Full Text Journal Articles by
Author Ruchika Goel

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Blood Product (Donor) Noninfectious and Infectious Testing and Modification.

Tania Sarker, Louis M Katz, Evan M Bloch, Ruchika Goel,

Blood transfusion begins with safe donor selection and testing. In the United States, the blood supply and transfusion are highly regulated. Blood transfusion safety is multifaceted, whereby each of the elements of the blood safety value chain, spanning donor recruitment and qualification, to collection, blood processing, testing, transfusion practice, and ... Read more >>

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):579-598]

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Donor genetic and non-genetic factors affecting red blood cell transfusion effectiveness.

Nareg H Roubinian, Sarah E Reese, Hannah Qiao, Colleen Plimier, Fang Fang, Grier P Page, Ritchard G Cable, Brian Custer, Mark T Gladwin, Ruchika Goel, Bob Harris, Jeanne E Hendrickson, Tamir Kanias, Steve Kleinman, Alan E Mast, Steven R Sloan, Bryan R Spencer, Steven L Spitalnik, Michael P Busch, Eldad A Hod,

<h4>Background</h4>Red blood cell (RBC) transfusion effectiveness varies due to donor, component, and recipient factors. Prior studies identified characteristics associated with variation in hemoglobin increments following transfusion. We extended these observations, examining donor genetic and non-genetic factors affecting transfusion effectiveness.<h4>Methods</h4>This is a multicenter retrospective study of 46,705 patients, and 102,043 evaluable ... Read more >>

JCI Insight (JCI insight)
[2021, :]

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Transfusion Practices in Pediatric Cardiac Surgery Requiring Cardiopulmonary Bypass: A Secondary Analysis of a Clinical Database.

Sheila J Hanson, Oliver Karam, Rebecca Birch, Ruchika Goel, Ravi M Patel, Martha Sola-Visner, Bruce S Sachais, Ronald G Hauser, Naomi L C Luban, Jerome Gottschall, Cassandra D Josephson, Jeanne E Hendrickson, Matthew S Karafin, Marianne E Nellis, ,

<h4>Objectives</h4>To describe blood component usage in transfused children with congenital heart disease undergoing cardiopulmonary bypass surgery across perioperative settings and diagnostic categories.<h4>Design</h4>Datasets from U.S. hospitals participating in the National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III were analyzed.<h4>Setting</h4>Inpatient admissions from three U.S. hospitals from 2013 to ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2021, 22(11):978-987]

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Reply.

Ruchika Goel, Joht Singh Chandan, Rasiah Thayakaran, Nicola J Adderley, Krishnarajah Nirantharakumar, Lorraine Harper,

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2021, 73(11):2145-2146]

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Doxycycline-induced acquired haemophilia A.

Ejaz Shah, Calvin Abro, Fawwad Zaidi, Ruchika Goel,

An 80-year-old man with no personal or family history of bleeding, presented to hospital with extensive haematomas and skin bruising after using doxycycline. His basic lab workup was concerning for a coagulopathy with an elevated activated partial thromboplastin time and significant anaemia. Mixing studies and other factor levels were tested ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(10):]

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Blood transfusion trends in the United States: national inpatient sample, 2015 to 2018.

Ruchika Goel, Xianming Zhu, Eshan U Patel, Elizabeth P Crowe, Paul M Ness, Louis M Katz, Evan M Bloch, Aaron A R Tobian,

Blood transfusions are among the most common therapeutic procedures performed in hospitalized patients. This study evaluates contemporary national trends in red blood cell (RBC), plasma, platelet, and cryoprecipitate transfusions. National Inpatient Sample, the largest all-payer inpatient database representing 94% to 97% of the US population, was evaluated from the fourth ... Read more >>

Blood Adv (Blood advances)
[2021, 5(20):4179-4184]

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Recognizing dysfunctional innate and adaptive immune responses contributing to liver damage in patients with cirrhosis.

Ruchika Goel, C E Eapen,

The human host immune system wards off attack by enemy such as viruses by mounting an inflammatory response which may sometimes injure self-tissues. Dysfunctional immune/inflammatory response by the host may affect the functioning of vital organs. The largest number of innate immune cells in the body resides in the liver. ... Read more >>

J Clin Exp Hepatol (Journal of clinical and experimental hepatology)
[2021, :]

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Anti-tumour necrosis factor treatment for the prevention of ischaemic events in patients with deficiency of adenosine deaminase 2 (DADA2).

