,

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):6454]

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Bcl-2 Antiapoptotic Family Proteins and Chemoresistance in Cancer.

Santanu Maji, Sanjay Panda, Sabindra K Samal, Omprakash Shriwas, Rachna Rath, Maurizio Pellecchia, Luni Emdad, Swadesh K Das, Paul B Fisher, Rupesh Dash,

Cancer is a daunting global problem confronting the world's population. The most frequent therapeutic approaches include surgery, chemotherapy, radiotherapy, and more recently immunotherapy. In the case of chemotherapy, patients ultimately develop resistance to both single and multiple chemotherapeutic agents, which can culminate in metastatic disease which is a major cause ... Read more >>

Adv Cancer Res (Advances in cancer research)
[2018, 137:37-75]

Cited: 29 times

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Establishing Fascin over-expression as a strategic regulator of neoplastic aggression and lymph node metastasis in oral squamous cell carcinoma tumor microenvironment.

Samapika Routray, Supriya Kheur, Hemlata M Chougule, Neeta Mohanty, Rupesh Dash,

<h4>Introduction</h4>Oral squamous cell carcinoma (OSCC) has an aggressive behaviour with high incidence of nodal metastasis, even in the early stages, leading to poor prognosis. For progression and metastasis of cancers, the dominant element considered is cell motility. Fascin, an actin-binding protein has emerged as a protein of general importance for ... Read more >>

Ann Diagn Pathol (Annals of diagnostic pathology)
[2017, 30:36-41]

Cited: 4 times

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Identification of oral cancer related candidate genes by integrating protein-protein interactions, gene ontology, pathway analysis and immunohistochemistry.

Ravindra Kumar, Sabindra K Samal, Samapika Routray, Rupesh Dash, Anshuman Dixit,

In the recent years, bioinformatics methods have been reported with a high degree of success for candidate gene identification. In this milieu, we have used an integrated bioinformatics approach assimilating information from gene ontologies (GO), protein-protein interaction (PPI) and network analysis to predict candidate genes related to oral squamous cell ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):2472]

Cited: 9 times

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Good's buffer derived highly emissive carbon quantum dots: excellent biocompatible anticancer drug carrier.

Aneeya K Samantara, Santanu Maji, Arnab Ghosh, Bamaprasad Bag, Rupesh Dash, Bikash Kumar Jena,

Here, a facile one-step approach has been developed for the synthesis of carbon quantum dots (CQDs) from Good's buffer. The as-synthesized CQDs emit a bright greenish blue coloured fluorescence after exposure to a 365 nm UV-lamp illumination. The bright fluorescence nature of the CQDs has proven them to be excellent ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2016, 4(14):2412-2420]

Cited: 0 times

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Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline.

Bridget A Quinn, Rupesh Dash, Siddik Sarkar, Belal Azab, Praveen Bhoopathi, Swadesh K Das, Luni Emdad, Jun Wei, Maurizio Pellecchia, Devanand Sarkar, Paul B Fisher,

Improved treatments for pancreatic cancer remain a clinical imperative. Sabutoclax, a small-molecule BH3 mimetic, inhibits the function of antiapoptotic Bcl-2 proteins. Minocycline, a synthetic tetracycline, displays antitumor activity. Here, we offer evidence of the combinatorial antitumor potency of these agents in several preclinical models of pancreatic cancer. Sabutoclax induced growth ... Read more >>

Cancer Res (Cancer research)
[2015, 75(11):2305-2315]

Cited: 9 times

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Mcl-1 is an important therapeutic target for oral squamous cell carcinomas.

Santanu Maji, Sabindra K Samal, Laxmipriya Pattanaik, Swagatika Panda, Bridget A Quinn, Swadesh K Das, Devanand Sarkar, Maurizio Pellecchia, Paul B Fisher, Rupesh Dash,

Oral and oropharyngeal cancers are the sixth most common cancers worldwide. Despite intensive investigation, oral squamous cell carcinomas (OSCC) represent a clinical challenge resulting in significant morbidity and mortality. Resistance to cell death is common in OSCC and is often mediated by the Bcl-2 family proteins. Among all anti-apoptotic Bcl-2 ... Read more >>

Oncotarget (Oncotarget)
[2015, 6(18):16623-16637]

Cited: 21 times

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Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics.

Keetae Kim, Seok-Geun Lee, Timothy P Kegelman, Zhao-Zhong Su, Swadesh K Das, Rupesh Dash, Santanu Dasgupta, Paola M Barral, Michael Hedvat, Paul Diaz, John C Reed, John L Stebbins, Maurizio Pellecchia, Devanand Sarkar, Paul B Fisher,

Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory amino acid transporter (EAAT)-2 is one of the major glutamate transporters expressed predominantly in astroglial cells and is responsible for 90% of total glutamate uptake. Glutamate transporters tightly regulate glutamate concentration in the synaptic cleft. Dysfunction of EAAT2 and accumulation ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2011, 226(10):2484-2493]

Cited: 161 times

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Polyacryloyl hydrazide based injectable & stimuli responsive hydrogels with tunable properties.

Anuj Kumar, Sabindra K Samal, Rupesh Dash, Umaprasana Ojha,

The synthesis and characterization of a series of injectable and stimuli responsive hydrogels based on polyacryloyl hydrazide have been accomplished using dimethyl 2,2'-thiodiacetate, acrylic acid (AA), diethyl malonate and polyethylene glycol diacrylate (PEGDA) as cross-linkers through a chemical or dual cross-linking pathway. The cross-linking reactions were carried out at room ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2014, 2(42):7429-7439]

Cited: 0 times

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Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules.

