Full Text Journal Articles by
Author Runhua Shi

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Do the 2013 United States Preventive Services Task Force guidelines for lung cancer screening fail high-risk African American smokers? An institutional retrospective observational cohort study.

Aswani Thurlapati, Carol S Velez-Martinez, Samina Hirani, Jade Abad, Runhua Shi, Kavitha Beedupalli, Richard P Mansour,

<h4>Background</h4>Lung cancer cause nearly 1.76 million deaths worldwide in 2018. In 2011, the National-Lung-Cancer-Screening-Trial showed 20% relative risk reduction with LDCT and subsequently led to the current USPSTF screening guidelines. However, the predominant focus on elderly, Caucasian questions its generalizability to communities with young, African Americans such as our institution. ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, 30(5):375-381]

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Propensity Score Matching Analysis of the Effect of Payer Status on the Survival of Colon Cancer Patients.

Lawrence Shi, Winston Suh, Mindie M Kavanaugh, Glenn Mills, Sarah Thayer, Runhua Shi,

Background and objective Colon cancer is one of the most common types of cancer globally. The factors that could affect colon cancer survival include age, stage, treatment, and other socioeconomic aspects. Payer status has been shown to be a significant predictor of cancer patient survival in retrospective studies. However, due ... Read more >>

Cureus (Cureus)
[2021, 13(6):e15748]

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Outcomes in patients with primary malignant cardiac tumors: A surveillance, epidemiology, and end results program (SEER) database analysis.

Aakash Rajendra Sheth, Udhayvir Singh Grewal, Sahith Reddy Thotamgari, Runhua Shi,

J Card Surg (Journal of cardiac surgery)
[2021, 36(9):3463-3465]

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The Effect of Payer Status on Survival of Patients With Prostate Cancer.

Winston Suh, Samip Master, Lihong Liu, Glenn Mills, Runhua Shi,

Background Disparities in access to care and proper treatment can have significant implications in patient survival outcome and mortality. This retrospective study of prostate cancer patients from the National Cancer Database (NCDB) between the years 2004 and 2014 and follow-up to the end of 2015 analyzed such effects that variation ... Read more >>

Cureus (Cureus)
[2021, 13(2):e13329]

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Neuroendocrine prostate cancer has distinctive, non-prostatic HOX code that is represented by the loss of HOXB13 expression.

Siyuan Cheng, Shu Yang, Yingli Shi, Runhua Shi, Yunshin Yeh, Xiuping Yu,

HOX gene-encoded homeobox proteins control body patterning during embryonic development; the specific expression pattern of HOX genes may correspond to tissue identity. In this study, using RNAseq data of 1019 human cancer cell lines that originated from 24 different anatomic sites, we established HOX codes for various types of tissues. ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):2778]

Cited: 2 times

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Loss of HOXB13 expression in neuroendocrine prostate cancer

Siyuan Cheng, Shu Yang, Yingli Shi, Runhua Shi, Yunshin Yeh, Xiuping Yu,

HOXB13, the most posterior HOX B gene, is primarily expressed in the prostate. Using immunohistochemical staining, we evaluated the expression of HOXB13 in prostatic tissues. We found that HOXB13 was expressed in both benign prostatic tissues and prostate adenocarcinoma (AdPCa) but its expression was reduced or lost in neuroendocrine prostate ... Read more >>

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The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer.

Siyuan Cheng, Nestor Prieto-Dominguez, Shu Yang, Zachary M Connelly, Samantha StPierre, Bryce Rushing, Andy Watkins, Lawrence Shi, Meredith Lakey, Lyndsey Buckner Baiamonte, Tajammul Fazili, Aubrey Lurie, Eva Corey, Runhua Shi, Yunshin Yeh, Xiuping Yu,

<h4>Background</h4>After long-term androgen deprivation therapy, 25-30% prostate cancer (PCa) acquires an aggressive neuroendocrine (NE) phenotype. Dysregulation of YAP1, a key transcription coactivator of the Hippo pathway, has been related to cancer progression. However, its role in neuroendocrine prostate cancer (NEPC) has not been assessed.<h4>Methods</h4>Immunohistochemistry and bioinformatics analysis were conducted to ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2020, 23(4):661-669]

Cited: 8 times

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Prostate-Derived ETS Factor (PDEF) Modulates Yes Associated Protein 1 (YAP1) in Prostate Cancer Cells: A Potential Cross-Talk between PDEF and Hippo Signaling.