Samantha Cooray, Ebun Omyinmi, Ying Hong, Charalampia Papadopoulou, Lorraine Harper, Eslam Al-Abadi, Ruchika Goel, Shirish Dubey, Mark Wood, Stephen Jolles, Stefan Berg, Maria Ekelund, Kate Armon, Despina Eleftheriou, Paul A Brogan,

<h4>Objective</h4>To evaluate the impact of anti-Tumour Necrosis Factor-α (anti-TNF) treatment on the occurrence of vasculitic ischaemic events in patients with deficiency of adenosine deaminase 2 (DADA2).<h4>Methods</h4>A retrospective analysis of DADA2 patients referred from six centres to Great Ormond Street Hospital for Children was conducted. Ischaemic events, vasculitic disease activity, biochemical, ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2021, 60(9):4373-4378]

Cited: 2 times

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Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

Ruchika Goel, Marianne E Nellis, Oliver Karam, Sheila J Hanson, Christopher A Tormey, Ravi M Patel, Rebecca Birch, Bruce S Sachais, Martha C Sola-Visner, Ronald G Hauser, Naomi L C Luban, Jerome Gottschall, Cassandra D Josephson, Jeanne E Hendrickson, Matthew S Karafin, ,

<h4>Background</h4>To evaluate transfusion practices in pediatric oncology and hematopoietic stem cell transplant (HSCT) patients.<h4>Study design and methods</h4>This is a multicenter retrospective study of children with oncologic diagnoses treated from 2013 to 2016 at hospitals participating in the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III. Transfusion ... Read more >>

Transfusion (Transfusion)
[2021, 61(9):2589-2600]

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Reply.

Ruchika Goel, Joht Singh Chandan, Rasiah Thayakaran, Nicola J Adderley, Krishnarajah Nirantharakumar, Lorraine Harper,

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2021, 73(10):1948-1950]

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Blood transfusions in gunshot-wound-related emergency department visits and hospitalizations in the United States.

Ruchika Goel, Xianming Zhu, Sarah Makhani, Molly R Petersen, Cassandra D Josephson, Louis M Katz, Beth H Shaz, Richard Austin, Elizabeth P Crowe, Paul M Ness, Eric A Gehrie, Steven M Frank, Evan M Bloch, Aaron A R Tobian,

<h4>Background</h4>The United States (US) leads all high-income countries in gunshot wound (GSW) deaths. However, previous US studies have not evaluated the national blood transfusion utilization patterns in hospitalized GSW patients.<h4>Methods</h4>Data from 2016 to 2017 were analyzed from the Nationwide Emergency Department Sample (NEDS) and Nationwide Inpatient Sample (NIS), the largest ... Read more >>

Transfusion (Transfusion)
[2021, 61(8):2277-2289]

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Rituximab 500 mg 6-monthly infusions is an option in maintenance therapy of ANCA-associated vasculitis.

Ruchika Goel, Matthew Morgan, Dimitrios Chanouzas, Joshua Caplan, Sarah Logan, Lorraine Harper,

Rheumatol Adv Pract (Rheumatology advances in practice)
[2021, 5(2):rkab039]

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Sequential dosing of convalescent COVID-19 plasma with significant temporal clinical improvements in a persistently SARS-COV-2 positive patient.

Noupama Mirihagalle, Priyanka Parajuli, Vidya Sundareshan, Debadoot Saha, Arpan Shah, Francine Chua, Sana Waqar, Vidhya Prakash, Aaron A R Tobian, Evan M Bloch, Louis M Katz, Ruchika Goel,

The current global pandemic, SARS-CoV-2 infection, is still extending across the world affecting millions of lives to the date. While new successful vaccines are available with promising outcomes to minimize the spread and to reduce the severity of the disease, optimal therapeutic options still remain elusive. COVID-19 convalescent plasma (CCP) ... Read more >>

Transfus Apher Sci (Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis)
[2021, 60(5):103180]

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Nailfold capillaroscopy changes associated with anti-RNP antibodies in systemic lupus erythematosus.

