Full Text Journal Articles by
Author Ruohong Chen

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Antiobesity and anti-inflammation effects of Hakka stir-fried tea of different storage years on high-fat diet-induced obese mice model via activating the AMPK/ACC/CPT1 pathway.

Qiuhua Li, Xingfei Lai, Lingli Sun, Junxi Cao, Caijin Ling, Wenji Zhang, Limin Xiang, Ruohong Chen, Dongli Li, Shili Sun,

Background:As a typical representative of metabolic syndrome, obesity is also one of the extremely dangerous factors of cardiovascular diseases. Thus, the prevention and treatment of obesity has gradually become a global campaign. There have been many reports that green tea is effective in preventing obesity, but as a kind of ... Read more >>

Food Nutr Res (Food & nutrition research)
[2020, 64:]

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Theaflavin TF3 Relieves Hepatocyte Lipid Deposition through Activating an AMPK Signaling Pathway by targeting Plasma Kallikrein.

Wenji Zhang, Ran An, Qiuhua Li, Lingli Sun, Xingfei Lai, Ruohong Chen, Dongli Li, Shili Sun,

Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the leading cause of chronic liver diseases throughout the world. The deficit of pharmacotherapy for NAFLD calls for an urgent need for a new drug discovery and lifestyle management. Black tea is the most popular and functional drink consumed worldwide. Its main ... Read more >>

J. Agric. Food Chem. (Journal of agricultural and food chemistry)
[2020, 68(9):2673-2683]

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Deoxynivalenol globally affects the selection of 3' splice sites in human cells by suppressing the splicing factors, U2AF1 and SF1.

Zhangsheng Hu, Yu Sun, Jiongjie Chen, Yurong Zhao, Han Qiao, Ruohong Chen, Xianhui Wen, Yiqun Deng, Jikai Wen,

Deoxynivalenol (DON) is one of the most abundant mycotoxins and has adverse effects on several biological processes, posing risks of protein synthesis-disrupting effects and ribotoxic response. Therefore, chronic exposure to DON would fundamentally reshape the global expression pattern. Whether DON causes toxic effects on mRNA splicing, a fundamental biological process, ... Read more >>

RNA Biol (RNA biology)
[2020, 17(4):584-595]

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T-2 toxin upregulates the expression of human cytochrome P450 1A1 (CYP1A1) by enhancing NRF1 and Sp1 interaction.

Wenchu Ye, Ruqin Lin, Xiaoxuan Chen, Jiongjie Chen, Ruohong Chen, Xuan Xie, Yiqun Deng, Jikai Wen,

T-2 toxin is a major pollutant in crops and feedstuffs. Due to its high toxicity in a variety of organisms, T-2 toxin is of great concern as a threat to humans and to animal breeding. Overexpression of CYP1A1 may contribute to carcinogenesis, and CYP1A1 may be a promising target for ... Read more >>

Toxicol. Lett. (Toxicology letters)
[2019, 315:77-86]

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AhR regulates the expression of human cytochrome P450 1A1 (CYP1A1) by recruiting Sp1.

Wenchu Ye, Ruohong Chen, Xiaoxuan Chen, Boyan Huang, Ruqin Lin, Xuan Xie, Jiongjie Chen, Jun Jiang, Yiqun Deng, Jikai Wen,

Cytochrome P450 1A1 (CYP1A1) is abundant in the kidney, liver, and intestine and is involved in the phase I metabolism of numerous endogenous and exogenous compounds. Therefore, exploring the regulatory mechanism of its basal expression in humans is particularly important to understand the bioactivation of several procarcinogens to their carcinogenic ... Read more >>

FEBS J. (The FEBS journal)
[2019, 286(21):4215-4231]

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Variable protein homeostasis in housekeeping and non-housekeeping pathways under mycotoxins stress.

Yu Sun, Jikai Wen, Ruohong Chen, Yiqun Deng,

Transcript levels are the primary factor determining protein levels, but for the majority of genes, fold changes in transcript levels are larger than the corresponding changes in protein levels, a phenomenon that is termed "protein homeostasis". However, this phenomenon is not well characterized in the context of environmental changes. In ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):7819]

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Coordinated Transcriptional Regulation of Cytochrome P450 3As by Nuclear Transcription Factor Y and Specificity Protein 1.