Michael Hedvat, Luni Emdad, Swadesh K Das, Keetae Kim, Santanu Dasgupta, Shibu Thomas, Bin Hu, Shan Zhu, Rupesh Dash, Bridget A Quinn, Regina A Oyesanya, Timothy P Kegelman, Upneet K Sokhi, Siddik Sarkar, Eda Erdogan, Mitchell E Menezes, Praveen Bhoopathi, Xiang-Yang Wang, Martin G Pomper, Jun Wei, Bainan Wu, John L Stebbins, Paul W Diaz, John C Reed, Maurizio Pellecchia, Devanand Sarkar, Paul B Fisher,

Structure-based modeling combined with rational drug design, and high throughput screening approaches offer significant potential for identifying and developing lead compounds with therapeutic potential. The present review focuses on these two approaches using explicit examples based on specific derivatives of Gossypol generated through rational design and applications of a cancer-specificpromoter ... Read more >>

Anticancer Agents Med Chem (Anti-cancer agents in medicinal chemistry)
[2012, 12(9):1143-1155]

Cited: 6 times

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mda-7/IL-24 expression inhibits breast cancer through upregulation of growth arrest-specific gene 3 (gas3) and disruption of β1 integrin function.

You-Jun Li, Guodong Liu, Yanmei Li, Laura M Vecchiarelli-Federico, Jeff C Liu, Eldad Zacksenhaus, Sze W Shan, Burton B Yang, Qi Li, Rupesh Dash, Paul B Fisher, Michael C Archer, Yaacov Ben-David,

Melanoma differentiation-associated gene (MDA)-7)/interleukin (IL)-24, a member of the IL-10 family of cytokines, inhibits growth of various human cancer cells, yet the underlying mechanism is largely unknown. Here, we report that mda-7/IL-24 efficiently suppresses the development of rat mammary tumors in vivo. Microarray analysis for genes differentially expressed in rat ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2013, 11(6):593-603]

Cited: 10 times

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Targeting the Bcl-2 family for cancer therapy.

Shibu Thomas, Bridget A Quinn, Swadesh K Das, Rupesh Dash, Luni Emdad, Santanu Dasgupta, Xiang-Yang Wang, Paul Dent, John C Reed, Maurizio Pellecchia, Devanand Sarkar, Paul B Fisher,

<h4>Introduction</h4>Programmed cell death is well-orchestrated process regulated by multiple pro-apoptotic and anti-apoptotic genes, particularly those of the Bcl-2 gene family. These genes are well documented in cancer with aberrant expression being strongly associated with resistance to chemotherapy and radiation.<h4>Areas covered</h4>This review focuses on the resistance induced by the Bcl-2 family ... Read more >>

Expert Opin Ther Targets (Expert opinion on therapeutic targets)
[2013, 17(1):61-75]

Cited: 104 times

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Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells.

Belal Azab, Rupesh Dash, Swadesh K Das, Sujit K Bhutia, Xue-Ning Shen, Bridget A Quinn, Siddik Sarkar, Xiang-Yang Wang, Michael Hedvat, Igor P Dmitriev, David T Curiel, Steven Grant, Paul Dent, John C Reed, Maurizio Pellecchia, Devanand Sarkar, Paul B Fisher,

Adenovirus (Ad)-based gene therapy represents a potentially viable strategy for treating colorectal cancer. The infectivity of serotype 5 adenovirus (Ad.5), routinely used as a transgene delivery vector, is dependent on Coxsackie-adenovirus receptors (CAR). CAR expression is downregulated in many cancers thus preventing optimum therapeutic efficiency of Ad.5-based therapies. To overcome ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2012, 227(5):2145-2153]

Cited: 26 times

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mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer.

Sujit K Bhutia, Swadesh K Das, Timothy P Kegelman, Belal Azab, Rupesh Dash, Zhao-Zhong Su, Xiang-Yang Wang, Federica Rizzi, Saverio Bettuzzi, Seok-Geun Lee, Paul Dent, Steven Grant, David T Curiel, Devanand Sarkar, Paul B Fisher,

Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24), a unique member of the IL-10 gene family, displays a broad range of antitumor properties including cancer-specific induction of apoptosis, inhibition of tumor angiogenesis, and modulation of anti-tumor immune responses. Here, we identify clusterin (CLU) as a MDA-7/IL-24 interacting protein in DU-145 cells and investigate the ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2012, 227(5):1805-1813]

Cited: 14 times

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A first-generation multi-functional cytokine for simultaneous optical tracking and tumor therapy.

Shawn Hingtgen, Randa Kasmieh, Elizabeth Elbayly, Irina Nesterenko, Jose-Luiz Figueiredo, Rupesh Dash, Devanand Sarkar, David Hall, Dima Kozakov, Sandor Vajda, Paul B Fisher, Khalid Shah,

Creating new molecules that simultaneously enhance tumor cell killing and permit diagnostic tracking is vital to overcoming the limitations rendering current therapeutic regimens for terminal cancers ineffective. Accordingly, we investigated the efficacy of an innovative new multi-functional targeted anti-cancer molecule, SM7L, using models of the lethal brain tumor Glioblastoma multiforme ... Read more >>

PLoS One (PloS one)
[2012, 7(7):e40234]

Cited: 16 times

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