Praveen Kumar Jaiswal, Suman Mohajan, Sweaty Koul, Fengtian Wang, Runhua Shi, Hari K Koul,

PDEF (prostate-derived ETS factor, also known as SAM-pointed domain containing ETS transcription factor (SPDEF)) is expressed in luminal epithelial cells of the prostate gland and associates with luminal phenotype. The Hippo pathway regulates cell growth/proliferation, cellular homeostasis, and organ development by modulating phosphorylation of its downstream effectors. In previous studies, ... Read more >>

Pharmaceuticals (Basel) (Pharmaceuticals (Basel, Switzerland))
[2019, 12(4):]

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The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer

Siyuan Cheng, Nestor Prieto-Dominguez, Shu Yang, Zachary Connelly, Samantha StPierre, Bryce Rushing, Andy Watkins, Lawrence Shi, Meredith Lakey, Lyndsey Buckner Baiamonte, Tajammul Fazili, Aubrey Lurie, Eva Corey, Runhua Shi, Yunshin Yeh, Xiuping Yu,

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> After long-term androgen deprivation therapy, 25-30% prostate cancer (PCa) acquires an aggressive neuroendocrine (NE) phenotype. Dysregulation of YAP1, a key transcription coactivator of the Hippo pathway, has been related to cancer progression. However, its role in neuroendocrine prostate cancer (NEPC) has not been assessed. <h4>METHODS</h4> Immunohistochemistry was used ... Read more >>

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Prostate-Derived ETS Factor (PDEF) Regulates Yes Associated Protein 1 (YAP1) in Prostate Cancer Cells: A Potential Cross-Talk between PDEF and Hippo Signaling

Praveen Kumar Jaiswal, Suman Mohajan, Sweaty Koul, Fengtian Wang, Runhua Shi, Hari Koul,

PDEF is expressed in luminal epithelial cells of the prostate gland and associates with luminal phenotype. Hippo pathway regulates cell growth/proliferation, cellular homeostasis, and organ development by modulating phosphorylation of its downstream effectors. In previous studies, we observed decreased levels of PDEF during prostate cancer progression. In the present studies, ... Read more >>

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Effect of Stem Cell Transplant on Survival in Adult Patients With Acute Lymphoblastic Leukemia: NCDB Analysis.

Samip Master, Nebu Koshy, Richard Mansour, Runhua Shi,

<h4>Background</h4>A retrospective analysis was performed to investigate the survival outcomes in adult acute lymphoblastic leukemia (ALL) based on treatment received.<h4>Materials and methods</h4>Data from 17,504 men and women (≥18 years of age) registered in the National Cancer Database who were diagnosed with ALL between 2004 and 2013 and had follow-up to ... Read more >>

Anticancer Res (Anticancer research)
[2019, 39(4):1899-1906]

Cited: 2 times

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Dose-Dependent Influences of Ethanol on Ischemic Stroke: Role of Inflammation.

Guodong Xu, Chun Li, Anne L Parsiola, Jiyu Li, Kimberly D McCarter, Runhua Shi, William G Mayhan, Hong Sun,

Chronic ethanol consumption dose-dependently affects both incidence and prognosis of ischemic stroke. Our goal was to determine whether the influence of chronic ethanol consumption on ischemic stroke is related to an altered inflammatory profile in the brain. Male C57BL/6J mice were divided into six groups and gavage fed with 0.175, ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2019, 13:6]

Cited: 6 times

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Utility of routine pretreatment evaluation of left ventricular ejection fraction in breast cancer patients receiving anthracyclines.

Prakash Peddi, Samip R Master, Ashish D Dwary, Hari P Ravipati, Abhishek H Patel, Avinash Pasam, Pavan K Katikaneni, Runhua Shi, Gary V Burton, Quyen D Chu,

Anthracycline-based chemotherapy is widely used in the management of breast cancer. Despite the lack of clinical evidence, obtaining prechemotherapy left ventricular ejection fraction (LVEF) by echocardiogram or multigated acquisition scan is a widely adopted practice throughout the world. We present here the results of a retrospective analysis of breast cancer ... Read more >>

Breast J (The breast journal)
[2019, 25(1):62-68]

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Pitfalls in anaphylaxis diagnosis and management at a university emergency department.