Pramod Prahlad Chebbi, Ruchika Goel, J Ramya, M Gowri, ArianeL Herrick, Debashish Danda,

Anti-U1RNP antibody is associated with distinct organ involvement in patients with systemic lupus erythematosus (SLE). Nailfold capillaroscopy (NFC) allows non-invasive assessment of microvascular abnormalities in several connective tissue diseases. The objective of this study is to determine the association of anti-U1RNP antibody with microvascular changes by NFC in RNP-positive SLE ... Read more >>

Rheumatol Int (Rheumatology international)
[2021, :]

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Clinical course of 602 patients with Takayasu's arteritis: comparison between Childhood-onset versus adult onset disease.

Debashish Danda, Ruchika Goel, George Joseph, Sathish T Kumar, Aswin Nair, Raheesh Ravindran, L Jeyaseelan, Peter A Merkel, Peter C Grayson,

<h4>Objectives</h4>To describe the clinical profile of Asian Indian patients with Takayasu's arteritis (TAK) and to compare clinical features and outcome of childhood-onset Takayasu's arteritis (cTAK) with adult-onset TAK (aTAK).<h4>Methods</h4>Data related to clinical features and response to treatment of patients with cTAK (age of onset <16 years) and aTAK from a large ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2021, 60(5):2246-2255]

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Epidemiology of the Use of Hemostatic Agents in Children Supported by Extracorporeal Membrane Oxygenation: A Pediatric Health Information System Database Study.

Marianne E Nellis, Ljiljana V Vasovic, Ruchika Goel, Oliver Karam,

<b>Objectives:</b> Children supported by extracorporeal membrane oxygenation (ECMO) are at high risk of bleeding. Though practitioners often prescribe blood components and/or medications to prevent or treat bleeding, the utilization of these hemostatic measures in children is not well-understood. We sought to evaluate the use of hemostatic blood products (platelet, plasma ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:673613]

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Transfusion practices in a large cohort of hospitalized children.

Marianne E Nellis, Ruchika Goel, Jeanne E Hendrickson, Rebecca Birch, Ravi M Patel, Matthew S Karafin, Sheila J Hanson, Bruce S Sachais, Ronald George Hauser, Naomi L C Luban, Jerome Gottschall, Martha Sola-Visner, Cassandra D Josephson, Oliver Karam, ,

<h4>Background</h4>While previous studies have described the use of blood components in subsets of children, such as the critically ill, little is known about transfusion practices in hospitalized children across all departments and diagnostic categories. We sought to describe the utilization of red blood cell, platelet, plasma, and cryoprecipitate transfusions across ... Read more >>

Transfusion (Transfusion)
[2021, 61(7):2042-2053]

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Variation in Neonatal Transfusion Practice.

Ravi M Patel, Jeanne E Hendrickson, Marianne E Nellis, Rebecca Birch, Ruchika Goel, Oliver Karam, Matthew S Karafin, Sheila J Hanson, Bruce S Sachais, Ronald George Hauser, Naomi L C Luban, Jerome Gottschall, Cassandra D Josephson, Martha Sola-Visner, ,

<h4>Objective</h4>To estimate the incidence of blood product transfusion, including red blood cells, platelets, and plasma, and characterize pretransfusion hematologic values for infants during their initial hospitalization after birth.<h4>Study design</h4>Retrospective cohort study using data from 7 geographically diverse US academic and community hospitals that participated in the National Heart Lung and ... Read more >>

J Pediatr (The Journal of pediatrics)
[2021, 235:92-99.e4]

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Lessons learned in the collection of convalescent plasma during the COVID-19 pandemic.

Silvano Wendel, Kevin Land, Dana V Devine, James Daly, Renée Bazin, Pierre Tiberghien, Cheuk-Kwong Lee, Satyam Arora, Gopal K Patidar, Kamini Khillan, Willem Martin Smid, Hans Vrielink, Adaeze Oreh, Arwa Z Al-Riyami, Salwa Hindawi, Marion Vermeulen, Vernon Louw, Thierry Burnouf, Evan M Bloch, Ruchika Goel, Mary Townsend, Cynthia So-Osman,

<h4>Background</h4>The lack of definitive treatment or preventative options for COVID-19 led many clinicians early on to consider convalescent plasma (CCP) as potentially therapeutic. Regulators, blood centres and hospitals worldwide worked quickly to get CCP to the bedside. Although response was admirable, several areas have been identified to help improve future ... Read more >>

Vox Sang (Vox sanguinis)
[2021, 116(8):872-879]

Cited: 1 time

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ABO blood group and COVID-19: a review on behalf of the ISBT COVID-19 Working Group.