Ruohong Chen, Jun Jiang, Zhangsheng Hu, Wenchu Ye, Qianqian Yuan, Mengyuan Li, Jikai Wen, Yiqun Deng,

The cytochrome P450 3A subfamily plays vital roles in the metabolism of endogenous chemicals and xenobiotics. Understanding the basal expression of CYP3A in humans and pigs is crucial for drug evaluation. In this study, we demonstrated that the basal transcriptional regulation of CYP3A genes in hepatocytes is evolutionarily conserved between ... Read more >>

Mol. Pharmacol. (Molecular pharmacology)
[2019, 95(5):507-518]

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sSema4D levels are increased in coronary heart disease and associated with the extent of coronary artery stenosis.

Hui Gong, Xing Lyu, Shizhen Li, Ruohong Chen, Min Hu, Xiangyu Zhang,

OBJECTIVE:The aim of this study was to evaluate the association between serum soluble semaphorin4D (sSema4D) and coronary heart disease (CHD) and the extent of coronary artery stenosis. METHODS:The study included 188 cases that underwent coronary angiography because of precordial pain. One hundred and twenty-eight cases were diagnosed with CHD; 60 ... Read more >>

Life Sci. (Life sciences)
[2019, 219:329-335]

Cited: 1 time

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Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine CYP1A1 at the Proximal Promoter.

Xuan Xie, Jun Jiang, Wenchu Ye, Ruohong Chen, Yiqun Deng, Jikai Wen,

Pigs are commonly used as an animal model to evaluate the toxic effects of exogenous compounds. Cytochrome P450 1A1 (CYP1A1) metabolizes numerous exogenous compounds and is abundantly expressed in the liver, kidneys, and intestines. The high amino acid similarity between human and porcine CYP1A1 indicates that they probably have the ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:927]

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T-2 toxin induces the expression of porcine CYP3A22 via the upregulation of the transcription factor, NF-Y.

Xin Liu, Jikai Wen, Ruohong Chen, Tingting Zhang, Jun Jiang, Yiqun Deng,

T-2 toxin is one of the major pollutants in crops and feedstuffs. CYP3A22, one of hCYP3A4 homologs, detoxifies T-2 toxin in pigs. We investigated the mechanisms of expression activation of CYP3A22 under basal and induced conditions.Based on MatInspector analysis, several mutations in the CYP3A22 promoter were assayed by dual luciferase ... Read more >>

Biochim. Biophys. Acta (Biochimica et biophysica acta)
[2016, 1860(10):2191-2201]

Cited: 1 time

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Bioactivation and Regioselectivity of Pig Cytochrome P450 3A29 towards Aflatoxin B₁.

Jun Wu, Ruohong Chen, Caihui Zhang, Kangbai Li, Weiying Xu, Lijuan Wang, Qingmei Chen, Peiqiang Mu, Jun Jiang, Jikai Wen, Yiqun Deng,

Due to unavoidable contaminations in feedstuff, pigs are easily exposed to aflatoxin B₁ (AFB₁) and suffer from poisoning, thus the poisoned products potentially affect human health. Heretofore, the metabolic process of AFB₁ in pigs remains to be clarified, especially the principal cytochrome P450 oxidases responsible for its activation. In this ... Read more >>

Toxins (Basel) (Toxins)
[2016, 8(9):]

Cited: 2 times

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[Concentration increase in Hcy and anti-CCP antibody in the serum of depression rat model induced by chronic unpredictable mild stress].

Yamei Tang, Yong Liu, Lixin Qin, Rensheng Zhang, Ruohong Chen,

OBJECTIVE: To observe the change of serum homocysteine (Hcy) and anti-citrullinated peptide (CCP) antibody concentration in depression rat model induced by chronic unpredictable mild stress (CUMS), and to explore the immunologic mechanism of depression and the relation between depression and its autoimmunity. METHODS: Sixty adult male SD rats were randomly ... Read more >>

Zhong Nan Da Xue Xue Bao Yi Xue Ban (Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences)
[2012, 37(8):790-795]

Cited: 0 times

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Full automatic determination of chlorophenols in water using solid-phase microextraction/on-fiber derivatization and gas chromatography-mass spectrometry.

Xiaowei Wang, Ruohong Chen, Tiangang Luan, Li Lin, Shichun Zou, Qingshu Yang,

A fully automated combination of solid-phase microextraction and on-fiber derivatization coupled with gas chromatography-mass spectrometry was developed to determine 17 chlorophenols in aqueous samples. Optimal parameters for the automated process, such as fiber coating (polyacrylate), derivatization reagent (N,O-bis(trimethylsilyl) trifluoroacetamide), extraction time (60 min), derivatization time (5 min), incubation temperature (35°C), ... Read more >>

J Sep Sci (Journal of separation science)
[2012, 35(8):1017-1026]

Cited: 9 times

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