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Author Ruisong Ye

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Human GPRC6A Mediates Testosterone-Induced Mitogen-Activated Protein Kinases and mTORC1 Signaling in Prostate Cancer Cells.

Ruisong Ye, Min Pi, Mohammed M Nooh, Suleiman W Bahout, L Darryl Quarles,

G protein-coupled receptor family C group 6 member A (GPRC6A) is activated by testosterone and modulates prostate cancer progression. Most humans have a GPRC6A variant that contains a recently evolved KGKY insertion/deletion in the third intracellular loop (ICL3) (designated as GPRC6AICL3_KGKY) that replaces the ancestral KGRKLP sequence (GPRC6AICL3_RKLP) present in ... Read more >>

Mol. Pharmacol. (Molecular pharmacology)
[2019, 95(5):563-572]

Cited: 0 times

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Cardiovascular Interactions between Fibroblast Growth Factor-23 and Angiotensin II.

Min Pi, Ruisong Ye, Xiaobin Han, Benjamin Armstrong, Xue Liu, Yuanjian Chen, Yao Sun, L Darryl Quarles,

Both the activation of the renin angiotensin aldosterone system (RAAS) and elevations of circulating Fibroblast Growth Factor-23 (FGF-23) have been implicated in the pathogenesis of left ventricular hypertrophy (LVH) in chronic kidney disease. To investigate potential cross-talk between RAAS and FGF-23, we administered angiotensin II (Ang II) to wild-type rodents ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):12398]

Cited: 3 times

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GPCR6A Is a Molecular Target for the Natural Products Gallate and EGCG in Green Tea.

Min Pi, Karan Kapoor, Ruisong Ye, Jeremy C Smith, Jerome Baudry, Leigh D Quarles,

SCOPE:The molecular mechanisms whereby gallates in green tea exert metabolic effects are poorly understood. METHODS AND RESULTS:We found that GPRC6A, a multi-ligand-sensing G-protein-coupled receptor that regulates energy metabolism, sex hormone production, and prostate cancer progression, is a target for gallates. Sodium gallate (SG), gallic acid (GA) > ethyl gallate (EG) ... Read more >>

Mol Nutr Food Res (Molecular nutrition & food research)
[2018, 62(8):e1700770]

Cited: 1 time

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CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model.

Ruisong Ye, Min Pi, John V Cox, Satoru K Nishimoto, L Darryl Quarles,

GPRC6A is implicated in the pathogenesis of prostate cancer, but its role remains uncertain because of a purported tolerant gene variant created by substitution of a K..Y polymorphism in the 3rd intracellular loop (IL) that evolved in the majority of humans and replaces the ancestral RKLP present in 40% of ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2017, 36(1):90]

Cited: 5 times

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Evidence for Osteocalcin Binding and Activation of GPRC6A in β-Cells.

Min Pi, Karan Kapoor, Ruisong Ye, Satoru Kenneth Nishimoto, Jeremy C Smith, Jerome Baudry, Leigh Darryl Quarles,

The possibility that G protein-coupled receptor family C member A (GPRC6A) is the osteocalcin (Ocn)-sensing G protein-coupled receptor that directly regulates pancreatic β-cell functions is controversial. In the current study, we found that Ocn and an Ocn-derived C-terminal hexapeptide directly activate GPRC6A-dependent ERK signaling in vitro. Computational models probe the ... Read more >>

Endocrinology (Endocrinology)
[2016, 157(5):1866-1880]

Cited: 23 times

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Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues.

Min Pi, Karan Kapoor, Yunpeng Wu, Ruisong Ye, Susan E Senogles, Satoru K Nishimoto, Dong-Jin Hwang, Duane D Miller, Ramesh Narayanan, Jeremy C Smith, Jerome Baudry, L Darryl Quarles,

G protein-coupled receptor (GPCR) family C group 6 member A (GPRC6A) is a multiligand GPCR that is activated by cations, L-amino acids, and osteocalcin. GPRC6A plays an important role in the regulation of testosterone (T) production and energy metabolism in mice. T has rapid, transcription-independent (nongenomic) effects that are mediated ... Read more >>

Mol. Endocrinol. (Molecular endocrinology (Baltimore, Md.))
[2015, 29(12):1759-1773]

Cited: 12 times

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