Amy Castilano, Britni Sternard, Earl D Cummings, Runhua Shi, Thomas Arnold, Sami L Bahna,

<h4>Background</h4>Some previous reports revealed suboptimal management of anaphylaxis (ANX) in the emergency department (ED).<h4>Objective</h4>To evaluate the recorded diagnosis and management of patients who presented with ANX at our university hospital ED and to assess how the management correlated with the severity of the case and the training level of the ... Read more >>

Allergy Asthma Proc (Allergy and asthma proceedings)
[2018, 39(4):316-321]

Cited: 1 time

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Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease.

Dhaval Patel, Chuan Xu, Sureshbabu Nagarajan, Zhengchang Liu, Wayne O Hemphill, Runhua Shi, Vladimir N Uversky, Guy A Caldwell, Kim A Caldwell, Stephan N Witt,

We probed the role of alpha-synuclein (α-syn) in modulating sorting nexin 3 (Snx3)-retromer-mediated recycling of iron transporters in Saccharomyces cerevisiae and Caenorhabditis elegans. In yeast, the membrane-bound heterodimer Fet3/Ftr1 is the high affinity iron importer. Fet3 is a membrane-bound multicopper ferroxidase, whose ferroxidase domain is orthologous to human ceruloplasmin (Cp), ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2018, 27(9):1514-1532]

Cited: 8 times

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Reduction of vascular complication rates from femoral artery access in contemporary women undergoing cardiac catheterization.

Hari Bogabathina, Runhua Shi, Sampath Singireddy, Liam Morris, Abdulrahman Abdulbaki, Henock Zabher, Pavan Katikaneni, Kalgi Modi,

BACKGROUND:Femoral arterial access (FAA) during diagnostic coronary angiography (CAG) and percutaneous coronary interventions (PCI) are associated with several vascular complications (VC). VC rate in our experience a decade ago was 3.02% and higher in women (4.7% in women, and 1.67% in men, p < 0.0006), with an OR of 2.81 (95% CI: ... Read more >>

Cardiovasc Revasc Med (Cardiovascular revascularization medicine : including molecular interventions)
[2018, 19(6S):27-30]

Cited: 1 time

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Does micropuncture technique really help reduce vascular complications?

Hari Bogabathina, Sampath Singireddy, Runhua Shi, Liam Morris, Abdulrahman Abdulbaki, Henock Zabher, Pavan Katikaneni, Kalgi Modi,

BACKGROUND:Micropuncture technique (MPT) is being adapted nationally to reduce vascular complications (VC). We initiated a quality improvement project in our cath lab to reduce VCs utilizing MPT. METHODS:We utilized MPT on all of our non-STEMI femoral artery (FA) access cases starting September 2016. As a comparator group, we collected data ... Read more >>

Cardiovasc Revasc Med (Cardiovascular revascularization medicine : including molecular interventions)
[2018, 19(7 Pt A):762-765]

Cited: 0 times

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Effect of Radiation Therapy on Survival in Hodgkin's Lymphoma: A SEER Data Analysis.

Samip Master, Nebu Koshy, Ben Wilkinson, Lane Rosen, Glenn Mills, Richard Mansour, Runhua Shi,

<h4>Background/aim</h4>Hodgkin's Lymphoma (HL) is curable in up to 80% of patients due, in part, to simultaneous advances in chemotherapy regimens as well as radiation therapy planning and delivery. Concerns regarding the historical use of large-field radiotherapy on overall survival have been published. In this study, we performed a Surveillance, epidemiology, ... Read more >>

Anticancer Res (Anticancer research)
[2017, 37(6):3035-3043]

Cited: 4 times

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UCP2 upregulation promotes PLCγ-1 signaling during skin cell transformation.

Annapoorna Sreedhar, Julia Lefort, Petra Petruska, Xin Gu, Runhua Shi, Sumitra Miriyala, Manikandan Panchatcharam, Yunfeng Zhao,

Uncoupling protein 2 (UCP2), whose physiological role is to decrease mitochondrial membrane potential and reactive oxygen species (ROS) production, is often overexpressed in human cancers. UCP2 upregulation has recently been proposed as a novel survival mechanism for cancer cells. However, until now, how exactly UCP2 promotes tumorigenesis remains inconclusive. Based ... Read more >>

Mol Carcinog (Molecular carcinogenesis)
[2017, 56(10):2290-2300]

Cited: 1 time

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Mycobacterium tuberculosis and Mycobacterium marinum non-homologous end-joining proteins can function together to join DNA ends in Escherichia coli.

