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Author Ruikai Du

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Effects of 60 days of 6 degrees head down bed rest on the composition and function of the human gut microbiota

Zizhong Liu, Yixuan Li, Gui Luo, Haiyun Lan, Pu Chen, Ruikai Du, Gongchao Jing, Lu Liu, Xiaohan Cui, Yongzhi LI, Yanping Han, Jian Xu, Hongwei Zhu, Shukuan Ling, Yingxian Li,

Spaceflight is rigorous and dangerous environment which can negatively affect astronauts’ health and the entire mission. Recently studies showed that the human gut microbiota were enormously affected by spaceflight. The 60 days of 6 degrees head down bed rest(HDBR) experiment provided us with an opportunity to trace the change of ... Read more >>

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Anoctamin 1 controls bone resorption by coupling Cl- channel activation with RANKL-RANK signaling transduction.

Weijia Sun, Shuai Guo, Yuheng Li, JianWei Li, Caizhi Liu, Yafei Chen, Xuzhao Wang, Yingjun Tan, Hua Tian, Cheng Wang, Ruikai Du, Guohui Zhong, Sai Shi, Biao Ma, Chang Qu, Jingxuan Fu, Xiaoyan Jin, Dingsheng Zhao, Yong Zhan, Shukuan Ling, Hailong An, Yingxian Li,

Osteoclast over-activation leads to bone loss and chloride homeostasis is fundamental importance for osteoclast function. The calcium-activated chloride channel Anoctamin 1 (also known as TMEM16A) is an important chloride channel involved in many physiological processes. However, its role in osteoclast remains unresolved. Here, we identified the existence of Anoctamin 1 in ... Read more >>

Nat Commun (Nature communications)
[2022, 13(1):2899]

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