Ruchika Goel, Evan M Bloch, France Pirenne, Arwa Z Al-Riyami, Elizabeth Crowe, Laetitia Dau, Kevin Land, Mary Townsend, Thachil Jecko, Naomi Rahimi-Levene, Gopal Patidar, Cassandra D Josephson, Satyam Arora, Marion Vermeulen, Hans Vrielink, Celina Montemayor, Adaeze Oreh, Salwa Hindawi, Karin van den Berg, Katherine Serrano, Cynthia So-Osman, Erica Wood, Dana V Devine, Steven L Spitalnik, ,

Growing evidence suggests that ABO blood group may play a role in the immunopathogenesis of SARS-CoV-2 infection, with group O individuals less likely to test positive and group A conferring a higher susceptibility to infection and propensity to severe disease. The level of evidence supporting an association between ABO type ... Read more >>

Vox Sang (Vox sanguinis)
[2021, 116(8):849-861]

Cited: 13 times

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The impact of COVID-19 on academic productivity by female physicians and researchers in transfusion medicine.

Tina S Ipe, Ruchika Goel, Lydia Howes, Sara Bakhtary,

<h4>Background</h4>Several studies have highlighted the disparities in gender equity that exist in different medical specialties. The COVID-19 pandemic has further heightened the inequity faced by female physicians as they are challenged by increasing household and childcare duties in addition to their professional responsibilities. Given these hurdles, fewer women than men ... Read more >>

Transfusion (Transfusion)
[2021, 61(6):1690-1693]

Cited: 2 times

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Mycophenolate in idiopathic inflammatory myositis: outcome data of a large South Asian cohort.

Aswin M Nair, John Mathew, Ruchika Goel, Pramod Chebbi, Ashish Jacob Mathew, G Arvind, Bijesh Yadav, Grace Rebekah, John A J Prakash, Debashish Danda,

<h4>Background</h4>Consensus on treatment of idiopathic inflammatory myositis (IIM), particularly with regard to flares and interstitial lung disease (ILD), does not exist. We studied the long-term outcome and treatment response in our large, retrospective cohort of adult South-Asian patients exclusively with IIM.<h4>Methodology</h4>Electronic records of IIM patients satisfying inclusion and exclusion criteria ... Read more >>

Clin Rheumatol (Clinical rheumatology)
[2021, 40(7):2805-2819]

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Cardiovascular and Renal Morbidity in Takayasu Arteritis: A Population-Based Retrospective Cohort Study From the United Kingdom.

Ruchika Goel, Joht Singh Chandan, Rasiah Thayakaran, Nicola J Adderley, Krishnarajah Nirantharakumar, Lorraine Harper,

<h4>Objective</h4>Cardiovascular disease (CVD) is a major complication and cause of mortality in Takayasu arteritis (TAK), but population-based controlled studies from the UK are lacking. We undertook the present study to investigate the frequency of morbidity and mortality related to CVD, as well as to cerebrovascular and kidney disease, among patients ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2021, 73(3):504-511]

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Survey of newborn direct antiglobulin testing practice in United States and Canadian transfusion services.

Elizabeth P Crowe, Ruchika Goel, Jennifer Andrews, Erin K Meyer, Trisha E Wong, Steven R Sloan, Meghan Delaney, Lani Lieberman, Melissa M Cushing,

<h4>Background</h4>We hypothesized that variability in practice exists for newborn immunohematology testing due to lack of consensus guidelines. We report the results of a survey assessing that variability at hospitals in the United States and Canada.<h4>Study design and methods</h4>An AABB Pediatric Subsection working party developed and validated a survey of newborn ... Read more >>

Transfusion (Transfusion)
[2021, 61(4):1080-1092]

Cited: 1 time

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Bacterial contamination of blood products in Africa.

Yembur Ahmad, Anne-Sophie Heroes, Heather A Hume, Mohammed Farouk, Alex Owusu-Ofori, Eric A Gehrie, Ruchika Goel, Paul M Ness, Aaron A R Tobian, Evan M Bloch,

<h4>Background</h4>Bacterial contamination of blood components (notably platelets) remains a leading infectious risk to the blood supply. There has been extensive research in high-income countries to characterize the risk of bacterial contamination along with adoption of strategies to mitigate that risk. By contrast, related data in Africa are lacking.<h4>Study design and ... Read more >>

Transfusion (Transfusion)
[2021, 61(3):767-780]

Cited: 1 time

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