Douglas G Wright, Reneau Castore, Runhua Shi, Amrita Mallick, Don G Ennis, Lynn Harrison,

Mycobacterium tuberculosis and Mycobacterium smegmatis express a Ku protein and a DNA ligase D and are able to repair DNA double strand breaks (DSBs) by non-homologous end-joining (NHEJ). This pathway protects against DNA damage when bacteria are in stationary phase. Mycobacterium marinum is a member of this mycobacterium family and ... Read more >>

Mutagenesis (Mutagenesis)
[2017, 32(2):245-256]

Cited: 5 times

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Exposure of Mycobacterium marinum to low-shear modeled microgravity: effect on growth, the transcriptome and survival under stress.

Camille F Abshire, Kanchanjunga Prasai, Israel Soto, Runhua Shi, Monica Concha, Melody Baddoo, Erik K Flemington, Don G Ennis, Rona S Scott, Lynn Harrison,

Waterborne pathogenic mycobacteria can form biofilms, and certain species can cause hard-to-treat human lung infections. Astronaut health could therefore be compromised if the spacecraft environment or water becomes contaminated with pathogenic mycobacteria. This work uses <i>Mycobacterium marinum</i> to determine the physiological changes in a pathogenic mycobacteria grown under low-shear modeled ... Read more >>

NPJ Microgravity (NPJ microgravity)
[2016, 2:16038]

Cited: 8 times

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Insurance Status and Other Non-biological Factors Predict Outcomes in Acute Myelogenous Leukemia: Analysis of Data from the National Cancer Database.

Samip Master, Reinhold Munker, Zhenzhen Shi, Glenn Mills, Runhua Shi,

<h4>Background</h4>The treatment of acute myeloid leukemia (AML) has made significant progress in the last 30 years; however, numerous factors affect outcomes in patients with AML. Well-known risk factors are age, cytogenetics, and treatment intensity. The purpose of our study was to investigate the effects of insurance status on the outcome ... Read more >>

Anticancer Res (Anticancer research)
[2016, 36(9):4915-4921]

Cited: 4 times

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Observations on failed retrieval of optional inferior vena cava filters.

David H Ballard, Daniel V Do, Jeremy J Laborde, Miguel A de Gregorio, Runhua Shi, Horacio B D'Agostino,

<h4>Purpose</h4>To evaluate causes of failed optional inferior vena cava filter (IVCF) retrievals.<h4>Methods</h4>Single-center retrospective study.<h4>Results</h4>IVCF retrievals were attempted in 26/211 (12%) patients at a mean 42.9 days. There were 9 failures (all OptEase) due to: inability to snare the hook (n=5), noncollapsible IVCF (n=3), and unusual procedural pain (n=1). Median duration ... Read more >>

Clin Imaging (Clinical imaging)
[2016, 40(5):931-935]

Cited: 1 time

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Circumferential Aortic Endarterectomy Followed with Immediate Infrarenal Clamping Obviates Suprarenal Clamping for Juxtarenal Aortoiliac Occlusion.

Frank B Pearce, Shu Yang, Runhua Shi, Tze-Woei Tan, Wayne W Zhang,

<h4>Background</h4>Traditional open surgery for juxtarenal aortoiliac occlusive disease (AIOD) requires suprarenal aortic cross-clamping (SRCC), which is associated with high incidence of acute kidney injury (AKI). This study was to compare the outcomes of circumferential aortic endarterectomy followed by immediate infrarenal cross-clamping (IRCC) with the traditional approach of SRCC during surgery ... Read more >>

Ann Vasc Surg (Annals of vascular surgery)
[2016, 34:48-54]

Cited: 0 times

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Predictors of Survival in Acute Myeloid Leukemia by Treatment Modality.

Samip Master, Richard Mansour, Srinivas S Devarakonda, Zhenzhen Shi, Glenn Mills, Runhua Shi,

<h4>Background/aim</h4>Evaluations of efficacy of treatment modality in analyses on patients with acute myeloid leukemia (AML) often combine chemotherapy and stem cell transplantation (SCT). To account for the effect of SCT and determine the impact of chemotherapy alone, the National Cancer Data Base from 1998-2011 was analyzed.<h4>Patients and methods</h4>Patients with AML ... Read more >>

Anticancer Res (Anticancer research)
[2016, 36(4):1719-1727]

Cited: 6 times

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